PHC3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description polyhomeotic homolog 3 (Drosophila)| (NCBI Entrez Gene Database, 80012)
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Genes

300 genes differentially expressed following the PHC3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.82962
PRICKLE4 prickle homolog 4 (Drosophila) 2.82962
MAGEA2 melanoma antigen family A2 2.82962
FGL2 fibrinogen-like 2 2.82962
MUC6 mucin 6, oligomeric mucus/gel-forming 2.82962
CELA3A chymotrypsin-like elastase family, member 3A 2.82962
PCDHB7 protocadherin beta 7 2.82962
TMEM244 transmembrane protein 244 2.82962
IQCJ IQ motif containing J 2.82962
APLN apelin 2.82962
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.82962
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.82962
FRMD7 FERM domain containing 7 2.82962
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.82962
COL19A1 collagen, type XIX, alpha 1 2.82962
FOXL1 forkhead box L1 2.82962
FOLR1 folate receptor 1 (adult) 2.82962
AGTR1 angiotensin II receptor, type 1 2.82962
LRRD1 leucine-rich repeats and death domain containing 1 2.82962
CEMP1 cementum protein 1 2.82962
ENAM enamelin 2.82962
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.82962
CD300A CD300a molecule 2.82962
GLRA3 glycine receptor, alpha 3 2.82962
CELA1 chymotrypsin-like elastase family, member 1 2.82962
WNT8A wingless-type MMTV integration site family, member 8A 2.82962
IDUA iduronidase, alpha-L- 2.82962
LBX2 ladybird homeobox 2 2.82962
OR2G6 olfactory receptor, family 2, subfamily G, member 6 2.82962
IL2RG interleukin 2 receptor, gamma 2.82962
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.82962
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.82962
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.82962
PTGFR prostaglandin F receptor (FP) 2.82962
XCL2 chemokine (C motif) ligand 2 2.82962
ASB12 ankyrin repeat and SOCS box containing 12 2.82962
FNDC7 fibronectin type III domain containing 7 2.82962
TUBB1 tubulin, beta 1 class VI 2.82962
RSPO1 R-spondin 1 2.82962
GPR20 G protein-coupled receptor 20 2.82962
ADAD2 adenosine deaminase domain containing 2 2.82962
OTUD6A OTU deubiquitinase 6A 2.82962
BIRC3 baculoviral IAP repeat containing 3 2.82962
SPACA5 sperm acrosome associated 5 2.82962
CIMAP1D CIMAP1 family member D 2.82962
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.82962
GBP4 guanylate binding protein 4 2.82962
C3AR1 complement component 3a receptor 1 2.82962
ZAR1 zygote arrest 1 2.82962
UNC93A unc-93 homolog A (C. elegans) 2.82962
AVPR1B arginine vasopressin receptor 1B 2.82962
DNAAF1 dynein, axonemal, assembly factor 1 2.82962
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.82962
KLB klotho beta 2.82962
H1-6 H1.6 linker histone, cluster member 2.82962
SGO2 shugoshin 2 2.82962
CD8B2 CD8b2 molecule 2.82962
GNG5B G protein subunit gamma 5B 2.82962
C20ORF204 chromosome 20 open reading frame 204 2.82962
SMIM31 small integral membrane protein 31 2.82962
POU2AF2 POU class 2 homeobox associating factor 2 2.82962
TEX55 testis expressed 55 2.82962
CFAP206 cilia and flagella associated protein 206 2.82962
H2BC3 H2B clustered histone 3 2.82962
SPACDR sperm acrosome developmental regulator 2.82962
LY6H lymphocyte antigen 6 complex, locus H 2.82962
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.82962
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.82962
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.82962
ZBTB16 zinc finger and BTB domain containing 16 2.82962
FAM240A family with sequence similarity 240 member A 2.82962
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.82962
PCDHA1 protocadherin alpha 1 2.82962
RAB44 RAB44, member RAS oncogene family 2.82962
