PIF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PIF1 5'-to-3' DNA helicase|This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013] (NCBI Entrez Gene Database, 80119)
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Genes

287 genes differentially expressed following the PIF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SIX6 SIX homeobox 6 2.52367
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 2.52367
MILR1 mast cell immunoglobulin-like receptor 1 2.52367
PNMA5 paraneoplastic Ma antigen family member 5 2.52367
RRAD Ras-related associated with diabetes 2.52367
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.52367
NRAP nebulin-related anchoring protein 2.52367
GJB3 gap junction protein, beta 3, 31kDa 2.52367
DSG3 desmoglein 3 2.52367
PAX8 paired box 8 2.52367
MAGEA2 melanoma antigen family A2 2.52367
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.52367
IGFL2 IGF-like family member 2 2.52367
RHOXF2B Rhox homeobox family, member 2B 2.52367
ALB albumin 2.52367
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.52367
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.52367
CDH5 cadherin 5, type 2 (vascular endothelium) 2.52367
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.52367
GPR55 G protein-coupled receptor 55 2.52367
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.52367
RXFP2 relaxin/insulin-like family peptide receptor 2 2.52367
ASB10 ankyrin repeat and SOCS box containing 10 2.52367
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.52367
IL5RA interleukin 5 receptor, alpha 2.52367
MROH6 maestro heat-like repeat family member 6 2.52367
GTPBP8 GTP-binding protein 8 (putative) 2.52367
CCDC38 coiled-coil domain containing 38 2.52367
COPZ2 coatomer protein complex, subunit zeta 2 2.52367
SETSIP SET-like protein 2.52367
MUC22 mucin 22 2.52367
ATOH8 atonal homolog 8 (Drosophila) 2.52367
ATOH7 atonal homolog 7 (Drosophila) 2.52367
SPNS2 spinster homolog 2 (Drosophila) 2.52367
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 2.52367
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.52367
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.52367
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.52367
FCRL5 Fc receptor-like 5 2.52367
GPR21 G protein-coupled receptor 21 2.52367
MYCT1 myc target 1 2.52367
TRIM74 tripartite motif containing 74 2.52367
CXCL2 chemokine (C-X-C motif) ligand 2 2.52367
HAS1 hyaluronan synthase 1 2.52367
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.52367
PRDM16 PR domain containing 16 2.52367
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.52367
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.52367
ZNF726 zinc finger protein 726 2.52367
CD300LF CD300 molecule-like family member f 2.52367
BNC1 basonuclin 1 2.52367
KRT80 keratin 80, type II 2.52367
C20ORF202 chromosome 20 open reading frame 202 2.52367
TSPAN1 tetraspanin 1 2.52367
GCSAM germinal center-associated, signaling and motility 2.52367
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.52367
HBG1 hemoglobin, gamma A 2.52367
STYXL2 serine/threonine/tyrosine interacting like 2 2.52367
FYB1 FYN binding protein 1 2.52367
PNMA6F PNMA family member 6F 2.52367
SPEGNB SPEG neighbor 2.52367
LRRC8C-DT LRRC8C divergent transcript 2.52367
ADISSP adipose secreted signaling protein 2.52367
SMIM35 small integral membrane protein 35 2.52367
MINDY4B MINDY family member 4B 2.52367
PEAK3 PEAK family member 3 2.52367
CFAP141 cilia and flagella associated protein 141 2.52367
DNAI7 dynein axonemal intermediate chain 7 2.52367
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.52367
CLEC6A C-type lectin domain family 6, member A 2.52367
CLIP3 CAP-GLY domain containing linker protein 3 2.52367
PRB4 proline-rich protein BstNI subfamily 4 2.52367
KLHL33 kelch-like family member 33 2.52367
SLC35D3 solute carrier family 35, member D3 2.52367
SECTM1 secreted and transmembrane 1 2.52367
IL12RB1 interleukin 12 receptor, beta 1 2.52367
IZUMO4 IZUMO family member 4 2.52367
RS1 retinoschisin 1 2.52367
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.52367
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.52367
GOLGA6L4 golgin A6 family-like 4 2.52367
CCDC92 coiled-coil domain containing 92 2.52367
HAL histidine ammonia-lyase 2.52367
OPN4 opsin 4 2.52367
OPN5 opsin 5 2.52367
ABHD15 abhydrolase domain containing 15 2.52367
CEP135 centrosomal protein 135kDa 2.52367
CREB3L3 cAMP responsive element binding protein 3-like 3 2.52367
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.52367
MYH11 myosin, heavy chain 11, smooth muscle 2.52367
IL5 interleukin 5 2.52367
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.52367
OVCH1 ovochymase 1 2.52367
WDFY4 WDFY family member 4 2.52367
