PHF2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PHD finger protein 2|This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5253)
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Genes

344 genes differentially expressed following the PHF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NXPE2 neurexophilin and PC-esterase domain family, member 2 2.83291
SELPLG selectin P ligand 2.83291
ALB albumin 2.83291
LAX1 lymphocyte transmembrane adaptor 1 2.83291
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.83291
RXFP2 relaxin/insulin-like family peptide receptor 2 2.83291
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.83291
IGFL3 IGF-like family member 3 2.83291
CABP4 calcium binding protein 4 2.83291
PRELP proline/arginine-rich end leucine-rich repeat protein 2.83291
MGAM2 maltase-glucoamylase 2 (putative) 2.83291
ZACN zinc activated ligand-gated ion channel 2.83291
CD6 CD6 molecule 2.83291
COL20A1 collagen, type XX, alpha 1 2.83291
WDR37 WD repeat domain 37 2.83291
MTNR1B melatonin receptor 1B 2.83291
KLHL30 kelch-like family member 30 2.83291
NKX2-6 NK2 homeobox 6 2.83291
CAPN14 calpain 14 2.83291
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.83291
OR2A2 olfactory receptor, family 2, subfamily A, member 2 2.83291
ISM2 isthmin 2 2.83291
RAET1E retinoic acid early transcript 1E 2.83291
TPBGL trophoblast glycoprotein-like 2.83291
CELA3A chymotrypsin-like elastase family, member 3A 2.83291
CELA3B chymotrypsin-like elastase family, member 3B 2.83291
ARSF arylsulfatase F 2.83291
GFI1 growth factor independent 1 transcription repressor 2.83291
OTUD6A OTU deubiquitinase 6A 2.83291
TMEM89 transmembrane protein 89 2.83291
OC90 otoconin 90 2.83291
S100A5 S100 calcium binding protein A5 2.83291
S100A9 S100 calcium binding protein A9 2.83291
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2.83291
ATOH8 atonal homolog 8 (Drosophila) 2.83291
CAPS calcyphosine 2.83291
PECAM1 platelet/endothelial cell adhesion molecule 1 2.83291
TNIP3 TNFAIP3 interacting protein 3 2.83291
SLC23A3 solute carrier family 23, member 3 2.83291
HGD homogentisate 1,2-dioxygenase 2.83291
HES3 hes family bHLH transcription factor 3 2.83291
NCF1 neutrophil cytosolic factor 1 2.83291
LRRC14B leucine rich repeat containing 14B 2.83291
LMO1 LIM domain only 1 (rhombotin 1) 2.83291
FFAR4 free fatty acid receptor 4 2.83291
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.83291
PAX6 paired box 6 2.83291
XCL1 chemokine (C motif) ligand 1 2.83291
RSPO1 R-spondin 1 2.83291
LGALS4 lectin, galactoside-binding, soluble, 4 2.83291
CHRD chordin 2.83291
DRC5 dynein regulatory complex subunit 5 2.83291
PTH1R parathyroid hormone 1 receptor 2.83291
GBP4 guanylate binding protein 4 2.83291
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.83291
TCERG1L transcription elongation regulator 1-like 2.83291
DNAAF1 dynein, axonemal, assembly factor 1 2.83291
OTOR otoraplin 2.83291
TMPRSS6 transmembrane protease, serine 6 2.83291
TREX2 three prime repair exonuclease 2 2.83291
MYPN myopalladin 2.83291
CFC1 cripto, FRL-1, cryptic family 1 2.83291
SPATS1 spermatogenesis associated, serine-rich 1 2.83291
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.83291
VEGFD vascular endothelial growth factor D 2.83291
GNG14 G protein subunit gamma 14 2.83291
EXOC1L exocyst complex component 1 like 2.83291
REELD1 reeler domain containing 1 2.83291
CD8B2 CD8b2 molecule 2.83291
C20ORF204 chromosome 20 open reading frame 204 2.83291
LY6L lymphocyte antigen 6 family member L 2.83291
H2AB1 H2A.B variant histone 1 2.83291
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.83291
DYNLT4 dynein light chain Tctex-type 4 2.83291
CIROP ciliated left-right organizer metallopeptidase 2.83291
FAM228A family with sequence similarity 228, member A 2.83291
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.83291
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.83291
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.83291
MYH15 myosin, heavy chain 15 2.83291
MYH13 myosin, heavy chain 13, skeletal muscle 2.83291
GZMM granzyme M (lymphocyte met-ase 1) 2.83291
DMBX1 diencephalon/mesencephalon homeobox 1 2.83291
HAPLN2 hyaluronan and proteoglycan link protein 2 2.83291
CXCL16 chemokine (C-X-C motif) ligand 16 2.83291
MSX2 msh homeobox 2 2.83291
