PHF21A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PHD finger protein 21A|The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010] (NCBI Entrez Gene Database, 51317)
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Genes

317 genes differentially expressed following the PHF21A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HLF hepatic leukemia factor 2.82669
EPPIN epididymal peptidase inhibitor 2.82669
FOXA2 forkhead box A2 2.82669
HES7 hes family bHLH transcription factor 7 2.82669
NCF1 neutrophil cytosolic factor 1 2.82669
UMOD uromodulin 2.82669
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.82669
PDZD9 PDZ domain containing 9 2.82669
DUSP15 dual specificity phosphatase 15 2.82669
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.82669
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.82669
PRSS41 protease, serine, 41 2.82669
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.82669
CLEC12A C-type lectin domain family 12, member A 2.82669
GPR55 G protein-coupled receptor 55 2.82669
DUXB double homeobox B 2.82669
GNLY granulysin 2.82669
NANOS3 nanos homolog 3 (Drosophila) 2.82669
TRIM15 tripartite motif containing 15 2.82669
MAGEA6 melanoma antigen family A6 2.82669
MGAM2 maltase-glucoamylase 2 (putative) 2.82669
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.82669
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.82669
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.82669
KRT73 keratin 73, type II 2.82669
OXT oxytocin/neurophysin I prepropeptide 2.82669
MMP20 matrix metallopeptidase 20 2.82669
BHMT2 betaine--homocysteine S-methyltransferase 2 2.82669
TRPC5OS TRPC5 opposite strand 2.82669
CAPS calcyphosine 2.82669
CPLX4 complexin 4 2.82669
C2ORF78 chromosome 2 open reading frame 78 2.82669
PRDM8 PR domain containing 8 2.82669
TRIM42 tripartite motif containing 42 2.82669
CLEC5A C-type lectin domain family 5, member A 2.82669
ASB10 ankyrin repeat and SOCS box containing 10 2.82669
NEU4 sialidase 4 2.82669
SHCBP1L SHC SH2-domain binding protein 1-like 2.82669
PECAM1 platelet/endothelial cell adhesion molecule 1 2.82669
SLC39A2 solute carrier family 39 (zinc transporter), member 2 2.82669
SPRR1B small proline-rich protein 1B 2.82669
BHLHE40 basic helix-loop-helix family, member e40 2.82669
TDRD6 tudor domain containing 6 2.82669
RGPD3 RANBP2-like and GRIP domain containing 3 2.82669
LEP leptin 2.82669
ACKR5 atypical chemokine receptor 5 2.82669
HBG2 hemoglobin, gamma G 2.82669
SCEL sciellin 2.82669
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.82669
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.82669
ACER1 alkaline ceramidase 1 2.82669
FMO2 flavin containing monooxygenase 2 (non-functional) 2.82669
PLCZ1 phospholipase C, zeta 1 2.82669
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.82669
IQCF1 IQ motif containing F1 2.82669
CLDN16 claudin 16 2.82669
TMEM275 transmembrane protein 275 2.82669
CIMIP2C ciliary microtubule inner protein 2C 2.82669
DPEP2NB DPEP2 neighbor 2.82669
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.82669
MYMK myomaker, myoblast fusion factor 2.82669
EZHIP EZH inhibitory protein 2.82669
IHO1 interactor of HORMAD1 1 2.82669
CCDC197 coiled-coil domain containing 197 2.82669
ELOA2 elongin A2 2.82669
ERFE erythroferrone 2.82669
MYPN myopalladin 2.82669
F5 coagulation factor V (proaccelerin, labile factor) 2.82669
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.82669
OLAH oleoyl-ACP hydrolase 2.82669
CCDC17 coiled-coil domain containing 17 2.82669
FOXD4 forkhead box D4 2.82669
HHEX hematopoietically expressed homeobox 2.82669
CATSPERH catsper channel auxiliary subunit eta 2.82669
USH1G Usher syndrome 1G (autosomal recessive) 2.82669
COL19A1 collagen, type XIX, alpha 1 2.82669
SRL sarcalumenin 2.82669
