| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11715767 |
| Similar Terms | |
| Downloads & Tools |
196 proteins with high or low expression in PHA 767491 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP53 | tumor protein p53 | 3.25 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 2.2 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.9 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 1.89 |
| TAGLN | transgelin | 1.37 |
| TPM2 | tropomyosin 2 (beta) | 1.29 |
| GLUL | glutamate-ammonia ligase | 1.24 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 1.23 |
| COL1A1 | collagen, type I, alpha 1 | 1.2 |
| TRIM29 | tripartite motif containing 29 | 1.2 |
| SLC30A5 | solute carrier family 30 (zinc transporter), member 5 | 1.19 |
| CPNE7 | copine VII | 1.01 |
| S100A3 | S100 calcium binding protein A3 | 1.0 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.98 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.96 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.95 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.93 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.92 |
| SELENOW | selenoprotein W | 0.89 |
| HBA1 | hemoglobin, alpha 1 | 0.89 |
| MYO15B | myosin XVB | 0.89 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.89 |
| TMEM205 | transmembrane protein 205 | 0.88 |
| TPM4 | tropomyosin 4 | 0.86 |
| VTN | vitronectin | 0.85 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.85 |
| AXL | AXL receptor tyrosine kinase | 0.84 |
| S100A5 | S100 calcium binding protein A5 | 0.83 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 0.83 |
| MYL9 | myosin, light chain 9, regulatory | 0.83 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.83 |
| PLEK | pleckstrin | 0.82 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | 0.82 |
| ARSD | arylsulfatase D | 0.8 |
| METTL26 | methyltransferase like 26 | 0.78 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 0.78 |
| AOC1 | amine oxidase, copper containing 1 | 0.78 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.78 |
| MGMT | O-6-methylguanine-DNA methyltransferase | 0.77 |
| FGB | fibrinogen beta chain | 0.76 |
| TPM3 | tropomyosin 3 | 0.76 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.76 |
| CD81 | CD81 molecule | 0.75 |
| RHOD | ras homolog family member D | 0.75 |
| UNG | uracil-DNA glycosylase | 0.74 |
| DAP | death-associated protein | 0.74 |
| RPLP1 | ribosomal protein, large, P1 | 0.74 |
| ABHD17A | abhydrolase domain containing 17A | 0.73 |
| CCDC158 | coiled-coil domain containing 158 | 0.72 |
| CRLF1 | cytokine receptor-like factor 1 | 0.71 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | 0.71 |
| CARD19 | caspase recruitment domain family member 19 | 0.71 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.71 |
| GSTO2 | glutathione S-transferase omega 2 | 0.7 |
| CSNK1G2 | casein kinase 1, gamma 2 | 0.7 |
| FN1 | fibronectin 1 | 0.7 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.7 |
| RPLP2 | ribosomal protein, large, P2 | 0.69 |
| HSBP1 | heat shock factor binding protein 1 | 0.69 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | 0.69 |
| MRPS18C | mitochondrial ribosomal protein S18C | 0.69 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.69 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 | 0.68 |
| DSTN | destrin (actin depolymerizing factor) | 0.68 |
| PTDSS1 | phosphatidylserine synthase 1 | 0.68 |
| ADIRF | adipogenesis regulatory factor | 0.68 |
| MXRA7 | matrix-remodelling associated 7 | 0.68 |
| SLC38A5 | solute carrier family 38, member 5 | 0.67 |
| TMOD2 | tropomodulin 2 (neuronal) | 0.67 |
| DYSF | dysferlin | 0.67 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | 0.66 |
| ABCB11 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | 0.66 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.66 |
| COMTD1 | catechol-O-methyltransferase domain containing 1 | 0.66 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.65 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.65 |
| TGM2 | transglutaminase 2 | 0.64 |
| FHIT | fragile histidine triad | 0.64 |
| TK1 | thymidine kinase 1, soluble | 0.63 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | 0.63 |
| GPX4 | glutathione peroxidase 4 | 0.63 |
| TAGLN2 | transgelin 2 | 0.63 |
| HEXD | hexosaminidase D | 0.62 |
| PLCD3 | phospholipase C, delta 3 | 0.62 |
| CD320 | CD320 molecule | 0.61 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.61 |
| ASS1 | argininosuccinate synthase 1 | 0.61 |
| MOSPD3 | motile sperm domain containing 3 | 0.61 |
| EML3 | echinoderm microtubule associated protein like 3 | 0.61 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.61 |
| SARDH | sarcosine dehydrogenase | 0.6 |
| SUSD2 | sushi domain containing 2 | 0.6 |
| MT-CO2 | cytochrome c oxidase subunit II | 0.6 |
| STMN1 | stathmin 1 | 0.6 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.6 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.59 |