CD79A CD79a molecule, immunoglobulin-associated alpha 2.83291
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.83291
CFAP45 cilia and flagella associated protein 45 2.83291
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.83291
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.83291
HNF1A HNF1 homeobox A 2.83291
ACE2 angiotensin I converting enzyme 2 2.83291
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.83291
TAS1R1 taste receptor, type 1, member 1 2.83291
OOSP1 oocyte secreted protein 1, pseudogene 2.83291
MTMR11 myotubularin related protein 11 2.83291
TACR2 tachykinin receptor 2 2.83291
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.83291
CCR4 chemokine (C-C motif) receptor 4 2.83291
VSX2 visual system homeobox 2 2.83291
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.83291
DBX2 developing brain homeobox 2 2.83291
VWA3A von Willebrand factor A domain containing 3A 2.83291
FAM25C family with sequence similarity 25, member C 2.83291
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.83291
NUTM2F NUT family member 2F 2.83291
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.83291
FADS6 fatty acid desaturase 6 2.83291
NR2E1 nuclear receptor subfamily 2, group E, member 1 2.83291
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.83291
MAGEA9B melanoma antigen family A9B 2.83291
C8G complement component 8, gamma polypeptide 2.83291
AQP10 aquaporin 10 2.83291
GLT6D1 glycosyltransferase 6 domain containing 1 2.83291
RERGL RERG/RAS-like 2.83291
LRRC74A leucine rich repeat containing 74A 2.83291
CPA1 carboxypeptidase A1 (pancreatic) 2.83291
DRD5 dopamine receptor D5 2.83291
AGR3 anterior gradient 3 2.83291
FNDC9 fibronectin type III domain containing 9 2.83291
OR5T3 olfactory receptor, family 5, subfamily T, member 3 2.83291
UBQLNL ubiquilin-like 2.83291
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.83291
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 2.83291
CRYBB2 crystallin, beta B2 2.83291
PCDHGB1 protocadherin gamma subfamily B, 1 2.83291
LRRC32 leucine rich repeat containing 32 2.83291
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.83291
CXCR2 chemokine (C-X-C motif) receptor 2 2.83291
CTAGE9 CTAGE family, member 9 2.83291
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.83291
CLEC4C C-type lectin domain family 4, member C 2.83291
POU2AF1 POU class 2 associating factor 1 2.83291
PDCD1 programmed cell death 1 2.83291
STMND1 stathmin domain containing 1 2.83291
TPPP3 tubulin polymerization-promoting protein family member 3 2.83291
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.83291
SPON2 spondin 2, extracellular matrix protein 2.83291
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.83291
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.83291
SH2D1A SH2 domain containing 1A 2.83291
KRTAP10-2 keratin associated protein 10-2 2.83291
PHGR1 proline/histidine/glycine-rich 1 2.83291
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.83291
GOLGA8H golgin A8 family, member H 2.83291
EFS embryonal Fyn-associated substrate 2.83291
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.83291
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.83291
FOXS1 forkhead box S1 2.83291
BRPF3 bromodomain and PHD finger containing, 3 2.83291
SP6 Sp6 transcription factor 2.83291
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.83291
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.83291
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.83291
RNASE6 ribonuclease, RNase A family, k6 2.83291
IRX5 iroquois homeobox 5 2.83291
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.83291
NLRP5 NLR family, pyrin domain containing 5 2.83291
INSM1 insulinoma-associated 1 2.83291
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.83291
PADI6 peptidyl arginine deiminase, type VI 2.83291
ANKRD30B ankyrin repeat domain 30B 2.83291
OR52I2 olfactory receptor, family 52, subfamily I, member 2 2.83291
CD22 CD22 molecule 2.83291
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.83291
DSPP dentin sialophosphoprotein 2.83291
NPR3 natriuretic peptide receptor 3 2.83291
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.83291
CTRB1 chymotrypsinogen B1 2.83291
PLPPR1 phospholipid phosphatase related 1 2.80563
