PHF5A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PHD finger protein 5A|This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 84844)
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Genes

350 genes differentially expressed following the PHF5A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PDLIM7 PDZ and LIM domain 7 (enigma) 2.60161
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.60161
SSTR5 somatostatin receptor 5 2.60161
NUGGC nuclear GTPase, germinal center associated 2.60161
MYOM2 myomesin 2 2.60161
YPEL4 yippee-like 4 (Drosophila) 2.60161
CA6 carbonic anhydrase VI 2.60161
OTUD6A OTU deubiquitinase 6A 2.60161
KRTAP4-12 keratin associated protein 4-12 2.60161
GBP3 guanylate binding protein 3 2.60161
NRROS negative regulator of reactive oxygen species 2.60161
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.60161
SIGLEC5 sialic acid binding Ig-like lectin 5 2.60161
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.60161
HYAL4 hyaluronoglucosaminidase 4 2.60161
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.60161
TM4SF20 transmembrane 4 L six family member 20 2.60161
IL5RA interleukin 5 receptor, alpha 2.60161
UMOD uromodulin 2.60161
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.60161
PDE7B phosphodiesterase 7B 2.60161
PAX9 paired box 9 2.60161
ARHGAP30 Rho GTPase activating protein 30 2.60161
TAS2R60 taste receptor, type 2, member 60 2.60161
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.60161
C9ORF152 chromosome 9 open reading frame 152 2.60161
PRDM16 PR domain containing 16 2.60161
C2ORF78 chromosome 2 open reading frame 78 2.60161
RTP3 receptor (chemosensory) transporter protein 3 2.60161
FAM9C family with sequence similarity 9, member C 2.60161
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.60161
ACRBP acrosin binding protein 2.60161
RHOJ ras homolog family member J 2.60161
PSD2 pleckstrin and Sec7 domain containing 2 2.60161
NAGLU N-acetylglucosaminidase, alpha 2.60161
ARL4C ADP-ribosylation factor-like 4C 2.60161
MPO myeloperoxidase 2.60161
ATOH8 atonal homolog 8 (Drosophila) 2.60161
CDK17 cyclin-dependent kinase 17 2.60161
CRH corticotropin releasing hormone 2.60161
CPB1 carboxypeptidase B1 (tissue) 2.60161
GIPC3 GIPC PDZ domain containing family, member 3 2.60161
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.60161
DERPC DERPC proline and glycine rich nuclear protein 2.60161
S100A1 S100 calcium binding protein A1 2.60161
TMEM127 transmembrane protein 127 2.60161
GNRHR gonadotropin-releasing hormone receptor 2.60161
RFX6 regulatory factor X, 6 2.60161
TOMT transmembrane O-methyltransferase 2.60161
IL37 interleukin 37 2.60161
CNTN6 contactin 6 2.60161
S100G S100 calcium binding protein G 2.60161
FOXI2 forkhead box I2 2.60161
FAM186A family with sequence similarity 186, member A 2.60161
LECT2 leukocyte cell-derived chemotaxin 2 2.60161
CREB3L3 cAMP responsive element binding protein 3-like 3 2.60161
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.60161
PGC progastricsin (pepsinogen C) 2.60161
IL5 interleukin 5 2.60161
LRIT1 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 2.60161
TMCO2 transmembrane and coiled-coil domains 2 2.60161
CLDN22 claudin 22 2.60161
C6 complement component 6 2.60161
VCX3A variable charge, X-linked 3A 2.60161
CSF1 colony stimulating factor 1 (macrophage) 2.60161
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.60161
DLK2 delta-like 2 homolog (Drosophila) 2.60161
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.60161
ROPN1 rhophilin associated tail protein 1 2.60161
TUBA4B tubulin, alpha 4b 2.60161
LRRC73 leucine rich repeat containing 73 2.60161
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.60161
OOSP2 oocyte secreted protein 2 2.60161
BLNK B-cell linker 2.60161
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.60161
TFF2 trefoil factor 2 2.60161
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.60161
GPR52 G protein-coupled receptor 52 2.60161
IZUMO3 IZUMO family member 3 2.60161
SLC46A2 solute carrier family 46, member 2 2.60161
HCRTR1 hypocretin (orexin) receptor 1 2.60161
PGAM2 phosphoglycerate mutase 2 (muscle) 2.60161
MUC1 mucin 1, cell surface associated 2.60161
TSGA13 testis specific, 13 2.60161
CAPN9 calpain 9 2.60161
