PIAS2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description protein inhibitor of activated STAT, 2|This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 9063)
External Link http://www.ncbi.nlm.nih.gov/gene/9063
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Genes

148 interacting proteins for PIAS2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADA adenosine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
BCL6 B-cell CLL/lymphoma 6
C1QA complement component 1, q subcomponent, A chain
CCNDBP1 cyclin D-type binding-protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHMP4B charged multivesicular body protein 4B
CLDN2 claudin 2
CTBP1 C-terminal binding protein 1
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF2 eukaryotic translation elongation factor 2
EIF2A eukaryotic translation initiation factor 2A, 65kDa
ELK1 ELK1, member of ETS oncogene family
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPAS1 endothelial PAS domain protein 1
ERCC4 excision repair cross-complementation group 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GFI1 growth factor independent 1 transcription repressor
GLUL glutamate-ammonia ligase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRM8 glutamate receptor, metabotropic 8
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
H2AFX H2A histone family, member X
HARS histidyl-tRNA synthetase
HDAC3 histone deacetylase 3
HIC1 hypermethylated in cancer 1
HIST2H2BE histone cluster 2, H2be
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFIH1 interferon induced with helicase C domain 1
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KARS lysyl-tRNA synthetase
LMNB1 lamin B1
MAGEA4 melanoma antigen family A4
MAPK8 mitogen-activated protein kinase 8
MAX MYC associated factor X
MBD1 methyl-CpG binding domain protein 1
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MITF microphthalmia-associated transcription factor
MSX2 msh homeobox 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NAE1 NEDD8 activating enzyme E1 subunit 1
NAV2 neuron navigator 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NGFR nerve growth factor receptor
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PGR progesterone receptor
PIAS1 protein inhibitor of activated STAT, 1
PIAS4 protein inhibitor of activated STAT, 4
PLAG1 pleiomorphic adenoma gene 1
PLAGL1 pleiomorphic adenoma gene-like 1
PML promyelocytic leukemia
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRPF3 pre-mRNA processing factor 3
RPL10A ribosomal protein L10a
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL13 ribosomal protein L13
RPL18 ribosomal protein L18
RPL21 ribosomal protein L21
RPL23 ribosomal protein L23
RPL24 ribosomal protein L24
RPL26 ribosomal protein L26
RPL27 ribosomal protein L27
RPL29 ribosomal protein L29
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPL35A ribosomal protein L35a
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPL7A ribosomal protein L7a
RPL8 ribosomal protein L8
RPS11 ribosomal protein S11
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS2 ribosomal protein S2
RPS20 ribosomal protein S20
RPS23 ribosomal protein S23
RPS26 ribosomal protein S26
RPS3 ribosomal protein S3
RPS4X ribosomal protein S4, X-linked
RPS6 ribosomal protein S6
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
RUFY1 RUN and FYVE domain containing 1
SCN1A sodium channel, voltage gated, type I alpha subunit
SF3B3 splicing factor 3b, subunit 3, 130kDa
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT1 sirtuin 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SNIP1 Smad nuclear interacting protein 1
SP1 Sp1 transcription factor
SREBF2 sterol regulatory element binding transcription factor 2
SSRP1 structure specific recognition protein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TARS threonyl-tRNA synthetase
TICAM2 toll-like receptor adaptor molecule 2
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRIM27 tripartite motif containing 27
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2M ubiquitin-conjugating enzyme E2M
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBTB4 zinc finger and BTB domain containing 4