PHOX2A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired-like homeobox 2a|The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 401)
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Genes

333 genes differentially expressed following the PHOX2A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.24729
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.24729
TKTL1 transketolase-like 1 3.24729
GDNF glial cell derived neurotrophic factor 3.24729
ASB10 ankyrin repeat and SOCS box containing 10 3.24729
NEU4 sialidase 4 3.24729
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.24729
MFAP5 microfibrillar associated protein 5 3.24729
PECAM1 platelet/endothelial cell adhesion molecule 1 3.24729
KCNRG potassium channel regulator 3.24729
DDO D-aspartate oxidase 3.24729
NCF1 neutrophil cytosolic factor 1 3.24729
FGD2 FYVE, RhoGEF and PH domain containing 2 3.24729
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.24729
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.24729
ADGRE3 adhesion G protein-coupled receptor E3 3.24729
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.24729
PCDHB6 protocadherin beta 6 3.24729
ADGRG4 adhesion G protein-coupled receptor G4 3.24729
SSTR1 somatostatin receptor 1 3.24729
OSGIN1 oxidative stress induced growth inhibitor 1 3.24729
LYZL6 lysozyme-like 6 3.24729
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.24729
C1ORF146 chromosome 1 open reading frame 146 3.24729
LUZP4 leucine zipper protein 4 3.24729
OR2B11 olfactory receptor, family 2, subfamily B, member 11 3.24729
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.24729
ERAP2 endoplasmic reticulum aminopeptidase 2 3.24729
IL23R interleukin 23 receptor 3.24729
CYSRT1 cysteine-rich tail protein 1 3.24729
CTAG2 cancer/testis antigen 2 3.24729
NEUROD1 neuronal differentiation 1 3.24729
NLRP11 NLR family, pyrin domain containing 11 3.24729
LGALS4 lectin, galactoside-binding, soluble, 4 3.24729
BMP5 bone morphogenetic protein 5 3.24729
RGPD4 RANBP2-like and GRIP domain containing 4 3.24729
S100A5 S100 calcium binding protein A5 3.24729
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.24729
GPR101 G protein-coupled receptor 101 3.24729
HBM hemoglobin, mu 3.24729
PTK6 protein tyrosine kinase 6 3.24729
MMP20 matrix metallopeptidase 20 3.24729
TAS2R10 taste receptor, type 2, member 10 3.24729
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 3.24729
MROH2A maestro heat-like repeat family member 2A 3.24729
PNMA6F PNMA family member 6F 3.24729
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 3.24729
MGAT4D MGAT4 family, member D 3.24729
ACER1 alkaline ceramidase 1 3.24729
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.24729
SAG S-antigen; retina and pineal gland (arrestin) 3.24729
ASB9 ankyrin repeat and SOCS box containing 9 3.24729
CFC1 cripto, FRL-1, cryptic family 1 3.24729
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.24729
SOAT2 sterol O-acyltransferase 2 3.24729
AVPR1B arginine vasopressin receptor 1B 3.24729
GIPC3 GIPC PDZ domain containing family, member 3 3.24729
THSD8 thrombospondin type 1 domain containing 8 3.24729
WASL-DT WASL divergent transcript 3.24729
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.24729
H3C13 H3 clustered histone 13 3.24729
DNAAF6 dynein axonemal assembly factor 6 3.24729
H2BW2 H2B.W histone 2 3.24729
MSANTD5 Myb/SANT DNA binding domain containing 5 3.24729
ALPG alkaline phosphatase, germ cell 3.24729
SQOR sulfide quinone oxidoreductase 3.24729
TMEM119 transmembrane protein 119 3.24729
FGFBP1 fibroblast growth factor binding protein 1 3.24729
IL1R2 interleukin 1 receptor, type II 3.24729
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.24729
FRMD7 FERM domain containing 7 3.24729
TBX20 T-box 20 3.24729
TAS2R3 taste receptor, type 2, member 3 3.24729
NRN1 neuritin 1 3.24729
TMPRSS11F transmembrane protease, serine 11F 3.24729
HLF hepatic leukemia factor 3.24729
CD93 CD93 molecule 3.24729
NAPSA napsin A aspartic peptidase 3.24729
