PI4KA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphatidylinositol 4-kinase, catalytic, alpha|This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 5297)
Similar Terms
Downloads & Tools

Genes

323 genes differentially expressed following the PI4KA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KANK4 KN motif and ankyrin repeat domains 4 2.45972
GAB3 GRB2-associated binding protein 3 2.45972
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.45972
CRACR2A calcium release activated channel regulator 2A 2.45972
PLAGL1 pleiomorphic adenoma gene-like 1 2.45972
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 2.45972
CCDC121 coiled-coil domain containing 121 2.45972
KIAA1614 KIAA1614 2.45972
FAM133A family with sequence similarity 133, member A 2.45972
SPACA3 sperm acrosome associated 3 2.45972
GMPR2 guanosine monophosphate reductase 2 2.45972
PSD pleckstrin and Sec7 domain containing 2.45972
A3GALT2 alpha 1,3-galactosyltransferase 2 2.45972
APC2 adenomatosis polyposis coli 2 2.45972
DNAI2 dynein, axonemal, intermediate chain 2 2.45972
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.45972
CGREF1 cell growth regulator with EF-hand domain 1 2.45972
PKLR pyruvate kinase, liver and RBC 2.45972
IAPP islet amyloid polypeptide 2.45972
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 2.45972
LHCGR luteinizing hormone/choriogonadotropin receptor 2.45972
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.45972
SPTBN5 spectrin, beta, non-erythrocytic 5 2.45972
HORMAD2 HORMA domain containing 2 2.45972
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.45972
RAG1 recombination activating gene 1 2.45972
OTOA otoancorin 2.45972
TMEM79 transmembrane protein 79 2.45972
ZBTB42 zinc finger and BTB domain containing 42 2.45972
LRRC24 leucine rich repeat containing 24 2.45972
SMIM17 small integral membrane protein 17 2.45972
C10ORF105 chromosome 10 open reading frame 105 2.45972
MTTP microsomal triglyceride transfer protein 2.45972
SPATA45 spermatogenesis associated 45 2.45972
SHCBP1L SHC SH2-domain binding protein 1-like 2.45972
HLA-G major histocompatibility complex, class I, G 2.45972
REC8 REC8 meiotic recombination protein 2.37623
MRPL22 mitochondrial ribosomal protein L22 2.28556
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.26115
CC2D2B coiled-coil and C2 domain containing 2B 2.26115
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.26115
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.26115
SLC23A3 solute carrier family 23, member 3 2.26115
IZUMO4 IZUMO family member 4 2.26115
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.26115
ASMT acetylserotonin O-methyltransferase 2.26115
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.26115
TSSK6 testis-specific serine kinase 6 2.26115
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.26115
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.26115
KLHL34 kelch-like family member 34 2.26115
NEU4 sialidase 4 2.26115
SOX14 SRY (sex determining region Y)-box 14 2.26115
HGD homogentisate 1,2-dioxygenase 2.26115
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.26115
PCDHB4 protocadherin beta 4 2.26115
CPNE2 copine II 2.26115
TM4SF20 transmembrane 4 L six family member 20 2.26115
NXPH4 neurexophilin 4 2.26115
PRICKLE4 prickle homolog 4 (Drosophila) 2.26115
SPINK6 serine peptidase inhibitor, Kazal type 6 2.26115
VSTM2B V-set and transmembrane domain containing 2B 2.26115
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.26115
ZNF75A zinc finger protein 75a 2.26115
TEX13B testis expressed 13B 2.26115
TUBB1 tubulin, beta 1 class VI 2.26115
MUSK muscle, skeletal, receptor tyrosine kinase 2.26115
INHBA inhibin, beta A 2.26115
LDHA lactate dehydrogenase A 2.26115
ZNF816 zinc finger protein 816 2.26115
LRRC8C-DT LRRC8C divergent transcript 2.26115
TBC1D3L TBC1 domain family, member 3L 2.26115
LPIN3 lipin 3 2.26115
TMPRSS6 transmembrane protease, serine 6 2.26115
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 2.26115
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.26115
SPATA22 spermatogenesis associated 22 2.26115