RAX retina and anterior neural fold homeobox 2.60161
ZACN zinc activated ligand-gated ion channel 2.60161
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 2.60161
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 2.60161
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.60161
PDF peptide deformylase (mitochondrial) 2.60161
C4ORF17 chromosome 4 open reading frame 17 2.60161
TUBA3D tubulin, alpha 3d 2.60161
PCDHB13 protocadherin beta 13 2.60161
KRT86 keratin 86, type II 2.60161
GGT6 gamma-glutamyltransferase 6 2.60161
ACTL10 actin-like 10 2.60161
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 2.60161
GJA5 gap junction protein, alpha 5, 40kDa 2.60161
HGD homogentisate 1,2-dioxygenase 2.60161
ADORA3 adenosine A3 receptor 2.60161
ISL1 ISL LIM homeobox 1 2.60161
LITAFD LITAF domain containing 2.60161
TEKT5 tektin 5 2.60161
NRIP2 nuclear receptor interacting protein 2 2.60161
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.60161
TBX2 T-box 2 2.60161
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.60161
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.60161
SHE Src homology 2 domain containing E 2.60161
ZC3H12C zinc finger CCCH-type containing 12C 2.60161
ISL2 ISL LIM homeobox 2 2.60161
LMOD2 leiomodin 2 (cardiac) 2.60161
C2CD4B C2 calcium-dependent domain containing 4B 2.60161
CTAGE4 CTAGE family, member 4 2.60161
ODAPH odontogenesis associated phosphoprotein 2.60161
MKRN3 makorin ring finger protein 3 2.60161
CMKLR2 chemerin chemokine-like receptor 2 2.60161
HAVCR1 hepatitis A virus cellular receptor 1 2.60161
TEX53 testis expressed 53 2.60161
EXOC1L exocyst complex component 1 like 2.60161
C11ORF16 chromosome 11 open reading frame 16 2.60161
POU2AF1 POU class 2 associating factor 1 2.60161
EMP3 epithelial membrane protein 3 2.60161
EPHA5 EPH receptor A5 2.60161
RBM24 RNA binding motif protein 24 2.60161
LGALS14 lectin, galactoside-binding, soluble, 14 2.60161
STOM stomatin 2.60161
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.60161
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.60161
CPN2 carboxypeptidase N, polypeptide 2 2.60161
LRRN4 leucine rich repeat neuronal 4 2.60161
ADRA2A adrenoceptor alpha 2A 2.60161
GJC2 gap junction protein, gamma 2, 47kDa 2.60161
GOLGA8N golgin A8 family, member N 2.60161
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.60161
NLRP14 NLR family, pyrin domain containing 14 2.60161
RIBC1 RIB43A domain with coiled-coils 1 2.60161
QRFP pyroglutamylated RFamide peptide 2.60161
CIMIP2C ciliary microtubule inner protein 2C 2.60161
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.60161
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.60161
SYNGR4 synaptogyrin 4 2.60161
GPR62 G protein-coupled receptor 62 2.60161
GPR65 G protein-coupled receptor 65 2.60161
CTSF cathepsin F 2.60161
LHX5 LIM homeobox 5 2.60161
CTRB1 chymotrypsinogen B1 2.60161
LYPD5 LY6/PLAUR domain containing 5 2.60161
CCDC177 coiled-coil domain containing 177 2.60161
AHSG alpha-2-HS-glycoprotein 2.60161
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.60161
CHRM1 cholinergic receptor, muscarinic 1 2.60161
FITM1 fat storage-inducing transmembrane protein 1 2.60161
ADGRF1 adhesion G protein-coupled receptor F1 2.60161
PRRX1 paired related homeobox 1 2.60161
STMND1 stathmin domain containing 1 2.60161
TBC1D28 TBC1 domain family, member 28 2.60161
SHOX short stature homeobox 2.60161
RUFY4 RUN and FYVE domain containing 4 2.60161
ITPKA inositol-trisphosphate 3-kinase A 2.60161
PTCRA pre T-cell antigen receptor alpha 2.60161
MMP13 matrix metallopeptidase 13 2.60161
ANGPTL5 angiopoietin-like 5 2.60161
TBXT T-box transcription factor T 2.60161
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.60161
SDSL serine dehydratase-like 2.60161
BPIFC BPI fold containing family C 2.60161
KCTD4 potassium channel tetramerization domain containing 4 2.60161
PTGDR prostaglandin D2 receptor (DP) 2.60161
DUOXA1 dual oxidase maturation factor 1 2.60161
ANKRD62 ankyrin repeat domain 62 2.60161
LRCOL1 leucine rich colipase-like 1 2.60161
PCDHGB1 protocadherin gamma subfamily B, 1 2.60161
MYF5 myogenic factor 5 2.60161
DUSP26 dual specificity phosphatase 26 (putative) 2.60161
CATSPERZ catsper channel auxiliary subunit zeta 2.60161
