PIEZO1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description piezo-type mechanosensitive ion channel component 1|Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010] (NCBI Entrez Gene Database, 9780)
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Genes

357 genes differentially expressed following the PIEZO1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PDCD11 programmed cell death 11 2.51801
DEPP1 DEPP autophagy regulator 1 2.51801
C3AR1 complement component 3a receptor 1 2.51801
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.51801
CD69 CD69 molecule 2.51801
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.51801
ZPLD1 zona pellucida-like domain containing 1 2.51801
GADL1 glutamate decarboxylase-like 1 2.51801
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.51801
SCG2 secretogranin II 2.51801
CC2D2B coiled-coil and C2 domain containing 2B 2.51801
GRXCR2 glutaredoxin, cysteine rich 2 2.51801
CLDN5 claudin 5 2.51801
OSTN osteocrin 2.51801
NFAM1 NFAT activating protein with ITAM motif 1 2.51801
CES3 carboxylesterase 3 2.51801
CLDN34 claudin 34 2.51801
PRR29 proline rich 29 2.51801
SCGN secretagogin, EF-hand calcium binding protein 2.51801
GALR2 galanin receptor 2 2.51801
TMEM132D transmembrane protein 132D 2.51801
NAPSA napsin A aspartic peptidase 2.51801
BFSP2 beaded filament structural protein 2, phakinin 2.51801
MDFIC2 MyoD family inhibitor domain containing 2 2.51801
TRIM7 tripartite motif containing 7 2.51801
CD93 CD93 molecule 2.51801
ADTRP androgen-dependent TFPI-regulating protein 2.40453
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.40453
GPR151 G protein-coupled receptor 151 2.40453
IGFL3 IGF-like family member 3 2.40453
UMOD uromodulin 2.40453
IL22RA1 interleukin 22 receptor, alpha 1 2.40453
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.40453
MAGEB16 melanoma antigen family B16 2.40453
DUXA double homeobox A 2.40453
NANOS2 nanos homolog 2 (Drosophila) 2.40453
ZEB2 zinc finger E-box binding homeobox 2 2.40453
DSG4 desmoglein 4 2.40453
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 2.40453
FOLR3 folate receptor 3 (gamma) 2.40453
ADAT3 adenosine deaminase, tRNA-specific 3 2.40453
FOXJ1 forkhead box J1 2.40453
HBZ hemoglobin, zeta 2.40453
MMP20 matrix metallopeptidase 20 2.40453
MYO1A myosin IA 2.40453
RNF139 ring finger protein 139 2.40453
MRPL22 mitochondrial ribosomal protein L22 2.40453
GYS2 glycogen synthase 2 (liver) 2.40453
DLL4 delta-like 4 (Drosophila) 2.40453
FABP12 fatty acid binding protein 12 2.40453
RLN3 relaxin 3 2.40453
SIGLEC7 sialic acid binding Ig-like lectin 7 2.40453
ASB10 ankyrin repeat and SOCS box containing 10 2.40453
ASPA aspartoacylase 2.40453
MFAP5 microfibrillar associated protein 5 2.40453
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.40453
GCKR glucokinase (hexokinase 4) regulator 2.40453
OR1L6 olfactory receptor, family 1, subfamily L, member 6 2.40453
PSCA prostate stem cell antigen 2.40453
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.40453
SPATA31G1 SPATA31 subfamily G member 1 2.40453
CCN5 cellular communication network factor 5 2.40453
CFAP65 cilia and flagella associated protein 65 2.40453
YIPF7 Yip1 domain family, member 7 2.40453
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.40453
SPI1 Spi-1 proto-oncogene 2.40453
RHCG Rh family, C glycoprotein 2.40453
ELOVL3 ELOVL fatty acid elongase 3 2.40453
FRG2C FSHD region gene 2 family, member C 2.40453
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.40453
SPATA46 spermatogenesis associated 46 2.40453
WDR97 WD repeat domain 97 2.40453
MUCL3 mucin like 3 2.40453
TEKTL1 tektin like 1 2.40453
CIMIP2A ciliary microtubule inner protein 2A 2.40453
SPMAP2 sperm microtubule associated protein 2 2.40453
ERLN endoregulin 2.40453
PNMA6F PNMA family member 6F 2.40453
EXOC1L exocyst complex component 1 like 2.40453
CIMAP1D CIMAP1 family member D 2.40453
SMIM31 small integral membrane protein 31 2.40453
GLYATL1B glycine-N-acyltransferase like 1B 2.40453
COL3A1 collagen, type III, alpha 1 2.40453
GRAP GRB2-related adaptor protein 2.40453
CLDN2 claudin 2 2.40453
TUBA3D tubulin, alpha 3d 2.40453
PTPRH protein tyrosine phosphatase, receptor type, H 2.40453
RLBP1 retinaldehyde binding protein 1 2.40453
PVRIG poliovirus receptor related immunoglobulin domain containing 2.40453
