PHF7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PHD finger protein 7|Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 51533)
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Genes

342 genes differentially expressed following the PHF7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MAGEB3 melanoma antigen family B3 3.82433
NXPH4 neurexophilin 4 3.82433
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.82433
LMO1 LIM domain only 1 (rhombotin 1) 3.82433
FFAR4 free fatty acid receptor 4 3.82433
ASB10 ankyrin repeat and SOCS box containing 10 3.82433
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.82433
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.82433
SERF1B small EDRK-rich factor 1B (centromeric) 3.82433
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.82433
ENTHD1 ENTH domain containing 1 3.82433
UCN urocortin 3.82433
MTNR1B melatonin receptor 1B 3.82433
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 3.82433
ATP13A5 ATPase type 13A5 3.82433
FOXQ1 forkhead box Q1 3.82433
MYBPHL myosin binding protein H-like 3.82433
LRRD1 leucine-rich repeats and death domain containing 1 3.82433
C7ORF25 chromosome 7 open reading frame 25 3.82433
FGF21 fibroblast growth factor 21 3.82433
ANKRD34A ankyrin repeat domain 34A 3.82433
ADGB androglobin 3.82433
TDRD6 tudor domain containing 6 3.82433
SPAG8 sperm associated antigen 8 3.82433
LEP leptin 3.82433
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.82433
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.82433
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.82433
WFDC13 WAP four-disulfide core domain 13 3.82433
CD22 CD22 molecule 3.82433
ZC2HC1B zinc finger, C2HC-type containing 1B 3.82433
TMEM132C transmembrane protein 132C 3.82433
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.82433
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.82433
F9 coagulation factor IX 3.82433
C8ORF74 chromosome 8 open reading frame 74 3.82433
DLL4 delta-like 4 (Drosophila) 3.82433
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 3.82433
TRPC5OS TRPC5 opposite strand 3.82433
MYO1G myosin IG 3.82433
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.82433
LDHC lactate dehydrogenase C 3.82433
CD34 CD34 molecule 3.82433
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.82433
CBLIF cobalamin binding intrinsic factor 3.82433
LBHD2 LBH domain containing 2 3.82433
HTD2 hydroxyacyl-thioester dehydratase type 2 3.82433
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.82433
ERVW-1 endogenous retrovirus group W, member 1 3.82433
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.82433
ZNF728 zinc finger protein 728 3.82433
OPRM1 opioid receptor, mu 1 3.82433
DIPK2B divergent protein kinase domain 2B 3.82433
DNAAF6 dynein axonemal assembly factor 6 3.82433
CFAP73 cilia and flagella associated protein 73 3.82433
DRC5 dynein regulatory complex subunit 5 3.82433
SPATA31F1 SPATA31 subfamily F member 1 3.82433
PNMA6F PNMA family member 6F 3.82433
PPIAL4H peptidylprolyl isomerase A like 4H 3.82433
WASL-DT WASL divergent transcript 3.82433
CPNE8-AS1 CPNE8 antisense RNA 1 3.82433
ANKRD42-DT ANKRD42 divergent transcript 3.82433
LOC124903372 uncharacterized LOC124903372 3.82433
LTB4R2 leukotriene B4 receptor 2 3.82433
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.82433
TREX2 three prime repair exonuclease 2 3.82433
ESR1 estrogen receptor 1 3.82433
MIA melanoma inhibitory activity 3.82433
TLR4 toll-like receptor 4 3.82433
IL6 interleukin 6 3.82433
ZNF575 zinc finger protein 575 3.82433
GAST gastrin 3.82433
DAO D-amino-acid oxidase 3.82433
AMBP alpha-1-microglobulin/bikunin precursor 3.82433
SPDYC speedy/RINGO cell cycle regulator family member C 3.82433
S100B S100 calcium binding protein B 3.82433
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.82433
ASB9 ankyrin repeat and SOCS box containing 9 3.82433
ASB5 ankyrin repeat and SOCS box containing 5 3.82433
SRPK3 SRSF protein kinase 3 3.82433
LY6K lymphocyte antigen 6 complex, locus K 3.82433
DYNAP dynactin associated protein 3.82433
LTK leukocyte receptor tyrosine kinase 3.82433
LTF lactotransferrin 3.82433
FGFBP1 fibroblast growth factor binding protein 1 3.82433
PYDC1 PYD (pyrin domain) containing 1 3.82433
