PIAS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein inhibitor of activated STAT, 1|This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8554)
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Genes

318 genes differentially expressed following the PIAS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHB12 protocadherin beta 12 2.46308
VCX2 variable charge, X-linked 2 2.46308
CLEC12A C-type lectin domain family 12, member A 2.46308
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.46308
CEMP1 cementum protein 1 2.46308
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.46308
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.46308
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.46308
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.46308
TMEM176B transmembrane protein 176B 2.46308
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.46308
SIX1 SIX homeobox 1 2.46308
PTPRH protein tyrosine phosphatase, receptor type, H 2.46308
REG4 regenerating islet-derived family, member 4 2.46308
PCDHA5 protocadherin alpha 5 2.46308
PCDHA2 protocadherin alpha 2 2.46308
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.46308
RGS9BP regulator of G protein signaling 9 binding protein 2.46308
PVRIG poliovirus receptor related immunoglobulin domain containing 2.46308
PKNOX1 PBX/knotted 1 homeobox 1 2.46308
TAS2R5 taste receptor, type 2, member 5 2.46308
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.46308
HCRTR1 hypocretin (orexin) receptor 1 2.46308
TRIM15 tripartite motif containing 15 2.46308
PCDH8 protocadherin 8 2.46308
TDRD9 tudor domain containing 9 2.46308
F2 coagulation factor II (thrombin) 2.46308
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.46308
MUC20 mucin 20, cell surface associated 2.46308
OR2G6 olfactory receptor, family 2, subfamily G, member 6 2.46308
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.46308
MRC1 mannose receptor, C type 1 2.46308
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.46308
TAL2 T-cell acute lymphocytic leukemia 2 2.46308
SHCBP1L SHC SH2-domain binding protein 1-like 2.46308
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.46308
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.46308
EPPIN epididymal peptidase inhibitor 2.46308
TNNI1 troponin I type 1 (skeletal, slow) 2.46308
SOX14 SRY (sex determining region Y)-box 14 2.46308
SSTR1 somatostatin receptor 1 2.46308
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.46308
APLN apelin 2.46308
TMEM191B transmembrane protein 191B 2.46308
ASGR2 asialoglycoprotein receptor 2 2.46308
PCDHB10 protocadherin beta 10 2.46308
LOC124901449 uncharacterized LOC124901449 2.46308
ACER1 alkaline ceramidase 1 2.46308
FRG2C FSHD region gene 2 family, member C 2.46308
FOXN4 forkhead box N4 2.46308
PDC phosducin 2.46308
KLB klotho beta 2.46308
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 2.46308
ASB9 ankyrin repeat and SOCS box containing 9 2.46308
ASB5 ankyrin repeat and SOCS box containing 5 2.46308
RDH8 retinol dehydrogenase 8 (all-trans) 2.46308
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.46308
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.46308
SPMAP2L sperm microtubule associated protein 2 like 2.46308
LRRC8C-DT LRRC8C divergent transcript 2.46308
NOTCH2NLB notch 2 N-terminal like B 2.46308
NPIPA6 nuclear pore complex interacting protein family, member A6 2.46308
GLYATL1B glycine-N-acyltransferase like 1B 2.46308
CCDC187 coiled-coil domain containing 187 2.46308
GIPC3 GIPC PDZ domain containing family, member 3 2.46308
OTOF otoferlin 2.46308
OPRM1 opioid receptor, mu 1 2.46308
WNT16 wingless-type MMTV integration site family, member 16 2.46308
FCMR Fc fragment of IgM receptor 2.46308
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.46308
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.46308
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.46308
