PHYH Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description phytanoyl-CoA 2-hydroxylase|This gene is a member of the PhyH family and encodes a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum disease (RD) and deficient protein activity has been associated with Zellweger syndrome and rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5264)
External Link https://ncbi.nlm.nih.gov/gene/5264
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Genes

500 genes differentially expressed following the PHYH gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
FABP4 fatty acid binding protein 4, adipocyte 0.0135411
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0131751
STK10 serine/threonine kinase 10 0.0127406
NIBAN1 niban apoptosis regulator 1 0.0122638
XIC X chromosome inactivation center 0.0120843
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.0117922
THBS4 thrombospondin 4 0.0106602
SFRP1 secreted frizzled-related protein 1 0.0102178
AKR1C3 aldo-keto reductase family 1, member C3 0.0102074
FXYD3 FXYD domain containing ion transport regulator 3 0.0102009
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00976294
NEFH neurofilament, heavy polypeptide 0.00948893
RB1 retinoblastoma 1 0.00936136
E2F2 E2F transcription factor 2 0.00892557
MB myoglobin 0.00891971
TACSTD2 tumor-associated calcium signal transducer 2 0.00890764
PEG10 paternally expressed 10 0.00887859
TM4SF1 transmembrane 4 L six family member 1 0.00885347
TSPAN13 tetraspanin 13 0.00876229
IFI27 interferon, alpha-inducible protein 27 0.00854706
CNTN1 contactin 1 0.0085115
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00849126
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.00827314
DES desmin 0.00823895
IGFBP5 insulin-like growth factor binding protein 5 0.00806455
S100P S100 calcium binding protein P 0.00802443
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.00802023
TTN titin 0.00794052
AKR1C2 aldo-keto reductase family 1, member C2 0.00778764
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.00770028
FILIP1L filamin A interacting protein 1-like 0.00765137
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00756162
CKM creatine kinase, muscle 0.00756032
VWF von Willebrand factor 0.00754919
GJA1 gap junction protein, alpha 1, 43kDa 0.00741722
COL15A1 collagen, type XV, alpha 1 0.00741599
AKR1C1 aldo-keto reductase family 1, member C1 0.00736555
ISG15 ISG15 ubiquitin-like modifier 0.00733572
LHFP lipoma HMGIC fusion partner 0.00729938
SRPX sushi-repeat containing protein, X-linked 0.00722737
ACTC1 actin, alpha, cardiac muscle 1 0.00719361
KLHL41 kelch-like family member 41 0.00714013
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.00709602
HSPB8 heat shock 22kDa protein 8 0.00704299
CRYAB crystallin, alpha B 0.00698048
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.00695869
ZFP36L1 ZFP36 ring finger protein-like 1 0.00690862
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.006904
KIF2C kinesin family member 2C 0.00689824
DAAM1 dishevelled associated activator of morphogenesis 1 0.00689254
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.00688418
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.00683542
C3 complement component 3 0.00682514
CPE carboxypeptidase E 0.0067981
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00679032
RNF167 ring finger protein 167 0.00677168
MEIS2 Meis homeobox 2 0.00676394
COL14A1 collagen, type XIV, alpha 1 0.00672969
IFITM3 interferon induced transmembrane protein 3 0.00672126
CAV2 caveolin 2 0.00671865
DLK1 delta-like 1 homolog (Drosophila) 0.00671418
TGM1 transglutaminase 1 0.00670603
PODXL podocalyxin-like 0.00663895
PCNA proliferating cell nuclear antigen 0.00662289
PPIC peptidylprolyl isomerase C (cyclophilin C) 0.00659622
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.00659363
CPB1 carboxypeptidase B1 (tissue) 0.00656289
PYCARD PYD and CARD domain containing 0.00651904
FRY furry homolog (Drosophila) 0.00649004
IFI44L interferon-induced protein 44-like 0.00648282
BLVRB biliverdin reductase B 0.00643638
AGR2 anterior gradient 2 0.00642535
PRDX2 peroxiredoxin 2 0.00632229
CD36 CD36 molecule (thrombospondin receptor) 0.00629527
PER3 period circadian clock 3 0.00629211
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 0.00625647
