PIAS3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description protein inhibitor of activated STAT, 3|This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10401)
External Link http://www.ncbi.nlm.nih.gov/gene/10401
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67 interacting proteins for PIAS3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AR androgen receptor
ATF7IP activating transcription factor 7 interacting protein
C19ORF60 chromosome 19 open reading frame 60
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBS cystathionine-beta-synthase
CREBBP CREB binding protein
CREM cAMP responsive element modulator
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
GEMIN4 gem (nuclear organelle) associated protein 4
GFI1 growth factor independent 1 transcription repressor
GLUL glutamate-ammonia ligase
HABP4 hyaluronan binding protein 4
HDAC1 histone deacetylase 1
HMGA2 high mobility group AT-hook 2
HNRNPK heterogeneous nuclear ribonucleoprotein K
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
JAK1 Janus kinase 1
LMO4 LIM domain only 4
MBD1 methyl-CpG binding domain protein 1
MITF microphthalmia-associated transcription factor
MYB v-myb avian myeloblastosis viral oncogene homolog
NCOA2 nuclear receptor coactivator 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
OPN1LW opsin 1 (cone pigments), long-wave-sensitive
PGR progesterone receptor
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SATB1 SATB homeobox 1
SERBP1 SERPINE1 mRNA binding protein 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT1 sirtuin 1
SKIL SKI-like proto-oncogene
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SREBF2 sterol regulatory element binding transcription factor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBP TATA box binding protein
TRIM27 tripartite motif containing 27
TRIM32 tripartite motif containing 32
TRIM8 tripartite motif containing 8
UBA1 ubiquitin-like modifier activating enzyme 1
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
ZFHX3 zinc finger homeobox 3
ZMIZ1 zinc finger, MIZ-type containing 1
ZMIZ2 zinc finger, MIZ-type containing 2