RAD21L1 RAD21-like 1 (S. pombe) 2.80469
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 2.80469
MUC16 mucin 16, cell surface associated 2.80469
HMGB1 high mobility group box 1 2.62461
TRIM39 tripartite motif containing 39 2.62461
DESI1 desumoylating isopeptidase 1 2.55589
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 2.55155
SGO2 shugoshin 2 2.54077
NOL12 nucleolar protein 12 2.48615
S100A10 S100 calcium binding protein A10 2.47743
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.43549
CYTL1 cytokine-like 1 2.41177
LY86 lymphocyte antigen 86 2.39959
MAGIX MAGI family member, X-linked 2.39443
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 2.38088
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.32745
KRT17 keratin 17, type I 2.3266
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.3266
TXNL4A thioredoxin-like 4A 2.32626
MED16 mediator complex subunit 16 2.32626
NECTIN2 nectin cell adhesion molecule 2 2.30937
SIT1 signaling threshold regulating transmembrane adaptor 1 2.30937
ZNF347 zinc finger protein 347 2.30052
MGA MGA, MAX dimerization protein 2.28441
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.28441
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.28053
PTX3 pentraxin 3, long 2.27608
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.2679
PPIA peptidylprolyl isomerase A (cyclophilin A) 2.24373
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.24373
SPATS2L spermatogenesis associated, serine-rich 2-like 2.24322
THAP12 THAP domain containing 12 2.24082
ING5 inhibitor of growth family, member 5 2.24082
SQLE squalene epoxidase 2.23322
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.22292
STK38 serine/threonine kinase 38 2.21703
RPL30 ribosomal protein L30 2.20775
MANBAL mannosidase, beta A, lysosomal-like 2.18858
ZBTB2 zinc finger and BTB domain containing 2 2.18352
TESC tescalcin 2.17763
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 2.16542
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 2.16542
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.15961
CEBPZOS CEBPZ opposite strand 2.15399
THOC7 THO complex 7 2.13996
ZNF689 zinc finger protein 689 2.1375
RPL21 ribosomal protein L21 2.1375
NBDY negative regulator of P-body association 2.1346
CEMIP2 cell migration inducing hyaluronidase 2 2.1346
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.13279
IFT27 intraflagellar transport 27 2.12731
MRPS33 mitochondrial ribosomal protein S33 2.12731
DRC4 dynein regulatory complex subunit 4 2.12108
TMED2 transmembrane emp24 domain trafficking protein 2 2.117
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.11542
MRPL3 mitochondrial ribosomal protein L3 2.10725
FAM110B family with sequence similarity 110, member B 2.09889
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.08149
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.08149
KRT10 keratin 10, type I 2.08149
EDRF1 erythroid differentiation regulatory factor 1 2.08095
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.08041
GAR1 GAR1 ribonucleoprotein 2.06999
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.06505
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 2.06096
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.05618
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.02376
GTPBP3 GTP binding protein 3 (mitochondrial) 2.01174
HMCN1 hemicentin 1 2.00958
EVI5 ecotropic viral integration site 5 2.00834

decreased expression

Symbol Name Standardized Value
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -2.83291
HCST hematopoietic cell signal transducer -2.83291
PF4 platelet factor 4 -2.83291
SCN1B sodium channel, voltage gated, type I beta subunit -2.83291
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.83291
ZNF319 zinc finger protein 319 -2.83291
ADCY2 adenylate cyclase 2 (brain) -2.83291
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.83291
LOC107985101 uncharacterized LOC107985101 -2.83291
IGSF9 immunoglobulin superfamily, member 9 -2.83291
RNF17 ring finger protein 17 -2.80563
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -2.80563
GJA9 gap junction protein, alpha 9, 59kDa -2.80563
CSMD3 CUB and Sushi multiple domains 3 -2.80563
SSTR5 somatostatin receptor 5 -2.80563
EPHB3 EPH receptor B3 -2.80563
