PIGA Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description phosphatidylinositol glycan anchor biosynthesis, class A|This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 5277)
External Link https://ncbi.nlm.nih.gov/gene/5277
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Genes

498 genes differentially expressed following the PIGA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
BCHE butyrylcholinesterase 0.0161593
EPHB2 EPH receptor B2 0.0132175
SUB1 SUB1 homolog (S. cerevisiae) 0.0128738
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0121023
IGFBP1 insulin-like growth factor binding protein 1 0.0119337
RAD23B RAD23 homolog B (S. cerevisiae) 0.0118936
DEGS1 delta(4)-desaturase, sphingolipid 1 0.0118728
NUSAP1 nucleolar and spindle associated protein 1 0.0118601
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0118098
GAL galanin/GMAP prepropeptide 0.0118035
MAOA monoamine oxidase A 0.0114198
MGP matrix Gla protein 0.0113523
PDLIM3 PDZ and LIM domain 3 0.0113149
FABP1 fatty acid binding protein 1, liver 0.0112833
METRN meteorin, glial cell differentiation regulator 0.0110921
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 0.0110845
OLFM1 olfactomedin 1 0.0109054
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0108794
PLN phospholamban 0.0107651
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0106876
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0105466
SH3BGRL SH3 domain binding glutamate-rich protein like 0.0105378
FADS1 fatty acid desaturase 1 0.0104791
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.0102101
KLHL23 kelch-like family member 23 0.0101191
DES desmin 0.00985247
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.00984831
CHP1 calcineurin-like EF-hand protein 1 0.00984165
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.00983543
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.00980232
NELL2 NEL-like 2 (chicken) 0.00977901
TGM2 transglutaminase 2 0.00969172
H2AFV H2A histone family, member V 0.00953785
PBX1 pre-B-cell leukemia homeobox 1 0.00943443
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00940865
SDC2 syndecan 2 0.00938859
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.00928959
CCL19 chemokine (C-C motif) ligand 19 0.00926563
YEATS4 YEATS domain containing 4 0.00924655
RAPSN receptor-associated protein of the synapse 0.00919908
NVL nuclear VCP-like 0.0091853
CPVL carboxypeptidase, vitellogenic-like 0.00892193
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.00887652
RTN1 reticulon 1 0.00874518
MBNL1 muscleblind-like splicing regulator 1 0.00857069
ACAT2 acetyl-CoA acetyltransferase 2 0.00854497
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00839767
FRS2 fibroblast growth factor receptor substrate 2 0.00831516
FXYD6 FXYD domain containing ion transport regulator 6 0.00826873
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.0081825
PRR7 proline rich 7 (synaptic) 0.00816206
FGL2 fibrinogen-like 2 0.00816073
SEPTIN7 septin 7 0.00811735
PBK PDZ binding kinase 0.00811296
ENO2 enolase 2 (gamma, neuronal) 0.00798799
CDCA4 cell division cycle associated 4 0.00795954
LGALS1 lectin, galactoside-binding, soluble, 1 0.00794787
SORBS1 sorbin and SH3 domain containing 1 0.00793813
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.00793172
C12ORF29 chromosome 12 open reading frame 29 0.00792003
XPO7 exportin 7 0.00791774
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00789962
CKAP2 cytoskeleton associated protein 2 0.0077598
FASN fatty acid synthase 0.00775552
DHFR dihydrofolate reductase 0.00772747
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.00771964
SPON2 spondin 2, extracellular matrix protein 0.00769965
CXCL9 chemokine (C-X-C motif) ligand 9 0.00768201
PCGF2 polycomb group ring finger 2 0.00768001
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.00766608
OIP5 Opa interacting protein 5 0.00758933
RPS4Y1 ribosomal protein S4, Y-linked 1 0.00757004
ELOVL6 ELOVL fatty acid elongase 6 0.00754306
ARID4A AT rich interactive domain 4A (RBP1-like) 0.00746974
LBR lamin B receptor 0.0074353
EIF4E eukaryotic translation initiation factor 4E 0.00739963
RNASE6 ribonuclease, RNase A family, k6 0.00738773
LRP4 low density lipoprotein receptor-related protein 4 0.00738306
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.00734792
ACTG2 actin, gamma 2, smooth muscle, enteric 0.00734239
