PHLPP1 Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description PH domain and leucine rich repeat protein phosphatase 1|This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011] (NCBI Entrez Gene Database, 23239)
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6 substrates of the phosphatase PHLPP1 from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
STK4 serine/threonine kinase 4