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.46308
RNF113B ring finger protein 113B 2.46308
NHLRC4 NHL repeat containing 4 2.46308
OVOL3 ovo-like zinc finger 3 2.46308
CXCL16 chemokine (C-X-C motif) ligand 16 2.46308
UROC1 urocanate hydratase 1 2.46308
CHRD chordin 2.46308
C7ORF57 chromosome 7 open reading frame 57 2.46308
SAA4 serum amyloid A4, constitutive 2.46308
GCSAM germinal center-associated, signaling and motility 2.46308
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.46308
KL klotho 2.46308
MROH5 maestro heat-like repeat family member 5 2.46308
POU2F2 POU class 2 homeobox 2 2.46308
CNTN4 contactin 4 2.46308
IL16 interleukin 16 2.46308
PRG4 proteoglycan 4 2.46308
IL1R1 interleukin 1 receptor, type I 2.46308
CCDC17 coiled-coil domain containing 17 2.46308
CARD9 caspase recruitment domain family, member 9 2.46308
GLOD5 glyoxalase domain containing 5 2.46308
TIGD3 tigger transposable element derived 3 2.46308
EMX2 empty spiracles homeobox 2 2.46308
SCT secretin 2.46308
AKNAD1 AKNA domain containing 1 2.46308
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.46308
MCCD1 mitochondrial coiled-coil domain 1 2.46308
MUC13 mucin 13, cell surface associated 2.46308
VWA7 von Willebrand factor A domain containing 7 2.46308
ISL1 ISL LIM homeobox 1 2.46308
BTNL8 butyrophilin-like 8 2.46308
EFCAB3 EF-hand calcium binding domain 3 2.46308
ACKR2 atypical chemokine receptor 2 2.46308
IHH indian hedgehog 2.46308
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.46308
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.46308
MAGEA2B melanoma antigen family A2B 2.46308
CCL27 chemokine (C-C motif) ligand 27 2.46308
CT55 cancer/testis antigen 55 2.46308
RGS11 regulator of G-protein signaling 11 2.46308
DNAH10 dynein, axonemal, heavy chain 10 2.46308
CST7 cystatin F (leukocystatin) 2.46308
IL19 interleukin 19 2.46308
PCDH12 protocadherin 12 2.46308
CSNK1A1L casein kinase 1, alpha 1-like 2.46308
HPGDS hematopoietic prostaglandin D synthase 2.46308
LMX1A LIM homeobox transcription factor 1, alpha 2.46308
PLA2G5 phospholipase A2, group V 2.46308
TTC24 tetratricopeptide repeat domain 24 2.46308
TMEM255A transmembrane protein 255A 2.46308
STRC stereocilin 2.46308
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.46308
GOLGA8R golgin A8 family, member R 2.46308
FOXS1 forkhead box S1 2.46308
TSPAN19 tetraspanin 19 2.46308
CLUL1 clusterin-like 1 (retinal) 2.46308
HRCT1 histidine rich carboxyl terminus 1 2.46308
KIAA1210 KIAA1210 2.46308
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 2.46308
GFRAL GDNF family receptor alpha like 2.46308
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.46308
CRHBP corticotropin releasing hormone binding protein 2.46308
NOBOX NOBOX oogenesis homeobox 2.46308
BCL2L15 BCL2-like 15 2.46308
PFN2 profilin 2 2.46308
EFCC1 EF-hand and coiled-coil domain containing 1 2.46308
CFI complement factor I 2.46308
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.46308
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.46308
C10ORF90 chromosome 10 open reading frame 90 2.46308
XPO4 exportin 4 2.46308
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.46308
AHSG alpha-2-HS-glycoprotein 2.46308
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.46308
NFRKB nuclear factor related to kappaB binding protein 2.46308
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.46308
SNAI3 snail family zinc finger 3 2.46308
LAMB3 laminin, beta 3 2.46308
FAM161B family with sequence similarity 161, member B 2.46308
KRTAP5-9 keratin associated protein 5-9 2.46308
TMEM132C transmembrane protein 132C 2.46308
PRDM1 PR domain containing 1, with ZNF domain 2.46308
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.46308
STK38 serine/threonine kinase 38 2.46308
C4BPA complement component 4 binding protein, alpha 2.46308
ARGFX arginine-fifty homeobox 2.46308
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.46308