ACTA1 actin, alpha 1, skeletal muscle 0.00623467
CDH5 cadherin 5, type 2 (vascular endothelium) 0.00622541
CD70 CD70 molecule 0.00621897
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.00621895
SPINK1 serine peptidase inhibitor, Kazal type 1 0.00621747
SYNM synemin, intermediate filament protein 0.00621656
LYPD1 LY6/PLAUR domain containing 1 0.00618296
LYPD3 LY6/PLAUR domain containing 3 0.0061729
TIMP3 TIMP metallopeptidase inhibitor 3 0.00617114
PLXDC1 plexin domain containing 1 0.00614865
TLE4 transducin-like enhancer of split 4 0.00612391
AMOTL2 angiomotin like 2 0.00611726
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.00608023
WWTR1 WW domain containing transcription regulator 1 0.00607947
TNNC1 troponin C type 1 (slow) 0.00606675
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.00605846
AQP1 aquaporin 1 (Colton blood group) 0.00605248
LUM lumican 0.00602283
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00598647
SPARCL1 SPARC-like 1 (hevin) 0.00597202
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.00595991
ITM2A integral membrane protein 2A 0.00595458
KANK1 KN motif and ankyrin repeat domains 1 0.00594831
KRT13 keratin 13, type I 0.00588229
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.00585885
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.00585489
OGN osteoglycin 0.00585203
GPC3 glypican 3 0.00584838
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.00584738
TNNC2 troponin C type 2 (fast) 0.00582741
TSPAN7 tetraspanin 7 0.00582463
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.00580173
ZNF589 zinc finger protein 589 0.0057933
IGF1 insulin-like growth factor 1 (somatomedin C) 0.0057927
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.00577824
MYBPC1 myosin binding protein C, slow type 0.00577336
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.00575751
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.00574868
LSP1 lymphocyte-specific protein 1 0.00574384
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.00574101
MFAP4 microfibrillar-associated protein 4 0.00573753
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.00573467
HLA-B major histocompatibility complex, class I, B 0.00570465
RHCG Rh family, C glycoprotein 0.0056796
FOXN3 forkhead box N3 0.00567059
PTCH1 patched 1 0.00565436
SLN sarcolipin 0.00564599
TNNI2 troponin I type 2 (skeletal, fast) 0.00564542
SEC16A SEC16 homolog A (S. cerevisiae) 0.00563893
HTRA1 HtrA serine peptidase 1 0.00563399
VASH1 vasohibin 1 0.00562899
TMPRSS11E transmembrane protease, serine 11E 0.00559676
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.00559674
TCF4 transcription factor 4 0.00558696
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.00557215
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.00557119
GPX1 glutathione peroxidase 1 0.00556296
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00555772
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 0.00554668
NID1 nidogen 1 0.00553474
GDF15 growth differentiation factor 15 0.00552215
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.00550766
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00549206
S100A2 S100 calcium binding protein A2 0.0054881
TAGLN transgelin 0.00548709
DHCR24 24-dehydrocholesterol reductase 0.00548613
AADAC arylacetamide deacetylase 0.00548149
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.00547225
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.00546849
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.00546704
KIF5C kinesin family member 5C 0.00545237
TGFBI transforming growth factor, beta-induced, 68kDa 0.00544311
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.00544248
ADGRL2 adhesion G protein-coupled receptor L2 0.00543373
MCL1 myeloid cell leukemia 1 0.0054257
CHMP4A charged multivesicular body protein 4A 0.00540847
IFI16 interferon, gamma-inducible protein 16 0.00540337
EFNB2 ephrin-B2 0.00540139
CERS4 ceramide synthase 4 0.00540013
PDLIM3 PDZ and LIM domain 3 0.00538013
FAM50A family with sequence similarity 50, member A 0.00537769
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00536556
FYCO1 FYVE and coiled-coil domain containing 1 0.00536381
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.00535533