| CDC37 | cell division cycle 37 | 0.59 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RTL6 | retrotransposon Gag like 6 | -4.21 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -3.56 |
| SOX4 | SRY (sex determining region Y)-box 4 | -3.53 |
| DEPDC1 | DEP domain containing 1 | -3.52 |
| IER2 | immediate early response 2 | -3.24 |
| TULP3 | tubby like protein 3 | -3.24 |
| PHF13 | PHD finger protein 13 | -3.22 |
| HES1 | hes family bHLH transcription factor 1 | -3.17 |
| CDCA4 | cell division cycle associated 4 | -3.15 |
| FAM110A | family with sequence similarity 110, member A | -3.15 |
| DUSP5 | dual specificity phosphatase 5 | -3.14 |
| TOB1 | transducer of ERBB2, 1 | -3.12 |
| TGIF1 | TGFB-induced factor homeobox 1 | -3.11 |
| AKIRIN2 | akirin 2 | -3.11 |
| AREG | amphiregulin | -3.1 |
| FYTTD1 | forty-two-three domain containing 1 | -3.02 |
| STK17A | serine/threonine kinase 17a | -3.02 |
| DBF4 | DBF4 zinc finger | -2.99 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -2.94 |
| SYTL3 | synaptotagmin-like 3 | -2.85 |
| ANGPTL4 | angiopoietin-like 4 | -2.83 |
| BMP4 | bone morphogenetic protein 4 | -2.81 |
| TIPE1 | TNF alpha induced protein 8 like 1 | -2.8 |
| AUNIP | aurora kinase A and ninein interacting protein | -2.79 |
| KLF10 | Kruppel-like factor 10 | -2.78 |
| CDCA7 | cell division cycle associated 7 | -2.75 |
| RIBC2 | RIB43A domain with coiled-coils 2 | -2.75 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -2.74 |
| CDC7 | cell division cycle 7 | -2.73 |
| LYPD3 | LY6/PLAUR domain containing 3 | -2.72 |
| C6ORF141 | chromosome 6 open reading frame 141 | -2.72 |
| ENKD1 | enkurin domain containing 1 | -2.7 |
| JAG1 | jagged 1 | -2.69 |
| ZNF526 | zinc finger protein 526 | -2.69 |
| CHTOP | chromatin target of PRMT1 | -2.69 |
| ZNF770 | zinc finger protein 770 | -2.68 |
| C5ORF34 | chromosome 5 open reading frame 34 | -2.68 |
| REST | RE1-silencing transcription factor | -2.68 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -2.67 |
| PER2 | period circadian clock 2 | -2.66 |
| ZNF749 | zinc finger protein 749 | -2.66 |
| MID1IP1 | MID1 interacting protein 1 | -2.59 |
| FEM1A | fem-1 homolog a (C. elegans) | -2.59 |
| FAM207A | family with sequence similarity 207, member A | -2.58 |
| POLDIP3 | polymerase (DNA-directed), delta interacting protein 3 | -2.57 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -2.53 |
| LNX2 | ligand of numb-protein X 2 | -2.53 |
| FEM1C | fem-1 homolog c (C. elegans) | -2.53 |
| AMD1 | adenosylmethionine decarboxylase 1 | -2.51 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -2.51 |
| ATMIN | ATM interactor | -2.5 |
| FBXO46 | F-box protein 46 | -2.49 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -2.49 |
| PRF1 | perforin 1 (pore forming protein) | -2.49 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | -2.49 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.48 |
| SGO2 | shugoshin 2 | -2.46 |
| MLPH | melanophilin | -2.46 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -2.44 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -2.44 |
| PRR3 | proline rich 3 | -2.43 |
| ZIC2 | Zic family member 2 | -2.42 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -2.41 |
| CCDC59 | coiled-coil domain containing 59 | -2.39 |
| RPF1 | ribosome production factor 1 homolog (S. cerevisiae) | -2.37 |
| ZNF302 | zinc finger protein 302 | -2.36 |
| PRELID3B | PRELI domain containing 3B | -2.36 |
| TMEM189 | transmembrane protein 189 | -2.34 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -2.34 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -2.34 |
| KLF2 | Kruppel-like factor 2 | -2.32 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -2.32 |
| CDC25B | cell division cycle 25B | -2.31 |
| GGNBP2 | gametogenetin binding protein 2 | -2.31 |
| CDC6 | cell division cycle 6 | -2.31 |
| MT2A | metallothionein 2A | -2.29 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -2.29 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -2.28 |
| UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | -2.28 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | -2.28 |
| ZNF395 | zinc finger protein 395 | -2.27 |
| TRIB1 | tribbles pseudokinase 1 | -2.25 |
| GMNN | geminin, DNA replication inhibitor | -2.24 |
| KDM4B | lysine (K)-specific demethylase 4B | -2.24 |
| SCAND1 | SCAN domain containing 1 | -2.24 |
| MCL1 | myeloid cell leukemia 1 | -2.23 |
| SURF6 | surfeit 6 | -2.22 |
| TNS4 | tensin 4 | -2.21 |
| ARHGAP11A | Rho GTPase activating protein 11A | -2.2 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -2.2 |
| WSB1 | WD repeat and SOCS box containing 1 | -2.19 |
| SPATA2L | spermatogenesis associated 2-like | -2.18 |
| SMAD1 | SMAD family member 1 | -2.17 |
| CCDC137 | coiled-coil domain containing 137 | -2.15 |
| STIL | SCL/TAL1 interrupting locus | -2.15 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | -2.13 |
| IRX4 | iroquois homeobox 4 | -2.1 |
| C19ORF44 | chromosome 19 open reading frame 44 | -2.06 |
| RESF1 | retroelement silencing factor 1 | -2.06 |