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.40453
SYCP2 synaptonemal complex protein 2 2.40453
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.40453
MYO7B myosin VIIB 2.40453
ITFG2 integrin alpha FG-GAP repeat containing 2 2.40453
TLR6 toll-like receptor 6 2.40453
TLR4 toll-like receptor 4 2.40453
TSPAN8 tetraspanin 8 2.40453
LY6H lymphocyte antigen 6 complex, locus H 2.40453
SELL selectin L 2.40453
DLK2 delta-like 2 homolog (Drosophila) 2.40453
ASIC3 acid sensing (proton gated) ion channel 3 2.40453
GPR85 G protein-coupled receptor 85 2.40453
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.40453
S100G S100 calcium binding protein G 2.40453
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.40453
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.40453
OIT3 oncoprotein induced transcript 3 2.40453
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.40453
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.40453
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.40453
AGR3 anterior gradient 3 2.40453
SIRPG signal-regulatory protein gamma 2.40453
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.40453
NUTM2B NUT family member 2B 2.40453
SPATA9 spermatogenesis associated 9 2.40453
TBX1 T-box 1 2.40453
EPO erythropoietin 2.40453
SCN3A sodium channel, voltage gated, type III alpha subunit 2.40453
VTCN1 V-set domain containing T cell activation inhibitor 1 2.40453
CHRM4 cholinergic receptor, muscarinic 4 2.40453
CHRM1 cholinergic receptor, muscarinic 1 2.40453
GOLGA8M golgin A8 family, member M 2.40453
FGF10 fibroblast growth factor 10 2.40453
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.40453
FBXO40 F-box protein 40 2.40453
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.40453
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.40453
HPX hemopexin 2.40453
CST1 cystatin SN 2.40453
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.40453
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.40453
CD5L CD5 molecule-like 2.40453
CNTF ciliary neurotrophic factor 2.40453
MEFV Mediterranean fever 2.40453
NIM1K NIM1 serine/threonine protein kinase 2.40453
PSKH2 protein serine kinase H2 2.40453
FAM209B family with sequence similarity 209, member B 2.40453
VWA7 von Willebrand factor A domain containing 7 2.40453
CYBB cytochrome b-245, beta polypeptide 2.40453
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.40453
ZMYND15 zinc finger, MYND-type containing 15 2.40453
APOL6 apolipoprotein L, 6 2.40453
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.40453
SNTN sentan, cilia apical structure protein 2.40453
MAGEC3 melanoma antigen family C3 2.40453
ADGRD1 adhesion G protein-coupled receptor D1 2.40453
TMPPE transmembrane protein with metallophosphoesterase domain 2.40453
CCDC171 coiled-coil domain containing 171 2.40453
ASCL5 achaete-scute family bHLH transcription factor 5 2.40453
AREG amphiregulin 2.40453
SLC25A34 solute carrier family 25, member 34 2.40453
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.40453
MYADML2 myeloid-associated differentiation marker-like 2 2.40453
GPR78 G protein-coupled receptor 78 2.40453
EMCN endomucin 2.40453
MEIS1 Meis homeobox 1 2.40453
ZW10 zw10 kinetochore protein 2.40453
MB myoglobin 2.40453
BTG4 B-cell translocation gene 4 2.40453
GPR153 G protein-coupled receptor 153 2.40453
GPR17 G protein-coupled receptor 17 2.40453
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 2.40453
ANXA1 annexin A1 2.40453
OCM oncomodulin 2.40453
ZC3H12D zinc finger CCCH-type containing 12D 2.40453
ALLC allantoicase 2.40453
TMPRSS13 transmembrane protease, serine 13 2.40453
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.40453
LHB luteinizing hormone beta polypeptide 2.40453
SMIM19 small integral membrane protein 19 2.40453
TTC36 tetratricopeptide repeat domain 36 2.40453
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.40453
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.40453
GREM1 gremlin 1, DAN family BMP antagonist 2.40453
AMDHD1 amidohydrolase domain containing 1 2.40453
SIGLEC15 sialic acid binding Ig-like lectin 15 2.40453
DMRT1 doublesex and mab-3 related transcription factor 1 2.40453
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 2.39211
AKNA AT-hook transcription factor 2.37908
DNAAF1 dynein, axonemal, assembly factor 1 2.36159