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 0.00732181
EMP3 epithelial membrane protein 3 0.0073032
CHN2 chimerin 2 0.00728703
GRB14 growth factor receptor-bound protein 14 0.00728228
METTL7A methyltransferase like 7A 0.00726351
MPHOSPH9 M-phase phosphoprotein 9 0.007242
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.00719192
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00717869
GINS1 GINS complex subunit 1 (Psf1 homolog) 0.007163
RBM8A RNA binding motif protein 8A 0.00715358
LMNB1 lamin B1 0.00714059
C7 complement component 7 0.00711091
SLC38A4 solute carrier family 38, member 4 0.00710581
HAT1 histone acetyltransferase 1 0.0070929
PWP1 PWP1 homolog (S. cerevisiae) 0.00708217
PRKCB protein kinase C, beta 0.00708055
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.00706775
SCUBE2 signal peptide, CUB domain, EGF-like 2 0.00706343
TSPYL5 TSPY-like 5 0.00701619
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.00698128
KANK2 KN motif and ankyrin repeat domains 2 0.00697773
KIF20A kinesin family member 20A 0.00695635
NFIB nuclear factor I/B 0.00693655
CD1E CD1e molecule 0.00690426
LGALS13 lectin, galactoside-binding, soluble, 13 0.00690221
FKBP10 FK506 binding protein 10, 65 kDa 0.00689853
CTSH cathepsin H 0.00686025
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.00682832
ACOX2 acyl-CoA oxidase 2, branched chain 0.00682731
C1R complement component 1, r subcomponent 0.00680138
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.00677402
IGSF6 immunoglobulin superfamily, member 6 0.00677332
CCL5 chemokine (C-C motif) ligand 5 0.00672423
CBX3 chromobox homolog 3 0.00671161
DBF4 DBF4 zinc finger 0.00670222
NCAM1 neural cell adhesion molecule 1 0.00668863
COL4A6 collagen, type IV, alpha 6 0.0066804
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 0.00667892
SRGN serglycin 0.00667875
C9 complement component 9 0.006643
PIPOX pipecolic acid oxidase 0.00662633
DPYD dihydropyrimidine dehydrogenase 0.00659319
PDE10A phosphodiesterase 10A 0.00658515
REG1B regenerating islet-derived 1 beta 0.00658006
KCTD3 potassium channel tetramerization domain containing 3 0.00656134
IPO5 importin 5 0.00655014
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.00653152
PSD3 pleckstrin and Sec7 domain containing 3 0.00652676
PCCA propionyl CoA carboxylase, alpha polypeptide 0.00651552
NUP107 nucleoporin 107kDa 0.0065093
PDGFRL platelet-derived growth factor receptor-like 0.00648618
ESD esterase D 0.00647645
NMU neuromedin U 0.00645797
HMGN5 high mobility group nucleosome binding domain 5 0.00644497
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00641164
SFRP1 secreted frizzled-related protein 1 0.00638937
PTCH1 patched 1 0.00638403
CES1 carboxylesterase 1 0.00637914
TLE2 transducin-like enhancer of split 2 0.00637182
SPC25 SPC25, NDC80 kinetochore complex component 0.0063704
TUSC3 tumor suppressor candidate 3 0.00635161
ADAMDEC1 ADAM-like, decysin 1 0.00635144
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.00634367
HOMER2 homer scaffolding protein 2 0.0063264
GTSE1 G-2 and S-phase expressed 1 0.0063179
BIRC5 baculoviral IAP repeat containing 5 0.00630847
FLNC filamin C, gamma 0.00630391
SORD sorbitol dehydrogenase 0.00627862
AK4 adenylate kinase 4 0.00625579
RMI1 RecQ mediated genome instability 1 0.00625043
GNG10 guanine nucleotide binding protein (G protein), gamma 10 0.00624277
PARPBP PARP1 binding protein 0.00624235
CXCL14 chemokine (C-X-C motif) ligand 14 0.00620227
AXL AXL receptor tyrosine kinase 0.00620202
ARHGAP6 Rho GTPase activating protein 6 0.00619734
COL6A2 collagen, type VI, alpha 2 0.00616784
NDN necdin, melanoma antigen (MAGE) family member 0.00616654
FBXW2 F-box and WD repeat domain containing 2 0.0061565
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.00614176
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.00613242
FERMT2 fermitin family member 2 0.00612936
TMPO thymopoietin 0.00612706
MYRIP myosin VIIA and Rab interacting protein 0.00610891
THAP11 THAP domain containing 11 0.00609446
RB1 retinoblastoma 1 0.00605992
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.00602809
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.00601205
IGF1 insulin-like growth factor 1 (somatomedin C) 0.00600507
PTPRD protein tyrosine phosphatase, receptor type, D 0.00599254
CHKB choline kinase beta 0.00598833
MCM6 minichromosome maintenance complex component 6 0.00598808
