PHYH Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phytanoyl-CoA 2-hydroxylase|This gene is a member of the PhyH family and encodes a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum disease (RD) and deficient protein activity has been associated with Zellweger syndrome and rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5264)
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Genes

310 genes differentially expressed following the PHYH gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IL6 interleukin 6 2.72682
IZUMO4 IZUMO family member 4 2.72682
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.72682
SIX3 SIX homeobox 3 2.72682
COL20A1 collagen, type XX, alpha 1 2.72682
ZNF503 zinc finger protein 503 2.72682
ZSCAN5B zinc finger and SCAN domain containing 5B 2.72682
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.72682
BTN1A1 butyrophilin, subfamily 1, member A1 2.72682
ANKRD22 ankyrin repeat domain 22 2.72682
IL12RB1 interleukin 12 receptor, beta 1 2.72682
PCDHA1 protocadherin alpha 1 2.72682
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.72682
CATSPER3 cation channel, sperm associated 3 2.72682
CBLN3 cerebellin 3 precursor 2.72682
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.72682
WNT11 wingless-type MMTV integration site family, member 11 2.72682
ZBTB16 zinc finger and BTB domain containing 16 2.72682
RHOXF2 Rhox homeobox family, member 2 2.72682
CCIN calicin 2.72682
PCDHA5 protocadherin alpha 5 2.72682
HCRTR1 hypocretin (orexin) receptor 1 2.72682
AKR1C2 aldo-keto reductase family 1, member C2 2.72682
ALPK2 alpha-kinase 2 2.72682
CARD18 caspase recruitment domain family, member 18 2.72682
ADGB androglobin 2.72682
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.72682
RAPSN receptor-associated protein of the synapse 2.72682
C9ORF152 chromosome 9 open reading frame 152 2.72682
GMFG glia maturation factor, gamma 2.72682
PARP10 poly (ADP-ribose) polymerase family, member 10 2.72682
OR52B4 olfactory receptor, family 52, subfamily B, member 4 (gene/pseudogene) 2.72682
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.72682
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.72682
MAGEA3 melanoma antigen family A3 2.72682
GFRA3 GDNF family receptor alpha 3 2.72682
SOX14 SRY (sex determining region Y)-box 14 2.72682
TNNT3 troponin T type 3 (skeletal, fast) 2.72682
GLYAT glycine-N-acyltransferase 2.72682
ATXN7 ataxin 7 2.72682
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.72682
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.72682
ARHGAP36 Rho GTPase activating protein 36 2.72682
TTPA tocopherol (alpha) transfer protein 2.72682
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.72682
SMIM45 small integral membrane protein 45 2.72682
ROPN1B rhophilin associated tail protein 1B 2.72682
OPRM1 opioid receptor, mu 1 2.72682
CD300LF CD300 molecule-like family member f 2.72682
VN1R1 vomeronasal 1 receptor 1 2.72682
SPI1 Spi-1 proto-oncogene 2.72682
SPEM1 spermatid maturation 1 2.72682
RHCE Rh blood group, CcEe antigens 2.72682
TCERG1L transcription elongation regulator 1-like 2.72682
SPRR2F small proline-rich protein 2F 2.72682
YIPF5 Yip1 domain family, member 5 2.72682
ZAR1 zygote arrest 1 2.72682
SMIM31 small integral membrane protein 31 2.72682
DNAAF6 dynein axonemal assembly factor 6 2.72682
CATSPERZ catsper channel auxiliary subunit zeta 2.72682
DEPP1 DEPP autophagy regulator 1 2.72682
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.72682
DERPC DERPC proline and glycine rich nuclear protein 2.72682
H3-5 H3.5 histone 2.72682
HBG1 hemoglobin, gamma A 2.72682
ZNF726 zinc finger protein 726 2.72682
MLN motilin 2.72682
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.72682
WNT9B wingless-type MMTV integration site family, member 9B 2.72682
FRK fyn-related Src family tyrosine kinase 2.72682