ZNF541 zinc finger protein 541 2.52367
RABGGTB Rab geranylgeranyltransferase, beta subunit 2.52367
EFCAB9 EF-hand calcium binding domain 9 2.52367
TNR tenascin R 2.52367
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.52367
C2ORF66 chromosome 2 open reading frame 66 2.52367
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.52367
ADAM7 ADAM metallopeptidase domain 7 2.52367
NPFFR1 neuropeptide FF receptor 1 2.52367
CT55 cancer/testis antigen 55 2.52367
CH25H cholesterol 25-hydroxylase 2.52367
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.52367
RUFY4 RUN and FYVE domain containing 4 2.52367
BARHL2 BarH-like homeobox 2 2.52367
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.52367
KRT15 keratin 15, type I 2.52367
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.52367
CDCA7L cell division cycle associated 7-like 2.52367
ATP10B ATPase, class V, type 10B 2.52367
ENDOU endonuclease, polyU-specific 2.52367
PKDREJ polycystin (PKD) family receptor for egg jelly 2.52367
TRIM50 tripartite motif containing 50 2.52367
CGB7 chorionic gonadotropin, beta polypeptide 7 2.52367
CA5A carbonic anhydrase VA, mitochondrial 2.52367
RFPL4B ret finger protein-like 4B 2.52367
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.52367
RIPK3 receptor-interacting serine-threonine kinase 3 2.52367
LAMB3 laminin, beta 3 2.52367
LMX1B LIM homeobox transcription factor 1, beta 2.52367
PLA2G5 phospholipase A2, group V 2.52367
CNGB1 cyclic nucleotide gated channel beta 1 2.52367
GOLGA8N golgin A8 family, member N 2.52367
NT5C1B 5'-nucleotidase, cytosolic IB 2.52367
CLEC9A C-type lectin domain family 9, member A 2.52367
C2CD4B C2 calcium-dependent domain containing 4B 2.52367
C17ORF99 chromosome 17 open reading frame 99 2.52367
FBXO40 F-box protein 40 2.52367
ZNF596 zinc finger protein 596 2.52367
SAMD9 sterile alpha motif domain containing 9 2.52367
TBX1 T-box 1 2.52367
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.52367
CTXN3 cortexin 3 2.52367
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.52367
SIDT1 SID1 transmembrane family, member 1 2.52367
EXOSC5 exosome component 5 2.52367
GCM1 glial cells missing homolog 1 (Drosophila) 2.52367
ZBED6 zinc finger, BED-type containing 6 2.52367
IL23R interleukin 23 receptor 2.52367
LRRC38 leucine rich repeat containing 38 2.52367
CD180 CD180 molecule 2.52367
IRX4 iroquois homeobox 4 2.52367
CYSRT1 cysteine-rich tail protein 1 2.52367
ANGPTL3 angiopoietin-like 3 2.52367
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.52367
PITX3 paired-like homeodomain 3 2.52367
FOXG1 forkhead box G1 2.52367
MROH2A maestro heat-like repeat family member 2A 2.52367
ICAM2 intercellular adhesion molecule 2 2.52367
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.52367
TCF3 transcription factor 3 2.52367
PCDHGA12 protocadherin gamma subfamily A, 12 2.52367
GPBAR1 G protein-coupled bile acid receptor 1 2.52367
ACKR2 atypical chemokine receptor 2 2.52367
C5AR2 complement component 5a receptor 2 2.52367
ACY3 aminoacylase 3 2.52367
ADIRF adipogenesis regulatory factor 2.52367
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.52367
LOC105378220 macrophage receptor MARCO-like 2.52367
STAP1 signal transducing adaptor family member 1 2.52367
PRR22 proline rich 22 2.52367
PRR27 proline rich 27 2.52367
REV1 REV1, polymerase (DNA directed) 2.52367
SPAG6 sperm associated antigen 6 2.52367
CCDC83 coiled-coil domain containing 83 2.52367
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.42544
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.39229
APOB apolipoprotein B 2.38973
NXPH3 neurexophilin 3 2.38973
AKR1D1 aldo-keto reductase family 1, member D1 2.38973
SFSWAP splicing factor, suppressor of white-apricot family 2.3875
ROMO1 reactive oxygen species modulator 1 2.38463
CLEC19A C-type lectin domain family 19, member A 2.37568
SLITRK3 SLIT and NTRK-like family, member 3 2.36542
MZT2A mitotic spindle organizing protein 2A 2.3415
ZPBP zona pellucida binding protein 2.33684
PLN phospholamban 2.33684
RBM23 RNA binding motif protein 23 2.30879
POSTN periostin, osteoblast specific factor 2.29982
CMSS1 cms1 ribosomal small subunit homolog (yeast) 2.2907
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.24958
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.24807
PIAS1 protein inhibitor of activated STAT, 1 2.24447
FSIP1 fibrous sheath interacting protein 1 2.22133
GABPA GA binding protein transcription factor, alpha subunit 60kDa 2.22133
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.21761
USP51 ubiquitin specific peptidase 51 2.1946
MTCP1 mature T-cell proliferation 1 2.18881
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.18881