PITX3 paired-like homeodomain 3 3.82433
AQP4 aquaporin 4 3.82433
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.82433
TREH trehalase (brush-border membrane glycoprotein) 3.82433
CBX8 chromobox homolog 8 3.82433
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.82433
C2CD4A C2 calcium-dependent domain containing 4A 3.82433
ESAM endothelial cell adhesion molecule 3.82433
LMOD2 leiomodin 2 (cardiac) 3.82433
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.82433
IL1B interleukin 1, beta 3.82433
IGF2 insulin-like growth factor 2 3.82433
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.82433
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.82433
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.82433
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 3.82433
GAL3ST2 galactose-3-O-sulfotransferase 2 3.82433
SPATA31A1 SPATA31 subfamily A, member 1 3.82433
CPSF4L cleavage and polyadenylation specific factor 4-like 3.82433
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.82433
CDHR5 cadherin-related family member 5 3.82433
ERICH3 glutamate-rich 3 3.82433
LCN1 lipocalin 1 3.82433
ARHGAP20 Rho GTPase activating protein 20 3.82433
KLF2 Kruppel-like factor 2 3.82433
RSAD2 radical S-adenosyl methionine domain containing 2 3.82433
SPZ1 spermatogenic leucine zipper 1 3.82433
EMX2 empty spiracles homeobox 2 3.82433
WFDC8 WAP four-disulfide core domain 8 3.82433
NTSR2 neurotensin receptor 2 3.82433
ECM1 extracellular matrix protein 1 3.82433
PRSS37 protease, serine, 37 3.82433
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.82433
MOG myelin oligodendrocyte glycoprotein 3.82433
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.82433
LPO lactoperoxidase 3.82433
NLRP6 NLR family, pyrin domain containing 6 3.82433
C1ORF105 chromosome 1 open reading frame 105 3.82433
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.82433
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.82433
NPC1L1 NPC1-like 1 3.82433
AMPD1 adenosine monophosphate deaminase 1 3.82433
TMEM52B transmembrane protein 52B 3.82433
PTCRA pre T-cell antigen receptor alpha 3.82433
DLX2 distal-less homeobox 2 3.82433
CXCR5 chemokine (C-X-C motif) receptor 5 3.82433
OR4D2 olfactory receptor, family 4, subfamily D, member 2 3.82433
LY96 lymphocyte antigen 96 3.82433
RBM24 RNA binding motif protein 24 3.82433
ALOX15B arachidonate 15-lipoxygenase, type B 3.82433
PLGLB2 plasminogen-like B2 3.82433
ANKRD55 ankyrin repeat domain 55 3.82433
WFDC10A WAP four-disulfide core domain 10A 3.82433
CLEC9A C-type lectin domain family 9, member A 3.82433
CD80 CD80 molecule 3.82433
APOL6 apolipoprotein L, 6 3.82433
CRTAM cytotoxic and regulatory T cell molecule 3.82433
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.80297
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.80297
EBF3 early B-cell factor 3 3.60391
FOXJ1 forkhead box J1 3.49061
PIGBOS1 PIGB opposite strand 1 3.35688
CERS5 ceramide synthase 5 3.19112
BEAN1 brain expressed, associated with NEDD4, 1 3.11432
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 3.05245
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.95266
STAB1 stabilin 1 2.95266
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.95266
MMRN2 multimerin 2 2.95266
MARCHF10 membrane associated ring-CH-type finger 10 2.95266
NANOS1 nanos homolog 1 (Drosophila) 2.90295
SCAF8 SR-related CTD-associated factor 8 2.87499
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.82206
JOSD1 Josephin domain containing 1 2.81856
NAGA N-acetylgalactosaminidase, alpha- 2.81669
RXRB retinoid X receptor, beta 2.80672
HHIP hedgehog interacting protein 2.80412
ARHGAP19 Rho GTPase activating protein 19 2.79894
NRIP3 nuclear receptor interacting protein 3 2.7574
OGA O-GlcNAcase 2.73592
CXXC4 CXXC finger protein 4 2.70746
SETD4 SET domain containing 4 2.70489
CD83 CD83 molecule 2.67919
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 2.63259
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.52845
NAP1L5 nucleosome assembly protein 1-like 5 2.52845
SLC10A4 solute carrier family 10, member 4 2.52845
UNC5B unc-5 homolog B (C. elegans) 2.48666
ZNF528 zinc finger protein 528 2.43242
HROB homologous recombination factor with OB-fold 2.39068
