PHF6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PHD finger protein 6|This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 84295)
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Genes

312 genes differentially expressed following the PHF6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHB7 protocadherin beta 7 3.03024
REN renin 3.03024
TCAF2 TRPM8 channel-associated factor 2 3.03024
BIRC7 baculoviral IAP repeat containing 7 3.03024
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.03024
TDRD6 tudor domain containing 6 3.03024
LCN10 lipocalin 10 3.03024
CLEC5A C-type lectin domain family 5, member A 3.03024
MEIKIN meiotic kinetochore factor 3.03024
RPE65 retinal pigment epithelium-specific protein 65kDa 3.03024
TLX2 T-cell leukemia homeobox 2 3.03024
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.03024
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.03024
HES7 hes family bHLH transcription factor 7 3.03024
C4A complement component 4A (Rodgers blood group) 3.03024
NCF1 neutrophil cytosolic factor 1 3.03024
LMO1 LIM domain only 1 (rhombotin 1) 3.03024
BMP8B bone morphogenetic protein 8b 3.03024
C6ORF58 chromosome 6 open reading frame 58 3.03024
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 3.03024
COPZ2 coatomer protein complex, subunit zeta 2 3.03024
S100A2 S100 calcium binding protein A2 3.03024
SPAG6 sperm associated antigen 6 3.03024
KRTAP5-7 keratin associated protein 5-7 3.03024
PLA2G10 phospholipase A2, group X 3.03024
BTBD19 BTB (POZ) domain containing 19 3.03024
MRGPRX2 MAS-related GPR, member X2 3.03024
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.03024
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.03024
MMP10 matrix metallopeptidase 10 3.03024
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.03024
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.03024
RPH3A rabphilin 3A 3.03024
COL15A1 collagen, type XV, alpha 1 3.03024
MUC22 mucin 22 3.03024
AVP arginine vasopressin 3.03024
JCHAIN joining chain of multimeric IgA and IgM 3.03024
VCX variable charge, X-linked 3.03024
ETV7 ets variant 7 3.03024
SIGLEC5 sialic acid binding Ig-like lectin 5 3.03024
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.03024
PADI1 peptidyl arginine deiminase, type I 3.03024
LOC107986837 uncharacterized LOC107986837 3.03024
SPATA22 spermatogenesis associated 22 3.03024
F5 coagulation factor V (proaccelerin, labile factor) 3.03024
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.03024
GATA6 GATA binding protein 6 3.03024
PRDM6 PR domain containing 6 3.03024
LTB lymphotoxin beta (TNF superfamily, member 3) 3.03024
GDF9 growth differentiation factor 9 3.03024
DDTL D-dopachrome tautomerase-like 3.03024
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.03024
NEURL2 neuralized E3 ubiquitin protein ligase 2 3.03024
ERVW-1 endogenous retrovirus group W, member 1 3.03024
CIMAP1B ciliary microtubule associated protein 1B 3.03024
ZNF593OS ZNF593 opposite strand 3.03024
STPG3 sperm-tail PG-rich repeat containing 3 3.03024
CCDC187 coiled-coil domain containing 187 3.03024
CCDC198 coiled-coil domain containing 198 3.03024
SMIM38 small integral membrane protein 38 3.03024
PHF24 PHD finger protein 24 3.03024
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.03024
PLB1 phospholipase B1 3.03024
GLI1 GLI family zinc finger 1 3.03024
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.03024
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.03024
CARD16 caspase recruitment domain family, member 16 3.03024
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.03024
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.03024
PI16 peptidase inhibitor 16 3.03024
SLC16A11 solute carrier family 16, member 11 3.03024
PRICKLE4 prickle homolog 4 (Drosophila) 3.03024
