PIAS2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein inhibitor of activated STAT, 2|This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 9063)
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Genes

357 genes differentially expressed following the PIAS2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ARL5C ADP-ribosylation factor-like 5C 2.78495
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.78495
GNLY granulysin 2.78495
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.78495
MUC1 mucin 1, cell surface associated 2.78495
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 2.78495
PCDHB6 protocadherin beta 6 2.78495
HGD homogentisate 1,2-dioxygenase 2.78495
HES7 hes family bHLH transcription factor 7 2.78495
HES3 hes family bHLH transcription factor 3 2.78495
HORMAD2 HORMA domain containing 2 2.78495
DUXA double homeobox A 2.78495
PI15 peptidase inhibitor 15 2.78495
FBXL8 F-box and leucine-rich repeat protein 8 2.78495
KLHL31 kelch-like family member 31 2.78495
IL12RB1 interleukin 12 receptor, beta 1 2.78495
LIPK lipase, family member K 2.78495
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.78495
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.78495
GUCA1C guanylate cyclase activator 1C 2.78495
FABP9 fatty acid binding protein 9, testis 2.78495
GJA9 gap junction protein, alpha 9, 59kDa 2.78495
HLF hepatic leukemia factor 2.78495
RHOXF2B Rhox homeobox family, member 2B 2.78495
PDZD9 PDZ domain containing 9 2.78495
OSR2 odd-skipped related transciption factor 2 2.78495
C9ORF152 chromosome 9 open reading frame 152 2.78495
FABP12 fatty acid binding protein 12 2.78495
LACTBL1 lactamase, beta-like 1 2.78495
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.78495
DLL4 delta-like 4 (Drosophila) 2.78495
COPZ2 coatomer protein complex, subunit zeta 2 2.78495
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.78495
TAS2R13 taste receptor, type 2, member 13 2.78495
CTPS1 CTP synthase 1 2.78495
SLC10A5 solute carrier family 10, member 5 2.78495
TPSD1 tryptase delta 1 2.78495
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.78495
BIRC3 baculoviral IAP repeat containing 3 2.78495
GJB1 gap junction protein, beta 1, 32kDa 2.78495
FFAR4 free fatty acid receptor 4 2.78495
PAX6 paired box 6 2.78495
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.78495
OPRL1 opiate receptor-like 1 2.78495
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.78495
GYPB glycophorin B (MNS blood group) 2.78495
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.78495
HCRTR2 hypocretin (orexin) receptor 2 2.78495
TCAF2 TRPM8 channel-associated factor 2 2.78495
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.78495
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.78495
DIPK1C divergent protein kinase domain 1C 2.78495
RTL5 retrotransposon Gag like 5 2.78495
DERPC DERPC proline and glycine rich nuclear protein 2.78495
ALPG alkaline phosphatase, germ cell 2.78495
PNMA8B PNMA family member 8B 2.78495
OTOF otoferlin 2.78495
FMO2 flavin containing monooxygenase 2 (non-functional) 2.78495
FOXN4 forkhead box N4 2.78495
PDC phosducin 2.78495
PDF peptide deformylase (mitochondrial) 2.78495
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.78495
H2AC1 H2A clustered histone 1 2.78495
H2BW2 H2B.W histone 2 2.78495
CIMIP2B ciliary microtubule inner protein 2B 2.78495
LRRC8C-DT LRRC8C divergent transcript 2.78495
ANKRD42-DT ANKRD42 divergent transcript 2.78495
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.78495
H3C13 H3 clustered histone 13 2.78495
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.78495
SMIM45 small integral membrane protein 45 2.78495
LHFPL7 LHFPL tetraspan subfamily member 7 2.78495
EZHIP EZH inhibitory protein 2.78495
HOATZ HOATZ cilia and flagella associated protein 2.78495
PLCZ1 phospholipase C, zeta 1 2.78495
LMNTD1 lamin tail domain containing 1 2.78495
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.78495
ZNF575 zinc finger protein 575 2.78495
DMBX1 diencephalon/mesencephalon homeobox 1 2.78495
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.78495
AMHR2 anti-Mullerian hormone receptor, type II 2.78495
GOLGA6L4 golgin A6 family-like 4 2.78495
C3ORF80 chromosome 3 open reading frame 80 2.78495
IL31RA interleukin 31 receptor A 2.78495
WNT11 wingless-type MMTV integration site family, member 11 2.78495
FAM43B family with sequence similarity 43, member B 2.78495