TAS1R2 taste receptor, type 1, member 2 2.72682
BLNK B-cell linker 2.72682
MTMR11 myotubularin related protein 11 2.72682
BARX1 BARX homeobox 1 2.72682
CELA2A chymotrypsin-like elastase family, member 2A 2.72682
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.72682
EXOC3L1 exocyst complex component 3-like 1 2.72682
ASIC4 acid sensing (proton gated) ion channel family member 4 2.72682
ROPN1 rhophilin associated tail protein 1 2.72682
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.72682
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.72682
TFF3 trefoil factor 3 (intestinal) 2.72682
TFF2 trefoil factor 2 2.72682
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.72682
SMPX small muscle protein, X-linked 2.72682
MYEOV myeloma overexpressed 2.72682
FAM228A family with sequence similarity 228, member A 2.72682
GATA5 GATA binding protein 5 2.72682
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.72682
TTLL8 tubulin tyrosine ligase-like family member 8 2.72682
ART1 ADP-ribosyltransferase 1 2.72682
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.72682
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.72682
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.72682
NPFFR1 neuropeptide FF receptor 1 2.72682
HAVCR1 hepatitis A virus cellular receptor 1 2.72682
GOLGA6B golgin A6 family, member B 2.72682
TAS2R50 taste receptor, type 2, member 50 2.72682
SLFNL1 schlafen-like 1 2.72682
HLA-G major histocompatibility complex, class I, G 2.72682
NXNL1 nucleoredoxin-like 1 2.72682
DNAH12 dynein, axonemal, heavy chain 12 2.72682
RSAD2 radical S-adenosyl methionine domain containing 2 2.72682
PALMD palmdelphin 2.72682
IL17REL interleukin 17 receptor E-like 2.72682
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.72682
ESAM endothelial cell adhesion molecule 2.72682
CPO carboxypeptidase O 2.72682
CNGB3 cyclic nucleotide gated channel beta 3 2.72682
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.72682
PTCH2 patched 2 2.72682
ZNF835 zinc finger protein 835 2.72682
C1ORF185 chromosome 1 open reading frame 185 2.72682
CLEC18B C-type lectin domain family 18, member B 2.72682
OR6V1 olfactory receptor, family 6, subfamily V, member 1 2.72682
CCNA1 cyclin A1 2.72682
CASQ2 calsequestrin 2 (cardiac muscle) 2.72682
POU4F1 POU class 4 homeobox 1 2.72682
NXF2B nuclear RNA export factor 2B 2.72682
CSF1R colony stimulating factor 1 receptor 2.72682
UBXN10 UBX domain protein 10 2.72682
XIRP2 xin actin binding repeat containing 2 2.72682
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 2.72682
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.72682
ZC3H11D zinc finger CCCH-type containing 11D 2.72682
SVOP SV2 related protein homolog (rat) 2.72682
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.72682
PRR15L proline rich 15-like 2.72682
ALOX15B arachidonate 15-lipoxygenase, type B 2.72682
GCM2 glial cells missing homolog 2 (Drosophila) 2.72682
APOA5 apolipoprotein A-V 2.72682
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.72682
IL32 interleukin 32 2.72682
TSSK1B testis-specific serine kinase 1B 2.72682
HEPN1 hepatocellular carcinoma, down-regulated 1 2.72682
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.72682
TGM2 transglutaminase 2 2.72682
CIB3 calcium and integrin binding family member 3 2.72682
CD8B CD8b molecule 2.72682
ATOH7 atonal homolog 7 (Drosophila) 2.72682
SP6 Sp6 transcription factor 2.72682
SYTL5 synaptotagmin-like 5 2.72682
METTL21C methyltransferase like 21C 2.72682
SOST sclerostin 2.72682
RGR retinal G protein coupled receptor 2.72682
R3HDML R3H domain containing-like 2.72682
AREG amphiregulin 2.72682
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.72682
TTC36 tetratricopeptide repeat domain 36 2.72682
OXA1L oxidase (cytochrome c) assembly 1-like 2.66657
UROD uroporphyrinogen decarboxylase 2.6628
CUL3 cullin 3 2.62828