DPPA3 developmental pluripotency associated 3 -2.80563
GMNC geminin coiled-coil domain containing -2.80563
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.80563
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.80563
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.80563
NDRG1 N-myc downstream regulated 1 -2.80563
ADIRF adipogenesis regulatory factor -2.80563
LMNTD2 lamin tail domain containing 2 -2.80563
CDKN2A cyclin-dependent kinase inhibitor 2A -2.80563
MIA melanoma inhibitory activity -2.80563
NLGN4X neuroligin 4, X-linked -2.80563
VWA7 von Willebrand factor A domain containing 7 -2.80563
OR8D4 olfactory receptor, family 8, subfamily D, member 4 -2.80563
PCDHB11 protocadherin beta 11 -2.80563
ZNF703 zinc finger protein 703 -2.80563
H2BC3 H2B clustered histone 3 -2.80563
PCDHB14 protocadherin beta 14 -2.80563
LAMA4 laminin, alpha 4 -2.78118
PRMT6 protein arginine methyltransferase 6 -2.75731
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -2.63582
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -2.62294
CCDC172 coiled-coil domain containing 172 -2.60173
SPATA2 spermatogenesis associated 2 -2.59588
NUP107 nucleoporin 107kDa -2.57338
RUNDC3A RUN domain containing 3A -2.56778
CSPG4 chondroitin sulfate proteoglycan 4 -2.56778
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.55589
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 -2.49843
WDR83 WD repeat domain 83 -2.49267
CADM2 cell adhesion molecule 2 -2.47743
DCHS1 dachsous cadherin-related 1 -2.45827
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -2.43549
SLITRK4 SLIT and NTRK-like family, member 4 -2.38235
MED28 mediator complex subunit 28 -2.37902
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.37045
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.34056
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.3259
PTPRS protein tyrosine phosphatase, receptor type, S -2.31955
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.28955
DENND5B DENN/MADD domain containing 5B -2.2679
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide -2.25312
TMX2 thioredoxin-related transmembrane protein 2 -2.25312
CATSPERG catsper channel auxiliary subunit gamma -2.20775
GGT1 gamma-glutamyltransferase 1 -2.20775
RASL11A RAS-like, family 11, member A -2.19495
SOX30 SRY (sex determining region Y)-box 30 -2.19495
AKIP1 A kinase (PRKA) interacting protein 1 -2.18598
PLCH1 phospholipase C, eta 1 -2.17763
NTS neurotensin -2.16542
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.16542
USP47 ubiquitin specific peptidase 47 -2.15399
WIPF3 WAS/WASL interacting protein family, member 3 -2.15399
STK32C serine/threonine kinase 32C -2.13996
CABP1 calcium binding protein 1 -2.13996
BANK1 B-cell scaffold protein with ankyrin repeats 1 -2.13996
TBX6 T-box 6 -2.1375
LOC112694756 uncharaterized LOC112694756 -2.1375
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -2.1375
GLIS1 GLIS family zinc finger 1 -2.1375
ICAM1 intercellular adhesion molecule 1 -2.1375
HIPK1 homeodomain interacting protein kinase 1 -2.1375
TEP1 telomerase-associated protein 1 -2.1346
ELP4 elongator acetyltransferase complex subunit 4 -2.13279
PRSS35 protease, serine, 35 -2.12731
C6ORF62 chromosome 6 open reading frame 62 -2.12731
FMN1 formin 1 -2.11248
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.10725
ZNF615 zinc finger protein 615 -2.10262
RHBDD2 rhomboid domain containing 2 -2.09652
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -2.08149
NBPF11 neuroblastoma breakpoint family, member 11 -2.08149
ZNF799 zinc finger protein 799 -2.06901
ZFP69 ZFP69 zinc finger protein -2.06505
THOP1 thimet oligopeptidase 1 -2.06505
PKDCC protein kinase domain containing, cytoplasmic -2.05941
KIF21B kinesin family member 21B -2.03623
STK3 serine/threonine kinase 3 -2.03588
ZNF814 zinc finger protein 814 -2.03511
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.01859
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.01577
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.01577
PDE8B phosphodiesterase 8B -2.00958
ZNF629 zinc finger protein 629 -2.00958
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -2.00958
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.00834
NIPAL2 NIPA-like domain containing 2 -2.00673
ACER2 alkaline ceramidase 2 -2.0029