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.26115
KHDC1L KH homology domain containing 1-like 2.26115
SPMIP11 sperm microtubule inner protein 11 2.26115
STING1 stimulator of interferon response cGAMP interactor 1 2.26115
VSIR V-set immunoregulatory receptor 2.26115
PWWP3B PWWP domain containing 3B 2.26115
H4C12 H4 clustered histone 12 2.26115
PVALEF parvalbumin like EF-hand containing 2.26115
CFAP276 cilia and flagella associated protein 276 2.26115
CFAP299 cilia and flagella associated protein 299 2.26115
TEX46 testis expressed 46 2.26115
CCNP cyclin P 2.26115
KASH5 KASH domain containing 5 2.26115
CFAP119 cilia and flagella associated protein 119 2.26115
LORICRIN loricrin cornified envelope precursor protein 2.26115
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.26115
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.26115
METTL1 methyltransferase like 1 2.26115
ZNF572 zinc finger protein 572 2.26115
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.26115
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.26115
CTU1 cytosolic thiouridylase subunit 1 2.26115
IDO2 indoleamine 2,3-dioxygenase 2 2.26115
IL31RA interleukin 31 receptor A 2.26115
CRLF2 cytokine receptor-like factor 2 2.26115
PCDHB11 protocadherin beta 11 2.26115
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.26115
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.26115
FAM186B family with sequence similarity 186, member B 2.26115
FAM186A family with sequence similarity 186, member A 2.26115
WNT9B wingless-type MMTV integration site family, member 9B 2.26115
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.26115
VCX3A variable charge, X-linked 3A 2.26115
ADPRH ADP-ribosylarginine hydrolase 2.26115
RBM44 RNA binding motif protein 44 2.26115
CCR9 chemokine (C-C motif) receptor 9 2.26115
EXOC3L1 exocyst complex component 3-like 1 2.26115
GJD3 gap junction protein, delta 3, 31.9kDa 2.26115
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.26115
DMP1 dentin matrix acidic phosphoprotein 1 2.26115
LIG3 ligase III, DNA, ATP-dependent 2.26115
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.26115
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.26115
FJX1 four jointed box 1 (Drosophila) 2.26115
WFDC1 WAP four-disulfide core domain 1 2.26115
PLET1 placenta expressed transcript 1 2.26115
TNNI3K TNNI3 interacting kinase 2.26115
SH2D4B SH2 domain containing 4B 2.26115
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.26115
CCDC27 coiled-coil domain containing 27 2.26115
CAGE1 cancer antigen 1 2.26115
QSOX2 quiescin Q6 sulfhydryl oxidase 2 2.26115
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.26115
VMAC vimentin-type intermediate filament associated coiled-coil protein 2.26115
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.26115
CYBB cytochrome b-245, beta polypeptide 2.26115
TMEM150B transmembrane protein 150B 2.26115
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.26115
SMIM22 small integral membrane protein 22 2.26115
PMP2 peripheral myelin protein 2 2.26115
EBF3 early B-cell factor 3 2.26115
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.26115
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.26115
PCDHGA3 protocadherin gamma subfamily A, 3 2.26115
PCDHGA8 protocadherin gamma subfamily A, 8 2.26115
CRHR1 corticotropin releasing hormone receptor 1 2.26115
NMBR neuromedin B receptor 2.26115
TSPAN16 tetraspanin 16 2.26115
RIN1 Ras and Rab interactor 1 2.26115
OPTC opticin 2.26115
MEIS2 Meis homeobox 2 2.26115
LAMB3 laminin, beta 3 2.26115
ADAM12 ADAM metallopeptidase domain 12 2.26115
GBX2 gastrulation brain homeobox 2 2.26115
LRRN4 leucine rich repeat neuronal 4 2.26115
DRC7 dynein regulatory complex subunit 7 2.26115
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.26115
FLRT3 fibronectin leucine rich transmembrane protein 3 2.26115
VWA3A von Willebrand factor A domain containing 3A 2.26115
FBXL22 F-box and leucine-rich repeat protein 22 2.26115
KLK7 kallikrein-related peptidase 7 2.26115
UTS2B urotensin 2B 2.26115
