PIAS3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein inhibitor of activated STAT, 3|This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10401)
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Genes

280 genes differentially expressed following the PIAS3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.54088
LMO1 LIM domain only 1 (rhombotin 1) 3.54088
EPPIN epididymal peptidase inhibitor 3.54088
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.54088
SCGB3A1 secretoglobin, family 3A, member 1 3.54088
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.54088
NPPB natriuretic peptide B 3.54088
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.54088
TP73 tumor protein p73 3.54088
WDR87 WD repeat domain 87 3.54088
FAM167A family with sequence similarity 167, member A 3.54088
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.54088
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.54088
LAPTM5 lysosomal protein transmembrane 5 3.54088
TPBGL trophoblast glycoprotein-like 3.54088
GPR4 G protein-coupled receptor 4 3.54088
LIPK lipase, family member K 3.54088
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 3.54088
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.54088
FOXR1 forkhead box R1 3.54088
CPLX3 complexin 3 3.54088
CPLX4 complexin 4 3.54088
CAPS calcyphosine 3.54088
HBZ hemoglobin, zeta 3.54088
S100A5 S100 calcium binding protein A5 3.54088
LGI1 leucine-rich, glioma inactivated 1 3.54088
PSCA prostate stem cell antigen 3.54088
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.54088
LCN12 lipocalin 12 3.54088
ZNF556 zinc finger protein 556 3.54088
ACER1 alkaline ceramidase 1 3.54088
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.54088
BIRC3 baculoviral IAP repeat containing 3 3.54088
MYCT1 myc target 1 3.54088
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.54088
ASB12 ankyrin repeat and SOCS box containing 12 3.54088
PAX6 paired box 6 3.54088
RHOXF2 Rhox homeobox family, member 2 3.54088
PCDHB11 protocadherin beta 11 3.54088
DSG1 desmoglein 1 3.54088
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.54088
CLDN16 claudin 16 3.54088
GPX6 glutathione peroxidase 6 3.54088
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.54088
ROPN1B rhophilin associated tail protein 1B 3.54088
ZAR1 zygote arrest 1 3.54088
GIPC3 GIPC PDZ domain containing family, member 3 3.54088
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.54088
CCDC9B coiled-coil domain containing 9B 3.54088
NSG2 neuronal vesicle trafficking associated 2 3.54088
CCDC198 coiled-coil domain containing 198 3.54088
ACOD1 aconitate decarboxylase 1 3.54088
DNAAF6 dynein axonemal assembly factor 6 3.54088
STPG3 sperm-tail PG-rich repeat containing 3 3.54088
POU2AF2 POU class 2 homeobox associating factor 2 3.54088
H3-7 H3.7 histone (putative) 3.54088
SPATA31G1 SPATA31 subfamily G member 1 3.54088
TFF2 trefoil factor 2 3.54088
ASB5 ankyrin repeat and SOCS box containing 5 3.54088
C3ORF80 chromosome 3 open reading frame 80 3.54088
TMCO2 transmembrane and coiled-coil domains 2 3.54088
OR11A1 olfactory receptor, family 11, subfamily A, member 1 3.54088
TFEC transcription factor EC 3.54088
MIP major intrinsic protein of lens fiber 3.54088
ZAN zonadhesin (gene/pseudogene) 3.54088
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.54088
PRR18 proline rich 18 3.54088
MYOT myotilin 3.54088
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.54088
PLB1 phospholipase B1 3.54088
SAA4 serum amyloid A4, constitutive 3.54088
OPN5 opsin 5 3.54088
STARD6 StAR-related lipid transfer (START) domain containing 6 3.54088
NPIPB8 nuclear pore complex interacting protein family, member B8 3.54088
ZG16B zymogen granule protein 16B 3.54088
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.54088
LOC124900192 uncharacterized LOC124900192 3.54088
EMP1 epithelial membrane protein 1 3.54088
TEKT2 tektin 2 (testicular) 3.54088
ADGRF1 adhesion G protein-coupled receptor F1 3.54088
C20ORF144 chromosome 20 open reading frame 144 3.54088
PATE2 prostate and testis expressed 2 3.54088
ZC3H12D zinc finger CCCH-type containing 12D 3.54088
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.54088
CLCNKB chloride channel, voltage-sensitive Kb 3.54088
LSMEM1 leucine-rich single-pass membrane protein 1 3.54088
TEX36 testis expressed 36 3.54088
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.54088
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.54088
BPIFC BPI fold containing family C 3.54088
