PHA-00767505E-6591 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the PHA-00767505E-6591 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTB actin, beta
ASIC1 acid sensing (proton gated) ion channel 1
ASTN2 astrotactin 2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BBS9 Bardet-Biedl syndrome 9
C14ORF1 chromosome 14 open reading frame 1
C16ORF59 chromosome 16 open reading frame 59
C6ORF62 chromosome 6 open reading frame 62
CCNG2 cyclin G2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
COL6A2 collagen, type VI, alpha 2
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNS cystinosin, lysosomal cystine transporter
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DIAPH1 diaphanous-related formin 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPS8L1 EPS8-like 1
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBLN1 fibulin 1
FH fumarate hydratase
FHL1 four and a half LIM domains 1
FNTB farnesyltransferase, CAAX box, beta
FUS FUS RNA binding protein
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATAD1 GATA zinc finger domain containing 1
GLUL glutamate-ammonia ligase
GMIP GEM interacting protein
GNS glucosamine (N-acetyl)-6-sulfatase
H2AFX H2A histone family, member X
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2AJ histone cluster 1, H2aj
HLA-G major histocompatibility complex, class I, G
HOOK1 hook microtubule-tethering protein 1
IL17RC interleukin 17 receptor C
ITGA10 integrin, alpha 10
LIMK2 LIM domain kinase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
METTL7A methyltransferase like 7A
MPPE1 metallophosphoesterase 1
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NEK2 NIMA-related kinase 2
NFRKB nuclear factor related to kappaB binding protein
NFYC nuclear transcription factor Y, gamma
NMT1 N-myristoyltransferase 1
NOTCH2 notch 2
OCRL oculocerebrorenal syndrome of Lowe
PLAU plasminogen activator, urokinase
PLEC plectin
POGK pogo transposable element with KRAB domain
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PPIF peptidylprolyl isomerase F
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRNP prion protein
PRPF31 pre-mRNA processing factor 31
PRPF4 pre-mRNA processing factor 4
PRUNE prune exopolyphosphatase
PSAT1 phosphoserine aminotransferase 1
PSEN1 presenilin 1
PTBP1 polypyrimidine tract binding protein 1
PTK2 protein tyrosine kinase 2
R3HDM4 R3H domain containing 4
RAB11B RAB11B, member RAS oncogene family
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RALB v-ral simian leukemia viral oncogene homolog B
RBBP4 retinoblastoma binding protein 4
RDX radixin
RNF126P1 ring finger protein 126 pseudogene 1
RNF24 ring finger protein 24
RNFT1 ring finger protein, transmembrane 1
SH3BP2 SH3-domain binding protein 2
SLC43A3 solute carrier family 43, member 3
SMAD3 SMAD family member 3
SMG9 SMG9 nonsense mediated mRNA decay factor
SPAG9 sperm associated antigen 9
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STIP1 stress-induced phosphoprotein 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFCP2 transcription factor CP2
TMED2 transmembrane emp24 domain trafficking protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52L1 tumor protein D52-like 1
TRADD TNFRSF1A-associated via death domain
TRIM29 tripartite motif containing 29
UBA6 ubiquitin-like modifier activating enzyme 6
UNC119 unc-119 homolog (C. elegans)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNK1 WNK lysine deficient protein kinase 1
ZNF324 zinc finger protein 324
ZNF45 zinc finger protein 45

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABHD8 abhydrolase domain containing 8
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARPIN actin-related protein 2/3 complex inhibitor
ATAT1 alpha tubulin acetyltransferase 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANP BTG3 associated nuclear protein
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP4 bone morphogenetic protein 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTBD18 BTB (POZ) domain containing 18
BTC betacellulin
C17ORF62 chromosome 17 open reading frame 62
C1S complement component 1, s subcomponent
C22ORF29 chromosome 22 open reading frame 29
CCNJL cyclin J-like
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CEL carboxyl ester lipase
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COBL cordon-bleu WH2 repeat protein
COL21A1 collagen, type XXI, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CREB5 cAMP responsive element binding protein 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSK cathepsin K
CXORF56 chromosome X open reading frame 56
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTX2 deltex 2, E3 ubiquitin ligase
EFCAB2 EF-hand calcium binding domain 2
ELP6 elongator acetyltransferase complex subunit 6
ERC2-IT1 ERC2 intronic transcript 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXL7 F-box and leucine-rich repeat protein 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLT4 fms-related tyrosine kinase 4
GAS8 growth arrest-specific 8
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GIPR gastric inhibitory polypeptide receptor
GSN-AS1 GSN antisense RNA 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
HOXC5 homeobox C5
HOXC8 homeobox C8
INCENP inner centromere protein antigens 135/155kDa
KLF3 Kruppel-like factor 3 (basic)
KLHDC4 kelch domain containing 4
KRT4 keratin 4, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIFR leukemia inhibitory factor receptor alpha
LMNB1 lamin B1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MEOX1 mesenchyme homeobox 1
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
NEK11 NIMA-related kinase 11
NRTN neurturin
NT5M 5',3'-nucleotidase, mitochondrial
PAIP2B poly(A) binding protein interacting protein 2B
PAQR5 progestin and adipoQ receptor family member V
PDLIM2 PDZ and LIM domain 2 (mystique)
PELP1 proline, glutamate and leucine rich protein 1
PHF14 PHD finger protein 14
PRAMEF11 PRAME family member 11
PRPH peripherin
PRR7 proline rich 7 (synaptic)
PTPRH protein tyrosine phosphatase, receptor type, H
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SF3A2 splicing factor 3a, subunit 2, 66kDa
SIPA1 signal-induced proliferation-associated 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLN sarcolipin
SNHG3 small nucleolar RNA host gene 3
SPATA2L spermatogenesis associated 2-like
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
TMEM183A transmembrane protein 183A
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TSC22D4 TSC22 domain family, member 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WDR25 WD repeat domain 25
XAB2 XPA binding protein 2
ZCCHC2 zinc finger, CCHC domain containing 2
ZFHX2 zinc finger homeobox 2
ZNF137P zinc finger protein 137, pseudogene
ZNF446 zinc finger protein 446