PHIP Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description pleckstrin homology domain interacting protein|PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009] (NCBI Entrez Gene Database, 55023)
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Genes

360 genes differentially expressed following the PHIP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ACTRT1 actin-related protein T1 3.27313
CD1C CD1c molecule 3.27313
BTC betacellulin 3.27313
MUC6 mucin 6, oligomeric mucus/gel-forming 3.27313
PEAR1 platelet endothelial aggregation receptor 1 3.27313
SGPP2 sphingosine-1-phosphate phosphatase 2 3.27313
GSTM5 glutathione S-transferase mu 5 3.27313
SKOR2 SKI family transcriptional corepressor 2 3.27313
CCL5 chemokine (C-C motif) ligand 5 3.27313
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.27313
KNG1 kininogen 1 3.27313
IZUMO3 IZUMO family member 3 3.27313
FPR1 formyl peptide receptor 1 3.27313
SRPX2 sushi-repeat containing protein, X-linked 2 3.27313
CFHR1 complement factor H-related 1 3.27313
TMPRSS11D transmembrane protease, serine 11D 3.27313
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 3.27313
CARD16 caspase recruitment domain family, member 16 3.27313
WDR87 WD repeat domain 87 3.27313
HPCAL4 hippocalcin like 4 3.27313
DUXA double homeobox A 3.27313
PAX2 paired box 2 3.27313
OLIG3 oligodendrocyte transcription factor 3 3.27313
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.27313
DLX4 distal-less homeobox 4 3.27313
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.27313
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.27313
ACY3 aminoacylase 3 3.27313
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.27313
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.27313
KCNU1 potassium channel, subfamily U, member 1 3.27313
LVRN laeverin 3.27313
SERTM1 serine-rich and transmembrane domain containing 1 3.27313
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.27313
SPNS2 spinster homolog 2 (Drosophila) 3.27313
GPR25 G protein-coupled receptor 25 3.27313
SLC9C2 solute carrier family 9, member C2 (putative) 3.27313
FAM221B family with sequence similarity 221, member B 3.27313
AVPR2 arginine vasopressin receptor 2 3.27313
PRAMEF20 PRAME family member 20 3.27313
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.27313
ALOX15 arachidonate 15-lipoxygenase 3.27313
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.27313
TMEM217 transmembrane protein 217 3.27313
CCDC83 coiled-coil domain containing 83 3.27313
HSFX3 heat shock transcription factor family, X-linked member 3 3.27313
OTOF otoferlin 3.27313
MCHR2 melanin-concentrating hormone receptor 2 3.27313
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.27313
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 3.27313
TMPRSS4 transmembrane protease, serine 4 3.27313
PAPOLB poly(A) polymerase beta (testis specific) 3.27313
CIMIP2C ciliary microtubule inner protein 2C 3.27313
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.27313
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.27313
SQOR sulfide quinone oxidoreductase 3.27313
STING1 stimulator of interferon response cGAMP interactor 1 3.27313
C1ORF232 chromosome 1 open reading frame 230 3.27313
C17ORF113 chromosome 17 open reading frame 113 3.27313
H4C15 H4 clustered histone 15 3.27313
H4C14 H4 clustered histone 14 3.27313
CFAP107 cilia and flagella associated protein 107 3.27313
DNAAF6 dynein axonemal assembly factor 6 3.27313
ODAPH odontogenesis associated phosphoprotein 3.27313
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.27313
DERPC DERPC proline and glycine rich nuclear protein 3.27313
TBX10 T-box 10 3.27313
CSAG1 chondrosarcoma associated gene 1 3.27313
SYT15 synaptotagmin XV 3.27313
IL5 interleukin 5 3.27313
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.27313
AXDND1 axonemal dynein light chain domain containing 1 3.27313
DSG1 desmoglein 1 3.27313
TEX101 testis expressed 101 3.27313
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.27313
RLBP1 retinaldehyde binding protein 1 3.27313
ATP13A4 ATPase type 13A4 3.27313
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.27313
NHLRC4 NHL repeat containing 4 3.27313
GDF10 growth differentiation factor 10 3.27313
CNTN6 contactin 6 3.27313
FAM131C family with sequence similarity 131, member C 3.27313
SAMD11 sterile alpha motif domain containing 11 3.27313
CAPN8 calpain 8 3.27313
EXOC3L1 exocyst complex component 3-like 1 3.27313
