PHA-00851261E-4330 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the PHA-00851261E-4330 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM12 ADAM metallopeptidase domain 12
ADAP2 ArfGAP with dual PH domains 2
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALDOB aldolase B, fructose-bisphosphate
APOD apolipoprotein D
AR androgen receptor
ARTN artemin
ATP10A ATPase, class V, type 10A
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
AVPR1B arginine vasopressin receptor 1B
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CCL27 chemokine (C-C motif) ligand 27
CELA3A chymotrypsin-like elastase family, member 3A
CEP152 centrosomal protein 152kDa
CFAP70 cilia and flagella associated protein 70
CHI3L2 chitinase 3-like 2
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CNTNAP2 contactin associated protein-like 2
COL14A1 collagen, type XIV, alpha 1
COPE coatomer protein complex, subunit epsilon
CRTC1 CREB regulated transcription coactivator 1
CTNS cystinosin, lysosomal cystine transporter
CXXC4 CXXC finger protein 4
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DLC1 DLC1 Rho GTPase activating protein
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EGOT eosinophil granule ontogeny transcript (non-protein coding)
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAAH fatty acid amide hydrolase
FBXO22 F-box protein 22
FGF1 fibroblast growth factor 1 (acidic)
FGFR2 fibroblast growth factor receptor 2
FRMD1 FERM domain containing 1
FRMD8 FERM domain containing 8
G6PC2 glucose-6-phosphatase, catalytic, 2
GK2 glycerol kinase 2
GPR137 G protein-coupled receptor 137
GPRC5D G protein-coupled receptor, class C, group 5, member D
GUCA1B guanylate cyclase activator 1B (retina)
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H4C histone cluster 1, H4c
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
ID2B inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein (pseudogene)
IGFBP5 insulin-like growth factor binding protein 5
IL36G interleukin 36, gamma
IQGAP2 IQ motif containing GTPase activating protein 2
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LDB3 LIM domain binding 3
LGALS8 lectin, galactoside-binding, soluble, 8
LOC157562 uncharacterized LOC157562
LOC390998 ribosomal protein L10 pseudogene
MBD2 methyl-CpG binding domain protein 2
MCHR1 melanin-concentrating hormone receptor 1
MMP10 matrix metallopeptidase 10
MPL MPL proto-oncogene, thrombopoietin receptor
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYRIP myosin VIIA and Rab interacting protein
NFIB nuclear factor I/B
NNAT neuronatin
NOS2 nitric oxide synthase 2, inducible
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFML2A olfactomedin-like 2A
PDIA2 protein disulfide isomerase family A, member 2
PMCH pro-melanin-concentrating hormone
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRDM14 PR domain containing 14
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBM26 RNA binding motif protein 26
RGS7 regulator of G-protein signaling 7
RNF43 ring finger protein 43
RPL3L ribosomal protein L3-like
S100A13 S100 calcium binding protein A13
SARDH sarcosine dehydrogenase
SF1 splicing factor 1
SFRP5 secreted frizzled-related protein 5
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STARD8 StAR-related lipid transfer (START) domain containing 8
TBR1 T-box, brain, 1
THBD thrombomodulin
TMEM206 transmembrane protein 206
TMPRSS3 transmembrane protease, serine 3
TXN thioredoxin
VPREB1 pre-B lymphocyte 1
WIZ widely interspaced zinc finger motifs
ZMYM2 zinc finger, MYM-type 2
ZNF407 zinc finger protein 407
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACIN1 apoptotic chromatin condensation inducer 1
AHDC1 AT hook, DNA binding motif, containing 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARSB arylsulfatase B
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
AXIN1 axin 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAK1 BCL2-antagonist/killer 1
BCL2L2 BCL2-like 2
C1S complement component 1, s subcomponent
C3ORF18 chromosome 3 open reading frame 18
C7ORF43 chromosome 7 open reading frame 43
CBX8 chromobox homolog 8
CLIP2 CAP-GLY domain containing linker protein 2
CNOT3 CCR4-NOT transcription complex, subunit 3
DEPTOR DEP domain containing MTOR-interacting protein
EGR2 early growth response 2
ELP6 elongator acetyltransferase complex subunit 6
EN2 engrailed homeobox 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM102A family with sequence similarity 102, member A
FAM86C1 family with sequence similarity 86, member C1
FBRS fibrosin
FPGS folylpolyglutamate synthase
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMIP GEM interacting protein
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
H1F0 H1 histone family, member 0
HDAC7 histone deacetylase 7
HYAL3 hyaluronoglucosaminidase 3
IGFBP4 insulin-like growth factor binding protein 4
INF2 inverted formin, FH2 and WH2 domain containing
ITK IL2-inducible T-cell kinase
JUP junction plakoglobin
KDM4D lysine (K)-specific demethylase 4D
KLK5 kallikrein-related peptidase 5
LRP2 low density lipoprotein receptor-related protein 2
LRP5 low density lipoprotein receptor-related protein 5
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MUC3A mucin 3A, cell surface associated
MYBBP1A MYB binding protein (P160) 1a
MYLK myosin light chain kinase
MYO19 myosin XIX
NABP2 nucleic acid binding protein 2
NBEAL2 neurobeachin-like 2
NECAP2 NECAP endocytosis associated 2
NKX3-2 NK3 homeobox 2
NTSR1 neurotensin receptor 1 (high affinity)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAX9 paired box 9
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PKM pyruvate kinase, muscle
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPL periplakin
PRICKLE3 prickle homolog 3 (Drosophila)
PRR15L proline rich 15-like
PTK7 protein tyrosine kinase 7 (inactive)
PTPRH protein tyrosine phosphatase, receptor type, H
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB5B RAB5B, member RAS oncogene family
SCAMP4 secretory carrier membrane protein 4
SETD1A SET domain containing 1A
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SMAD7 SMAD family member 7
SND1-IT1 SND1 intronic transcript 1
SOD3 superoxide dismutase 3, extracellular
SSBP3 single stranded DNA binding protein 3
STRN4 striatin, calmodulin binding protein 4
STX1A syntaxin 1A (brain)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TEAD3 TEA domain family member 3
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIPRL TOR signaling pathway regulator
TLN1 talin 1
TMEM8A transmembrane protein 8A
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TOR4A torsin family 4, member A
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC23 tetratricopeptide repeat domain 23
TXLNG taxilin gamma
UNKL unkempt family zinc finger-like
USP21 ubiquitin specific peptidase 21
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VGLL3 vestigial-like family member 3
VWA1 von Willebrand factor A domain containing 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZC3H12A zinc finger CCCH-type containing 12A
ZNF571 zinc finger protein 571