RNF222 ring finger protein 222 2.46308
LRRC74A leucine rich repeat containing 74A 2.46308
CHAD chondroadherin 2.46308
LAMP3 lysosomal-associated membrane protein 3 2.46308
CD8A CD8a molecule 2.46308
SNTN sentan, cilia apical structure protein 2.46308
CHRM4 cholinergic receptor, muscarinic 4 2.46308
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.46308
FCAR Fc fragment of IgA receptor 2.46308
DCSTAMP dendrocyte expressed seven transmembrane protein 2.46308
FGF16 fibroblast growth factor 16 2.46308
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 2.45734
PTPN2 protein tyrosine phosphatase, non-receptor type 2 2.4498
GALR3 galanin receptor 3 2.40515
C1ORF167 chromosome 1 open reading frame 167 2.36382
XKR9 XK, Kell blood group complex subunit-related family, member 9 2.36189
SPATS1 spermatogenesis associated, serine-rich 1 2.36189
LARP4B La ribonucleoprotein domain family, member 4B 2.3312
CYBA cytochrome b-245, alpha polypeptide 2.32429
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 2.29512
YIPF4 Yip1 domain family, member 4 2.24455
CUX1 cut-like homeobox 1 2.232
GTPBP8 GTP-binding protein 8 (putative) 2.22854
IFT46 intraflagellar transport 46 2.21246
RGS20 regulator of G-protein signaling 20 2.19424
ERBB4 erb-b2 receptor tyrosine kinase 4 2.17356
NBEAL1 neurobeachin-like 1 2.17149
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.16991
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.15674
RTL8A retrotransposon Gag like 8A 2.13307
STEAP1B STEAP family member 1B 2.12077
GPRC5C G protein-coupled receptor, class C, group 5, member C 2.08219
EIF3E eukaryotic translation initiation factor 3, subunit E 2.08219
FDXR ferredoxin reductase 2.06634
CCDC68 coiled-coil domain containing 68 2.05786
WIPF1 WAS/WASL interacting protein family, member 1 2.04076
SUGP1 SURP and G patch domain containing 1 2.04076
ETV1 ets variant 1 2.03304
TP53RK TP53 regulating kinase 2.0295
SORBS2 sorbin and SH3 domain containing 2 2.02631
TSPAN3 tetraspanin 3 2.00255

decreased expression

Symbol Name Standardized Value
MARCHF4 membrane associated ring-CH-type finger 4 -2.46308
RAB26 RAB26, member RAS oncogene family -2.46308
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.46308
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -2.46308
ATG4C autophagy related 4C, cysteine peptidase -2.46308
HBEGF heparin-binding EGF-like growth factor -2.46308
EFS embryonal Fyn-associated substrate -2.46308
TSHR thyroid stimulating hormone receptor -2.46308
CCR10 chemokine (C-C motif) receptor 10 -2.46308
PIAS1 protein inhibitor of activated STAT, 1 -2.46308
AGBL2 ATP/GTP binding protein-like 2 -2.46308
REEP4 receptor accessory protein 4 -2.46308
FSCN3 fascin actin-bundling protein 3, testicular -2.46308
COA5 cytochrome c oxidase assembly factor 5 -2.46308
PMFBP1 polyamine modulated factor 1 binding protein 1 -2.46308
FAAP24 FA core complex associated protein 24 -2.46308
GRAMD2B GRAM domain containing 2B -2.46308
ACTL6B actin-like 6B -2.46308
BARX1 BARX homeobox 1 -2.46308
LENG9 leukocyte receptor cluster (LRC) member 9 -2.46308
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.46308
OSCP1 organic solute carrier partner 1 -2.46308
GSPT1 G1 to S phase transition 1 -2.46308
ACTRT3 actin-related protein T3 -2.46308
GFRA2 GDNF family receptor alpha 2 -2.46308
STAG3 stromal antigen 3 -2.46308
EFHC1 EF-hand domain (C-terminal) containing 1 -2.46308
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.46308
GFY golgi-associated, olfactory signaling regulator -2.46308
WDR91 WD repeat domain 91 -2.46308
LSMEM2 leucine-rich single-pass membrane protein 2 -2.46308
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -2.46308
ARG1 arginase 1 -2.46308
ZNF350 zinc finger protein 350 -2.46187
ZDHHC14 zinc finger, DHHC-type containing 14 -2.44955
SPTSSA serine palmitoyltransferase, small subunit A -2.41611
CPNE3 copine III -2.41152