ZBED6 zinc finger, BED-type containing 6 3.54088
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.54088
CARNS1 carnosine synthase 1 3.54088
POU3F3 POU class 3 homeobox 3 3.54088
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.54088
ADAM7 ADAM metallopeptidase domain 7 3.54088
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.54088
C11ORF91 chromosome 11 open reading frame 91 3.54088
DRD5 dopamine receptor D5 3.54088
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.54088
SCGB1D2 secretoglobin, family 1D, member 2 3.54088
MUC13 mucin 13, cell surface associated 3.54088
LCT lactase 3.54088
SOWAHA sosondowah ankyrin repeat domain family member A 3.54088
BAIAP3 BAI1-associated protein 3 3.54088
TAT tyrosine aminotransferase 3.54088
FZD1 frizzled class receptor 1 3.54088
NUTM2F NUT family member 2F 3.54088
PF4V1 platelet factor 4 variant 1 3.54088
IL37 interleukin 37 3.54088
GPR17 G protein-coupled receptor 17 3.54088
FAM151A family with sequence similarity 151, member A 3.54088
IL23R interleukin 23 receptor 3.54088
SLC36A3 solute carrier family 36, member 3 3.54088
FGF9 fibroblast growth factor 9 3.54088
ERAP2 endoplasmic reticulum aminopeptidase 2 3.54088
ADAM18 ADAM metallopeptidase domain 18 3.54088
LRRN4 leucine rich repeat neuronal 4 3.54088
BAHCC1 BAH domain and coiled-coil containing 1 3.54088
EPHB3 EPH receptor B3 3.54088
TMEM132C transmembrane protein 132C 3.54088
LOC105378220 macrophage receptor MARCO-like 3.54088
PLXNA2 plexin A2 3.54088
TMEM184A transmembrane protein 184A 3.54088
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.54088
CDCP2 CUB domain containing protein 2 3.54088
LPA lipoprotein, Lp(a) 3.54088
SLC38A3 solute carrier family 38, member 3 3.54088
MOBP myelin-associated oligodendrocyte basic protein 3.54088
NRGN neurogranin (protein kinase C substrate, RC3) 3.54088
CAPSL calcyphosine-like 3.54088
OTP orthopedia homeobox 3.54088
FXYD4 FXYD domain containing ion transport regulator 4 3.54088
NPR3 natriuretic peptide receptor 3 3.54088
XIRP2 xin actin binding repeat containing 2 3.5047
SMCO2 single-pass membrane protein with coiled-coil domains 2 3.5047
PRSS36 protease, serine, 36 3.5047
C1ORF94 chromosome 1 open reading frame 94 3.38474
GRK3 G protein-coupled receptor kinase 3 3.35227
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 3.15421
SPMIP3 sperm microtubule inner protein 3 3.06916
PLAC8 placenta-specific 8 3.00242
RBM45 RNA binding motif protein 45 2.89728
LBR lamin B receptor 2.88579
OSBPL11 oxysterol binding protein-like 11 2.79039
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.76221
ELP1 elongator acetyltransferase complex subunit 1 2.73348
SPN sialophorin 2.68864
CLDND2 claudin domain containing 2 2.68768
E2F7 E2F transcription factor 7 2.68516
RHOT1 ras homolog family member T1 2.68344
IQCN IQ motif containing N 2.62829
PAX7 paired box 7 2.62829
PIGBOS1 PIGB opposite strand 1 2.60623
BTN3A3 butyrophilin, subfamily 3, member A3 2.55738
PCDH7 protocadherin 7 2.55522
PDZD7 PDZ domain containing 7 2.5478
SMIM3 small integral membrane protein 3 2.50087
MRPL32 mitochondrial ribosomal protein L32 2.48694
UBL5 ubiquitin-like 5 2.40751
DAPK1 death-associated protein kinase 1 2.36919
RNF31 ring finger protein 31 2.33421
CSTL1 cystatin-like 1 2.32746
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.31989
AKAP12 A kinase (PRKA) anchor protein 12 2.31925
HKDC1 hexokinase domain containing 1 2.31702
TAS2R19 taste receptor, type 2, member 19 2.31702
ANKHD1 ankyrin repeat and KH domain containing 1 2.252
MAST3 microtubule associated serine/threonine kinase 3 2.21369
LYAR Ly1 antibody reactive 2.21369
ECE1 endothelin converting enzyme 1 2.1814
TMEM218 transmembrane protein 218 2.13228
RAB9A RAB9A, member RAS oncogene family 2.1252
FHL1 four and a half LIM domains 1 2.12123
VSTM2A V-set and transmembrane domain containing 2A 2.11309
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.10623
RPL37 ribosomal protein L37 2.09874
H4C3 H4 clustered histone 3 2.09308
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.09308
TACR3 tachykinin receptor 3 2.08028
STARD4 StAR-related lipid transfer (START) domain containing 4 2.06238
CCDC88A coiled-coil domain containing 88A 2.05364
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 2.04967
LRP3 low density lipoprotein receptor-related protein 3 2.03626
ARHGAP32 Rho GTPase activating protein 32 2.01385

decreased expression

Symbol Name Standardized Value
AQP4 aquaporin 4 -3.54088