C1QL3 complement component 1, q subcomponent-like 3 2.78495
GJD3 gap junction protein, delta 3, 31.9kDa 2.78495
CCR3 chemokine (C-C motif) receptor 3 2.78495
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.78495
SAG S-antigen; retina and pineal gland (arrestin) 2.78495
KHDC1L KH homology domain containing 1-like 2.78495
STRN3 striatin, calmodulin binding protein 3 2.78495
TAS1R1 taste receptor, type 1, member 1 2.78495
SAMD15 sterile alpha motif domain containing 15 2.78495
IL1RN interleukin 1 receptor antagonist 2.78495
ABHD15 abhydrolase domain containing 15 2.78495
VCX3A variable charge, X-linked 3A 2.78495
S100P S100 calcium binding protein P 2.78495
VIT vitrin 2.78495
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.78495
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.78495
ANKRD62 ankyrin repeat domain 62 2.78495
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.78495
TRADD TNFRSF1A-associated via death domain 2.78495
SPATA4 spermatogenesis associated 4 2.78495
CPA2 carboxypeptidase A2 (pancreatic) 2.78495
KIF4B kinesin family member 4B 2.78495
IHH indian hedgehog 2.78495
FZD1 frizzled class receptor 1 2.78495
PAGE4 P antigen family, member 4 (prostate associated) 2.78495
PRR15L proline rich 15-like 2.78495
NUTM2D NUT family member 2D 2.78495
AMER2 APC membrane recruitment protein 2 2.78495
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.78495
WBP2NL WBP2 N-terminal like 2.78495
CERCAM cerebral endothelial cell adhesion molecule 2.78495
CHRM4 cholinergic receptor, muscarinic 4 2.78495
TDRD10 tudor domain containing 10 2.78495
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.78495
ADAM2 ADAM metallopeptidase domain 2 2.78495
HCRT hypocretin (orexin) neuropeptide precursor 2.78495
RGSL1 regulator of G-protein signaling like 1 2.78495
LCNL1 lipocalin-like 1 2.78495
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.78495
THTPA thiamine triphosphatase 2.78495
RAD21L1 RAD21-like 1 (S. pombe) 2.78495
OR2M3 olfactory receptor, family 2, subfamily M, member 3 2.78495
HAMP hepcidin antimicrobial peptide 2.78495
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.78495
ANKRD63 ankyrin repeat domain 63 2.78495
RTBDN retbindin 2.78495
KLHL41 kelch-like family member 41 2.78495
A3GALT2 alpha 1,3-galactosyltransferase 2 2.78495
NPPA natriuretic peptide A 2.78495
DUSP26 dual specificity phosphatase 26 (putative) 2.78495
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.78495
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.78495
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.78495
DEFB134 defensin, beta 134 2.78495
PRCD progressive rod-cone degeneration 2.78495
ART1 ADP-ribosyltransferase 1 2.78495
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.78495
KIF19 kinesin family member 19 2.78495
CPN2 carboxypeptidase N, polypeptide 2 2.78495
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.78495
TMEM52B transmembrane protein 52B 2.78495
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.78495
CXORF49C chromosome X open reading frame 49C 2.78495
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.78495
TTC24 tetratricopeptide repeat domain 24 2.78495
SGSM3 small G protein signaling modulator 3 2.78495
KRTAP13-4 keratin associated protein 13-4 2.78495
WFDC13 WAP four-disulfide core domain 13 2.78495
SIDT1 SID1 transmembrane family, member 1 2.78495
CFB complement factor B 2.78495
BTBD19 BTB (POZ) domain containing 19 2.78495
NLRP14 NLR family, pyrin domain containing 14 2.78495
MYLK2 myosin light chain kinase 2 2.78495
CCNI2 cyclin I family, member 2 2.78495
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.78495
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.78495
CD8A CD8a molecule 2.78495
EGR2 early growth response 2 2.78495
GRAPL GRB2-related adaptor protein-like 2.78495
MAGEA10 melanoma antigen family A10 2.78495
KLK7 kallikrein-related peptidase 7 2.78495
EPHA5 EPH receptor A5 2.78495
SIGLEC15 sialic acid binding Ig-like lectin 15 2.78495
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.78495
ST18 suppression of tumorigenicity 18, zinc finger 2.78495
TP63 tumor protein p63 2.78495
TNS2 tensin 2 2.78495
QRFP pyroglutamylated RFamide peptide 2.78495
SSX3 synovial sarcoma, X breakpoint 3 2.78495
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.76825
PTAFR platelet-activating factor receptor 2.76122
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 2.72418