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 2.26115
RBM20 RNA binding motif protein 20 2.26115
ANKRD55 ankyrin repeat domain 55 2.26115
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.26115
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.26115
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.26115
BTG2 BTG family, member 2 2.26115
BOLL boule-like RNA-binding protein 2.26115
SFTPD surfactant protein D 2.26115
TMC3 transmembrane channel-like 3 2.26115
SPX spexin hormone 2.26115
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 2.26115
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.26115
EVPL envoplakin 2.26115
LYPLA1 lysophospholipase I 2.26115
ZNF804B zinc finger protein 804B 2.26115
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.26115
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.26115
TECTA tectorin alpha 2.26115
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.26115
ACOT12 acyl-CoA thioesterase 12 2.26115
FAM194C family with sequence similarity 149 member C 2.26115
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.26115
CPB2 carboxypeptidase B2 (plasma) 2.26115
C16ORF86 chromosome 16 open reading frame 86 2.26115
HEPHL1 hephaestin-like 1 2.26115
LRRC61 leucine rich repeat containing 61 2.26115
RFX6 regulatory factor X, 6 2.26115
BRICD5 BRICHOS domain containing 5 2.26115
NOXO1 NADPH oxidase organizer 1 2.26115
OXT oxytocin/neurophysin I prepropeptide 2.26115
TPH1 tryptophan hydroxylase 1 2.26115
ECM1 extracellular matrix protein 1 2.26115
APOL6 apolipoprotein L, 6 2.26115
AJAP1 adherens junctions associated protein 1 2.26115
CHRM1 cholinergic receptor, muscarinic 1 2.26115
ANKRD62 ankyrin repeat domain 62 2.26115
MST1 macrophage stimulating 1 2.26115
LIMS1 LIM and senescent cell antigen-like domains 1 2.26115
PRAM1 PML-RARA regulated adaptor molecule 1 2.26115
NTSR1 neurotensin receptor 1 (high affinity) 2.26115
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.26115
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.26115
SYTL5 synaptotagmin-like 5 2.26115
ZC2HC1B zinc finger, C2HC-type containing 1B 2.26115
LYPD6 LY6/PLAUR domain containing 6 2.26115
CACNG7 calcium channel, voltage-dependent, gamma subunit 7 2.26115
IL17C interleukin 17C 2.26115
AZU1 azurocidin 1 2.26115
GPNMB glycoprotein (transmembrane) nmb 2.26115
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.26115
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2.25952
ARL11 ADP-ribosylation factor-like 11 2.20966
CD200R1L CD200 receptor 1-like 2.20966
CCDC62 coiled-coil domain containing 62 2.17687
PAM peptidylglycine alpha-amidating monooxygenase 2.15349
CADM4 cell adhesion molecule 4 2.15349
CATSPERG catsper channel auxiliary subunit gamma 2.13769
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.11271
GSDMB gasdermin B 2.06154
GARRE1 granule associated Rac and RHOG effector 1 2.04278
MFSD2A major facilitator superfamily domain containing 2A 2.00225

decreased expression

Symbol Name Standardized Value
NR2C2AP nuclear receptor 2C2-associated protein -2.45972
RET ret proto-oncogene -2.45972
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.45972
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 -2.45972
CERCAM cerebral endothelial cell adhesion molecule -2.45972
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.45972
ASPN asporin -2.45972
EIF1AD eukaryotic translation initiation factor 1A domain containing -2.45972
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.45972
GRPR gastrin-releasing peptide receptor -2.45972
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.39914
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.37623
MCOLN1 mucolipin 1 -2.36549
MED19 mediator complex subunit 19 -2.26115
DPEP1 dipeptidase 1 (renal) -2.26115
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.26115
BSN bassoon presynaptic cytomatrix protein -2.26115
GPR183 G protein-coupled receptor 183 -2.26115
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 -2.26115
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.26115
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.26115