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.82962
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.82962
CALCA calcitonin-related polypeptide alpha 2.82962
S100G S100 calcium binding protein G 2.82962
OSTN osteocrin 2.82962
MROH5 maestro heat-like repeat family member 5 2.82962
ASIC4 acid sensing (proton gated) ion channel family member 4 2.82962
LGSN lengsin, lens protein with glutamine synthetase domain 2.82962
TARM1 T cell-interacting, activating receptor on myeloid cells 1 2.82962
SAA1 serum amyloid A1 2.82962
TACR2 tachykinin receptor 2 2.82962
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.82962
GSC goosecoid homeobox 2.82962
ERAS ES cell expressed Ras 2.82962
MAB21L2 mab-21-like 2 (C. elegans) 2.82962
SLC25A52 solute carrier family 25, member 52 2.82962
DES desmin 2.82962
PRSS38 protease, serine, 38 2.82962
PRSS37 protease, serine, 37 2.82962
PENK proenkephalin 2.82962
FIGLA folliculogenesis specific basic helix-loop-helix 2.82962
CA5A carbonic anhydrase VA, mitochondrial 2.82962
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.82962
AGO4 argonaute RISC catalytic component 4 2.82962
FZD1 frizzled class receptor 1 2.82962
PLGLB1 plasminogen-like B1 2.82962
AMER2 APC membrane recruitment protein 2 2.82962
CDH22 cadherin 22, type 2 2.82962
CABP7 calcium binding protein 7 2.82962
DCN decorin 2.82962
ARMCX5 armadillo repeat containing, X-linked 5 2.82962
CHRM4 cholinergic receptor, muscarinic 4 2.82962
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.82962
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.82962
CD244 CD244 molecule, natural killer cell receptor 2B4 2.82962
PAGE4 P antigen family, member 4 (prostate associated) 2.82962
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.82962
MXRA7 matrix-remodelling associated 7 2.82962
TG thyroglobulin 2.82962
RBM24 RNA binding motif protein 24 2.82962
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.82962
ADAM7 ADAM metallopeptidase domain 7 2.82962
C2ORF66 chromosome 2 open reading frame 66 2.82962
TAS2R50 taste receptor, type 2, member 50 2.82962
CRYBB2 crystallin, beta B2 2.82962
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.82962
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.82962
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.82962
FNDC9 fibronectin type III domain containing 9 2.82962
A3GALT2 alpha 1,3-galactosyltransferase 2 2.82962
PCDHGB2 protocadherin gamma subfamily B, 2 2.82962
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.82962
PFN4 profilin family, member 4 2.82962
APOL1 apolipoprotein L, 1 2.82962
NEUROD2 neuronal differentiation 2 2.82962
SFTA2 surfactant associated 2 2.82962
ABRA actin binding Rho activating protein 2.82962
CD209 CD209 molecule 2.82962
GRM6 glutamate receptor, metabotropic 6 2.82962
NPY2R neuropeptide Y receptor Y2 2.82962
SYT5 synaptotagmin V 2.82962
EVI2A ecotropic viral integration site 2A 2.82962
METTL21C methyltransferase like 21C 2.82962
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.82962
PHACTR3 phosphatase and actin regulator 3 2.82962
ITGAD integrin, alpha D 2.82962
ZNF563 zinc finger protein 563 2.82962
EMCN endomucin 2.82962
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.82962
EVPL envoplakin 2.82962
PRR29 proline rich 29 2.82962
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.82962
NLRP9 NLR family, pyrin domain containing 9 2.82962
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.82962
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 2.82962
CD86 CD86 molecule 2.82962
SNTN sentan, cilia apical structure protein 2.82962
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.82962
ADAP1 ArfGAP with dual PH domains 1 2.82962
TM4SF19 transmembrane 4 L six family member 19 2.82962