NRSN1 neurensin 1 2.72418
CEP57L1 centrosomal protein 57kDa-like 1 2.6935
ZNF37A zinc finger protein 37A 2.6935
EPC2 enhancer of polycomb homolog 2 (Drosophila) 2.6935
EFHD2 EF-hand domain family, member D2 2.67538
TYK2 tyrosine kinase 2 2.61151
ANXA7 annexin A7 2.6056
MROH9 maestro heat-like repeat family member 9 2.57909
NUCB1 nucleobindin 1 2.57262
PARP8 poly (ADP-ribose) polymerase family, member 8 2.56081
SELENOW selenoprotein W 2.53957
ZNF525 zinc finger protein 525 2.5169
MINDY4B MINDY family member 4B 2.49634
BAAT bile acid CoA:amino acid N-acyltransferase 2.49634
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 2.4773
ZNF358 zinc finger protein 358 2.46506
TMEM123 transmembrane protein 123 2.46018
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.42457
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.42457
FBXW12 F-box and WD repeat domain containing 12 2.39814
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.39231
ZNF879 zinc finger protein 879 2.37637
CHODL chondrolectin 2.36536
CDK20 cyclin-dependent kinase 20 2.35576
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.33506
SPC24 SPC24, NDC80 kinetochore complex component 2.33434
PARVB parvin, beta 2.30641
XYLB xylulokinase homolog (H. influenzae) 2.30557
ZNF287 zinc finger protein 287 2.30491
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2.30491
NUP62CL nucleoporin 62kDa C-terminal like 2.2937
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.28758
PILRA paired immunoglobin-like type 2 receptor alpha 2.27508
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.25728
PXDN peroxidasin 2.25728
PSPH phosphoserine phosphatase 2.25206
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.24492
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.24309
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.24309
RFC2 replication factor C (activator 1) 2, 40kDa 2.20234
DYNC2I2 dynein 2 intermediate chain 2 2.19751
BRWD1 bromodomain and WD repeat domain containing 1 2.18186
PLCE1 phospholipase C, epsilon 1 2.18186
POU6F2 POU class 6 homeobox 2 2.16372
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 2.14591
PHB1 prohibitin 1 2.14408
CARM1 coactivator-associated arginine methyltransferase 1 2.09684
APH1A APH1A gamma secretase subunit 2.09
ACBD4 acyl-CoA binding domain containing 4 2.07947
ECT2L epithelial cell transforming 2 like 2.07323
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.07323
ZNF446 zinc finger protein 446 2.07323
PTBP2 polypyrimidine tract binding protein 2 2.07323
GTF2B general transcription factor IIB 2.06472
TEAD3 TEA domain family member 3 2.04939
CSDE1 cold shock domain containing E1, RNA-binding 2.04887
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.0444
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.0444
LRRC4B leucine rich repeat containing 4B 2.01173
CIAO3 cytosolic iron-sulfur assembly component 3 2.01044
SNF8 SNF8, ESCRT-II complex subunit 2.01044
OLFM1 olfactomedin 1 2.01044
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.0068
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2.00611
TBC1D20 TBC1 domain family, member 20 2.00352
RNF185 ring finger protein 185 2.00352

decreased expression

Symbol Name Standardized Value
GRK4 G protein-coupled receptor kinase 4 -2.78495
GPR82 G protein-coupled receptor 82 -2.78495
SPINK8 serine peptidase inhibitor, Kazal type 8 (putative) -2.78495
FAM168A family with sequence similarity 168, member A -2.78495
ISCA2 iron-sulfur cluster assembly 2 -2.78495
ZBTB2 zinc finger and BTB domain containing 2 -2.78495
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.78495
TOR4A torsin family 4, member A -2.78495
FOXO4 forkhead box O4 -2.78495
PROX1 prospero homeobox 1 -2.78495
PIAS2 protein inhibitor of activated STAT, 2 -2.78495
TMOD1 tropomodulin 1 -2.78495
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.78495
GPM6A glycoprotein M6A -2.72905
EBI3 Epstein-Barr virus induced 3 -2.72418
TMPRSS11F transmembrane protease, serine 11F -2.72418
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.72418
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.72418
PRDM16 PR domain containing 16 -2.72418
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -2.72418
SCIN scinderin -2.72418
C17ORF114 chromosome 17 open reading frame 114 -2.72418
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.72418
ARSA arylsulfatase A -2.72418