RELT RELT tumor necrosis factor receptor 2.58401
LIF leukemia inhibitory factor 2.58401
SIN3B SIN3 transcription regulator family member B 2.53453
CLCNKA chloride channel, voltage-sensitive Ka 2.43619
METAP2 methionyl aminopeptidase 2 2.40473
MBTD1 mbt domain containing 1 2.37178
NCAM1 neural cell adhesion molecule 1 2.34991
ENO3 enolase 3 (beta, muscle) 2.34082
HAS1 hyaluronan synthase 1 2.33318
RASL11A RAS-like, family 11, member A 2.33204
ADAMTSL1 ADAMTS-like 1 2.32401
CPHXL cytoplasmic polyadenylated homeobox like 2.31158
LRRC19 leucine rich repeat containing 19 2.31101
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 2.31101
ROGDI rogdi homolog (Drosophila) 2.3014
SCAMP1 secretory carrier membrane protein 1 2.3014
MTARC2 mitochondrial amidoxime reducing component 2 2.29588
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 2.27011
TSPAN11 tetraspanin 11 2.26395
ERLIN2 ER lipid raft associated 2 2.2424
OMD osteomodulin 2.2424
CAPN1 calpain 1, (mu/I) large subunit 2.24175
CRPPA CDP-L-ribitol pyrophosphorylase A 2.24175
OTOF otoferlin 2.24175
FETUB fetuin B 2.24175
PFDN4 prefoldin subunit 4 2.24175
ZNF853 zinc finger protein 853 2.23329
TNRC6B trinucleotide repeat containing 6B 2.2315
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.2154
GPC1 glypican 1 2.2154
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 2.20917
LIN54 lin-54 DREAM MuvB core complex component 2.18474
ZNF181 zinc finger protein 181 2.18332
HPS1 Hermansky-Pudlak syndrome 1 2.18332
WBP4 WW domain binding protein 4 2.17488
CXXC1 CXXC finger protein 1 2.16392
MRPL42 mitochondrial ribosomal protein L42 2.15743
ZNF639 zinc finger protein 639 2.14405
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.14281
CTNNBIP1 catenin, beta interacting protein 1 2.14281
REST RE1-silencing transcription factor 2.14099
WWP2 WW domain containing E3 ubiquitin protein ligase 2 2.14099
ESRRA estrogen-related receptor alpha 2.14099
ZFR2 zinc finger RNA binding protein 2 2.13109
MYO3B myosin IIIB 2.10438
PRLR prolactin receptor 2.10438
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2.09114
PRICKLE1 prickle homolog 1 (Drosophila) 2.08991
MIEF1 mitochondrial elongation factor 1 2.08991
FANCB Fanconi anemia, complementation group B 2.06563
LY75 lymphocyte antigen 75 2.04544
LRR1 leucine rich repeat protein 1 2.04503
FAXDC2 fatty acid hydroxylase domain containing 2 2.04113

decreased expression

Symbol Name Standardized Value
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) -2.72682
VSTM2A V-set and transmembrane domain containing 2A -2.72682
TAL2 T-cell acute lymphocytic leukemia 2 -2.72682
OXTR oxytocin receptor -2.72682
TTLL2 tubulin tyrosine ligase-like family member 2 -2.72682
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -2.72682
CAPS calcyphosine -2.72682
WNT5B wingless-type MMTV integration site family, member 5B -2.72682
AZU1 azurocidin 1 -2.72682
PEAR1 platelet endothelial aggregation receptor 1 -2.72682
NAP1L5 nucleosome assembly protein 1-like 5 -2.72682
PRKG2 protein kinase, cGMP-dependent, type II -2.72682
PRSS51 protease, serine, 51 -2.72682
ATP11A ATPase, class VI, type 11A -2.72682
ZNF99 zinc finger protein 99 -2.72682
ZNF597 zinc finger protein 597 -2.72682
ZFTRAF1 zinc finger TRAF-type containing 1 -2.72682
HJV hemojuvelin BMP co-receptor -2.72682
TEDC1 tubulin epsilon and delta complex 1 -2.72682
STAC2 SH3 and cysteine rich domain 2 -2.72682
SAMD15 sterile alpha motif domain containing 15 -2.72682
SPAG4 sperm associated antigen 4 -2.72682
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.72682
PRR19 proline rich 19 -2.72682
PRRT1 proline-rich transmembrane protein 1 -2.72682
HAPLN2 hyaluronan and proteoglycan link protein 2 -2.72682
RHOBTB2 Rho-related BTB domain containing 2 -2.72682
TLE6 transducin-like enhancer of split 6 -2.72682
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.72682