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.54088
G0S2 G0/G1 switch 2 -3.54088
OTX1 orthodenticle homeobox 1 -3.54088
PRB2 proline-rich protein BstNI subfamily 2 -3.54088
ADRA1D adrenoceptor alpha 1D -3.54088
VSTM2B V-set and transmembrane domain containing 2B -3.54088
SYT5 synaptotagmin V -3.54088
CCDC83 coiled-coil domain containing 83 -3.38474
CPB2 carboxypeptidase B2 (plasma) -3.38474
LCNL1 lipocalin-like 1 -3.38474
EDN3 endothelin 3 -3.38474
OIT3 oncoprotein induced transcript 3 -3.38474
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 -3.38474
PRKCG protein kinase C, gamma -3.38474
A1CF APOBEC1 complementation factor -3.38474
SP6 Sp6 transcription factor -3.38474
ETV2 ets variant 2 -3.38474
PRELP proline/arginine-rich end leucine-rich repeat protein -3.38474
NWD2 NACHT and WD repeat domain containing 2 -3.38474
ICAM5 intercellular adhesion molecule 5, telencephalin -3.38474
GJB3 gap junction protein, beta 3, 31kDa -3.38474
NRSN1 neurensin 1 -3.38474
BTBD19 BTB (POZ) domain containing 19 -3.38474
CCDC38 coiled-coil domain containing 38 -3.38474
WNT16 wingless-type MMTV integration site family, member 16 -3.38474
CYS1 cystin 1 -3.38474
LPAR5 lysophosphatidic acid receptor 5 -3.38474
PENK proenkephalin -3.38474
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.38474
FAIM2 Fas apoptotic inhibitory molecule 2 -3.38474
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -3.38474
ETV3L ets variant 3-like -3.38474
ZNF831 zinc finger protein 831 -3.38474
UBE2L5 ubiquitin conjugating enzyme E2 L5 -3.38474
TF transferrin -3.38474
FGR FGR proto-oncogene, Src family tyrosine kinase -3.38474
CDK20 cyclin-dependent kinase 20 -3.38474
UTS2R urotensin 2 receptor -3.38474
CCER2 coiled-coil glutamate-rich protein 2 -3.38474
TBXA2R thromboxane A2 receptor -3.38474
SCN1B sodium channel, voltage gated, type I beta subunit -3.10078
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -3.00242
SH2D3A SH2 domain containing 3A -2.82636
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -2.7797
KPNA6 karyopherin alpha 6 (importin alpha 7) -2.77351
FKBP6 FK506 binding protein 6, 36kDa -2.76221
MXRA8 matrix-remodelling associated 8 -2.73614
S1PR1 sphingosine-1-phosphate receptor 1 -2.69585
GTF2IRD2 GTF2I repeat domain containing 2 -2.69021
NDC80 NDC80 kinetochore complex component -2.63792
USP15 ubiquitin specific peptidase 15 -2.62648
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.62379
GANC glucosidase, alpha; neutral C -2.61087
PMM1 phosphomannomutase 1 -2.57668
FXYD1 FXYD domain containing ion transport regulator 1 -2.50357
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.46969
TSPYL1 TSPY-like 1 -2.40633
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.39706
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.39058
TKFC triokinase/FMN cyclase -2.38114
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.36999
PLD6 phospholipase D family, member 6 -2.33013
PTAFR platelet-activating factor receptor -2.33013
TXNL1 thioredoxin-like 1 -2.32221
SYT17 synaptotagmin XVII -2.21512
CPEB2 cytoplasmic polyadenylation element binding protein 2 -2.2019
KIAA0930 KIAA0930 -2.2019
RETREG3 reticulophagy regulator family member 3 -2.2019
WASHC2A WASH complex subunit 2A -2.2019
PPP1R37 protein phosphatase 1, regulatory subunit 37 -2.19064
DRC3 dynein regulatory complex subunit 3 -2.1814
MPPED1 metallophosphoesterase domain containing 1 -2.1814
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.1814
ADH6 alcohol dehydrogenase 6 (class V) -2.1814
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.17132
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.16615
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.1616
ADRA1A adrenoceptor alpha 1A -2.15191
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.1277
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.1277
GPR162 G protein-coupled receptor 162 -2.1252
PTK2 protein tyrosine kinase 2 -2.1252
LEMD2 LEM domain containing 2 -2.1252
ENSA endosulfine alpha -2.11014
BAK1 BCL2-antagonist/killer 1 -2.10623
VRK2 vaccinia related kinase 2 -2.10623
UBAC2 UBA domain containing 2 -2.09308
CORO2A coronin, actin binding protein, 2A -2.09308
RREB1 ras responsive element binding protein 1 -2.09202
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -2.05567
ZFYVE16 zinc finger, FYVE domain containing 16 -2.05287
SKAP1 src kinase associated phosphoprotein 1 -2.03891
IFI30 interferon, gamma-inducible protein 30 -2.02971
MPV17L MPV17 mitochondrial membrane protein-like -2.02263