FNDC7 fibronectin type III domain containing 7 -2.72418
UNC93A unc-93 homolog A (C. elegans) -2.72418
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.72418
AGA-DT AGA divergent transcript -2.72418
SMIM36 small integral membrane protein 36 -2.72418
OVGP1 oviductal glycoprotein 1, 120kDa -2.72418
H2BC3 H2B clustered histone 3 -2.72418
TERB1 telomere repeat binding bouquet formation protein 1 -2.72418
SPAAR small regulatory polypeptide of amino acid response -2.72418
TBC1D3L TBC1 domain family, member 3L -2.72418
TGM1 transglutaminase 1 -2.72418
LAMP3 lysosomal-associated membrane protein 3 -2.72418
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -2.72418
NLRC3 NLR family, CARD domain containing 3 -2.72418
CERS3 ceramide synthase 3 -2.72418
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 -2.72418
IRGM immunity-related GTPase family, M -2.72418
WFDC10A WAP four-disulfide core domain 10A -2.72418
PCDHA13 protocadherin alpha 13 -2.72418
TMEM132E transmembrane protein 132E -2.72418
ARGFX arginine-fifty homeobox -2.72418
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.72418
TMPRSS13 transmembrane protease, serine 13 -2.72418
WDR72 WD repeat domain 72 -2.72017
VAMP5 vesicle-associated membrane protein 5 -2.72017
ARMCX1 armadillo repeat containing, X-linked 1 -2.70643
HCCS holocytochrome c synthase -2.65586
PCDHB15 protocadherin beta 15 -2.63306
SHISAL2A shisa like 2A -2.61973
SBK2 SH3 domain binding kinase family, member 2 -2.61973
SETD6 SET domain containing 6 -2.60563
NATD1 N-acetyltransferase domain containing 1 -2.52375
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G -2.50684
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -2.48858
PET100 PET100 homolog (S. cerevisiae) -2.46018
PDS5B PDS5 cohesin associated factor B -2.42264
FNDC3A fibronectin type III domain containing 3A -2.42264
EPAS1 endothelial PAS domain protein 1 -2.4018
HTATSF1 HIV-1 Tat specific factor 1 -2.38788
GRN granulin -2.38775
TMED1 transmembrane emp24 protein transport domain containing 1 -2.38463
FSD1L fibronectin type III and SPRY domain containing 1-like -2.3756
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -2.33434
SEZ6 seizure related 6 homolog (mouse) -2.32489
CAMLG calcium modulating ligand -2.31454
LMOD1 leiomodin 1 (smooth muscle) -2.29843
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.29169
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -2.29155
ARID3B AT rich interactive domain 3B (BRIGHT-like) -2.28301
SUMO1 small ubiquitin-like modifier 1 -2.2819
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -2.28134
TMPO thymopoietin -2.27931
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.25728
STX1A syntaxin 1A (brain) -2.18683
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -2.18186
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.18186
GRPR gastrin-releasing peptide receptor -2.18157
ZNF763 zinc finger protein 763 -2.18157
PTPRD protein tyrosine phosphatase, receptor type, D -2.18157
GLI2 GLI family zinc finger 2 -2.16913
ANGPT4 angiopoietin 4 -2.16283
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.1576
IFT70B intraflagellar transport 70B -2.1576
TXLNG taxilin gamma -2.1509
PGM1 phosphoglucomutase 1 -2.14763
PGD phosphogluconate dehydrogenase -2.12387
NRG1 neuregulin 1 -2.12353
RPN1 ribophorin I -2.12278
D2HGDH D-2-hydroxyglutarate dehydrogenase -2.11489
RGPD6 RANBP2-like and GRIP domain containing 6 -2.10871
NGEF neuronal guanine nucleotide exchange factor -2.10871
ACE angiotensin I converting enzyme -2.10871
CD248 CD248 molecule, endosialin -2.10871
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -2.10252
SETD1A SET domain containing 1A -2.09
GEM GTP binding protein overexpressed in skeletal muscle -2.09
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.08918
RPL34 ribosomal protein L34 -2.08676
PRMT3 protein arginine methyltransferase 3 -2.08067
KIAA1614 KIAA1614 -2.06561
SYCE2 synaptonemal complex central element protein 2 -2.04688
C1ORF50 chromosome 1 open reading frame 50 -2.02758
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.01173
PLEKHM3 pleckstrin homology domain containing, family M, member 3 -2.01044
B9D1 B9 protein domain 1 -2.01044
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase -2.01044
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -2.0065
IRX2 iroquois homeobox 2 -2.00611
AKAP5 A kinase (PRKA) anchor protein 5 -2.0058