TCF23 transcription factor 23 3.27313
SLAMF1 signaling lymphocytic activation molecule family member 1 3.27313
RNF113B ring finger protein 113B 3.27313
PGC progastricsin (pepsinogen C) 3.27313
PVRIG poliovirus receptor related immunoglobulin domain containing 3.27313
TPH1 tryptophan hydroxylase 1 3.27313
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.27313
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.27313
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.27313
ISL2 ISL LIM homeobox 2 3.27313
TEX19 testis expressed 19 3.27313
KISS1 KiSS-1 metastasis-suppressor 3.27313
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.27313
CALML6 calmodulin-like 6 3.27313
AGR3 anterior gradient 3 3.27313
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.27313
LRRK2 leucine-rich repeat kinase 2 3.27313
MST1 macrophage stimulating 1 3.27313
EGR2 early growth response 2 3.27313
NPAS4 neuronal PAS domain protein 4 3.27313
C20ORF144 chromosome 20 open reading frame 144 3.27313
FIBIN fin bud initiation factor homolog (zebrafish) 3.27313
NPBWR1 neuropeptides B/W receptor 1 3.27313
WNT7B wingless-type MMTV integration site family, member 7B 3.27313
POF1B premature ovarian failure, 1B 3.27313
CNTF ciliary neurotrophic factor 3.27313
CLIC3 chloride intracellular channel 3 3.27313
A3GALT2 alpha 1,3-galactosyltransferase 2 3.27313
CTAGE4 CTAGE family, member 4 3.27313
NPPA natriuretic peptide A 3.27313
KLF2 Kruppel-like factor 2 3.27313
ALAS2 5'-aminolevulinate synthase 2 3.27313
MKRN3 makorin ring finger protein 3 3.27313
TDRD10 tudor domain containing 10 3.27313
G0S2 G0/G1 switch 2 3.27313
PYHIN1 pyrin and HIN domain family, member 1 3.27313
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.27313
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 3.27313
APOL4 apolipoprotein L, 4 3.27313
TMEM86A transmembrane protein 86A 3.27313
RERGL RERG/RAS-like 3.27313
MGP matrix Gla protein 3.27313
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.27313
PADI1 peptidyl arginine deiminase, type I 3.27313
ICAM2 intercellular adhesion molecule 2 3.27313
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.27313
POPDC2 popeye domain containing 2 3.27313
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.27313
UPK1B uroplakin 1B 3.27313
FAM151A family with sequence similarity 151, member A 3.27313
ADAM18 ADAM metallopeptidase domain 18 3.27313
MMEL1 membrane metallo-endopeptidase-like 1 3.27313
TGM1 transglutaminase 1 3.27313
BPIFC BPI fold containing family C 3.27313
TEX35 testis expressed 35 3.27313
OCM oncomodulin 3.27313
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.27313
TCAP titin-cap 3.27313
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.27313
MYLK2 myosin light chain kinase 2 3.27313
CIB3 calcium and integrin binding family member 3 3.27313
MAGEA12 melanoma antigen family A12 3.27313
BCL2A1 BCL2-related protein A1 3.27313
TSPAN19 tetraspanin 19 3.27313
TMPRSS15 transmembrane protease, serine 15 3.27313
HPGDS hematopoietic prostaglandin D synthase 3.27313
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.27313
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.23078
PIH1D2 PIH1 domain containing 2 3.23078
ZDHHC17 zinc finger, DHHC-type containing 17 3.20009
TSSK3 testis-specific serine kinase 3 3.12222
NPNT nephronectin 2.9887
ANO3 anoctamin 3 2.96165
KIAA0408 KIAA0408 2.94991
TAFA2 TAFA chemokine like family member 2 2.92892
SPACDR sperm acrosome developmental regulator 2.88288
MATR3 matrin 3 2.82451
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.81444
TENM2 teneurin transmembrane protein 2 2.77317
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 2.7315
NBPF12 neuroblastoma breakpoint family, member 12 2.68022
GAL galanin/GMAP prepropeptide 2.62698
PRPF31 pre-mRNA processing factor 31 2.62218
CRACR2A calcium release activated channel regulator 2A 2.58111
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.55224
SAMD13 sterile alpha motif domain containing 13 2.53902
DUT deoxyuridine triphosphatase 2.49186
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.48957
L2HGDH L-2-hydroxyglutarate dehydrogenase 2.47761
DGKA diacylglycerol kinase, alpha 80kDa 2.45017
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.44824
MYG1 MYG1 exonuclease 2.42386
MADD MAP-kinase activating death domain 2.41652
FBXL7 F-box and leucine-rich repeat protein 7 2.38755
ATG3 autophagy related 3 2.36313