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.00531202
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.00530459
C1QA complement component 1, q subcomponent, A chain 0.00530282
KLK12 kallikrein-related peptidase 12 0.00529757
TGFBR3 transforming growth factor, beta receptor III 0.00529278
FN1 fibronectin 1 0.00529219
IRF9 interferon regulatory factor 9 0.00528823
ACP3 acid phosphatase 3 0.00527741
GCLC glutamate-cysteine ligase, catalytic subunit 0.0052472
PDLIM5 PDZ and LIM domain 5 0.00524661
KAZN kazrin, periplakin interacting protein 0.00522657
FGG fibrinogen gamma chain 0.0052205
CFB complement factor B 0.00517828
CCNG2 cyclin G2 0.00516143
PLAGL1 pleiomorphic adenoma gene-like 1 0.00515518
UGCG UDP-glucose ceramide glucosyltransferase 0.00514868
PCCB propionyl CoA carboxylase, beta polypeptide 0.00514851
THBD thrombomodulin 0.00514247
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00511539
FMOD fibromodulin 0.00511263
SFRP4 secreted frizzled-related protein 4 0.00510684
IFI44 interferon-induced protein 44 0.00510683
TFPI2 tissue factor pathway inhibitor 2 0.00509892
AKAP8L A kinase (PRKA) anchor protein 8-like 0.00509605
RTN2 reticulon 2 0.00506788
ECM1 extracellular matrix protein 1 0.00504141
VLDLR very low density lipoprotein receptor 0.00504015
GREB1 growth regulation by estrogen in breast cancer 1 0.00503213
RABAC1 Rab acceptor 1 (prenylated) 0.0050315
PDZK1IP1 PDZK1 interacting protein 1 0.00501678
TNXB tenascin XB 0.00499471
TPM3 tropomyosin 3 0.004994
LRRC17 leucine rich repeat containing 17 0.00498855
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.00496979
ADAM12 ADAM metallopeptidase domain 12 0.00496206
SH3GLB2 SH3-domain GRB2-like endophilin B2 0.00496104
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.00496066
CAV1 caveolin 1, caveolae protein, 22kDa 0.00493942
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.004925
PALMD palmdelphin 0.00492173
FGF13 fibroblast growth factor 13 0.00488091
BST2 bone marrow stromal cell antigen 2 0.00488037
DUSP5 dual specificity phosphatase 5 0.00487514
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.00487419
RBM47 RNA binding motif protein 47 0.00487251
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.00485613
STAB1 stabilin 1 0.00485563
CYB5A cytochrome b5 type A (microsomal) 0.00484294
SPRR3 small proline-rich protein 3 0.00482878
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.00481695
ELP1 elongator acetyltransferase complex subunit 1 0.00480075
TNS1 tensin 1 0.00478932
PDGFD platelet derived growth factor D 0.00476686
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.004765
ACTN2 actinin, alpha 2 0.00476409
ADARB1 adenosine deaminase, RNA-specific, B1 0.00475682
COL5A1 collagen, type V, alpha 1 0.00475136
ADIPOQ adiponectin, C1Q and collagen domain containing 0.00474273
TRIB2 tribbles pseudokinase 2 0.00472386
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00472188
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.00471976
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00470543
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.00469023
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.00467949
TGFB1 transforming growth factor, beta 1 0.00467682
HLA-C major histocompatibility complex, class I, C 0.00465661
ANXA9 annexin A9 0.00464464
MX1 MX dynamin-like GTPase 1 0.00464378
CSTA cystatin A (stefin A) 0.0046314
PTPRG protein tyrosine phosphatase, receptor type, G 0.00463044
LCN2 lipocalin 2 0.00462926
TNNI1 troponin I type 1 (skeletal, slow) 0.00462584
GPATCH8 G patch domain containing 8 0.00461961
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.00460891
FBLN1 fibulin 1 0.00460181
TSC22D2 TSC22 domain family, member 2 0.00459808
EDNRA endothelin receptor type A 0.00459222
CRABP2 cellular retinoic acid binding protein 2 0.00458702
ZNF185 zinc finger protein 185 (LIM domain) 0.00455844
CHRDL1 chordin-like 1 0.00455454
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.00453808
MEIS1 Meis homeobox 1 0.00453711
WLS wntless Wnt ligand secretion mediator 0.00453616
CD34 CD34 molecule 0.00453535
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.00453279
YAP1 Yes-associated protein 1 0.00452945
MYBPC2 myosin binding protein C, fast type 0.00451672