SBK3 SH3 domain binding kinase family, member 3 2.82669
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.82669
HAPLN2 hyaluronan and proteoglycan link protein 2 2.82669
LTK leukocyte receptor tyrosine kinase 2.82669
PRG4 proteoglycan 4 2.82669
PLEK2 pleckstrin 2 2.82669
C7 complement component 7 2.82669
GTSF1 gametocyte specific factor 1 2.82669
SAA1 serum amyloid A1 2.82669
GSC goosecoid homeobox 2.82669
PRR18 proline rich 18 2.82669
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.82669
GJA4 gap junction protein, alpha 4, 37kDa 2.82669
ASTL astacin-like metallo-endopeptidase (M12 family) 2.82669
CH25H cholesterol 25-hydroxylase 2.82669
ZSCAN1 zinc finger and SCAN domain containing 1 2.82669
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.82669
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.82669
LRRC46 leucine rich repeat containing 46 2.82669
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.82669
CABP7 calcium binding protein 7 2.82669
GPR62 G protein-coupled receptor 62 2.82669
BCL2L15 BCL2-like 15 2.82669
PSG8 pregnancy specific beta-1-glycoprotein 8 2.82669
KRT17 keratin 17, type I 2.82669
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.82669
SERINC4 serine incorporator 4 2.82669
RORC RAR-related orphan receptor C 2.82669
CLEC1A C-type lectin domain family 1, member A 2.82669
CALML6 calmodulin-like 6 2.82669
AGR2 anterior gradient 2 2.82669
RAD51AP2 RAD51 associated protein 2 2.82669
ADORA3 adenosine A3 receptor 2.82669
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.82669
KLK8 kallikrein-related peptidase 8 2.82669
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.82669
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.82669
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.82669
KLK12 kallikrein-related peptidase 12 2.82669
KLK11 kallikrein-related peptidase 11 2.82669
CTXN2 cortexin 2 2.82669
ZCCHC12 zinc finger, CCHC domain containing 12 2.82669
RGCC regulator of cell cycle 2.82669
COL17A1 collagen, type XVII, alpha 1 2.82669
TTC9B tetratricopeptide repeat domain 9B 2.82669
MAB21L1 mab-21-like 1 (C. elegans) 2.82669
CBX6 chromobox homolog 6 2.82669
SPINK9 serine peptidase inhibitor, Kazal type 9 2.82669
ITGB7 integrin, beta 7 2.82669
ZC3H12D zinc finger CCCH-type containing 12D 2.82669
GML glycosylphosphatidylinositol anchored molecule like 2.82669
MAPK11 mitogen-activated protein kinase 11 2.82669
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.82669
CLCNKB chloride channel, voltage-sensitive Kb 2.82669
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.82669
VAX2 ventral anterior homeobox 2 2.82669
FXYD3 FXYD domain containing ion transport regulator 3 2.82669
WNT4 wingless-type MMTV integration site family, member 4 2.82669
IFITM10 interferon induced transmembrane protein 10 2.82669
ANGPTL5 angiopoietin-like 5 2.82669
OR6B3 olfactory receptor, family 6, subfamily B, member 3 2.82669
ANGPTL3 angiopoietin-like 3 2.82669
MMP13 matrix metallopeptidase 13 2.82669
CD226 CD226 molecule 2.82669
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.82669
TTC36 tetratricopeptide repeat domain 36 2.82669
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.82669
PCDHB9 protocadherin beta 9 2.82669
BCL2A1 BCL2-related protein A1 2.82669
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.82669
GRM6 glutamate receptor, metabotropic 6 2.82669
KCTD14 potassium channel tetramerization domain containing 14 2.82669
ITPKA inositol-trisphosphate 3-kinase A 2.82669
RTN4RL1 reticulon 4 receptor-like 1 2.82669
FGF6 fibroblast growth factor 6 2.82669
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.82669
NNMT nicotinamide N-methyltransferase 2.82669
TYR tyrosinase 2.82669
ITGA8 integrin, alpha 8 2.82669
LRRC74B leucine rich repeat containing 74B 2.82669
