PIAS1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description protein inhibitor of activated STAT, 1|This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8554)
External Link http://www.ncbi.nlm.nih.gov/gene/8554
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Genes

223 interacting proteins for PIAS1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATXN1 ataxin 1
ATXN7 ataxin 7
AXIN1 axin 1
BARD1 BRCA1 associated RING domain 1
BRCA1 breast cancer 1, early onset
CARM1 coactivator-associated arginine methyltransferase 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CBS cystathionine-beta-synthase
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CEP250 centrosomal protein 250kDa
CHUK conserved helix-loop-helix ubiquitous kinase
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSRP2 cysteine and glycine-rich protein 2
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
DCLRE1A DNA cross-link repair 1A
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNM1 dynamin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF2 eukaryotic translation elongation factor 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF2A eukaryotic translation initiation factor 2A, 65kDa
ELAVL1 ELAV like RNA binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERCC4 excision repair cross-complementation group 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FBL fibrillarin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GATA4 GATA binding protein 4
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GLUL glutamate-ammonia ligase
GRM8 glutamate receptor, metabotropic 8
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HARS histidyl-tRNA synthetase
HIC1 hypermethylated in cancer 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HTT huntingtin
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
JAK1 Janus kinase 1
JUN jun proto-oncogene
KARS lysyl-tRNA synthetase
L3MBTL2 l(3)mbt-like 2 (Drosophila)
LMO4 LIM domain only 4
MAML1 mastermind-like 1 (Drosophila)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAX MYC associated factor X
MBD1 methyl-CpG binding domain protein 1
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MSX1 msh homeobox 1
MX1 MX dynamin-like GTPase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAE1 NEDD8 activating enzyme E1 subunit 1
NAT10 N-acetyltransferase 10 (GCN5-related)
NCOR1 nuclear receptor corepressor 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NIN ninein (GSK3B interacting protein)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NONO non-POU domain containing, octamer-binding
NOP2 NOP2 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUCLEOLIN nucleolin multifunctional protein
PARP1 poly (ADP-ribose) polymerase 1
PASK PAS domain containing serine/threonine kinase
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PGR progesterone receptor
PIAS2 protein inhibitor of activated STAT, 2
PIAS4 protein inhibitor of activated STAT, 4
PLAG1 pleiomorphic adenoma gene 1
PML promyelocytic leukemia
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRDM1 PR domain containing 1, with ZNF domain
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT1 protein arginine methyltransferase 1
PRMT6 protein arginine methyltransferase 6
PRPF3 pre-mRNA processing factor 3
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPF8 pre-mRNA processing factor 8
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBBP6 retinoblastoma binding protein 6
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPL10A ribosomal protein L10a
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL13 ribosomal protein L13
RPL18 ribosomal protein L18
RPL21 ribosomal protein L21
RPL23 ribosomal protein L23
RPL24 ribosomal protein L24
RPL26 ribosomal protein L26
RPL27 ribosomal protein L27
RPL29 ribosomal protein L29
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPL35A ribosomal protein L35a
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPL7A ribosomal protein L7a
RPL8 ribosomal protein L8
RPS11 ribosomal protein S11
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS2 ribosomal protein S2
RPS20 ribosomal protein S20
RPS23 ribosomal protein S23
RPS26 ribosomal protein S26
RPS3 ribosomal protein S3
RPS4X ribosomal protein S4, X-linked
RPS6 ribosomal protein S6
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
SAFB scaffold attachment factor B
SATB1 SATB homeobox 1
SATB2 SATB homeobox 2
SCN1A sodium channel, voltage gated, type I alpha subunit
SERBP1 SERPINE1 mRNA binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFPQ splicing factor proline/glutamine-rich
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SKIL SKI-like proto-oncogene
SMAD1 SMAD family member 1
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SNIP1 Smad nuclear interacting protein 1
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SOX2 SRY (sex determining region Y)-box 2
SP3 Sp3 transcription factor
SPOP speckle-type POZ protein
SREBF2 sterol regulatory element binding transcription factor 2
SRSF1 serine/arginine-rich splicing factor 1
SSRP1 structure specific recognition protein 1
STAB2 stabilin 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUFU suppressor of fused homolog (Drosophila)
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TARS threonyl-tRNA synthetase
TBP TATA box binding protein
TCOF1 Treacher Collins-Franceschetti syndrome 1
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP73 tumor protein p73
TRIM27 tripartite motif containing 27
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
UBD ubiquitin D
UBE2I ubiquitin-conjugating enzyme E2I
UBE2M ubiquitin-conjugating enzyme E2M
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZMIZ2 zinc finger, MIZ-type containing 2
ZMYND11 zinc finger, MYND-type containing 11
ZNF76 zinc finger protein 76