SOWAHC sosondowah ankyrin repeat domain family member C 0.00450745
HLA-A major histocompatibility complex, class I, A 0.00450293
TSPAN12 tetraspanin 12 0.00450101

decreased expression

Symbol Name Standardized Value
CHP1 calcineurin-like EF-hand protein 1 -0.0108402
ADD3 adducin 3 (gamma) -0.0107392
PRR7 proline rich 7 (synaptic) -0.00889344
SNAP25 synaptosomal-associated protein, 25kDa -0.00888145
TLCD3A TLC domain containing 3A -0.00868753
CD1E CD1e molecule -0.00846814
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 -0.00839747
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.00826287
SDC2 syndecan 2 -0.00808694
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -0.00803498
NRGN neurogranin (protein kinase C substrate, RC3) -0.00789944
MMP12 matrix metallopeptidase 12 -0.0077934
NEFM neurofilament, medium polypeptide -0.00763776
KDM5D lysine (K)-specific demethylase 5D -0.00757246
IFT57 intraflagellar transport 57 -0.00749325
PUF60 poly-U binding splicing factor 60KDa -0.00732677
PRKCA protein kinase C, alpha -0.0073034
DAXX death-domain associated protein -0.00728347
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.00725359
FAR2 fatty acyl CoA reductase 2 -0.00724176
NT5E 5'-nucleotidase, ecto (CD73) -0.00714809
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.00705816
DMTF1 cyclin D binding myb-like transcription factor 1 -0.00702887
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00700784
PROM1 prominin 1 -0.00689022
CD1B CD1b molecule -0.00683464
CD27 CD27 molecule -0.00682604
CXCL9 chemokine (C-X-C motif) ligand 9 -0.00669902
CXCL13 chemokine (C-X-C motif) ligand 13 -0.00669868
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.00669209
C11ORF49 chromosome 11 open reading frame 49 -0.00666243
RTN3 reticulon 3 -0.00664441
ACOT9 acyl-CoA thioesterase 9 -0.00663773
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.00661364
POSTN periostin, osteoblast specific factor -0.00651066
CD1A CD1a molecule -0.0065062
ADAMDEC1 ADAM-like, decysin 1 -0.00650238
MCOLN1 mucolipin 1 -0.00645052
BEX1 brain expressed, X-linked 1 -0.00644906
CIAO3 cytosolic iron-sulfur assembly component 3 -0.0064405
EMP3 epithelial membrane protein 3 -0.00643848
RETREG1 reticulophagy regulator 1 -0.00630188
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00627886
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -0.00627582
SPA17 sperm autoantigenic protein 17 -0.00624324
CCDC86 coiled-coil domain containing 86 -0.00623413
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -0.006211
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.0062042
NME5 NME/NM23 family member 5 -0.00610968
SEPTIN11 septin 11 -0.00610274
NELL2 NEL-like 2 (chicken) -0.00600262
DNM1L dynamin 1-like -0.00598308
GLUL glutamate-ammonia ligase -0.00597594
ASRGL1 asparaginase like 1 -0.00595726
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -0.00594794
FYB1 FYN binding protein 1 -0.00593332
CSTB cystatin B (stefin B) -0.0059166
HMGA1 high mobility group AT-hook 1 -0.00588664
TCF7 transcription factor 7 (T-cell specific, HMG-box) -0.00585559
MARCKSL1 MARCKS-like 1 -0.00584644
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.00582822
NBPF10 neuroblastoma breakpoint family, member 10 -0.00576916
TOX thymocyte selection-associated high mobility group box -0.00572442
LZTFL1 leucine zipper transcription factor-like 1 -0.00571677
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene -0.00567411
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -0.00559654
PLK1 polo-like kinase 1 -0.00558261
LGALS13 lectin, galactoside-binding, soluble, 13 -0.00557226
LRP4 low density lipoprotein receptor-related protein 4 -0.00555191
SAP30 Sin3A-associated protein, 30kDa -0.00552174
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.00550503
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.00549894
CDC42 cell division cycle 42 -0.00547616
IGFBP1 insulin-like growth factor binding protein 1 -0.00545261
CXADR coxsackie virus and adenovirus receptor -0.0054471
ANXA4 annexin A4 -0.00543375
PITX3 paired-like homeodomain 3 -0.00541669
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.00541327
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -0.00539963
BMP2 bone morphogenetic protein 2 -0.00536276
FAM13A family with sequence similarity 13, member A -0.00536035