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.03024
AGTR1 angiotensin II receptor, type 1 3.03024
TMEM212 transmembrane protein 212 3.03024
CCR3 chemokine (C-C motif) receptor 3 3.03024
PGC progastricsin (pepsinogen C) 3.03024
NHLRC4 NHL repeat containing 4 3.03024
IL5 interleukin 5 3.03024
VSX2 visual system homeobox 2 3.03024
PTPRC protein tyrosine phosphatase, receptor type, C 3.03024
PCDHA3 protocadherin alpha 3 3.03024
RAB41 RAB41, member RAS oncogene family 3.03024
TRIM15 tripartite motif containing 15 3.03024
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.03024
GML glycosylphosphatidylinositol anchored molecule like 3.03024
IL1A interleukin 1, alpha 3.03024
RGCC regulator of cell cycle 3.03024
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 3.03024
ENDOU endonuclease, polyU-specific 3.03024
SVOP SV2 related protein homolog (rat) 3.03024
UTS2B urotensin 2B 3.03024
NEK6 NIMA-related kinase 6 3.03024
GOLGA8N golgin A8 family, member N 3.03024
IL9R interleukin 9 receptor 3.03024
CYBB cytochrome b-245, beta polypeptide 3.03024
NTN5 netrin 5 3.03024
SYNGR4 synaptogyrin 4 3.03024
SEMG1 semenogelin I 3.03024
RSAD2 radical S-adenosyl methionine domain containing 2 3.03024
CALHM1 calcium homeostasis modulator 1 3.03024
FAM177B family with sequence similarity 177, member B 3.03024
OAZ2 ornithine decarboxylase antizyme 2 3.03024
KLF2 Kruppel-like factor 2 3.03024
CPA2 carboxypeptidase A2 (pancreatic) 3.03024
DRD2 dopamine receptor D2 3.03024
C2CD4A C2 calcium-dependent domain containing 4A 3.03024
AGXT2 alanine--glyoxylate aminotransferase 2 3.03024
ARR3 arrestin 3, retinal (X-arrestin) 3.03024
CST9 cystatin 9 (testatin) 3.03024
VWA3A von Willebrand factor A domain containing 3A 3.03024
OPRK1 opioid receptor, kappa 1 3.03024
NTSR2 neurotensin receptor 2 3.03024
IP6K3 inositol hexakisphosphate kinase 3 3.03024
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.03024
RNF224 ring finger protein 224 3.03024
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.03024
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.03024
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 3.03024
LRRN4 leucine rich repeat neuronal 4 3.03024
EOMES eomesodermin 3.03024
RHAG Rh-associated glycoprotein 3.03024
CD80 CD80 molecule 3.03024
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.03024
SLC51B solute carrier family 51, beta subunit 3.03024
DMRTC1 DMRT-like family C1 3.03024
DEFB134 defensin, beta 134 3.03024
PXT1 peroxisomal, testis specific 1 3.03024
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 3.03024
TAGAP T-cell activation RhoGTPase activating protein 3.03024
WDFY4 WDFY family member 4 3.03024
CTSO cathepsin O 3.03024
ACKR3 atypical chemokine receptor 3 3.03024
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 3.03024
ORM1 orosomucoid 1 3.03024
MAGEA9B melanoma antigen family A9B 3.03024
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 3.03024
MTRFR mitochondrial translation release factor in rescue 2.96654
MATN2 matrilin 2 2.9539
TRIM11 tripartite motif containing 11 2.9539
MOG myelin oligodendrocyte glycoprotein 2.9539
SPATA45 spermatogenesis associated 45 2.9539
KLHL42 kelch-like family member 42 2.9539
CEP70 centrosomal protein 70kDa 2.8296
PDLIM1 PDZ and LIM domain 1 2.80857
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.78284
NHP2 NHP2 ribonucleoprotein 2.74982
STK39 serine threonine kinase 39 2.68453
AGRN agrin 2.68277
HEATR1 HEAT repeat containing 1 2.59974
SP8 Sp8 transcription factor 2.55272
C6ORF132 chromosome 6 open reading frame 132 2.46763
THAP7 THAP domain containing 7 2.4426
MUC16 mucin 16, cell surface associated 2.4334
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.4334
MED29 mediator complex subunit 29 2.42704
ETV1 ets variant 1 2.42704
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.42704