SKAP2 src kinase associated phosphoprotein 2 2.3553
PGLYRP1 peptidoglycan recognition protein 1 2.3553
PDCD2L programmed cell death 2-like 2.33462
FNDC10 fibronectin type III domain containing 10 2.33251
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.33251
TFF3 trefoil factor 3 (intestinal) 2.33207
FLRT3 fibronectin leucine rich transmembrane protein 3 2.33207
FAM228A family with sequence similarity 228, member A 2.33207
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.33207
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.33207
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) 2.32799
HARS2 histidyl-tRNA synthetase 2, mitochondrial 2.29347
MAP2K5 mitogen-activated protein kinase kinase 5 2.291
PAAF1 proteasomal ATPase-associated factor 1 2.27719
ZNF384 zinc finger protein 384 2.27257
PARD6B par-6 family cell polarity regulator beta 2.27085
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.27061
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2.267
CEP290 centrosomal protein 290kDa 2.25756
PLEC plectin 2.25203
GGPS1 geranylgeranyl diphosphate synthase 1 2.23689
KLHL2 kelch-like family member 2 2.23323
MRC2 mannose receptor, C type 2 2.21915
RPL18A ribosomal protein L18a 2.2131
SARNP SAP domain containing ribonucleoprotein 2.20781
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.19286
RGS6 regulator of G-protein signaling 6 2.18259
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.18003
ZNF334 zinc finger protein 334 2.17751
ESRP2 epithelial splicing regulatory protein 2 2.16578
MORC4 MORC family CW-type zinc finger 4 2.16578
WDR33 WD repeat domain 33 2.16326
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.1603
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.1603
KAZN kazrin, periplakin interacting protein 2.15708
TYK2 tyrosine kinase 2 2.14551
USP15 ubiquitin specific peptidase 15 2.14551
ZNF3 zinc finger protein 3 2.13082
E2F1 E2F transcription factor 1 2.12639
NRXN1 neurexin 1 2.11937
MAML2 mastermind-like 2 (Drosophila) 2.11567
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 2.11072
MPHOSPH8 M-phase phosphoprotein 8 2.10033
FGD4 FYVE, RhoGEF and PH domain containing 4 2.06688
RNF135 ring finger protein 135 2.06655
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.06051
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.05863
ATP5MJ ATP synthase membrane subunit j 2.05603
MBTD1 mbt domain containing 1 2.05306
HSPB2 heat shock 27kDa protein 2 2.05126
LARGE2 LARGE xylosyl- and glucuronyltransferase 2 2.04777
VSNL1 visinin-like 1 2.04746
ZNF143 zinc finger protein 143 2.04744
SMIM3 small integral membrane protein 3 2.03005
AUNIP aurora kinase A and ninein interacting protein 2.02703
NCAM2 neural cell adhesion molecule 2 2.02692

decreased expression

Symbol Name Standardized Value
NGEF neuronal guanine nucleotide exchange factor -3.27313
TTC29 tetratricopeptide repeat domain 29 -3.27313
CARMIL3 capping protein regulator and myosin 1 linker 3 -3.27313
INHA inhibin, alpha -3.27313
EDA ectodysplasin A -3.23324
STMN2 stathmin 2 -3.23324
ADAM7 ADAM metallopeptidase domain 7 -3.23078
GMFG glia maturation factor, gamma -3.23078
CAMK2B calcium/calmodulin-dependent protein kinase II beta -3.23078
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -3.23078
SH2D4B SH2 domain containing 4B -3.23078
BHLHA15 basic helix-loop-helix family, member a15 -3.23078
THSD1 thrombospondin, type I, domain containing 1 -3.23078
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -3.23078
TWIST1 twist family bHLH transcription factor 1 -3.23078
ASCL2 achaete-scute family bHLH transcription factor 2 -3.23078
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -3.23078
DEFB134 defensin, beta 134 -3.23078
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -3.23078
IFI16 interferon, gamma-inducible protein 16 -3.23078
C3ORF22 chromosome 3 open reading frame 22 -3.23078
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -3.23078
LY6L lymphocyte antigen 6 family member L -3.23078
GPRC6A G protein-coupled receptor, class C, group 6, member A -3.23078
PCDHAC1 protocadherin alpha subfamily C, 1 -3.23078
FMO3 flavin containing monooxygenase 3 -3.23078
VCX3A variable charge, X-linked 3A -3.23078
C6ORF118 chromosome 6 open reading frame 118 -3.23078
IL12A interleukin 12A -3.23078
CCNI2 cyclin I family, member 2 -3.23078
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.23078
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -3.23078
