PHA-00745360-4381 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PHA-00745360-4381 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ADCK4 aarF domain containing kinase 4
AFF2 AF4/FMR2 family, member 2
ALDOB aldolase B, fructose-bisphosphate
AP3B2 adaptor-related protein complex 3, beta 2 subunit
APOC1 apolipoprotein C-I
ARHGAP24 Rho GTPase activating protein 24
ART1 ADP-ribosyltransferase 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF7IP activating transcription factor 7 interacting protein
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BLK BLK proto-oncogene, Src family tyrosine kinase
C17ORF53 chromosome 17 open reading frame 53
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CD58 CD58 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLTA clathrin, light chain A
CPEB3 cytoplasmic polyadenylation element binding protein 3
ECM1 extracellular matrix protein 1
ELN elastin
EMID1 EMI domain containing 1
EN2 engrailed homeobox 2
ERN1 endoplasmic reticulum to nucleus signaling 1
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FBXL7 F-box and leucine-rich repeat protein 7
FOXP3 forkhead box P3
GLIPR1 GLI pathogenesis-related 1
GPATCH4 G patch domain containing 4
GPER1 G protein-coupled estrogen receptor 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HIST1H2AB histone cluster 1, H2ab
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL10 interleukin 10
INO80D INO80 complex subunit D
ITGA9 integrin, alpha 9
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNIP1 Kv channel interacting protein 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KMT2A lysine (K)-specific methyltransferase 2A
LEPR leptin receptor
LIMK1 LIM domain kinase 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP2K5 mitogen-activated protein kinase kinase 5
MR1 major histocompatibility complex, class I-related
MRPL41 mitochondrial ribosomal protein L41
MST1 macrophage stimulating 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NPAT nuclear protein, ataxia-telangiectasia locus
NPY4R neuropeptide Y receptor Y4
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUP54 nucleoporin 54kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAX8 paired box 8
PCDHGA3 protocadherin gamma subfamily A, 3
PLCL1 phospholipase C-like 1
PLVAP plasmalemma vesicle associated protein
POPDC3 popeye domain containing 3
POU4F2 POU class 4 homeobox 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PQLC2 PQ loop repeat containing 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PSG6 pregnancy specific beta-1-glycoprotein 6
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SCN4A sodium channel, voltage gated, type IV alpha subunit
SH3GL3 SH3-domain GRB2-like 3
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SOX15 SRY (sex determining region Y)-box 15
SPDEF SAM pointed domain containing ETS transcription factor
TBX3 T-box 3
TMEM254 transmembrane protein 254
TTC39A tetratricopeptide repeat domain 39A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC5B unc-5 homolog B (C. elegans)
USP22 ubiquitin specific peptidase 22
WSCD1 WSC domain containing 1
XYLB xylulokinase homolog (H. influenzae)
ZER1 zyg-11 related, cell cycle regulator
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF236 zinc finger protein 236
ZNF259P1 zinc finger protein 259 pseudogene 1
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTL8 actin-like 8
ADGRE3 adhesion G protein-coupled receptor E3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
C11ORF63 chromosome 11 open reading frame 63
C8ORF44 chromosome 8 open reading frame 44
CASC1 cancer susceptibility candidate 1
CD70 CD70 molecule
CD8A CD8a molecule
CFHR4 complement factor H-related 4
CIDEB cell death-inducing DFFA-like effector b
CORT cortistatin
CTSF cathepsin F
DNAH17 dynein, axonemal, heavy chain 17
DNASE1L2 deoxyribonuclease I-like 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPYS dihydropyrimidinase
ERC2-IT1 ERC2 intronic transcript 1
EXOC6B exocyst complex component 6B
FGF22 fibroblast growth factor 22
FGL1 fibrinogen-like 1
FSHB follicle stimulating hormone, beta polypeptide
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GATA4 GATA binding protein 4
GFI1 growth factor independent 1 transcription repressor
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR3 G protein-coupled receptor 3
GPRC5D G protein-coupled receptor, class C, group 5, member D
GREB1L growth regulation by estrogen in breast cancer-like
GSTP1 glutathione S-transferase pi 1
HAMP hepcidin antimicrobial peptide
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AI histone cluster 1, H2ai
HOXA4 homeobox A4
HPS6 Hermansky-Pudlak syndrome 6
IDI2-AS1 IDI2 antisense RNA 1
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCTD17 potassium channel tetramerization domain containing 17
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA1462 KIAA1462
LAMA3 laminin, alpha 3
LGALS9 lectin, galactoside-binding, soluble, 9
LINC01587 long intergenic non-protein coding RNA 1587
LONRF3 LON peptidase N-terminal domain and ring finger 3
MMRN2 multimerin 2
MYL5 myosin, light chain 5, regulatory
NNAT neuronatin
NPR3 natriuretic peptide receptor 3
NTF3 neurotrophin 3
OLFML2A olfactomedin-like 2A
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTOR otoraplin
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCDHB3 protocadherin beta 3
PDE8B phosphodiesterase 8B
PLA2G3 phospholipase A2, group III
POM121L2 POM121 transmembrane nucleoporin-like 2
POU3F2 POU class 3 homeobox 2
PROL1 proline rich, lacrimal 1
PRR4 proline rich 4 (lacrimal)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB40C RAB40C, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A7 S100 calcium binding protein A7
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SETBP1 SET binding protein 1
SETD1A SET domain containing 1A
SETD1B SET domain containing 1B
SGCE sarcoglycan, epsilon
SLIT2 slit homolog 2 (Drosophila)
SNTA1 syntrophin, alpha 1
SPRR1B small proline-rich protein 1B
SRPX sushi-repeat containing protein, X-linked
SSTR5 somatostatin receptor 5
STIM1 stromal interaction molecule 1
TCP10 t-complex 10
TEX14 testis expressed 14
TFF2 trefoil factor 2
TLR5 toll-like receptor 5
TM4SF4 transmembrane 4 L six family member 4
TMEM209 transmembrane protein 209
TMEM40 transmembrane protein 40
TMEM8B transmembrane protein 8B
TMPRSS4 transmembrane protease, serine 4
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TSNAXIP1 translin-associated factor X interacting protein 1
VEGFC vascular endothelial growth factor C
VNN2 vanin 2
WDR78 WD repeat domain 78
XAB2 XPA binding protein 2
ZBTB22 zinc finger and BTB domain containing 22
ZC2HC1C zinc finger, C2HC-type containing 1C
ZMAT4 zinc finger, matrin-type 4
ZNF137P zinc finger protein 137, pseudogene
ZNF250 zinc finger protein 250
ZNF639 zinc finger protein 639
Funding