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.82962
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.82962
GREM1 gremlin 1, DAN family BMP antagonist 2.82962
ADAM21 ADAM metallopeptidase domain 21 2.82962
CLEC18B C-type lectin domain family 18, member B 2.82962
MMEL1 membrane metallo-endopeptidase-like 1 2.82962
ANXA1 annexin A1 2.82962
PLA2G5 phospholipase A2, group V 2.82962
ANGPTL5 angiopoietin-like 5 2.82962
ANGPTL3 angiopoietin-like 3 2.82962
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.82962
CDK3 cyclin-dependent kinase 3 2.76263
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.76263
GLIS1 GLIS family zinc finger 1 2.76263
ANXA6 annexin A6 2.68596
SETD6 SET domain containing 6 2.47127
COLEC12 collectin sub-family member 12 2.47127
OPRM1 opioid receptor, mu 1 2.4089
DNALI1 dynein, axonemal, light intermediate chain 1 2.4089
RGCC regulator of cell cycle 2.4089
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.4089
USP24 ubiquitin specific peptidase 24 2.40372
SERGEF secretion regulating guanine nucleotide exchange factor 2.36012
ZC2HC1B zinc finger, C2HC-type containing 1B 2.33672
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.33218
PHACTR4 phosphatase and actin regulator 4 2.3168
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.29364
SCARB1 scavenger receptor class B, member 1 2.27819
TTC12 tetratricopeptide repeat domain 12 2.27819
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.27104
OTUD6B OTU domain containing 6B 2.26903
ANKHD1 ankyrin repeat and KH domain containing 1 2.22295
DOCK1 dedicator of cytokinesis 1 2.21259
TSLIG1 tRNA splicing ligase complex subunit 1 2.17912
BAD BCL2-associated agonist of cell death 2.15629
RAB11B RAB11B, member RAS oncogene family 2.11742
TCF20 transcription factor 20 (AR1) 2.11139
THSD7B thrombospondin, type I, domain containing 7B 2.1113
WDR45B WD repeat domain 45B 2.08471
ERCC6L2 excision repair cross-complementation group 6-like 2 2.0831
PLPP5 phospholipid phosphatase 5 2.07733
PCCB propionyl CoA carboxylase, beta polypeptide 2.07008
MTNR1A melatonin receptor 1A 2.0605
CYB561D1 cytochrome b561 family, member D1 2.0562
COL25A1 collagen, type XXV, alpha 1 2.02345
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2.01748
PLPP7 phospholipid phosphatase 7 (inactive) 2.01016
NBPF26 neuroblastoma breakpoint family, member 26 2.00112
RORA RAR-related orphan receptor A 2.0006

decreased expression

Symbol Name Standardized Value
LOC114841035 uncharacterized LOC114841035 -2.82962
TRIM17 tripartite motif containing 17 -2.82962
MBLAC1 metallo-beta-lactamase domain containing 1 -2.82962
FAM90A1 family with sequence similarity 90, member A1 -2.82962
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.82962
SKOR2 SKI family transcriptional corepressor 2 -2.82962
COL15A1 collagen, type XV, alpha 1 -2.82962
CRYGN crystallin, gamma N -2.82962
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.82962
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.82962
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.82962
OXER1 oxoeicosanoid (OXE) receptor 1 -2.82962
PRELP proline/arginine-rich end leucine-rich repeat protein -2.82962
NOTO notochord homeobox -2.82962
COX4I1 cytochrome c oxidase subunit IV isoform 1 -2.82962
LINC02762 long intergenic non-protein coding RNA 2762 -2.82962
H3C13 H3 clustered histone 13 -2.82962
AJM1 apical junction component 1 homolog -2.82962
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.82962
CXCL13 chemokine (C-X-C motif) ligand 13 -2.82962
TIMD4 T-cell immunoglobulin and mucin domain containing 4 -2.82962
LECT2 leukocyte cell-derived chemotaxin 2 -2.82962
CD79A CD79a molecule, immunoglobulin-associated alpha -2.82962