RASIP1 Ras interacting protein 1 -2.26115
FAM89B family with sequence similarity 89, member B -2.26115
FA2H fatty acid 2-hydroxylase -2.26115
DUSP5 dual specificity phosphatase 5 -2.26115
CTBS chitobiase, di-N-acetyl- -2.26115
NECTIN3 nectin cell adhesion molecule 3 -2.26115
PIERCE1 piercer of microtubule wall 1 -2.26115
CFAP77 cilia and flagella associated protein 77 -2.26115
DEUP1 deuterosome assembly protein 1 -2.26115
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -2.26115
DYNLT2 dynein light chain Tctex-type 2 -2.26115
SPRR2F small proline-rich protein 2F -2.26115
PABPC5 poly(A) binding protein, cytoplasmic 5 -2.26115
S100PBP S100P binding protein -2.26115
AKAP9 A kinase (PRKA) anchor protein 9 -2.26115
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.26115
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.26115
KLF11 Kruppel-like factor 11 -2.26115
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.26115
CLIP2 CAP-GLY domain containing linker protein 2 -2.26115
PGF placental growth factor -2.26115
CIMAP2 ciliary microtubule associated protein 2 -2.26115
CYSRT1 cysteine-rich tail protein 1 -2.26115
LRRC20 leucine rich repeat containing 20 -2.26115
CTXN1 cortexin 1 -2.26115
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -2.26115
ERCC4 excision repair cross-complementation group 4 -2.26115
FOS FBJ murine osteosarcoma viral oncogene homolog -2.26115
CDK20 cyclin-dependent kinase 20 -2.26115
ZFP90 ZFP90 zinc finger protein -2.26115
MUC4 mucin 4, cell surface associated -2.26115
MAML3 mastermind-like 3 (Drosophila) -2.26115
TSLIG3C tRNA splicing ligase complex subunit 3C -2.26115
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -2.26115
FERMT3 fermitin family member 3 -2.26115
C16ORF46 chromosome 16 open reading frame 46 -2.26115
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.26115
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.26115
HLA-DMB major histocompatibility complex, class II, DM beta -2.26115
TM4SF19 transmembrane 4 L six family member 19 -2.26115
TEX22 testis expressed 22 -2.26115
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.26115
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.26115
CRABP2 cellular retinoic acid binding protein 2 -2.26115
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.26115
RASL12 RAS-like, family 12 -2.26115
RPS6KL1 ribosomal protein S6 kinase-like 1 -2.26115
PPP1R3B protein phosphatase 1, regulatory subunit 3B -2.26115
C5ORF47 chromosome 5 open reading frame 47 -2.26115
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -2.26115
CLEC2L C-type lectin domain family 2, member L -2.26115
ENG endoglin -2.26115
RUFY4 RUN and FYVE domain containing 4 -2.26115
IFIH1 interferon induced with helicase C domain 1 -2.26115
LIG4 ligase IV, DNA, ATP-dependent -2.26115
MTO1 mitochondrial tRNA translation optimization 1 -2.26115
RPP21 ribonuclease P/MRP 21kDa subunit -2.25952
ADGRL1 adhesion G protein-coupled receptor L1 -2.25952
H2BC12 H2B clustered histone 12 -2.22494
GPATCH11 G patch domain containing 11 -2.22494
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.20113
DYNC2I2 dynein 2 intermediate chain 2 -2.17199
FECH ferrochelatase -2.16
MEGF10 multiple EGF-like-domains 10 -2.15048
TMEM106B transmembrane protein 106B -2.14342
VAMP5 vesicle-associated membrane protein 5 -2.14342
FAAP24 FA core complex associated protein 24 -2.14342
SEPTIN1 septin 1 -2.14342
ILDR1 immunoglobulin-like domain containing receptor 1 -2.14342
CYB5R1 cytochrome b5 reductase 1 -2.14342
GDF5 growth differentiation factor 5 -2.14342
MGLL monoglyceride lipase -2.14342
CBR1 carbonyl reductase 1 -2.12131
GDAP2 ganglioside induced differentiation associated protein 2 -2.11646
GATAD2A GATA zinc finger domain containing 2A -2.10593
IRAK4 interleukin-1 receptor-associated kinase 4 -2.09338
ZNF268 zinc finger protein 268 -2.05125
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.04293
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.03512
ZSCAN10 zinc finger and SCAN domain containing 10 -2.00529
MREG melanoregulin -2.00529