LINS1 lines homolog 1 2.4204
MYF6 myogenic factor 6 (herculin) 2.40611
TBC1D28 TBC1 domain family, member 28 2.39866
ARL13A ADP-ribosylation factor-like 13A 2.39866
PTGES2 prostaglandin E synthase 2 2.37522
PHF19 PHD finger protein 19 2.3684
ZNF263 zinc finger protein 263 2.35986
ADSS2 adenylosuccinate synthase 2 2.35986
PSD3 pleckstrin and Sec7 domain containing 3 2.35986
TCAIM T cell activation inhibitor, mitochondrial 2.34504
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 2.30291
ZFAT zinc finger and AT hook domain containing 2.30212
PBLD phenazine biosynthesis-like protein domain containing 2.30012
MIEF1 mitochondrial elongation factor 1 2.28736
CACYBP calcyclin binding protein 2.27779
GRM5 glutamate receptor, metabotropic 5 2.27148
RINL Ras and Rab interactor-like 2.25808
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.25808
CCDC137 coiled-coil domain containing 137 2.2462
DPPA4 developmental pluripotency associated 4 2.22413
EXOSC5 exosome component 5 2.20705
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.20287
PODXL podocalyxin-like 2.18841
CUL4B cullin 4B 2.18841
IRGQ immunity-related GTPase family, Q 2.16848
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 2.15776
ZNF510 zinc finger protein 510 2.15636
ACSF3 acyl-CoA synthetase family member 3 2.15636
SLC16A12 solute carrier family 16, member 12 2.14713
CDK6 cyclin-dependent kinase 6 2.14597
SERINC5 serine incorporator 5 2.14228
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.11787
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.11787
CFAP54 cilia and flagella associated 54 2.11787
STK31 serine/threonine kinase 31 2.11787
CFAP144 cilia and flagella associated protein 144 2.11787
POM121L2 POM121 transmembrane nucleoporin-like 2 2.11787
VSIG10L V-set and immunoglobulin domain containing 10 like 2.11787
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 2.11649
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.11068
PRSS3 protease, serine, 3 2.08413
TPP2 tripeptidyl peptidase II 2.08115
SAP130 Sin3A-associated protein, 130kDa 2.08004
ATP5MF ATP synthase membrane subunit f 2.08004
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.07633
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.07336
ARG2 arginase 2 2.07336
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.06587
ERLEC1 endoplasmic reticulum lectin 1 2.06587
HPN hepsin 2.05042
MTMR12 myotubularin related protein 12 2.02196
RAB11FIP4 RAB11 family interacting protein 4 (class II) 2.00704

decreased expression

Symbol Name Standardized Value
YAP1 Yes-associated protein 1 -3.03024
PADI2 peptidyl arginine deiminase, type II -3.03024
BRWD1 bromodomain and WD repeat domain containing 1 -3.03024
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -3.03024
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -3.03024
AKR1C3 aldo-keto reductase family 1, member C3 -3.03024
MARCHF9 membrane associated ring-CH-type finger 9 -3.03024
PNMA1 paraneoplastic Ma antigen 1 -3.03024
ODC1 ornithine decarboxylase 1 -3.00774
KHDC3L KH domain containing 3-like, subcortical maternal complex member -2.9539
AKAP14 A kinase (PRKA) anchor protein 14 -2.9539
SLC22A14 solute carrier family 22, member 14 -2.9539
C1ORF146 chromosome 1 open reading frame 146 -2.9539
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -2.9539
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.9539
FXYD2 FXYD domain containing ion transport regulator 2 -2.9539
LKAAEAR1 LKAAEAR motif containing 1 -2.9539
FGF21 fibroblast growth factor 21 -2.9539
GPT glutamic-pyruvate transaminase (alanine aminotransferase) -2.9539
SOX7 SRY (sex determining region Y)-box 7 -2.9539
ZNF469 zinc finger protein 469 -2.9539
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) -2.9539
C1QL2 complement component 1, q subcomponent-like 2 -2.9539