RBM24 RNA binding motif protein 24 -3.23078
TF transferrin -3.23078
ITGA11 integrin, alpha 11 -3.23078
FAM90A1 family with sequence similarity 90, member A1 -3.23078
ADAMTSL2 ADAMTS-like 2 -3.23078
ANKRD42 ankyrin repeat domain 42 -3.1936
DRC10 dynein regulatory complex subunit 10 -3.1936
FAT2 FAT atypical cadherin 2 -3.14616
RBM46 RNA binding motif protein 46 -3.12835
HCLS1 hematopoietic cell-specific Lyn substrate 1 -3.12222
SLC30A10 solute carrier family 30, member 10 -2.88288
C16ORF86 chromosome 16 open reading frame 86 -2.88288
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 -2.88246
ZNF263 zinc finger protein 263 -2.80293
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.7305
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.72929
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.71164
KCTD14 potassium channel tetramerization domain containing 14 -2.70056
ACTN4 actinin, alpha 4 -2.67538
CAMTA1 calmodulin binding transcription activator 1 -2.63388
HMGN3 high mobility group nucleosomal binding domain 3 -2.62055
PHIP pleckstrin homology domain interacting protein -2.61846
MMP9 matrix metallopeptidase 9 -2.59564
ODC1 ornithine decarboxylase 1 -2.54823
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -2.50631
FAM13B family with sequence similarity 13, member B -2.48957
FBXW10 F-box and WD repeat domain containing 10 -2.48894
UBOX5 U-box domain containing 5 -2.4824
SFXN5 sideroflexin 5 -2.47845
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.46708
RASD1 RAS, dexamethasone-induced 1 -2.42386
NECAP2 NECAP endocytosis associated 2 -2.42386
ZNF778 zinc finger protein 778 -2.41652
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -2.40754
CS citrate synthase -2.40011
ANGEL2 angel homolog 2 (Drosophila) -2.3553
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.35259
KAT5 K(lysine) acetyltransferase 5 -2.33251
PLAU plasminogen activator, urokinase -2.33207
BCDIN3D BCDIN3 domain containing -2.27677
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.27481
NRCAM neuronal cell adhesion molecule -2.27085
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.267
SYCP3 synaptonemal complex protein 3 -2.267
C1ORF202 chromosome 1 open reading frame 202 -2.267
CRYGN crystallin, gamma N -2.267
BTLA B and T lymphocyte associated -2.267
TTF2 transcription termination factor, RNA polymerase II -2.25468
C6ORF47 chromosome 6 open reading frame 47 -2.24447
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -2.23896
PRKCI protein kinase C, iota -2.23052
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.20781
MRPL54 mitochondrial ribosomal protein L54 -2.19435
CDH8 cadherin 8, type 2 -2.18003
RAB9A RAB9A, member RAS oncogene family -2.18003
STMN1 stathmin 1 -2.18003
EPHB6 EPH receptor B6 -2.17098
USHBP1 Usher syndrome 1C binding protein 1 -2.1691
PROSER2 proline and serine rich 2 -2.1691
ZFP62 ZFP62 zinc finger protein -2.16607
SLA2 Src-like-adaptor 2 -2.16578
AKR1D1 aldo-keto reductase family 1, member D1 -2.16578
PMM2 phosphomannomutase 2 -2.16578
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.16578
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 -2.16578
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.16578
MYL5 myosin, light chain 5, regulatory -2.16578
SCFD1 sec1 family domain containing 1 -2.16578
PVALEF parvalbumin like EF-hand containing -2.16544
NRM nurim (nuclear envelope membrane protein) -2.15209
IKBIP IKBKB interacting protein -2.13625
GLE1 GLE1 RNA export mediator -2.12464
TBL2 transducin (beta)-like 2 -2.12002
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.11033
STIM2 stromal interaction molecule 2 -2.10143
NPTX2 neuronal pentraxin II -2.101
CHMP2B charged multivesicular body protein 2B -2.09335
SYT9 synaptotagmin IX -2.08371
DNAAF5 dynein, axonemal, assembly factor 5 -2.07359
GATAD2A GATA zinc finger domain containing 2A -2.06872
IL23A interleukin 23, alpha subunit p19 -2.06337
KIF27 kinesin family member 27 -2.05713
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.05698
CERCAM cerebral endothelial cell adhesion molecule -2.04839
OGA O-GlcNAcase -2.04777
TUBA1C tubulin, alpha 1c -2.04777
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.04746
NSD1 nuclear receptor binding SET domain protein 1 -2.03047
MICA MHC class I polypeptide-related sequence A -2.02692
S100A6 S100 calcium binding protein A6 -2.0221
TRAPPC12 trafficking protein particle complex 12 -2.01663
DNASE1 deoxyribonuclease I -2.00421