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.18677
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.12663
SAXO6 stabilizer of axonemal microtubules 6 2.10594
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.09468
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.08639
SYMPK symplekin 2.07869
USP45 ubiquitin specific peptidase 45 2.07869
TCEA2 transcription elongation factor A (SII), 2 2.05708
PDE4A phosphodiesterase 4A, cAMP-specific 2.05708
ZNF431 zinc finger protein 431 2.03811
OXR1 oxidation resistance 1 2.02865
BZW2 basic leucine zipper and W2 domains 2 2.02528

decreased expression

Symbol Name Standardized Value
TMEM184A transmembrane protein 184A -2.52367
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.52367
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -2.52367
FBXO2 F-box protein 2 -2.52367
OLFM4 olfactomedin 4 -2.52367
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.52367
ABHD17C abhydrolase domain containing 17C -2.52367
FETUB fetuin B -2.52367
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) -2.52367
UBAP2L ubiquitin associated protein 2-like -2.52367
BTF3L4 basic transcription factor 3-like 4 -2.52367
MEIG1 meiosis/spermiogenesis associated 1 -2.52367
ZFR zinc finger RNA binding protein -2.52367
NPIPA8 nuclear pore complex interacting protein family, member A8 -2.52367
ICAM5 intercellular adhesion molecule 5, telencephalin -2.52367
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.52367
ATP8B4 ATPase, class I, type 8B, member 4 -2.52367
TDRD1 tudor domain containing 1 -2.52367
FOXO3 forkhead box O3 -2.52367
BRDT bromodomain, testis-specific -2.52367
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -2.52367
DCTN4 dynactin 4 (p62) -2.52367
UPK3A uroplakin 3A -2.52367
ADGRD1 adhesion G protein-coupled receptor D1 -2.52367
CFAP99 cilia and flagella associated protein 99 -2.52367
ZNF776 zinc finger protein 776 -2.52367
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.52367
CRACDL CRACD like -2.52367
LRRC26 leucine rich repeat containing 26 -2.52367
CFAP70 cilia and flagella associated protein 70 -2.52367
ADGRE5 adhesion G protein-coupled receptor E5 -2.52367
CHIT1 chitinase 1 (chitotriosidase) -2.52367
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.52367
BTNL8 butyrophilin-like 8 -2.52367
GJB5 gap junction protein, beta 5, 31.1kDa -2.52367
RANBP3L RAN binding protein 3-like -2.52367
FIBIN fin bud initiation factor homolog (zebrafish) -2.52367
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -2.52367
CDK20 cyclin-dependent kinase 20 -2.52367
DROSHA drosha, ribonuclease type III -2.52367
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -2.42985
C19ORF38 chromosome 19 open reading frame 38 -2.42544
PCDHGB7 protocadherin gamma subfamily B, 7 -2.42544
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.38778
CRTC1 CREB regulated transcription coactivator 1 -2.35101
DRG1 developmentally regulated GTP binding protein 1 -2.32094
RUFY1 RUN and FYVE domain containing 1 -2.29982
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -2.29589
RIN3 Ras and Rab interactor 3 -2.2775
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) -2.27103
DISP3 dispatched RND transporter family member 3 -2.26683
NME8 NME/NM23 family member 8 -2.26092
RNF20 ring finger protein 20, E3 ubiquitin protein ligase -2.22133
CRY1 cryptochrome circadian clock 1 -2.22133
MAOA monoamine oxidase A -2.22133
RNF6 ring finger protein (C3H2C3 type) 6 -2.21682
STK26 serine/threonine protein kinase 26 -2.1963
USP21 ubiquitin specific peptidase 21 -2.18589
INO80 INO80 complex subunit -2.1807
EID3 EP300 interacting inhibitor of differentiation 3 -2.1584
CLK2 CDC-like kinase 2 -2.1584
EPHA6 EPH receptor A6 -2.14166
KDM5A lysine (K)-specific demethylase 5A -2.12663
HNRNPL heterogeneous nuclear ribonucleoprotein L -2.12324
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.11801
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.10949
PLPPR4 phospholipid phosphatase related 4 -2.10594
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.10142
RPL30 ribosomal protein L30 -2.10142
TUBB6 tubulin, beta 6 class V -2.09468
SEC63 SEC63 homolog (S. cerevisiae) -2.09468
C17ORF100 chromosome 17 open reading frame 100 -2.09468
SIAE sialic acid acetylesterase -2.07869
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.07869
ZBED4 zinc finger, BED-type containing 4 -2.07869
STK32C serine/threonine kinase 32C -2.0755
C1ORF122 chromosome 1 open reading frame 122 -2.06407
RAB27A RAB27A, member RAS oncogene family -2.06294
SH2B1 SH2B adaptor protein 1 -2.06294
ZNF414 zinc finger protein 414 -2.06294
PAWR PRKC, apoptosis, WT1, regulator -2.03848
THOC6 THO complex 6 -2.03811
OSBPL7 oxysterol binding protein-like 7 -2.01251