OR4N2 olfactory receptor, family 4, subfamily N, member 2 3.24729
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.24729
CNTFR ciliary neurotrophic factor receptor 3.24729
CCR3 chemokine (C-C motif) receptor 3 3.24729
TBX3 T-box 3 3.24729
TLR6 toll-like receptor 6 3.24729
IL6 interleukin 6 3.24729
TMEM235 transmembrane protein 235 3.24729
CBLN3 cerebellin 3 precursor 3.24729
C4ORF17 chromosome 4 open reading frame 17 3.24729
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.24729
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 3.24729
NPPA natriuretic peptide A 3.24729
C2CD4B C2 calcium-dependent domain containing 4B 3.24729
C2CD4A C2 calcium-dependent domain containing 4A 3.24729
SHISA8 shisa family member 8 3.24729
CCDC185 coiled-coil domain containing 185 3.24729
MUC13 mucin 13, cell surface associated 3.24729
ISL2 ISL LIM homeobox 2 3.24729
IL1A interleukin 1, alpha 3.24729
TEKT4 tektin 4 3.24729
MAB21L1 mab-21-like 1 (C. elegans) 3.24729
MAB21L3 mab-21-like 3 (C. elegans) 3.24729
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.24729
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.24729
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 3.24729
AQP7 aquaporin 7 3.24729
GCOM1 GRINL1A complex locus 1 3.24729
GLOD5 glyoxalase domain containing 5 3.24729
WFDC9 WAP four-disulfide core domain 9 3.24729
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 3.24729
SH2D4B SH2 domain containing 4B 3.24729
SFRP4 secreted frizzled-related protein 4 3.24729
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 3.24729
LRRC15 leucine rich repeat containing 15 3.24729
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.24729
MYLK2 myosin light chain kinase 2 3.24729
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.24729
NYX nyctalopin 3.24729
CAPSL calcyphosine-like 3.24729
FAIM2 Fas apoptotic inhibitory molecule 2 3.24729
TTC24 tetratricopeptide repeat domain 24 3.24729
ZPBP zona pellucida binding protein 3.24729
IBSP integrin-binding sialoprotein 3.24729
SOSTDC1 sclerostin domain containing 1 3.24729
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.24729
UTS2R urotensin 2 receptor 3.24729
TAAR1 trace amine associated receptor 1 3.24729
CD200R1 CD200 receptor 1 3.24729
TPPP2 tubulin polymerization-promoting protein family member 2 3.24729
PHOX2A paired-like homeobox 2a 3.24729
NT5DC4 5'-nucleotidase domain containing 4 3.24729
CLEC9A C-type lectin domain family 9, member A 3.24729
GFRAL GDNF family receptor alpha like 3.24729
GOLGA8O golgin A8 family, member O 3.24729
SLFN12L schlafen family member 12-like 3.24729
CIB3 calcium and integrin binding family member 3 3.24729
TSPAN32 tetraspanin 32 3.24729
KRTAP9-9 keratin associated protein 9-9 3.24729
CETP cholesteryl ester transfer protein, plasma 3.24729
PATE2 prostate and testis expressed 2 3.24729
FZD1 frizzled class receptor 1 3.24729
PRRX1 paired related homeobox 1 3.24729
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.24729
GPR45 G protein-coupled receptor 45 3.24729
SLC7A4 solute carrier family 7, member 4 3.24729
MMP3 matrix metallopeptidase 3 3.24729
THEM5 thioesterase superfamily member 5 3.24729
ADAM29 ADAM metallopeptidase domain 29 3.24729
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.24729
CABP7 calcium binding protein 7 3.24729
ANGPTL6 angiopoietin-like 6 3.24729
TRAF3IP3 TRAF3 interacting protein 3 3.24729
NUTM2D NUT family member 2D 3.24729
SSX3 synovial sarcoma, X breakpoint 3 3.24729
SCN3A sodium channel, voltage gated, type III alpha subunit 3.24729
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.24729
TGM5 transglutaminase 5 3.24729
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.24729
AATF apoptosis antagonizing transcription factor 3.23091
RNF222 ring finger protein 222 3.20076
PALS2 protein associated with LIN7 2, MAGUK p55 family member 3.20076
KLF5 Kruppel-like factor 5 (intestinal) 3.20076
MMP19 matrix metallopeptidase 19 3.20076
PARP4 poly (ADP-ribose) polymerase family, member 4 3.07625
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 3.07197
