PH-797804_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PH-797804_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.110991
TPT1 tumor protein, translationally-controlled 1 0.0997673
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0782522
MACF1 microtubule-actin crosslinking factor 1 0.0673594
RPS12 ribosomal protein S12 0.0584066
MT2A metallothionein 2A 0.0563347
ATXN1 ataxin 1 0.0552813
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0545145
HMGA2 high mobility group AT-hook 2 0.0492601
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0486638
SMYD3 SET and MYND domain containing 3 0.0484728
FMNL2 formin-like 2 0.046377
SH3KBP1 SH3-domain kinase binding protein 1 0.0451538
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0450732
ZSWIM6 zinc finger, SWIM-type containing 6 0.0448425
SMAD3 SMAD family member 3 0.0444584
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0431249
LDHA lactate dehydrogenase A 0.0430351
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0422056
AHNAK AHNAK nucleoprotein 0.0412017
SVIL supervillin 0.0406414
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0404061
ZFAND3 zinc finger, AN1-type domain 3 0.0390616
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0389602
ANGPTL4 angiopoietin-like 4 0.0387278
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0383969
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0375116
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0362441
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0360683
ANO6 anoctamin 6 0.0353824
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0353125
RPS3 ribosomal protein S3 0.0352986
JARID2 jumonji, AT rich interactive domain 2 0.0337475
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.033387
AKAP13 A kinase (PRKA) anchor protein 13 0.0331657
PGK1 phosphoglycerate kinase 1 0.0327233
AFF4 AF4/FMR2 family, member 4 0.0327072
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0322141
DST dystonin 0.0319472
RPL23 ribosomal protein L23 0.0312192
ASPH aspartate beta-hydroxylase 0.0311992
SLC38A2 solute carrier family 38, member 2 0.031132
SDC4 syndecan 4 0.0305626
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0302477
CD44 CD44 molecule (Indian blood group) 0.0300944
PKM pyruvate kinase, muscle 0.0300724
TMSB10 thymosin beta 10 0.0298262
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0298143
AKAP12 A kinase (PRKA) anchor protein 12 0.0289842
KTN1 kinectin 1 (kinesin receptor) 0.0289375
TPI1 triosephosphate isomerase 1 0.0289081
RPLP1 ribosomal protein, large, P1 0.0288269
JAK1 Janus kinase 1 0.0286801
TIMP1 TIMP metallopeptidase inhibitor 1 0.0286299
HLA-B major histocompatibility complex, class I, B 0.0285967
B2M beta-2-microglobulin 0.0284775
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0281779
AGO3 argonaute RISC catalytic component 3 0.0279861
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0277726
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0275741
LOC112694756 uncharaterized LOC112694756 0.0269635
POTEF POTE ankyrin domain family, member F 0.0268801
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.026574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.026525
EGFR epidermal growth factor receptor 0.0264194
DTNA dystrobrevin, alpha 0.0264125
VIM vimentin 0.0261515
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0259206
RPL37A ribosomal protein L37a 0.025876
RPL31 ribosomal protein L31 0.0255879
LOC102724023 ES1 protein homolog, mitochondrial 0.0253586
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0249558
PRSS23 protease, serine, 23 0.024727
CAVIN1 caveolae associated protein 1 0.0244259
ENO1 enolase 1, (alpha) 0.0243762
MYH9 myosin, heavy chain 9, non-muscle 0.0240611
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0238812
BIRC2 baculoviral IAP repeat containing 2 0.0237603
IER3 immediate early response 3 0.0237254
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0235873
ERBIN erbb2 interacting protein 0.0233809
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.023345
ENO2 enolase 2 (gamma, neuronal) 0.0232911
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0232432
FTL ferritin, light polypeptide 0.0232397
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0231119
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0228861
CYTH1 cytohesin 1 0.0227976
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0227409
GPC5 glypican 5 0.0227095
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0225285
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0224398
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0224351
CAPRIN2 caprin family member 2 0.0224272
EXT1 exostosin glycosyltransferase 1 0.022402
S100A10 S100 calcium binding protein A10 0.0222627
WSB1 WD repeat and SOCS box containing 1 0.02224
BCAR3 breast cancer anti-estrogen resistance 3 0.0222315
SEPTIN9 septin 9 0.0222025
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0219913

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.217556
WAC WW domain containing adaptor with coiled-coil -0.0472706
GNAS GNAS complex locus -0.0469121