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.72682
ADGRL4 adhesion G protein-coupled receptor L4 -2.72682
PHYH phytanoyl-CoA 2-hydroxylase -2.72682
OAZ3 ornithine decarboxylase antizyme 3 -2.72682
MYLK4 myosin light chain kinase family, member 4 -2.72682
FAT2 FAT atypical cadherin 2 -2.72682
IFFO2 intermediate filament family orphan 2 -2.72682
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.72682
ALOXE3 arachidonate lipoxygenase 3 -2.72682
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.72682
LOC124903233 uncharacterized LOC124903233 -2.72682
CTXN2 cortexin 2 -2.72682
RASA3 RAS p21 protein activator 3 -2.72682
TMEM61 transmembrane protein 61 -2.72682
SV2C synaptic vesicle glycoprotein 2C -2.72682
BHLHA15 basic helix-loop-helix family, member a15 -2.72682
SOWAHD sosondowah ankyrin repeat domain family member D -2.68195
ZNF43 zinc finger protein 43 -2.68195
GEM GTP binding protein overexpressed in skeletal muscle -2.64235
GAL3ST3 galactose-3-O-sulfotransferase 3 -2.62903
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.62828
TOGARAM2 TOG array regulator of axonemal microtubules 2 -2.62517
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 -2.62205
RUMY1 regulator of UNG2 and MKLN1 interacting yippee protein 1 -2.58845
TMPRSS11D transmembrane protease, serine 11D -2.58845
EFCAB8 EF-hand calcium binding domain 8 -2.58845
ANKRD33B ankyrin repeat domain 33B -2.57249
ZNF274 zinc finger protein 274 -2.52841
ZNF107 zinc finger protein 107 -2.5271
PCSK5 proprotein convertase subtilisin/kexin type 5 -2.52311
NKX1-2 NK1 homeobox 2 -2.43806
SHOX short stature homeobox -2.43806
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -2.43806
MRPL54 mitochondrial ribosomal protein L54 -2.41291
EXOC8 exocyst complex component 8 -2.38461
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -2.34437
LNPEP leucyl/cystinyl aminopeptidase -2.34082
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.31101
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.31085
CHSY3 chondroitin sulfate synthase 3 -2.3014
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.29964
CFAP410 cilia and flagella associated protein 410 -2.29588
RAB43 RAB43, member RAS oncogene family -2.29107
BCL6 B-cell CLL/lymphoma 6 -2.28857
PDLIM1 PDZ and LIM domain 1 -2.24503
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.23116
MCAM melanoma cell adhesion molecule -2.23116
NOP16 NOP16 nucleolar protein -2.2154
PCYT1B phosphate cytidylyltransferase 1, choline, beta -2.20978
PLPP6 phospholipid phosphatase 6 -2.20482
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.20482
TRO trophinin -2.19321
PRPF38B pre-mRNA processing factor 38B -2.16572
ZNF177 zinc finger protein 177 -2.15045
NUP62 nucleoporin 62kDa -2.14319
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.14281
PDCD6IP programmed cell death 6 interacting protein -2.1422
MED9 mediator complex subunit 9 -2.1422
PAQR8 progestin and adipoQ receptor family member VIII -2.14099
NAGS N-acetylglutamate synthase -2.14099
HIPK4 homeodomain interacting protein kinase 4 -2.14099
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.14099
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -2.14099
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.13661
TCHP trichoplein, keratin filament binding -2.13661
DNAAF10 dynein axonemal assembly factor 10 -2.13646
ANKRD13D ankyrin repeat domain 13 family, member D -2.13646
SDCBP2 syndecan binding protein (syntenin) 2 -2.13379
RAB38 RAB38, member RAS oncogene family -2.12908
RNF19B ring finger protein 19B -2.10488
ZBTB17 zinc finger and BTB domain containing 17 -2.10438
ZDHHC7 zinc finger, DHHC-type containing 7 -2.08991
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.06563
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.04503
ZSWIM9 zinc finger SWIM-type containing 9 -2.04239
TTN titin -2.03813