OR8D4 olfactory receptor, family 8, subfamily D, member 4 -2.82962
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H -2.82962
SCARA5 scavenger receptor class A, member 5 -2.82962
ANXA9 annexin A9 -2.82962
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 -2.82962
KLHDC1 kelch domain containing 1 -2.82962
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.82962
RNF112 ring finger protein 112 -2.82962
CNR2 cannabinoid receptor 2 (macrophage) -2.82962
RPS21 ribosomal protein S21 -2.82962
RPS27 ribosomal protein S27 -2.82962
C2CD4C C2 calcium-dependent domain containing 4C -2.82962
WFDC1 WAP four-disulfide core domain 1 -2.82962
S100Z S100 calcium binding protein Z -2.82962
SIAH3 siah E3 ubiquitin protein ligase family member 3 -2.82962
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 -2.82962
CRAT carnitine O-acetyltransferase -2.79498
MT1X metallothionein 1X -2.76263
TIMCC TIM double twin CX3C motif chaperone -2.68687
CIDEB cell death-inducing DFFA-like effector b -2.59627
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.59627
C2ORF72 chromosome 2 open reading frame 72 -2.59627
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.59369
HACD4 3-hydroxyacyl-CoA dehydratase 4 -2.56776
MATN4 matrilin 4 -2.50008
TOX4 TOX high mobility group box family member 4 -2.462
FARSA phenylalanyl-tRNA synthetase, alpha subunit -2.43301
PEX13 peroxisomal biogenesis factor 13 -2.40372
CCDC33 coiled-coil domain containing 33 -2.40372
CFAP20 cilia and flagella associated protein 20 -2.40372
MPST mercaptopyruvate sulfurtransferase -2.36619
COPS3 COP9 signalosome subunit 3 -2.35002
TFPI2 tissue factor pathway inhibitor 2 -2.33705
MRPS16 mitochondrial ribosomal protein S16 -2.3168
ZC3H7A zinc finger CCCH-type containing 7A -2.30721
BBS5 Bardet-Biedl syndrome 5 -2.27104
CNR1 cannabinoid receptor 1 (brain) -2.27104
PADI4 peptidyl arginine deiminase, type IV -2.27104
ICAM1 intercellular adhesion molecule 1 -2.27104
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.27104
GRIK5 glutamate receptor, ionotropic, kainate 5 -2.26969
ZNF841 zinc finger protein 841 -2.26027
LEAP2 liver expressed antimicrobial peptide 2 -2.26027
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -2.23785
RPL35A ribosomal protein L35a -2.22269
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F -2.21974
RPUSD1 RNA pseudouridylate synthase domain containing 1 -2.21411
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.21411
SLC16A14 solute carrier family 16, member 14 -2.21411
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.21183
PDAP1 PDGFA associated protein 1 -2.19985
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.17764
C1ORF174 chromosome 1 open reading frame 174 -2.16565
BHMT betaine--homocysteine S-methyltransferase -2.15629
SYPL2 synaptophysin-like 2 -2.15629
TYW2 tRNA wybutosine-synthesizing protein 2 -2.15611
PRX periaxin -2.1508
SH2D2A SH2 domain containing 2A -2.11347
CFAP144 cilia and flagella associated protein 144 -2.1113
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.1113
FAM86B2 family with sequence similarity 86, member B2 -2.1113
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.1113
SH2D3A SH2 domain containing 3A -2.09074
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.08985
XPR1 xenotropic and polytropic retrovirus receptor 1 -2.0867
NOP9 NOP9 nucleolar protein -2.08471
SERP1 stress-associated endoplasmic reticulum protein 1 -2.0831
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.0831
WDR31 WD repeat domain 31 -2.07733
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -2.07733
ARL4A ADP-ribosylation factor-like 4A -2.0562
HDAC6 histone deacetylase 6 -2.05225
LMNB2 lamin B2 -2.02315
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 -2.01006