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0437478
SETD5 SET domain containing 5 -0.0426152
PUM2 pumilio RNA-binding family member 2 -0.0349948
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0331987
GOLGA4 golgin A4 -0.0329951
HJURP Holliday junction recognition protein -0.0319907
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0302877
PRPF8 pre-mRNA processing factor 8 -0.0298633
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0297491
WDR43 WD repeat domain 43 -0.0296435
HILPDA hypoxia inducible lipid droplet-associated -0.029626
SPAG9 sperm associated antigen 9 -0.0295144
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0291428
GPBP1 GC-rich promoter binding protein 1 -0.0288405
CHD1 chromodomain helicase DNA binding protein 1 -0.0282666
RBM27 RNA binding motif protein 27 -0.0280437
ICAM1 intercellular adhesion molecule 1 -0.0275276
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0273757
NIPBL Nipped-B homolog (Drosophila) -0.0273108
IPO7 importin 7 -0.0269868
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0265227
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0264234
TUBB tubulin, beta class I -0.0257933
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0252057
TAS2R14 taste receptor, type 2, member 14 -0.0251178
THSD4 thrombospondin, type I, domain containing 4 -0.0248389
RPS20 ribosomal protein S20 -0.0246834
GGNBP2 gametogenetin binding protein 2 -0.0240961
ZNF292 zinc finger protein 292 -0.0235971
BSG basigin (Ok blood group) -0.0235536
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0230445
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0226739
WDPCP WD repeat containing planar cell polarity effector -0.0226707
DNER delta/notch-like EGF repeat containing -0.0225778
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0221972
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0221109
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0221103
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0220912
MRE11 MRE11 homolog, double strand break repair nuclease -0.0214938
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0214389
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0212411
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0208823
RAB7A RAB7A, member RAS oncogene family -0.0204677
RPL11 ribosomal protein L11 -0.0195792
KIF5B kinesin family member 5B -0.0193036
MARF1 meiosis regulator and mRNA stability factor 1 -0.0192481
PLCB4 phospholipase C, beta 4 -0.01924
KMT2E lysine (K)-specific methyltransferase 2E -0.0190178
MATR3 matrin 3 -0.0189807
TTK TTK protein kinase -0.0188093
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0187266
RBM25 RNA binding motif protein 25 -0.018644
RPL4 ribosomal protein L4 -0.0185855
ATF6 activating transcription factor 6 -0.0183729
ECT2 epithelial cell transforming 2 -0.0182139
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0181798
PRR11 proline rich 11 -0.0180009
ZNF148 zinc finger protein 148 -0.0179746
MED17 mediator complex subunit 17 -0.0179708
DIAPH3 diaphanous-related formin 3 -0.0179253
TMEM39A transmembrane protein 39A -0.0179033
YBX3 Y box binding protein 3 -0.0178179
GRB2 growth factor receptor-bound protein 2 -0.0178007
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0176784
PAIP2 poly(A) binding protein interacting protein 2 -0.0176542
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -0.0173467
SRRM1 serine/arginine repetitive matrix 1 -0.017332
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0172873
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0171712
EFL1 elongation factor like GTPase 1 -0.0171412
PUM1 pumilio RNA-binding family member 1 -0.016917
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0168529
TCERG1 transcription elongation regulator 1 -0.0168403
RSF1 remodeling and spacing factor 1 -0.0167844
RAP1B RAP1B, member of RAS oncogene family -0.0167639
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.016715
NCKAP1 NCK-associated protein 1 -0.0166183
FBXO42 F-box protein 42 -0.0165663
OSBP oxysterol binding protein -0.0164478
POT1 protection of telomeres 1 -0.0164148
TM9SF2 transmembrane 9 superfamily member 2 -0.0163916
PTBP2 polypyrimidine tract binding protein 2 -0.0163563
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0163514
NCOA6 nuclear receptor coactivator 6 -0.0163365
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0163178
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0162565
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0160741
IST1 increased sodium tolerance 1 homolog (yeast) -0.0160494
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0160153
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0159443
TARS1 threonyl-tRNA synthetase 1 -0.0157133
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0156732
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0156327
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0155409
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.0154544
RACGAP1 Rac GTPase activating protein 1 -0.0153791
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0153582