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.00532686
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00531214
ZNF580 zinc finger protein 580 -0.00531101
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00527022
CRLF1 cytokine receptor-like factor 1 -0.00526202
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.00525972
MMP9 matrix metallopeptidase 9 -0.00525916
RGS10 regulator of G-protein signaling 10 -0.00525009
OPHN1 oligophrenin 1 -0.00523466
FBXL2 F-box and leucine-rich repeat protein 2 -0.00522805
EVI2A ecotropic viral integration site 2A -0.00520703
SRPK1 SRSF protein kinase 1 -0.00520584
ANGPT1 angiopoietin 1 -0.00516564
SDC4 syndecan 4 -0.00516469
POU2AF1 POU class 2 associating factor 1 -0.00515701
GTPBP8 GTP-binding protein 8 (putative) -0.00514904
CSPP1 centrosome and spindle pole associated protein 1 -0.00514686
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.00514191
AZIN1 antizyme inhibitor 1 -0.00513628
SAMHD1 SAM domain and HD domain 1 -0.00510035
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.00509808
CD52 CD52 molecule -0.00509455
CHPT1 choline phosphotransferase 1 -0.00507754
MLX MLX, MAX dimerization protein -0.00507046
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 -0.00505346
BRD2 bromodomain containing 2 -0.0050419
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.00503551
C2CD5 C2 calcium-dependent domain containing 5 -0.00501832
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.00498604
TAGLN3 transgelin 3 -0.00497818
WEE1 WEE1 G2 checkpoint kinase -0.00496034
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.00495693
FLOT1 flotillin 1 -0.0049532
CD9 CD9 molecule -0.00495103
FAM169A family with sequence similarity 169, member A -0.00494642
SORBS2 sorbin and SH3 domain containing 2 -0.00494408
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.0049424
FADS1 fatty acid desaturase 1 -0.00493594
PECR peroxisomal trans-2-enoyl-CoA reductase -0.0049152
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -0.00491132
NINJ1 ninjurin 1 -0.00490977
AK5 adenylate kinase 5 -0.00490399
SCRG1 stimulator of chondrogenesis 1 -0.00489249
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.00488881
GREM1 gremlin 1, DAN family BMP antagonist -0.00486376
GAL galanin/GMAP prepropeptide -0.00485965
CD44 CD44 molecule (Indian blood group) -0.00485547
MAOA monoamine oxidase A -0.00483835
AHNAK AHNAK nucleoprotein -0.00482627
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.00482404
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -0.00481909
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -0.00481415
SORBS3 sorbin and SH3 domain containing 3 -0.00481231
RIMBP2 RIMS binding protein 2 -0.00480178
VSNL1 visinin-like 1 -0.00479333
CCDC92 coiled-coil domain containing 92 -0.00479118
CCDC68 coiled-coil domain containing 68 -0.00479068
DIO1 deiodinase, iodothyronine, type I -0.00479041
UGP2 UDP-glucose pyrophosphorylase 2 -0.00478595
ELANE elastase, neutrophil expressed -0.00476597
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -0.00475226
OAT ornithine aminotransferase -0.00472647
LRRC6 leucine rich repeat containing 6 -0.00472565
TSHR thyroid stimulating hormone receptor -0.00470641
SELENBP1 selenium binding protein 1 -0.00469871
ACVR1B activin A receptor, type IB -0.00468568
TG thyroglobulin -0.00467766
CRABP1 cellular retinoic acid binding protein 1 -0.00467483
BTG3 BTG family, member 3 -0.00466752
HMGB1 high mobility group box 1 -0.00466593
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.00464846
FNTA farnesyltransferase, CAAX box, alpha -0.00463036
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -0.00462182
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -0.00461491
RTN1 reticulon 1 -0.00458845
AOC1 amine oxidase, copper containing 1 -0.00458765
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.00458165
PHKG2 phosphorylase kinase, gamma 2 (testis) -0.0045787
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.00455491
CD2 CD2 molecule -0.00455427
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.00454276
CTSZ cathepsin Z -0.00453815
FAM171A1 family with sequence similarity 171, member A1 -0.00453709
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -0.00453671
