| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PH-797804 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PH-797804_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.237236 |
| TXNRD1 | thioredoxin reductase 1 | 0.20916 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.167433 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.145916 |
| VIM | vimentin | 0.111534 |
| GRAMD1B | GRAM domain containing 1B | 0.0943919 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0889075 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0879559 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0818208 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0799788 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0740076 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0650097 |
| YBX3 | Y box binding protein 3 | 0.0624256 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0584086 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0575374 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0551905 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.053935 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0537973 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0527015 |
| PGK1 | phosphoglycerate kinase 1 | 0.0518758 |
| PTMA | prothymosin, alpha | 0.0504585 |
| RRM2 | ribonucleotide reductase M2 | 0.0502884 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0491679 |
| TPI1 | triosephosphate isomerase 1 | 0.0488254 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0487223 |
| ACTG1 | actin gamma 1 | 0.0466225 |
| ATP11A | ATPase, class VI, type 11A | 0.0456556 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0453819 |
| KRT18 | keratin 18, type I | 0.0449856 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0431255 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0418887 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0418447 |
| UBC | ubiquitin C | 0.0404402 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0403063 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0400806 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0395754 |
| RTN4 | reticulon 4 | 0.0394412 |
| MYL12B | myosin, light chain 12B, regulatory | 0.039394 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0391707 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0391689 |
| TPM3 | tropomyosin 3 | 0.038964 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0383871 |
| RPLP1 | ribosomal protein, large, P1 | 0.0380335 |
| RPL12 | ribosomal protein L12 | 0.0376269 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0373121 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0360563 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0357502 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0356698 |
| RPS4X | ribosomal protein S4, X-linked | 0.0343603 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.03346 |
| RPLP0 | ribosomal protein, large, P0 | 0.0331963 |
| IPO7 | importin 7 | 0.033179 |
| KLF6 | Kruppel-like factor 6 | 0.0329853 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0329229 |
| ENO1 | enolase 1, (alpha) | 0.032884 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0324004 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.032206 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0319328 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0317911 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0312423 |
| CLTC | clathrin, heavy chain (Hc) | 0.0312051 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0310582 |
| SPAG9 | sperm associated antigen 9 | 0.0309798 |
| STC1 | stanniocalcin 1 | 0.0307915 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0307713 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0304261 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0303173 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0299575 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0296754 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0292314 |
| CD164 | CD164 molecule, sialomucin | 0.0290939 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0286654 |
| ADAR | adenosine deaminase, RNA-specific | 0.0281214 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0276285 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0273529 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0271597 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0270665 |
| MKI67 | marker of proliferation Ki-67 | 0.0269333 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0268672 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0268128 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0267102 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0266608 |
| OSMR | oncostatin M receptor | 0.02657 |
| AHNAK | AHNAK nucleoprotein | 0.0261545 |
| TMSB10 | thymosin beta 10 | 0.0260799 |
| TMEM41B | transmembrane protein 41B | 0.0254681 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0250834 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0250779 |
| CAVIN1 | caveolae associated protein 1 | 0.0250007 |
| PHIP | pleckstrin homology domain interacting protein | 0.0249761 |
| RPL23 | ribosomal protein L23 | 0.0248874 |
| RPS3 | ribosomal protein S3 | 0.0247822 |
| RPS8 | ribosomal protein S8 | 0.0247189 |
| SET | SET nuclear proto-oncogene | 0.024658 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0244062 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 0.0242419 |
| B2M | beta-2-microglobulin | 0.0241273 |
| RPS27A | ribosomal protein S27a | 0.0240945 |
| LDHA | lactate dehydrogenase A | 0.0239368 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.023846 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.108914 |
| AFF3 | AF4/FMR2 family, member 3 | -0.063703 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0568897 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0556678 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0533788 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0527103 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0517587 |
| EGR1 | early growth response 1 | -0.0485015 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0469176 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0441806 |
| AEBP2 | AE binding protein 2 | -0.0425348 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0387342 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0385815 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0379552 |
| RYR3 | ryanodine receptor 3 | -0.0372856 |
| ATXN1 | ataxin 1 | -0.0370579 |
| WDR43 | WD repeat domain 43 | -0.0352426 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0341351 |
| EGFR | epidermal growth factor receptor | -0.032668 |
| CCNL1 | cyclin L1 | -0.0324867 |
| GPATCH2L | G patch domain containing 2-like | -0.0317552 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0315347 |
| RSF1 | remodeling and spacing factor 1 | -0.0300747 |
| USP34 | ubiquitin specific peptidase 34 | -0.0299037 |
| RYK | receptor-like tyrosine kinase | -0.0294698 |
| FNDC3B | fibronectin type III domain containing 3B | -0.029203 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0290471 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0281265 |
| RAD51B | RAD51 paralog B | -0.0277649 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0276224 |
| INTS6 | integrator complex subunit 6 | -0.0273154 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0266678 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0261775 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0248068 |
| RBM39 | RNA binding motif protein 39 | -0.0245751 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0244183 |
| FMN1 | formin 1 | -0.0242797 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0240163 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0237469 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0231352 |
| RBM25 | RNA binding motif protein 25 | -0.0225638 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0224216 |
| PRELID2 | PRELI domain containing 2 | -0.0224172 |
| SBF2 | SET binding factor 2 | -0.0222923 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0222155 |
| TAPBP | TAP binding protein (tapasin) | -0.0214827 |
| ZNF292 | zinc finger protein 292 | -0.0213978 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0213451 |
| IGF2 | insulin-like growth factor 2 | -0.0211206 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0206573 |
| HMGA2 | high mobility group AT-hook 2 | -0.0197747 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0194325 |
| PTK2 | protein tyrosine kinase 2 | -0.0192276 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.019126 |
| COPA | coatomer protein complex, subunit alpha | -0.0187293 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0187027 |
| ZNF207 | zinc finger protein 207 | -0.0186955 |
| ZNF407 | zinc finger protein 407 | -0.0186684 |
| SEM1 | SEM1 26S proteasome subunit | -0.0186039 |
| PFN1 | profilin 1 | -0.0185206 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0183513 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0182889 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0181907 |
| PPHLN1 | periphilin 1 | -0.017856 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0176498 |
| FNIP1 | folliculin interacting protein 1 | -0.0176317 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0176214 |
| PHF21A | PHD finger protein 21A | -0.0176196 |
| PRPF3 | pre-mRNA processing factor 3 | -0.0174685 |
| NEK10 | NIMA-related kinase 10 | -0.0174353 |
| MEF2D | myocyte enhancer factor 2D | -0.0173199 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0172976 |
| TFG | TRK-fused gene | -0.0172815 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0169416 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0168225 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0168157 |
| HDAC8 | histone deacetylase 8 | -0.016815 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0166418 |
| MTERF1 | mitochondrial transcription termination factor 1 | -0.016332 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0162468 |
| NOTCH2 | notch 2 | -0.0160904 |
| NDRG1 | N-myc downstream regulated 1 | -0.0158508 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0155535 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.0154027 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0153679 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0153501 |
| FOXJ3 | forkhead box J3 | -0.0153104 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0152652 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.014999 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0148822 |
| AGRN | agrin | -0.0148352 |
| FAM193A | family with sequence similarity 193, member A | -0.0147795 |
| KAZN | kazrin, periplakin interacting protein | -0.0147762 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0147402 |
| POTEF | POTE ankyrin domain family, member F | -0.0147396 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0147264 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0146834 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0145211 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0141613 |
| DIAPH2 | diaphanous-related formin 2 | -0.0141003 |