TGM6 transglutaminase 6 2.82669
PCDHGA12 protocadherin gamma subfamily A, 12 2.82669
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 2.7818
SPACA9 sperm acrosome associated 9 2.75593
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.75593
TBC1D24 TBC1 domain family, member 24 2.73454
MRPL23 mitochondrial ribosomal protein L23 2.70782
TRIM16 tripartite motif containing 16 2.64663
C17ORF49 chromosome 17 open reading frame 49 2.60808
ZFYVE27 zinc finger, FYVE domain containing 27 2.6069
UBE2D2 ubiquitin-conjugating enzyme E2D 2 2.57539
ZWILCH zwilch kinetochore protein 2.53487
DEAF1 DEAF1 transcription factor 2.51143
PPP1R36 protein phosphatase 1, regulatory subunit 36 2.50994
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.50994
NUSAP1 nucleolar and spindle associated protein 1 2.50237
IQCK IQ motif containing K 2.46545
CAPN6 calpain 6 2.4582
GYS2 glycogen synthase 2 (liver) 2.45077
HASPIN histone H3 associated protein kinase 2.4298
LOC124902694 uncharacterized LOC124902694 2.40438
GPR179 G protein-coupled receptor 179 2.37553
FBXO33 F-box protein 33 2.37432
HRH3 histamine receptor H3 2.37105
CERKL ceramide kinase-like 2.36609
FBP1 fructose-1,6-bisphosphatase 1 2.35444
CRACR2B calcium release activated channel regulator 2B 2.35111
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.34534
AVPR1B arginine vasopressin receptor 1B 2.34042
UPP1 uridine phosphorylase 1 2.30407
FGF2 fibroblast growth factor 2 (basic) 2.21792
CCDC3 coiled-coil domain containing 3 2.17337
TBRG4 transforming growth factor beta regulator 4 2.15992
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.15917
MCUR1 mitochondrial calcium uniporter regulator 1 2.15087
METTL2B methyltransferase like 2B 2.14365
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.13897
C17ORF78 chromosome 17 open reading frame 78 2.13166
MSRB3 methionine sulfoxide reductase B3 2.1271
ALAD aminolevulinate dehydratase 2.1271
NLGN3 neuroligin 3 2.11871
PANK1 pantothenate kinase 1 2.11037
BORCS5 BLOC-1 related complex subunit 5 2.07417
GFRA1 GDNF family receptor alpha 1 2.06481
ZXDC ZXD family zinc finger C 2.06481
RANBP17 RAN binding protein 17 2.06481
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.05237
COPS4 COP9 signalosome subunit 4 2.05178
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.04954
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.04954
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 2.0398
COL26A1 collagen, type XXVI, alpha 1 2.03774
HES6 hes family bHLH transcription factor 6 2.01691
HACD2 3-hydroxyacyl-CoA dehydratase 2 2.01454
ADCK5 aarF domain containing kinase 5 2.01163
ZNF680 zinc finger protein 680 2.00941
TXNDC9 thioredoxin domain containing 9 2.00812
ZNF572 zinc finger protein 572 2.00063
STBD1 starch binding domain 1 2.00063

decreased expression

Symbol Name Standardized Value
FGF4 fibroblast growth factor 4 -2.82669
HSPB2 heat shock 27kDa protein 2 -2.82669
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) -2.82669
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.82669
SMIM22 small integral membrane protein 22 -2.82669
CNN2 calponin 2 -2.82669
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -2.82669
CRYGN crystallin, gamma N -2.82669
CORIN corin, serine peptidase -2.82669
PCDHB12 protocadherin beta 12 -2.82669
SLC41A3 solute carrier family 41, member 3 -2.82669
TTC29 tetratricopeptide repeat domain 29 -2.82669
SYBU syntabulin (syntaxin-interacting) -2.82669
MAP2K5-DT MAP2K5 divergent transcript -2.82669
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -2.82669
KLHL35 kelch-like family member 35 -2.75593
ADAP1 ArfGAP with dual PH domains 1 -2.75593
SNTN sentan, cilia apical structure protein -2.75593
NAT16 N-acetyltransferase 16 (GCN5-related, putative) -2.75593