GLDC glycine dehydrogenase (decarboxylating) -0.00452882
IL17RB interleukin 17 receptor B -0.00451607
CXCL14 chemokine (C-X-C motif) ligand 14 -0.00450926
CD4 CD4 molecule -0.0045017
TYRP1 tyrosinase-related protein 1 -0.00449499
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -0.00449326
SCN3B sodium channel, voltage gated, type III beta subunit -0.00448574
SOD1 superoxide dismutase 1, soluble -0.0044821
APLP1 amyloid beta (A4) precursor-like protein 1 -0.00448088
ISYNA1 inositol-3-phosphate synthase 1 -0.00447647
EREG epiregulin -0.00446822
CLEC11A C-type lectin domain family 11, member A -0.0044509
ESD esterase D -0.00444994
NVL nuclear VCP-like -0.00444702
BBX bobby sox homolog (Drosophila) -0.00444363
STMN2 stathmin 2 -0.00444049
CD3E CD3e molecule, epsilon (CD3-TCR complex) -0.00443229
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -0.0044101
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -0.00439426
LY75 lymphocyte antigen 75 -0.00439318
ENO2 enolase 2 (gamma, neuronal) -0.00435564
LGALS2 lectin, galactoside-binding, soluble, 2 -0.00434713
SLAMF7 SLAM family member 7 -0.00434629
MAGEA3 melanoma antigen family A3 -0.00434008
FXYD2 FXYD domain containing ion transport regulator 2 -0.00433358
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.00433297
IL7R interleukin 7 receptor -0.00431968
TPH1 tryptophan hydroxylase 1 -0.00431576
TSPYL5 TSPY-like 5 -0.00430909
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -0.00430491
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -0.00430458
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.00429181
CEP43 centrosomal protein 43 -0.00429101
MUC2 mucin 2, oligomeric mucus/gel-forming -0.0042839
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.00427808
HDAC9 histone deacetylase 9 -0.00427432
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.00427193
CLDN8 claudin 8 -0.00426738
SMYD2 SET and MYND domain containing 2 -0.00426458
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -0.00424632
ACOT13 acyl-CoA thioesterase 13 -0.00424127
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -0.00423922
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 -0.0042383
TIPRL TOR signaling pathway regulator -0.00423823
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -0.00423646
TCTN2 tectonic family member 2 -0.00423625
APOO apolipoprotein O -0.00423274
DMXL2 Dmx-like 2 -0.00422367
CD3D CD3d molecule, delta (CD3-TCR complex) -0.00421262
PSD3 pleckstrin and Sec7 domain containing 3 -0.00420937
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0042046
PCDH9 protocadherin 9 -0.00418936
DPYSL2 dihydropyrimidinase-like 2 -0.00418822
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.00418629
XPO7 exportin 7 -0.00418152
STMN4 stathmin-like 4 -0.00418069
PHIP pleckstrin homology domain interacting protein -0.00417391
C4BPA complement component 4 binding protein, alpha -0.00416556
KLF6 Kruppel-like factor 6 -0.00416139
MTCH1 mitochondrial carrier 1 -0.00416119
USH1C Usher syndrome 1C (autosomal recessive, severe) -0.00415367
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.00415044
IQCK IQ motif containing K -0.00414419
PPA1 pyrophosphatase (inorganic) 1 -0.00414168
CYTIP cytohesin 1 interacting protein -0.00413837
PBLD phenazine biosynthesis-like protein domain containing -0.00413811
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -0.00412754
FKBP5 FK506 binding protein 5 -0.00412114
TXN thioredoxin -0.00411847
USP9Y ubiquitin specific peptidase 9, Y-linked -0.00411569
CR2 complement component (3d/Epstein Barr virus) receptor 2 -0.00410709
PON3 paraoxonase 3 -0.00410701
CHN1 chimerin 1 -0.00410232
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.0040993
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -0.00409241
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -0.00409214
H1-4 H1.4 linker histone, cluster member -0.00409125
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -0.00409115
AQP8 aquaporin 8 -0.00408934
ADAM28 ADAM metallopeptidase domain 28 -0.00408842
EPCAM epithelial cell adhesion molecule -0.0040846
ACAA1 acetyl-CoA acyltransferase 1 -0.00407812
F5 coagulation factor V (proaccelerin, labile factor) -0.00406931
SCAMP1 secretory carrier membrane protein 1 -0.00406608
NRXN1 neurexin 1 -0.00406053