DPY19L4 dpy-19-like 4 (C. elegans) 2.36278
MOB3A MOB kinase activator 3A 2.35681
CTSZ cathepsin Z 2.34352
SLC25A27 solute carrier family 25, member 27 2.34352
FAM43B family with sequence similarity 43, member B 2.33648
SLX4 SLX4 structure-specific endonuclease subunit 2.33229
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.33178
QTMAN queuosine-tRNA mannosyltransferase 2.32888
C6ORF89 chromosome 6 open reading frame 89 2.30579
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.30045
THADA thyroid adenoma associated 2.2799
ERRFI1 ERBB receptor feedback inhibitor 1 2.27793
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 2.26761
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.25458
PIWIL4 piwi-like RNA-mediated gene silencing 4 2.25458
TRIM9 tripartite motif containing 9 2.25458
CCDC174 coiled-coil domain containing 174 2.20996
PDGFRL platelet-derived growth factor receptor-like 2.20996
CYB5RL cytochrome b5 reductase-like 2.17539
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.17539
GPX8 glutathione peroxidase 8 (putative) 2.16436
CAMLG calcium modulating ligand 2.16079
PGAP3 post-GPI attachment to proteins 3 2.15441
KIAA0408 KIAA0408 2.15441
GLOD4 glyoxalase domain containing 4 2.14577
LCK LCK proto-oncogene, Src family tyrosine kinase 2.14121
TNPO3 transportin 3 2.12883
PARP14 poly (ADP-ribose) polymerase family, member 14 2.11961
PLPBP pyridoxal phosphate binding protein 2.11191
ARL15 ADP-ribosylation factor-like 15 2.11191
BOK BCL2-related ovarian killer 2.11191
PROS1 protein S (alpha) 2.09012
CTU1 cytosolic thiouridylase subunit 1 2.08181
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.07478
PAQR3 progestin and adipoQ receptor family member III 2.07418
PCSK4 proprotein convertase subtilisin/kexin type 4 2.05116
ZNF700 zinc finger protein 700 2.04239
SIPA1L2 signal-induced proliferation-associated 1 like 2 2.04239
SRPK2 SRSF protein kinase 2 2.04153
CTRL chymotrypsin-like 2.03886
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.03589
FANCB Fanconi anemia, complementation group B 2.00607
MOGAT1 monoacylglycerol O-acyltransferase 1 2.00445

decreased expression

Symbol Name Standardized Value
CATSPERT catsper channel auxiliary subunit tau -3.82433
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -3.82433
AZU1 azurocidin 1 -3.82433
TMEM278 transmembrane protein 278 -3.82433
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -3.82433
TMEM150B transmembrane protein 150B -3.65157
GPRC5A G protein-coupled receptor, class C, group 5, member A -3.65157
ANGPTL6 angiopoietin-like 6 -3.65157
AMDHD1 amidohydrolase domain containing 1 -3.65157
DAND5 DAN domain family member 5, BMP antagonist -3.65157
LRRC38 leucine rich repeat containing 38 -3.65157
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -3.65157
PCDHGB1 protocadherin gamma subfamily B, 1 -3.65157
GATA2 GATA binding protein 2 -3.65157
CSAG3 CSAG family, member 3 -3.65157
TEX12 testis expressed 12 -3.65157
POTEJ POTE ankyrin domain family, member J -3.65157
GADL1 glutamate decarboxylase-like 1 -3.65157
C2ORF80 chromosome 2 open reading frame 80 -3.65157
LCN15 lipocalin 15 -3.65157
PAX5 paired box 5 -3.65157
ZNF491 zinc finger protein 491 -3.65157
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -3.65157
TMC2 transmembrane channel-like 2 -3.65157
CARD18 caspase recruitment domain family, member 18 -3.65157
CHADL chondroadherin-like -3.65157
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -3.65157
PCDHA1 protocadherin alpha 1 -3.65157
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -3.65157
NPIPB9 nuclear pore complex interacting protein family, member B9 -3.65157
SLA2 Src-like-adaptor 2 -3.65157
CLIC5 chloride intracellular channel 5 -3.65157
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 -3.65157
ODAPH odontogenesis associated phosphoprotein -3.65157
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -3.65157
CFAP276 cilia and flagella associated protein 276 -3.65157
NPM2 nucleophosmin/nucleoplasmin 2 -3.65157
H4C12 H4 clustered histone 12 -3.65157
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 -3.65157
NPIPB12 nuclear pore complex interacting protein family member B12 -3.65157
SIDT1 SID1 transmembrane family, member 1 -3.65157