WNT5A wingless-type MMTV integration site family, member 5A 2.93497
GAN gigaxonin 2.86076
TBC1D24 TBC1 domain family, member 24 2.84233
COPE coatomer protein complex, subunit epsilon 2.8057
VSIG1 V-set and immunoglobulin domain containing 1 2.79472
RPS27L ribosomal protein S27-like 2.72752
TMED3 transmembrane emp24 protein transport domain containing 3 2.70139
TRIML2 tripartite motif family-like 2 2.64817
CRYM crystallin, mu 2.55187
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.53692
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.49307
CHMP4B charged multivesicular body protein 4B 2.48281
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.47828
INPPL1 inositol polyphosphate phosphatase-like 1 2.46143
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.45549
HES2 hes family bHLH transcription factor 2 2.45002
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.42691
HEXIM2 hexamethylene bis-acetamide inducible 2 2.42245
MFSD12 major facilitator superfamily domain containing 12 2.39517
RRAGC Ras-related GTP binding C 2.3619
CTPS2 CTP synthase 2 2.34236
GDF9 growth differentiation factor 9 2.33728
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 2.32833
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 2.3089
RNF113A ring finger protein 113A 2.30879
VAT1 vesicle amine transport 1 2.30219
WNT3A wingless-type MMTV integration site family, member 3A 2.29931
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.29931
MANSC4 MANSC domain containing 4 2.29931
LRRC43 leucine rich repeat containing 43 2.29931
TMEM14B transmembrane protein 14B 2.25291
IGFL3 IGF-like family member 3 2.25131
SFXN5 sideroflexin 5 2.22002
OXR1 oxidation resistance 1 2.19376
ATP10A ATPase, class V, type 10A 2.19202
PLA2G3 phospholipase A2, group III 2.12958
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.12426
COX6C cytochrome c oxidase subunit VIc 2.11029
GSS glutathione synthetase 2.10773
ZNF322 zinc finger protein 322 2.10712
MTFR1 mitochondrial fission regulator 1 2.10616
AMER1 APC membrane recruitment protein 1 2.10433
TXLNA taxilin alpha 2.09489
TUBA1A tubulin, alpha 1a 2.09344
EFNA3 ephrin-A3 2.09342
SS18 synovial sarcoma translocation, chromosome 18 2.09102
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.08867
ATF6 activating transcription factor 6 2.08363
ACAT1 acetyl-CoA acetyltransferase 1 2.08083
ZCWPW2 zinc finger, CW type with PWWP domain 2 2.07886
HSPA1B heat shock 70kDa protein 1B 2.07886
ZNF630 zinc finger protein 630 2.07817
AFTPH aftiphilin 2.07723
KIAA1549L KIAA1549-like 2.07601
PROK2 prokineticin 2 2.07601
MT1X metallothionein 1X 2.03365
BTBD9 BTB (POZ) domain containing 9 2.03212
ZNF566 zinc finger protein 566 2.02601
GRPEL2 GrpE-like 2, mitochondrial (E. coli) 2.02168
RSU1 Ras suppressor protein 1 2.00568

decreased expression

Symbol Name Standardized Value
MXRA5 matrix-remodelling associated 5 -3.24729
ACTA1 actin, alpha 1, skeletal muscle -3.24729
ZNF532 zinc finger protein 532 -3.24729
REEP4 receptor accessory protein 4 -3.24729
DOK3 docking protein 3 -3.24729
STRADB STE20-related kinase adaptor beta -3.24729
SAXO4 stabilizer of axonemal microtubules 4 -3.24729
RP1L1 retinitis pigmentosa 1-like 1 -3.24729
ABI3 ABI family, member 3 -3.24729
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -3.20076
TMEM82 transmembrane protein 82 -3.20076
ALG10B ALG10B, alpha-1,2-glucosyltransferase -3.20076
CHRM4 cholinergic receptor, muscarinic 4 -3.20076
LEP leptin -3.20076
PIKFYVE phosphoinositide kinase, FYVE finger containing -3.20076
PLEK2 pleckstrin 2 -3.20076
TSKS testis-specific serine kinase substrate -3.20076
CLCNKB chloride channel, voltage-sensitive Kb -3.20076
MRC1 mannose receptor, C type 1 -3.20076
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -3.20076
IRX1 iroquois homeobox 1 -3.20076
TDO2 tryptophan 2,3-dioxygenase -3.20076
CCDC87 coiled-coil domain containing 87 -3.20076
FNDC8 fibronectin type III domain containing 8 -3.20076
LCN15 lipocalin 15 -3.20076