ZFP3 ZFP3 zinc finger protein -2.9539
SAMD15 sterile alpha motif domain containing 15 -2.9539
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.9539
GTF2A1L general transcription factor IIA, 1-like -2.9539
IGF1 insulin-like growth factor 1 (somatomedin C) -2.9539
TPPP2 tubulin polymerization-promoting protein family member 2 -2.9539
OTOF otoferlin -2.9539
LAMP3 lysosomal-associated membrane protein 3 -2.9539
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.9539
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -2.9539
TTC22 tetratricopeptide repeat domain 22 -2.9539
OTOA otoancorin -2.9539
LIPH lipase, member H -2.9539
C1ORF141 chromosome 1 open reading frame 141 -2.9539
GPX2 glutathione peroxidase 2 -2.9539
SMTNL1 smoothelin-like 1 -2.9539
KLHL6 kelch-like family member 6 -2.9539
SYNM synemin, intermediate filament protein -2.93575
MT1X metallothionein 1X -2.8997
RAB40B RAB40B, member RAS oncogene family -2.84968
HAPLN1 hyaluronan and proteoglycan link protein 1 -2.79451
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.79451
DAP death-associated protein -2.78357
MGST2 microsomal glutathione S-transferase 2 -2.75092
FBRS fibrosin -2.68453
LIMK1 LIM domain kinase 1 -2.68132
SEPTIN6 septin 6 -2.64924
ZNF165 zinc finger protein 165 -2.63699
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.63291
ARL11 ADP-ribosylation factor-like 11 -2.61672
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa -2.56928
ERMAP erythroblast membrane-associated protein (Scianna blood group) -2.55272
CIAO3 cytosolic iron-sulfur assembly component 3 -2.52048
LRWD1 leucine-rich repeats and WD repeat domain containing 1 -2.50454
LEFTY1 left-right determination factor 1 -2.4826
CD101 CD101 molecule -2.44114
SVOPL SVOP-like -2.43839
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.42704
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.40708
WRAP53 WD repeat containing, antisense to TP53 -2.39866
EP400 E1A binding protein p400 -2.39736
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.38397
MINDY3 MINDY lysine 48 deubiquitinase 3 -2.38196
DPH5 diphthamide biosynthesis 5 -2.36915
ZNF837 zinc finger protein 837 -2.30291
ANPEP alanyl (membrane) aminopeptidase -2.30012
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.30012
TMEM106C transmembrane protein 106C -2.30012
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.2668
NUP37 nucleoporin 37kDa -2.25808
BOK BCL2-related ovarian killer -2.25794
CCL26 chemokine (C-C motif) ligand 26 -2.2516
ANKRD12 ankyrin repeat domain 12 -2.23826
PGAM1 phosphoglycerate mutase 1 (brain) -2.2374
H3-3B H3.3 histone B -2.23423
H2BC11 H2B clustered histone 11 -2.22413
MRPL17 mitochondrial ribosomal protein L17 -2.20287
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.16848
ZNF502 zinc finger protein 502 -2.16848
PHF6 PHD finger protein 6 -2.15636
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.1407
MAP1A microtubule-associated protein 1A -2.10771
SACK1A scaffolding CK1 anchoring protein A -2.08581
NLRP7 NLR family, pyrin domain containing 7 -2.08581
SCART1 scavenger receptor protein family member -2.08581
CD47 CD47 molecule -2.08152
PREPL prolyl endopeptidase-like -2.07633
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.06587
RPS15A ribosomal protein S15a -2.06281
THSD7B thrombospondin, type I, domain containing 7B -2.05771
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit -2.04189
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.03119
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.02196
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 -2.02196
WDR47 WD repeat domain 47 -2.02032
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.01389
WDR43 WD repeat domain 43 -2.00704
SPAG17 sperm associated antigen 17 -2.00704
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.00704