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.36159
TFEB transcription factor EB 2.36159
SFRP5 secreted frizzled-related protein 5 2.36159
LCN2 lipocalin 2 2.36159
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.36159
GSG1 germ cell associated 1 2.36159
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.36159
CLIC2 chloride intracellular channel 2 2.36159
MROH2A maestro heat-like repeat family member 2A 2.36159
SLC9C2 solute carrier family 9, member C2 (putative) 2.36159
CGN cingulin 2.35562
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.34743
LOC102723564 uncharacterized LOC102723564 2.30345
HADH hydroxyacyl-CoA dehydrogenase 2.30238
MRPL44 mitochondrial ribosomal protein L44 2.29892
HMOX1 heme oxygenase 1 2.29574
ZNF574 zinc finger protein 574 2.27539
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.26454
ZDHHC14 zinc finger, DHHC-type containing 14 2.26323
DMGDH dimethylglycine dehydrogenase 2.26323
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 2.26323
CUTA cutA divalent cation tolerance homolog (E. coli) 2.24688
PRPF4 pre-mRNA processing factor 4 2.23965
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.2222
UBL4A ubiquitin-like 4A 2.21252
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 2.19302
ZNF497 zinc finger protein 497 2.19302
MDFIC MyoD family inhibitor domain containing 2.19302
MRPS6 mitochondrial ribosomal protein S6 2.17884
GRK3 G protein-coupled receptor kinase 3 2.17027
UTP4 UTP4 small subunit processome component 2.1653
FLOT1 flotillin 1 2.16424
RIOX1 ribosomal oxygenase 1 2.16424
URM1 ubiquitin related modifier 1 2.16424
CNTN1 contactin 1 2.16424
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2.16185
C19ORF53 chromosome 19 open reading frame 53 2.16177
SIMC1 SUMO-interacting motifs containing 1 2.15369
GLE1 GLE1 RNA export mediator 2.14421
PMPCA peptidase (mitochondrial processing) alpha 2.13837
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.13697
ARL5B ADP-ribosylation factor-like 5B 2.1329
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.1329
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.12831
DERA deoxyribose-phosphate aldolase (putative) 2.11659
H4C8 H4 clustered histone 8 2.11563
FAM50A family with sequence similarity 50, member A 2.10442
MRPL20 mitochondrial ribosomal protein L20 2.09606
IL6R interleukin 6 receptor 2.0792
KATNBL1 katanin p80 subunit B-like 1 2.07673
MAPRE2 microtubule-associated protein, RP/EB family, member 2 2.07297
MRFAP1 Morf4 family associated protein 1 2.07235
TAGLN transgelin 2.03871
RDX radixin 2.03817
LRRC17 leucine rich repeat containing 17 2.03817
CCDC200 coiled-coil domain containing 200 2.03783
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 2.03342
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.03045
SLC25A46 solute carrier family 25, member 46 2.0251
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.02346
TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast) 2.02331
FAAP100 FA core complex associated protein 100 2.02331
PAIP1 poly(A) binding protein interacting protein 1 2.02161
HDAC3 histone deacetylase 3 2.01352
PLPBP pyridoxal phosphate binding protein 2.00751
TRABD2B TraB domain containing 2B 2.00622
SRSF2 serine/arginine-rich splicing factor 2 2.00337
GRM8 glutamate receptor, metabotropic 8 2.00337
CORT cortistatin 2.00337
RIBC2 RIB43A domain with coiled-coils 2 2.00337

decreased expression

Symbol Name Standardized Value
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -2.51801
KDM6B lysine (K)-specific demethylase 6B -2.51801
CD101 CD101 molecule -2.51801
CASZ1 castor zinc finger 1 -2.51801
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.43288
S1PR1 sphingosine-1-phosphate receptor 1 -2.40553
TMEM190 transmembrane protein 190 -2.40553
DENND4A DENN/MADD domain containing 4A -2.40453
FOXP2 forkhead box P2 -2.40453
CCDC30 coiled-coil domain containing 30 -2.40453
SPDYE1 speedy/RINGO cell cycle regulator family member E1 -2.40453
NPIPA2 nuclear pore complex interacting protein family, member A2 -2.40453
PTPRN protein tyrosine phosphatase, receptor type, N -2.40453
SPARCL1 SPARC-like 1 (hevin) -2.40453
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.40453
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -2.40453
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.40453
NDC80 NDC80 kinetochore complex component -2.40453