CST3 cystatin C 0.00598607
MATN2 matrilin 2 0.00597863
GNMT glycine N-methyltransferase 0.00596831
CHRDL1 chordin-like 1 0.00596084
LIMCH1 LIM and calponin homology domains 1 0.00595782
TYROBP TYRO protein tyrosine kinase binding protein 0.00594066
RELN reelin 0.00593393
LGALS2 lectin, galactoside-binding, soluble, 2 0.00592306
BMPR1A bone morphogenetic protein receptor, type IA 0.0059206
GANAB glucosidase, alpha; neutral AB 0.00590301
CCNA2 cyclin A2 0.00589446
ADAMTSL3 ADAMTS-like 3 0.00589322
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.00588268
CRY1 cryptochrome circadian clock 1 0.00586532
MMP12 matrix metallopeptidase 12 0.00586259
PRELID3B PRELI domain containing 3B 0.00585775
PSIP1 PC4 and SFRS1 interacting protein 1 0.0058358
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.00583424
MYH11 myosin, heavy chain 11, smooth muscle 0.00583407
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 0.00581663
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.00581616
OSBPL11 oxysterol binding protein-like 11 0.00581481
TMEM38B transmembrane protein 38B 0.00581183
PAK1IP1 PAK1 interacting protein 1 0.00581007
SNX10 sorting nexin 10 0.00577629
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.00577186
PRKCQ protein kinase C, theta 0.00577025
IL7R interleukin 7 receptor 0.00576543
INSIG1 insulin induced gene 1 0.00576314
CAND1 cullin-associated and neddylation-dissociated 1 0.005762
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 0.00575985
HMGB1 high mobility group box 1 0.00575876
DLD dihydrolipoamide dehydrogenase 0.00575727
THOC7 THO complex 7 0.00573316
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0057167
PIR pirin (iron-binding nuclear protein) 0.00571286
HMGN4 high mobility group nucleosomal binding domain 4 0.00570953
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.00570919
DEFA5 defensin, alpha 5, Paneth cell-specific 0.00570698
EXOSC8 exosome component 8 0.00568247
PRUNE2 prune homolog 2 (Drosophila) 0.00567729
CNPY3 canopy FGF signaling regulator 3 0.00565892
PRC1 protein regulator of cytokinesis 1 0.00565179
RACGAP1 Rac GTPase activating protein 1 0.00563348
ZCCHC24 zinc finger, CCHC domain containing 24 0.0056333
LAMP5 lysosomal-associated membrane protein family, member 5 0.00562731
OPA1 optic atrophy 1 (autosomal dominant) 0.00561257
CBX6 chromobox homolog 6 0.00561066
ZMYM4 zinc finger, MYM-type 4 0.0055904
DKFZP586I1420 uncharacterized protein DKFZp586I1420 0.00558301
PDE4D phosphodiesterase 4D, cAMP-specific 0.00557831
FECH ferrochelatase 0.00557199
RGS5 regulator of G-protein signaling 5 0.00556766
TMEM109 transmembrane protein 109 0.0055586
ZWILCH zwilch kinetochore protein 0.00555692
EIF4B eukaryotic translation initiation factor 4B 0.00554724
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.00554678
FKTN fukutin 0.00554569
CBS cystathionine-beta-synthase 0.00553117
AMD1 adenosylmethionine decarboxylase 1 0.00552854
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.00551816
USP1 ubiquitin specific peptidase 1 0.00551376
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.00551344
TUBA1A tubulin, alpha 1a 0.00550956
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0055026
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.00549992
LEFTY1 left-right determination factor 1 0.00549644
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.00549315
CSDE1 cold shock domain containing E1, RNA-binding 0.00549101
F12 coagulation factor XII (Hageman factor) 0.00548499
FBXO5 F-box protein 5 0.00547825
TCEAL2 transcription elongation factor A (SII)-like 2 0.00547404
KIF18B kinesin family member 18B 0.00547372
IGFBP4 insulin-like growth factor binding protein 4 0.00547123
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.00546525
PTPA protein phosphatase 2 phosphatase activator 0.0054562
PDZK1 PDZ domain containing 1 0.00545586
NANOG Nanog homeobox 0.005454
CD320 CD320 molecule 0.00545033

decreased expression

Symbol Name Standardized Value
IFI27 interferon, alpha-inducible protein 27 -0.0192105
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0190306
LTF lactotransferrin -0.0172116
FOLR1 folate receptor 1 (adult) -0.015859
EGR1 early growth response 1 -0.0152086
KRT14 keratin 14, type I -0.015072
DSP desmoplakin -0.0149586
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.0145265
TM4SF1 transmembrane 4 L six family member 1 -0.0142308
