PH-797804_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PH-797804_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.156117
VIM vimentin 0.155575
TMSB10 thymosin beta 10 0.114764
CXCL8 chemokine (C-X-C motif) ligand 8 0.0714719
B2M beta-2-microglobulin 0.0659387
CALR calreticulin 0.0648743
TGFBI transforming growth factor, beta-induced, 68kDa 0.0608941
ENO1 enolase 1, (alpha) 0.059382
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0583665
IGFBP3 insulin-like growth factor binding protein 3 0.0578783
TIMP3 TIMP metallopeptidase inhibitor 3 0.0545634
IL6 interleukin 6 0.0522648
TPT1 tumor protein, translationally-controlled 1 0.0490911
NDRG1 N-myc downstream regulated 1 0.0488394
RPL37A ribosomal protein L37a 0.0486226
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0485459
HLA-B major histocompatibility complex, class I, B 0.0459624
RPS8 ribosomal protein S8 0.0454725
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0438481
LDHA lactate dehydrogenase A 0.0432119
RPS12 ribosomal protein S12 0.0396856
KYNU kynureninase 0.0357436
RPS3 ribosomal protein S3 0.0343933
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0338176
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0330858
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0330779
RPS6 ribosomal protein S6 0.0330769
ASPH aspartate beta-hydroxylase 0.0315487
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0309632
PSD3 pleckstrin and Sec7 domain containing 3 0.0305857
PTK2 protein tyrosine kinase 2 0.0302576
FTL ferritin, light polypeptide 0.0299921
PTMA prothymosin, alpha 0.0296415
EXT1 exostosin glycosyltransferase 1 0.0290621
MYH9 myosin, heavy chain 9, non-muscle 0.0288522
ZSWIM6 zinc finger, SWIM-type containing 6 0.0283161
RPLP1 ribosomal protein, large, P1 0.0282779
TRIO trio Rho guanine nucleotide exchange factor 0.0279774
LOC102724023 ES1 protein homolog, mitochondrial 0.0279604
PDIA6 protein disulfide isomerase family A, member 6 0.0279412
CD44 CD44 molecule (Indian blood group) 0.0268098
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0267245
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0264104
AKAP12 A kinase (PRKA) anchor protein 12 0.0263558
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0263512
SOD2 superoxide dismutase 2, mitochondrial 0.0254981
FNDC3A fibronectin type III domain containing 3A 0.0254547
RPS19 ribosomal protein S19 0.0249463
FNDC3B fibronectin type III domain containing 3B 0.0243231
RPL35A ribosomal protein L35a 0.0242185
RPL23 ribosomal protein L23 0.0242125
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0241315
ATXN1 ataxin 1 0.0236791
RACK1 receptor for activated C kinase 1 0.0234368
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0234355
ADM adrenomedullin 0.0233384
EXOC4 exocyst complex component 4 0.0229322
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0226468
LMNA lamin A/C 0.0220644
VEGFC vascular endothelial growth factor C 0.022011
RPLP2 ribosomal protein, large, P2 0.0217971
DSCAM Down syndrome cell adhesion molecule 0.0217068
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0217048
FMNL2 formin-like 2 0.0213547
RPS27 ribosomal protein S27 0.0213151
VDAC1 voltage-dependent anion channel 1 0.021277
MSN moesin 0.0212028
WSB1 WD repeat and SOCS box containing 1 0.0210546
PHF14 PHD finger protein 14 0.0206969
LMO7 LIM domain 7 0.0206071
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0205487
RAD51B RAD51 paralog B 0.020165
BTBD9 BTB (POZ) domain containing 9 0.0200337
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0197966
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0197932
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0196948
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0195085
S100A6 S100 calcium binding protein A6 0.0193768
NAP1L1 nucleosome assembly protein 1-like 1 0.0192948
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0192028
RPL26 ribosomal protein L26 0.0190534
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0189693
RNF213 ring finger protein 213 0.0185885
RPL9 ribosomal protein L9 0.0185857
GOLGB1 golgin B1 0.0185488
SAMD4A sterile alpha motif domain containing 4A 0.0185013
MAGT1 magnesium transporter 1 0.018468
RPS25 ribosomal protein S25 0.0184313
ITGAV integrin, alpha V 0.0181043
ENO2 enolase 2 (gamma, neuronal) 0.0178117
ALCAM activated leukocyte cell adhesion molecule 0.0176629
RPS27A ribosomal protein S27a 0.0173722
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.017365
ESYT2 extended synaptotagmin-like protein 2 0.0173331
COG6 component of oligomeric golgi complex 6 0.0170936
RPL19 ribosomal protein L19 0.017028
HDAC9 histone deacetylase 9 0.0170243
MACF1 microtubule-actin crosslinking factor 1 0.0169908
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0168685
CALD1 caldesmon 1 0.0167282

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0638568
ELL2 elongation factor, RNA polymerase II, 2 -0.0579513