JAML junction adhesion molecule like 2.60161
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.60161
SHOX2 short stature homeobox 2 2.60161
DNAAF8 dynein axonemal assembly factor 8 2.60161
SMIM22 small integral membrane protein 22 2.60161
PMP2 peripheral myelin protein 2 2.60161
CDC20B cell division cycle 20B 2.60161
ESAM endothelial cell adhesion molecule 2.60161
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1 2.59969
APOLD1 apolipoprotein L domain containing 1 2.59656
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.56163
PSD3 pleckstrin and Sec7 domain containing 3 2.5179
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.48695
C16ORF86 chromosome 16 open reading frame 86 2.47387
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.46702
OTUD5 OTU deubiquitinase 5 2.46702
GALR3 galanin receptor 3 2.46137
ATM ATM serine/threonine kinase 2.42695
PEX13 peroxisomal biogenesis factor 13 2.41315
FRRS1L ferric-chelate reductase 1-like 2.4065
TEX30 testis expressed 30 2.40471
PLS1 plastin 1 2.37166
COL27A1 collagen, type XXVII, alpha 1 2.36595
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 2.34447
EHD1 EH-domain containing 1 2.32219
TOM1 target of myb1 (chicken) 2.32092
COL4A2 collagen, type IV, alpha 2 2.32092
ERCC5 excision repair cross-complementation group 5 2.32092
GOLT1B golgi transport 1B 2.313
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 2.31125
MAMLD1 mastermind-like domain containing 1 2.29495
PRSS3 protease, serine, 3 2.29364
FBXO30 F-box protein 30 2.27315
HBEGF heparin-binding EGF-like growth factor 2.27053
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.26
MACIR macrophage immunometabolism regulator 2.24901
ZNF827 zinc finger protein 827 2.24571
CHD8 chromodomain helicase DNA binding protein 8 2.23924
EXOSC10 exosome component 10 2.22769
XAB2 XPA binding protein 2 2.21786
ATF6B activating transcription factor 6 beta 2.21601
MRPL32 mitochondrial ribosomal protein L32 2.21601
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.18406
CHMP2A charged multivesicular body protein 2A 2.18355
SLC38A10 solute carrier family 38, member 10 2.18355
CFAP97 cilia and flagella associated protein 97 2.18271
PCGF2 polycomb group ring finger 2 2.16911
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 2.16911
SMO smoothened, frizzled class receptor 2.16461
LDB1 LIM domain binding 1 2.15693
MRPS28 mitochondrial ribosomal protein S28 2.1562
SLC16A4 solute carrier family 16, member 4 2.12794
AMT aminomethyltransferase 2.12487
ATP13A1 ATPase type 13A1 2.12307
PTPRG protein tyrosine phosphatase, receptor type, G 2.09655
ITGB8 integrin, beta 8 2.09266
HSPA14 heat shock 70kDa protein 14 2.09003
SPRY2 sprouty homolog 2 (Drosophila) 2.07534
CUL2 cullin 2 2.07349
NELFE negative elongation factor complex member E 2.07349
ABHD12B abhydrolase domain containing 12B 2.07349
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 2.05588
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 2.0463
PTK2 protein tyrosine kinase 2 2.03997
TBC1D10A TBC1 domain family, member 10A 2.03997
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2.03911
SEC13 SEC13 homolog (S. cerevisiae) 2.03896
RNF13 ring finger protein 13 2.03676
TEKT3 tektin 3 2.02921
RNF144A ring finger protein 144A 2.02921
GAK cyclin G associated kinase 2.02921
AK7 adenylate kinase 7 2.01957
IRF7 interferon regulatory factor 7 2.01328
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 2.01097
NTM neurotrimin 2.00957
CAMTA1 calmodulin binding transcription activator 1 2.00526

decreased expression

Symbol Name Standardized Value
AHNAK2 AHNAK nucleoprotein 2 -2.60161
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.60161
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.60161
CCDC87 coiled-coil domain containing 87 -2.60161
LDHAL6A lactate dehydrogenase A-like 6A -2.60161
BTBD18 BTB (POZ) domain containing 18 -2.60161
ZNF396 zinc finger protein 396 -2.60161
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.60161
IFNE interferon, epsilon -2.60161
SMIM10L1 small integral membrane protein 10 like 1 -2.60161
CLCNKB chloride channel, voltage-sensitive Kb -2.60161
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -2.60161
KANK1 KN motif and ankyrin repeat domains 1 -2.60161
