PHF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PHD finger protein 1|This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (NCBI Entrez Gene Database, 5252)
Similar Terms
Downloads & Tools

Genes

278 genes differentially expressed following the PHF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CCDC177 coiled-coil domain containing 177 2.99647
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.99647
TCEA3 transcription elongation factor A (SII), 3 2.99647
ZC2HC1B zinc finger, C2HC-type containing 1B 2.99647
CNTN6 contactin 6 2.99647
CCDC42 coiled-coil domain containing 42 2.99647
NUPR1 nuclear protein, transcriptional regulator, 1 2.99647
DRD2 dopamine receptor D2 2.99647
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.99647
DIPK1C divergent protein kinase domain 1C 2.99647
FNDC9 fibronectin type III domain containing 9 2.99647
C2ORF78 chromosome 2 open reading frame 78 2.99647
GPR62 G protein-coupled receptor 62 2.99647
PGR progesterone receptor 2.99647
CALCA calcitonin-related polypeptide alpha 2.99647
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.99647
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.99647
MYBPC3 myosin binding protein C, cardiac 2.96607
MAGEB3 melanoma antigen family B3 2.96607
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.96607
PGBDF plakoglobin binding and degradation factor 2.96607
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.96607
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.96607
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.96607
CDH5 cadherin 5, type 2 (vascular endothelium) 2.96607
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.96607
OR5H2 olfactory receptor, family 5, subfamily H, member 2 2.96607
KLF17 Kruppel-like factor 17 2.96607
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.96607
PAX3 paired box 3 2.96607
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.96607
TREML1 triggering receptor expressed on myeloid cells-like 1 2.96607
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.96607
OR52B2 olfactory receptor, family 52, subfamily B, member 2 2.96607
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.96607
RGPD4 RANBP2-like and GRIP domain containing 4 2.96607
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.96607
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.96607
TPSD1 tryptase delta 1 2.96607
ADAMTSL5 ADAMTS-like 5 2.96607
MYOM2 myomesin 2 2.96607
GPR26 G protein-coupled receptor 26 2.96607
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.96607
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.96607
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 2.96607
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.96607
LBX2 ladybird homeobox 2 2.96607
VSX2 visual system homeobox 2 2.96607
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.96607
SPEM1 spermatid maturation 1 2.96607
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.96607
GPR35 G protein-coupled receptor 35 2.96607
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.96607
YIPF2 Yip1 domain family, member 2 2.96607
PPP1R2B PPP1R2 family member B 2.96607
BNIP5 BCL2 interacting protein 5 2.96607
H2BW1 H2B.W histone 1 2.96607
H2BW2 H2B.W histone 2 2.96607
TMEM238L transmembrane protein 238 like 2.96607
SPAAR small regulatory polypeptide of amino acid response 2.96607
CPNE8-AS1 CPNE8 antisense RNA 1 2.96607
PPIAL4H peptidylprolyl isomerase A like 4H 2.96607
FMOD fibromodulin 2.96607
PKD2L1 polycystic kidney disease 2-like 1 2.96607
TBC1D3B TBC1 domain family, member 3B 2.96607
UROC1 urocanate hydratase 1 2.96607
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.96607
OR1R1 olfactory receptor family 1 subfamily R member 1 2.96607
TLR1 toll-like receptor 1 2.96607
KLF18 KLF transcription factor 18 2.96607
TBX3 T-box 3 2.96607
TCF23 transcription factor 23 2.96607
ARMS2 age-related maculopathy susceptibility 2 2.96607
CCR3 chemokine (C-C motif) receptor 3 2.96607
FGFBP2 fibroblast growth factor binding protein 2 2.96607
TAS1R1 taste receptor, type 1, member 1 2.96607
DOK2 docking protein 2, 56kDa 2.96607
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.96607
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.96607
TBC1D3I TBC1 domain family member 3I 2.96607
RORA RAR-related orphan receptor A 2.96607
SMIM23 small integral membrane protein 23 2.96607
C2ORF66 chromosome 2 open reading frame 66 2.96607
MAB21L2 mab-21-like 2 (C. elegans) 2.96607
RNF224 ring finger protein 224 2.96607
APOL4 apolipoprotein L, 4 2.96607
AGXT2 alanine--glyoxylate aminotransferase 2 2.96607
GCM1 glial cells missing homolog 1 (Drosophila) 2.96607