SNX1 sorting nexin 1 -2.40453
AOAH acyloxyacyl hydrolase (neutrophil) -2.40453
PTX3 pentraxin 3, long -2.40453
NOTCH3 notch 3 -2.40453
HMGN3 high mobility group nucleosomal binding domain 3 -2.40453
IL20RB interleukin 20 receptor beta -2.40453
PRSS35 protease, serine, 35 -2.40453
SFTPD surfactant protein D -2.40453
NLK nemo-like kinase -2.39867
H4C11 H4 clustered histone 11 -2.39211
EPHA4 EPH receptor A4 -2.37908
RNF157 ring finger protein 157 -2.36159
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) -2.36159
SPHK2 sphingosine kinase 2 -2.36159
CLCN1 chloride channel, voltage-sensitive 1 -2.36159
ATOH7 atonal homolog 7 (Drosophila) -2.36159
EVL Enah/Vasp-like -2.36159
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -2.36159
CAMK1G calcium/calmodulin-dependent protein kinase IG -2.36159
CD226 CD226 molecule -2.36159
EMILIN1 elastin microfibril interfacer 1 -2.36159
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -2.36159
EPCIP exosomal polycystin 1 interacting protein -2.36159
COL5A2 collagen, type V, alpha 2 -2.36159
TBX10 T-box 10 -2.36159
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -2.36159
FZD1 frizzled class receptor 1 -2.36159
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -2.36159
JAML junction adhesion molecule like -2.36159
MT1M metallothionein 1M -2.36159
SAMD11 sterile alpha motif domain containing 11 -2.36159
EXOC3L1 exocyst complex component 3-like 1 -2.36159
TRAF3IP3 TRAF3 interacting protein 3 -2.36159
FAM186A family with sequence similarity 186, member A -2.36159
OXER1 oxoeicosanoid (OXE) receptor 1 -2.36159
ZNF396 zinc finger protein 396 -2.36159
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -2.36159
MTMR2 myotubularin related protein 2 -2.33207
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.33007
SREBF2 sterol regulatory element binding transcription factor 2 -2.33007
FAM222A family with sequence similarity 222, member A -2.33007
PMEL premelanosome protein -2.33007
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.33007
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -2.33007
NNT nicotinamide nucleotide transhydrogenase -2.32638
ZNF883 zinc finger protein 883 -2.32132
SNIP1 Smad nuclear interacting protein 1 -2.32049
HERPUD2 HERPUD family member 2 -2.31481
GLT8D2 glycosyltransferase 8 domain containing 2 -2.30318
PANX1 pannexin 1 -2.27154
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 -2.26323
RNF10 ring finger protein 10 -2.26313
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.26309
SCAMP1 secretory carrier membrane protein 1 -2.26309
CMYA5 cardiomyopathy associated 5 -2.26309
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -2.26309
GLIS1 GLIS family zinc finger 1 -2.26309
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -2.23965
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.22561
TSC22D4 TSC22 domain family, member 4 -2.21371
NAGK N-acetylglucosamine kinase -2.19302
SPICP3 Spi-C transcription factor pseudogene 3 -2.19302
FOXK2 forkhead box K2 -2.1653
RFESD Rieske (Fe-S) domain containing -2.16424
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.14839
C1QL3 complement component 1, q subcomponent-like 3 -2.14839
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.1434
NOTCH1 notch 1 -2.12831
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.12831
ADCY10 adenylate cyclase 10 (soluble) -2.12831
CCDC183 coiled-coil domain containing 183 -2.12831
STX2 syntaxin 2 -2.12831
SFPQ splicing factor proline/glutamine-rich -2.12831
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -2.12116
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.12116
KCTD19 potassium channel tetramerization domain containing 19 -2.12112
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.10442
ANXA4 annexin A4 -2.07387
TTC6 tetratricopeptide repeat domain 6 -2.07297
IFT57 intraflagellar transport 57 -2.07297
PLAC1 placenta-specific 1 -2.03817
IVD isovaleryl-CoA dehydrogenase -2.03783
SOCS2 suppressor of cytokine signaling 2 -2.03584
ZFTRAF1 zinc finger TRAF-type containing 1 -2.03342
ZNF600 zinc finger protein 600 -2.02263
MOAP1 modulator of apoptosis 1 -2.02161
EIF3A eukaryotic translation initiation factor 3, subunit A -2.02084
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.01487
VSTM5 V-set and transmembrane domain containing 5 -2.0066