GOLGA8H golgin A8 family, member H -3.65157
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -3.65157
C6ORF163 chromosome 6 open reading frame 163 -3.65157
STYXL2 serine/threonine/tyrosine interacting like 2 -3.65157
HCRT hypocretin (orexin) neuropeptide precursor -3.65157
GRAP GRB2-related adaptor protein -3.65157
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -3.65157
GBA1 glucosylceramidase beta 1 -3.65157
H1-1 H1.1 linker histone, cluster member -3.61382
DHRS11 dehydrogenase/reductase (SDR family) member 11 -3.59442
GPC3 glypican 3 -3.29382
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -3.17075
PPP6C protein phosphatase 6, catalytic subunit -3.01611
TRPC5 transient receptor potential cation channel, subfamily C, member 5 -3.00511
EXD1 exonuclease 3'-5' domain containing 1 -2.84947
TCF15 transcription factor 15 (basic helix-loop-helix) -2.82419
H3C4 H3 clustered histone 4 -2.82206
BID BH3 interacting domain death agonist -2.81856
MRPS23 mitochondrial ribosomal protein S23 -2.70489
ZNF518B zinc finger protein 518B -2.67919
TOX2 TOX high mobility group box family member 2 -2.67299
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.64765
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -2.62359
RNF145 ring finger protein 145 -2.5812
CHPF2 chondroitin polymerizing factor 2 -2.55762
CCP110 centriolar coiled coil protein 110kDa -2.51401
CLSTN3 calsyntenin 3 -2.50796
ZFAND4 zinc finger, AN1-type domain 4 -2.50317
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -2.46581
ZNF300 zinc finger protein 300 -2.4631
IMP3 IMP3, U3 small nucleolar ribonucleoprotein -2.4631
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.44667
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.41414
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.41414
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.41414
NPTX1 neuronal pentraxin I -2.41414
ZNF319 zinc finger protein 319 -2.41414
PWP2 PWP2 periodic tryptophan protein homolog (yeast) -2.39617
MB21D2 Mab-21 domain containing 2 -2.39217
MACO1 macoilin 1 -2.37555
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.35315
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 -2.34871
IDUA iduronidase, alpha-L- -2.33648
USP37 ubiquitin specific peptidase 37 -2.31782
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.30045
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.25458
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -2.25458
ZMAT2 zinc finger, matrin-type 2 -2.25458
BRICD5 BRICHOS domain containing 5 -2.25458
ANGPT2 angiopoietin 2 -2.24639
PXMP4 peroxisomal membrane protein 4, 24kDa -2.20996
MBOAT7 membrane bound O-acyltransferase domain containing 7 -2.19372
UBAP1 ubiquitin associated protein 1 -2.19058
ZBTB1 zinc finger and BTB domain containing 1 -2.18702
TFEB transcription factor EB -2.17915
SALL1 spalt-like transcription factor 1 -2.17539
FAM171B family with sequence similarity 171, member B -2.17539
RHBDD1 rhomboid domain containing 1 -2.17117
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 -2.17117
LY6E lymphocyte antigen 6 complex, locus E -2.16436
OAF OAF homolog (Drosophila) -2.1466
LRRC8B leucine rich repeat containing 8 family, member B -2.1466
PTPRB protein tyrosine phosphatase, receptor type, B -2.11782
GLRX3 glutaredoxin 3 -2.11782
ACOT7 acyl-CoA thioesterase 7 -2.11426
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.10072
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.10047
TM7SF2 transmembrane 7 superfamily member 2 -2.07483
SMG9 SMG9 nonsense mediated mRNA decay factor -2.07418
SGO2 shugoshin 2 -2.07418
AHR aryl hydrocarbon receptor -2.07227
RBP7 retinol binding protein 7, cellular -2.07227
SP8 Sp8 transcription factor -2.06683
AARD alanine and arginine rich domain containing protein -2.06683
MARVELD2 MARVEL domain containing 2 -2.0595
ZBTB22 zinc finger and BTB domain containing 22 -2.05116
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) -2.03651
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) -2.0356
LOXL1 lysyl oxidase-like 1 -2.02839
HDGFL2 HDGF like 2 -2.00607
EFCAB10 EF-hand calcium binding domain 10 -2.00505
PLEKHN1 pleckstrin homology domain containing, family N member 1 -2.00505