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.96607
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.96607
PATE2 prostate and testis expressed 2 2.96607
NANOGNB NANOG neighbor homeobox 2.96607
TRIP6 thyroid hormone receptor interactor 6 2.96607
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.96607
C18ORF63 chromosome 18 open reading frame 63 2.96607
EFCAB3 EF-hand calcium binding domain 3 2.96607
MC5R melanocortin 5 receptor 2.96607
ADGRA1 adhesion G protein-coupled receptor A1 2.96607
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.96607
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.96607
CHRM4 cholinergic receptor, muscarinic 4 2.96607
DNTT DNA nucleotidylexotransferase 2.96607
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.96607
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.96607
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.96607
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.96607
CASQ2 calsequestrin 2 (cardiac muscle) 2.96607
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.96607
ADAM18 ADAM metallopeptidase domain 18 2.96607
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.96607
TAS2R10 taste receptor, type 2, member 10 2.96607
BTG4 B-cell translocation gene 4 2.96607
CTRB1 chymotrypsinogen B1 2.96607
SPATA31A1 SPATA31 subfamily A, member 1 2.96607
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 2.96607
KLK15 kallikrein-related peptidase 15 2.96607
EPGN epithelial mitogen 2.96607
SPATA9 spermatogenesis associated 9 2.96607
AMIGO3 adhesion molecule with Ig-like domain 3 2.96607
SPINK6 serine peptidase inhibitor, Kazal type 6 2.96607
C8B complement component 8, beta polypeptide 2.96607
GPR61 G protein-coupled receptor 61 2.96607
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.96607
AVP arginine vasopressin 2.96607
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.90867
PADI4 peptidyl arginine deiminase, type IV 2.90867
GOLGB1 golgin B1 2.8816
PHF12 PHD finger protein 12 2.70401
TOB1 transducer of ERBB2, 1 2.66472
GK glycerol kinase 2.65499
TGFBR3L transforming growth factor, beta receptor III-like 2.61544
TSC2 tuberous sclerosis 2 2.60729
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.55052
GSTA4 glutathione S-transferase alpha 4 2.54691
MCM4 minichromosome maintenance complex component 4 2.4904
CCNT1 cyclin T1 2.48117
FBXO38 F-box protein 38 2.47817
DBF4B DBF4 zinc finger B 2.44821
TRO trophinin 2.44092
NRSN1 neurensin 1 2.42643
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.41996
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2.41568
ATXN7L3B ataxin 7-like 3B 2.41385
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.38058
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.37813
C1ORF35 chromosome 1 open reading frame 35 2.37759
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 2.37759
EEF2 eukaryotic translation elongation factor 2 2.36177
TOR1AIP1 torsin A interacting protein 1 2.34544
ZNF404 zinc finger protein 404 2.3135
CCDC50 coiled-coil domain containing 50 2.30157
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 2.2718
MTMR9 myotubularin related protein 9 2.26223
PAX5 paired box 5 2.26223
IL2RA interleukin 2 receptor, alpha 2.21275
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.21275
TMEM263 transmembrane protein 263 2.20979
PTGR3 prostaglandin reductase 3 2.20979
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.20979
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.18431
NEU4 sialidase 4 2.17378
CIRSR corepressor of RBPJ and splicing regulator 2.15819
ZNF337 zinc finger protein 337 2.15819
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.14267
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.1415
USP42 ubiquitin specific peptidase 42 2.13871
GPBP1 GC-rich promoter binding protein 1 2.12965
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.10218
COX17 COX17 cytochrome c oxidase copper chaperone 2.09321
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.08403
MERTK MER proto-oncogene, tyrosine kinase 2.07568
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.06963
AEBP2 AE binding protein 2 2.06953
ZNF532 zinc finger protein 532 2.0592
STX2 syntaxin 2 2.05011
SRFBP1 serum response factor binding protein 1 2.04285
DMAC2L distal membrane arm assembly component 2 like 2.03175
TMEM109 transmembrane protein 109 2.02182
MRPS23 mitochondrial ribosomal protein S23 2.00063

decreased expression

Symbol Name Standardized Value
C11ORF16 chromosome 11 open reading frame 16 -2.99647
DKKL1 dickkopf-like 1 -2.99647
ERFE erythroferrone -2.99647