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0497262
COL6A3 collagen, type VI, alpha 3 -0.0410771
HOOK2 hook microtubule-tethering protein 2 -0.0368349
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0324172
COL1A2 collagen, type I, alpha 2 -0.0320266
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0262583
COL1A1 collagen, type I, alpha 1 -0.0253122
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0253112
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0226298
ATP13A3 ATPase type 13A3 -0.0225163
LOX lysyl oxidase -0.0215126
TM4SF1 transmembrane 4 L six family member 1 -0.0210475
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.020934
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0209041
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0205034
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0200879
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0189628
TXNIP thioredoxin interacting protein -0.0186547
FUS FUS RNA binding protein -0.0182548
FTH1 ferritin, heavy polypeptide 1 -0.0182207
HDLBP high density lipoprotein binding protein -0.017132
NAMPT nicotinamide phosphoribosyltransferase -0.017123
COL6A2 collagen, type VI, alpha 2 -0.0170202
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0166666
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0164641
ANXA2 annexin A2 -0.0163612
LMAN1 lectin, mannose-binding, 1 -0.0163404
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0163292
KCTD9 potassium channel tetramerization domain containing 9 -0.0159627
SRP54 signal recognition particle 54kDa -0.0159471
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0155898
CAV1 caveolin 1, caveolae protein, 22kDa -0.0153773
ARF1 ADP-ribosylation factor 1 -0.0151115
FAM13A family with sequence similarity 13, member A -0.0148335
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0145339
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0145272
FUBP1 far upstream element (FUSE) binding protein 1 -0.0145063
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0144458
UBE2H ubiquitin-conjugating enzyme E2H -0.0144144
EMP1 epithelial membrane protein 1 -0.0140758
SSBP2 single-stranded DNA binding protein 2 -0.0137016
OSBPL9 oxysterol binding protein-like 9 -0.0135532
NT5C2 5'-nucleotidase, cytosolic II -0.0135175
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0135113
LOC112694756 uncharaterized LOC112694756 -0.0131662
COL4A2 collagen, type IV, alpha 2 -0.0131581
CTSB cathepsin B -0.013133
ANKRD33B ankyrin repeat domain 33B -0.0130721
THY1 Thy-1 cell surface antigen -0.012942
KMT2E lysine (K)-specific methyltransferase 2E -0.0126837
SAR1A secretion associated, Ras related GTPase 1A -0.0126253
NOP58 NOP58 ribonucleoprotein -0.0124983
SCFD2 sec1 family domain containing 2 -0.0124854
CANX calnexin -0.0124269
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0124258
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0123765
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0123652
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0123127
CAMTA1 calmodulin binding transcription activator 1 -0.012279
CALCOCO2 calcium binding and coiled-coil domain 2 -0.0122569
UBC ubiquitin C -0.0122327
COPB1 coatomer protein complex, subunit beta 1 -0.0121435
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0119864
LAMA4 laminin, alpha 4 -0.011974
DPYD dihydropyrimidine dehydrogenase -0.0119165
MATR3 matrin 3 -0.0118705
TBC1D23 TBC1 domain family, member 23 -0.011829
SSR1 signal sequence receptor, alpha -0.0118286
ATP11B ATPase, class VI, type 11B -0.0117639
DYM dymeclin -0.0117266
ZNF644 zinc finger protein 644 -0.0117082
MARCHF6 membrane associated ring-CH-type finger 6 -0.0116865
SP140L SP140 nuclear body protein-like -0.0115456
NIPBL Nipped-B homolog (Drosophila) -0.0114705
PRRC1 proline-rich coiled-coil 1 -0.0114199
FAM162A family with sequence similarity 162, member A -0.0113155
LMAN2 lectin, mannose-binding 2 -0.0113075
GMPS guanine monphosphate synthase -0.0111834
FGGY FGGY carbohydrate kinase domain containing -0.0111833
TPST1 tyrosylprotein sulfotransferase 1 -0.0111731
LONP2 lon peptidase 2, peroxisomal -0.0110359
BIRC2 baculoviral IAP repeat containing 2 -0.0110314
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0109783
CDK7 cyclin-dependent kinase 7 -0.0108414
VCL vinculin -0.0108343
ACVR1 activin A receptor, type I -0.0108235
XAF1 XIAP associated factor 1 -0.010823
KLHDC10 kelch domain containing 10 -0.0108047
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0107853
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0107455
UBB ubiquitin B -0.0106979
IST1 increased sodium tolerance 1 homolog (yeast) -0.0106766
LIFR leukemia inhibitory factor receptor alpha -0.0105951
MACO1 macoilin 1 -0.0105814
RHEB Ras homolog enriched in brain -0.0105699
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0105685
WTAP Wilms tumor 1 associated protein -0.0105646
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -0.010546