ERICH6B glutamate-rich 6B -3.20076
MEP1B meprin A, beta -3.20076
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -3.20076
AMN amnion associated transmembrane protein -3.20076
DRICH1 aspartate-rich 1 -3.20076
TMPPE transmembrane protein with metallophosphoesterase domain -3.20076
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -3.20076
NLRP14 NLR family, pyrin domain containing 14 -3.20076
C11ORF86 chromosome 11 open reading frame 86 -3.20076
CRYBB3 crystallin, beta B3 -3.20076
DUSP8 dual specificity phosphatase 8 -3.20076
CAPN9 calpain 9 -3.20076
GMFG glia maturation factor, gamma -3.20076
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -3.20076
HAS1 hyaluronan synthase 1 -3.20076
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -3.20076
B2M beta-2-microglobulin -3.1343
SLC46A1 solute carrier family 46 (folate transporter), member 1 -3.09394
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3 -2.82725
RPSA ribosomal protein SA -2.7637
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.75982
SAP18 Sin3A-associated protein, 18kDa -2.71176
SRBD1 S1 RNA binding domain 1 -2.64817
RAB2A RAB2A, member RAS oncogene family -2.64817
C1D C1D nuclear receptor corepressor -2.61826
POGLUT2 protein O-glucosyltransferase 2 -2.55187
ADAM9 ADAM metallopeptidase domain 9 -2.54393
LMBRD2 LMBR1 domain containing 2 -2.53692
C1QTNF12 C1q and TNF related 12 -2.53193
CALY calcyon neuron-specific vesicular protein -2.53193
OXTR oxytocin receptor -2.53193
TFF3 trefoil factor 3 (intestinal) -2.53193
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.52273
MCM5 minichromosome maintenance complex component 5 -2.45492
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.43755
FLYWCH1 FLYWCH-type zinc finger 1 -2.37724
MRPS10 mitochondrial ribosomal protein S10 -2.37686
RENBP renin binding protein -2.36594
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.36092
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.34537
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -2.3089
ENKD1 enkurin domain containing 1 -2.3089
MAP2K6 mitogen-activated protein kinase kinase 6 -2.30738
TMEM54 transmembrane protein 54 -2.30738
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.30738
FGF16 fibroblast growth factor 16 -2.30738
BMP6 bone morphogenetic protein 6 -2.29931
FBN1 fibrillin 1 -2.29061
KLHL5 kelch-like family member 5 -2.2902
CCDC74B coiled-coil domain containing 74B -2.2831
CFAP43 cilia and flagella associated protein 43 -2.26679
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.24579
LCOR ligand dependent nuclear receptor corepressor -2.24579
TOB1 transducer of ERBB2, 1 -2.2429
HINT3 histidine triad nucleotide binding protein 3 -2.23442
TP53BP2 tumor protein p53 binding protein 2 -2.22664
ERICH6 glutamate-rich 6 -2.22002
WDR93 WD repeat domain 93 -2.22002
EXOC4 exocyst complex component 4 -2.21906
SAP30L SAP30-like -2.20513
ASB7 ankyrin repeat and SOCS box containing 7 -2.17657
RAB20 RAB20, member RAS oncogene family -2.13877
SLC25A51 solute carrier family 25, member 51 -2.123
VCF1 VCP nuclear cofactor family member 1 -2.10053
NOXA1 NADPH oxidase activator 1 -2.09948
C20ORF203 chromosome 20 open reading frame 203 -2.09948
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -2.09948
INSYN1 inhibitory synaptic factor 1 -2.09948
FADS3 fatty acid desaturase 3 -2.09344
AQR aquarius intron-binding spliceosomal factor -2.09344
CPNE1 copine I -2.09102
PTK7 protein tyrosine kinase 7 (inactive) -2.08335
COPZ1 coatomer protein complex, subunit zeta 1 -2.07886
CCDC196 coiled-coil domain containing 196 -2.07601
SMC2 structural maintenance of chromosomes 2 -2.07601
PEX11G peroxisomal biogenesis factor 11 gamma -2.07601
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.06968
SYPL1 synaptophysin-like 1 -2.06081
TPO thyroid peroxidase -2.05582
ATE1 arginyltransferase 1 -2.04337
NSUN7 NOP2/Sun domain family, member 7 -2.04306
GPS2 G protein pathway suppressor 2 -2.02601
TARDBP TAR DNA binding protein -2.01903
TMEM200A transmembrane protein 200A -2.00488