C17ORF100 chromosome 17 open reading frame 100 -2.99647
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -2.99243
C1ORF162 chromosome 1 open reading frame 162 -2.96607
C6ORF118 chromosome 6 open reading frame 118 -2.96607
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.96607
FRK fyn-related Src family tyrosine kinase -2.96607
LAMP3 lysosomal-associated membrane protein 3 -2.96607
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.96607
FOLR1 folate receptor 1 (adult) -2.96607
ANKRD33 ankyrin repeat domain 33 -2.96607
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.96607
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.96607
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.96607
ASB12 ankyrin repeat and SOCS box containing 12 -2.96607
ADGB androglobin -2.96607
DRP2 dystrophin related protein 2 -2.96607
CD164L2 CD164 sialomucin-like 2 -2.96607
DLX4 distal-less homeobox 4 -2.96607
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.96607
CATSPER3 cation channel, sperm associated 3 -2.96607
CCDC83 coiled-coil domain containing 83 -2.96607
CMKLR1 chemerin chemokine-like receptor 1 -2.96607
PCDHGB1 protocadherin gamma subfamily B, 1 -2.96607
FAM135B family with sequence similarity 135, member B -2.96607
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -2.96607
LRRC25 leucine rich repeat containing 25 -2.96607
PLET1 placenta expressed transcript 1 -2.96607
KLHDC2 kelch domain containing 2 -2.96607
H3-5 H3.5 histone -2.96607
DKK1 dickkopf WNT signaling pathway inhibitor 1 -2.96607
HAO2 hydroxyacid oxidase 2 (long chain) -2.96607
PCDHGB2 protocadherin gamma subfamily B, 2 -2.96607
PRRT1 proline-rich transmembrane protein 1 -2.96607
ACER1 alkaline ceramidase 1 -2.96607
F11 coagulation factor XI -2.9486
CCNYL1 cyclin Y-like 1 -2.75895
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -2.722
NRIP3 nuclear receptor interacting protein 3 -2.67661
ZNF749 zinc finger protein 749 -2.6657
COL16A1 collagen, type XVI, alpha 1 -2.59736
FAM13B family with sequence similarity 13, member B -2.54691
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.53096
LAMB2 laminin, beta 2 (laminin S) -2.52509
FDX2 ferredoxin 2 -2.47136
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 -2.43907
RAB37 RAB37, member RAS oncogene family -2.39473
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.37813
DMKN dermokine -2.36977
C7ORF25 chromosome 7 open reading frame 25 -2.36079
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.35827
MUC1 mucin 1, cell surface associated -2.34544
UBXN2A UBX domain protein 2A -2.28653
FBP1 fructose-1,6-bisphosphatase 1 -2.28562
INO80C INO80 complex subunit C -2.28231
PCDHA9 protocadherin alpha 9 -2.2778
MET MET proto-oncogene, receptor tyrosine kinase -2.26281
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein -2.25845
NR2E3 nuclear receptor subfamily 2, group E, member 3 -2.25377
TET1 tet methylcytosine dioxygenase 1 -2.23569
RNF180 ring finger protein 180 -2.20979
S100A16 S100 calcium binding protein A16 -2.18431
ARHGAP29 Rho GTPase activating protein 29 -2.17484
CBX7 chromobox homolog 7 -2.17484
ATL1 atlastin GTPase 1 -2.17218
RHEB Ras homolog enriched in brain -2.16455
SPINT1 serine peptidase inhibitor, Kunitz type 1 -2.15819
RILPL2 Rab interacting lysosomal protein-like 2 -2.15819
SEC61B Sec61 beta subunit -2.15819
TTYH1 tweety family member 1 -2.15161
PDCD1 programmed cell death 1 -2.14663
RABIF RAB interacting factor -2.14564
CFAP99 cilia and flagella associated protein 99 -2.14093
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -2.14093
ADHFE1 alcohol dehydrogenase, iron containing, 1 -2.11268
CARF calcium responsive transcription factor -2.10218
SYCP2L synaptonemal complex protein 2-like -2.10218
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.09019
THOC1 THO complex 1 -2.08403
GLA galactosidase, alpha -2.08367
SYN1 synapsin I -2.06495
MBLAC1 metallo-beta-lactamase domain containing 1 -2.04396
DYDC1 DPY30 domain containing 1 -2.04396
FRMPD1 FERM and PDZ domain containing 1 -2.04396
SYP synaptophysin -2.04396
KIF12 kinesin family member 12 -2.04396
NGFR nerve growth factor receptor -2.04285
TMEM80 transmembrane protein 80 -2.04285
TJP1 tight junction protein 1 -2.0424
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.04014
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 -2.0316
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.02182
LINGO2 leucine rich repeat and Ig domain containing 2 -2.01111
TMEM204 transmembrane protein 204 -2.0047
ANXA1 annexin A1 -2.0047
H4C11 H4 clustered histone 11 -2.0047
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 -2.0007