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.40269
SSRP1 structure specific recognition protein 1 -2.38242
SIRAL2 SIR2 antiphage like 2 -2.3661
MTMR14 myotubularin related protein 14 -2.36382
CTSA cathepsin A -2.35842
ZYX zyxin -2.35842
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.35842
ASPA aspartoacylase -2.29512
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.29512
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.29512
VWF von Willebrand factor -2.29512
C1ORF116 chromosome 1 open reading frame 116 -2.29512
ATR ATR serine/threonine kinase -2.29512
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.29512
SCARA5 scavenger receptor class A, member 5 -2.29512
SLC35D3 solute carrier family 35, member D3 -2.29512
SPACDR sperm acrosome developmental regulator -2.29512
FBXO15 F-box protein 15 -2.29512
DLK1 delta-like 1 homolog (Drosophila) -2.29512
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.29512
SPEGNB SPEG neighbor -2.29512
ADGRB2 adhesion G protein-coupled receptor B2 -2.29512
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -2.29512
AMBP alpha-1-microglobulin/bikunin precursor -2.29512
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -2.29512
PCDHA1 protocadherin alpha 1 -2.29512
ADGB androglobin -2.29512
PTGER4 prostaglandin E receptor 4 (subtype EP4) -2.29512
ABHD1 abhydrolase domain containing 1 -2.29512
FAM216B family with sequence similarity 216, member B -2.29512
C17ORF99 chromosome 17 open reading frame 99 -2.29512
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.29512
MYO16 myosin XVI -2.29512
HSPB9 heat shock protein, alpha-crystallin-related, B9 -2.29512
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -2.29512
AARD alanine and arginine rich domain containing protein -2.29512
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.29512
KIF26B kinesin family member 26B -2.27813
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -2.22726
AK6 adenylate kinase 6 -2.18709
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -2.17823
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.17823
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -2.17823
ARL3 ADP-ribosylation factor-like 3 -2.17356
ETFB electron-transfer-flavoprotein, beta polypeptide -2.17245
PYGO1 pygopus family PHD finger 1 -2.1699
DSP desmoplakin -2.16474
MACROD1 MACRO domain containing 1 -2.16145
CKAP2 cytoskeleton associated protein 2 -2.15308
PHIP pleckstrin homology domain interacting protein -2.14062
PRH1 proline-rich protein HaeIII subfamily 1 -2.1397
TFIP11 tuftelin interacting protein 11 -2.12872
ZNF624 zinc finger protein 624 -2.12077
TP63 tumor protein p63 -2.11737
SIK3 SIK family kinase 3 -2.09629
ADAM23 ADAM metallopeptidase domain 23 -2.08412
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.07951
H2BC12 H2B clustered histone 12 -2.07237
BGLAP bone gamma-carboxyglutamate (gla) protein -2.07237
ADIPOR2 adiponectin receptor 2 -2.06634
CFAP96 cilia and flagella associated protein 96 -2.06634
POLM polymerase (DNA directed), mu -2.06122
GRID1 glutamate receptor, ionotropic, delta 1 -2.04543
BMP2 bone morphogenetic protein 2 -2.04543
PHF19 PHD finger protein 19 -2.04543
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -2.04543
PLK2 polo-like kinase 2 -2.04188
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -2.04076
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -2.04076
PDPK1 3-phosphoinositide dependent protein kinase 1 -2.0295
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.0295
TRIM21 tripartite motif containing 21 -2.02631
BEST2 bestrophin 2 -2.02307
PTCH1 patched 1 -2.02127
PROKR2 prokineticin receptor 2 -2.00898
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -2.00898
CUZD1 CUB and zona pellucida-like domains 1 -2.00898
NICN1 nicolin 1 -2.00898
ZBTB10 zinc finger and BTB domain containing 10 -2.00857
DROSHA drosha, ribonuclease type III -2.00766
RO60 Ro60, Y RNA binding protein -2.00766