PRSS50 protease, serine, 50 -2.60161
ZMYND10 zinc finger, MYND-type containing 10 -2.60161
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.60161
PGBD4 piggyBac transposable element derived 4 -2.60161
ADAT3 adenosine deaminase, tRNA-specific 3 -2.60161
C9ORF43 chromosome 9 open reading frame 43 -2.60161
ZNF25 zinc finger protein 25 -2.60161
LIX1 Lix1 homolog (chicken) -2.60161
PRB2 proline-rich protein BstNI subfamily 2 -2.60161
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -2.60161
ACOT6 acyl-CoA thioesterase 6 -2.60161
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -2.60161
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.60161
N4BP2 NEDD4 binding protein 2 -2.60161
CSTL1 cystatin-like 1 -2.60161
TCL1B T-cell leukemia/lymphoma 1B -2.60161
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.60161
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.60161
DLX4 distal-less homeobox 4 -2.60161
LAGE3 L antigen family, member 3 -2.60161
AQP3 aquaporin 3 (Gill blood group) -2.60161
ADAP2 ArfGAP with dual PH domains 2 -2.60161
SLC38A8 solute carrier family 38, member 8 -2.60161
S100A14 S100 calcium binding protein A14 -2.60161
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -2.60161
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.60161
KLK5 kallikrein-related peptidase 5 -2.60161
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 -2.60161
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.60161
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.60161
FAIM2 Fas apoptotic inhibitory molecule 2 -2.60161
GBX1 gastrulation brain homeobox 1 -2.60161
TMEM168 transmembrane protein 168 -2.60161
ACOX2 acyl-CoA oxidase 2, branched chain -2.60161
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -2.60161
CLIC5 chloride intracellular channel 5 -2.60161
DNAH12 dynein, axonemal, heavy chain 12 -2.60161
NLRC3 NLR family, CARD domain containing 3 -2.60161
DNAI3 dynein axonemal intermediate chain 3 -2.60092
ARID5A AT rich interactive domain 5A (MRF1-like) -2.57748
PCNP PEST proteolytic signal containing nuclear protein -2.40333
CCDC158 coiled-coil domain containing 158 -2.39688
MAST2 microtubule associated serine/threonine kinase 2 -2.37888
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.37166
COPS8 COP9 signalosome subunit 8 -2.37166
POR P450 (cytochrome) oxidoreductase -2.36281
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 -2.34447
LRRC58 leucine rich repeat containing 58 -2.32092
EFCAB5 EF-hand calcium binding domain 5 -2.32092
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.32092
PRADC1 protease-associated domain containing 1 -2.31099
GJA1 gap junction protein, alpha 1, 43kDa -2.29495
PARVB parvin, beta -2.26997
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.22769
SLC25A53 solute carrier family 25, member 53 -2.18406
STIP1 stress-induced phosphoprotein 1 -2.18355
FAM133A family with sequence similarity 133, member A -2.18355
SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C -2.18355
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit -2.16963
CCDC33 coiled-coil domain containing 33 -2.16911
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.16689
MRPL40 mitochondrial ribosomal protein L40 -2.15693
H1-1 H1.1 linker histone, cluster member -2.15573
RESF1 retroelement silencing factor 1 -2.15447
CDKN2AIP CDKN2A interacting protein -2.12992
LCOR ligand dependent nuclear receptor corepressor -2.10592
ZNF879 zinc finger protein 879 -2.10223
LIPE lipase, hormone-sensitive -2.09266
GON4L gon-4-like (C. elegans) -2.09266
CFAP73 cilia and flagella associated protein 73 -2.08802
FBXO31 F-box protein 31 -2.07349
CTSK cathepsin K -2.07063
TIAM1 T-cell lymphoma invasion and metastasis 1 -2.06014
XPOT exportin, tRNA -2.05426
RAP2B RAP2B, member of RAS oncogene family -2.05112
ZNF320 zinc finger protein 320 -2.04274
SORBS3 sorbin and SH3 domain containing 3 -2.03997
FBXO41 F-box protein 41 -2.02921
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.02921
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.02921
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.02581
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -2.01607
POMT1 protein-O-mannosyltransferase 1 -2.00526
DBF4B DBF4 zinc finger B -2.00211