MLANA melan-A -2.75593
C11ORF42 chromosome 11 open reading frame 42 -2.75593
SPMIP9 sperm microtubule inner protein 9 -2.75593
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -2.75593
MYOM2 myomesin 2 -2.75593
ZC2HC1B zinc finger, C2HC-type containing 1B -2.75593
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.75593
TNS4 tensin 4 -2.75593
ECM1 extracellular matrix protein 1 -2.75593
LRRC56 leucine rich repeat containing 56 -2.75593
PAX7 paired box 7 -2.75593
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -2.75593
FAM177B family with sequence similarity 177, member B -2.75593
DCLK3 doublecortin-like kinase 3 -2.75593
LRTM3 leucine rich repeat transmembrane protein 3 -2.75593
DEFB131B defensin beta 131B -2.75593
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -2.75593
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.75593
ZNF98 zinc finger protein 98 -2.75593
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -2.75593
PCDHGB7 protocadherin gamma subfamily B, 7 -2.75593
KIF12 kinesin family member 12 -2.75593
PHF21A PHD finger protein 21A -2.72862
SNX31 sorting nexin 31 -2.66373
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.663
GSG1 germ cell associated 1 -2.663
DPPA3 developmental pluripotency associated 3 -2.663
CRIP1 cysteine-rich protein 1 (intestinal) -2.663
GMPR2 guanosine monophosphate reductase 2 -2.64663
ADRA1A adrenoceptor alpha 1A -2.62063
CCNE2 cyclin E2 -2.62063
TCTA T-cell leukemia translocation altered -2.54098
ARHGAP15 Rho GTPase activating protein 15 -2.50122
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.50122
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.48769
TBC1D14 TBC1 domain family, member 14 -2.47232
PHC1 polyhomeotic homolog 1 (Drosophila) -2.45077
PRKD1 protein kinase D1 -2.45067
GALK2 galactokinase 2 -2.44273
NFYB nuclear transcription factor Y, beta -2.42876
AURKB aurora kinase B -2.42024
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.40938
UBALD2 UBA-like domain containing 2 -2.37553
BRSK2 BR serine/threonine kinase 2 -2.36866
CETN3 centrin, EF-hand protein, 3 -2.35674
SP4 Sp4 transcription factor -2.34534
BOLA2B bolA family member 2B -2.33318
UNC5CL unc-5 homolog C (C. elegans)-like -2.32182
CCR9 chemokine (C-C motif) receptor 9 -2.32182
SHISAL2A shisa like 2A -2.32182
CYCS cytochrome c, somatic -2.30669
MAP2 microtubule-associated protein 2 -2.28289
NRBF2 nuclear receptor binding factor 2 -2.27748
C9ORF40 chromosome 9 open reading frame 40 -2.26456
CCDC138 coiled-coil domain containing 138 -2.24679
PRPS1 phosphoribosyl pyrophosphate synthetase 1 -2.23505
WDTC1 WD and tetratricopeptide repeats 1 -2.21792
CD38 CD38 molecule -2.14813
ATXN2L ataxin 2-like -2.12731
TSPYL1 TSPY-like 1 -2.12731
MATK megakaryocyte-associated tyrosine kinase -2.1271
TCF25 transcription factor 25 (basic helix-loop-helix) -2.1271
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.11871
DMXL1 Dmx-like 1 -2.1183
CGNL1 cingulin-like 1 -2.11517
FAIM Fas apoptotic inhibitory molecule -2.09789
CHN1 chimerin 1 -2.09404
TRIM52 tripartite motif containing 52 -2.08397
MCM9 minichromosome maintenance complex component 9 -2.08397
NRXN3 neurexin 3 -2.08125
GRM2 glutamate receptor, metabotropic 2 -2.06481
TOP6BL TOP6B like initiator of meiotic double strand breaks -2.06481
MGAT4C MGAT4 family, member C -2.06481
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.05178
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -2.05178
UBL5 ubiquitin-like 5 -2.03703
SUSD1 sushi domain containing 1 -2.02213
CEP350 centrosomal protein 350kDa -2.01665
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -2.01665
TMEM91 transmembrane protein 91 -2.01665
BICDL1 BICD family like cargo adaptor 1 -2.00181
SLC25A44 solute carrier family 25, member 44 -2.00181