IFI44L interferon-induced protein 44-like -0.0141533
ATF3 activating transcription factor 3 -0.0141012
KRT5 keratin 5, type II -0.0134924
ISG15 ISG15 ubiquitin-like modifier -0.0133909
PERP PERP, TP53 apoptosis effector -0.013157
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0129803
HSPA1A heat shock 70kDa protein 1A -0.0126782
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0125505
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0125288
AKR1C3 aldo-keto reductase family 1, member C3 -0.0125257
STC2 stanniocalcin 2 -0.0123829
SCGB2A1 secretoglobin, family 2A, member 1 -0.0121528
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0120794
KRT19 keratin 19, type I -0.0120513
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.0119499
KRT17 keratin 17, type I -0.0119456
EGR3 early growth response 3 -0.0118058
S100P S100 calcium binding protein P -0.01159
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0115883
SIRT3 sirtuin 3 -0.0115342
TACSTD2 tumor-associated calcium signal transducer 2 -0.0114529
S100A9 S100 calcium binding protein A9 -0.0114022
AREG amphiregulin -0.0113666
MX1 MX dynamin-like GTPase 1 -0.0113364
EMP1 epithelial membrane protein 1 -0.0112804
ADM adrenomedullin -0.0112718
FXYD3 FXYD domain containing ion transport regulator 3 -0.0111801
AUTS2 autism susceptibility candidate 2 -0.0111217
KRT6A keratin 6A, type II -0.0109577
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.0108178
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -0.0107315
ELANE elastase, neutrophil expressed -0.0107263
GSTP1 glutathione S-transferase pi 1 -0.0105936
IL1B interleukin 1, beta -0.0105663
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0105407
KRT6B keratin 6B, type II -0.0105075
CCN2 cellular communication network factor 2 -0.01043
RCAN1 regulator of calcineurin 1 -0.0103696
S100A14 S100 calcium binding protein A14 -0.0103283
SLPI secretory leukocyte peptidase inhibitor -0.0103266
TUBB2A tubulin, beta 2A class IIa -0.01024
AZU1 azurocidin 1 -0.010166
IQCG IQ motif containing G -0.0101652
SEPP1 selenoprotein P, plasma, 1 -0.0101269
PEG10 paternally expressed 10 -0.0100302
TRIM22 tripartite motif containing 22 -0.00990156
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.00989423
RGCC regulator of cell cycle -0.00982163
ABLIM1 actin binding LIM protein 1 -0.00977946
RTP4 receptor (chemosensory) transporter protein 4 -0.0097158
KLK5 kallikrein-related peptidase 5 -0.00971141
TRIM29 tripartite motif containing 29 -0.00969217
PRTN3 proteinase 3 -0.00965584
VTCN1 V-set domain containing T cell activation inhibitor 1 -0.00964669
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00958647
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.00951729
GPM6B glycoprotein M6B -0.00949799
KLK10 kallikrein-related peptidase 10 -0.00943614
ANXA3 annexin A3 -0.00938366
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.00936068
CSTA cystatin A (stefin A) -0.00929582
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.00929453
SCGB1D2 secretoglobin, family 1D, member 2 -0.00921574
FOXG1 forkhead box G1 -0.00919377
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.00917624
MX2 MX dynamin-like GTPase 2 -0.00915315
CLDN10 claudin 10 -0.00913669
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0090925
CXCL2 chemokine (C-X-C motif) ligand 2 -0.00892936
COL11A1 collagen, type XI, alpha 1 -0.00892836
XIC X chromosome inactivation center -0.00892536
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.00884666
IFI6 interferon, alpha-inducible protein 6 -0.00883025
BTG3 BTG family, member 3 -0.00881041
ISG20 interferon stimulated exonuclease gene 20kDa -0.00880716
IFI44 interferon-induced protein 44 -0.00880206
SAT1 spermidine/spermine N1-acetyltransferase 1 -0.00878347
BIK BCL2-interacting killer (apoptosis-inducing) -0.00876103
EPCAM epithelial cell adhesion molecule -0.00873512
KRT16 keratin 16, type I -0.00871969
CXCL8 chemokine (C-X-C motif) ligand 8 -0.00861135
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.00860936
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00859566
S100A8 S100 calcium binding protein A8 -0.00855611
INHBA inhibin, beta A -0.00854932
HBEGF heparin-binding EGF-like growth factor -0.00853627
SOX9 SRY (sex determining region Y)-box 9 -0.00845135
SPRR2B small proline-rich protein 2B -0.0084362
FGF13 fibroblast growth factor 13 -0.00837743
IFI35 interferon-induced protein 35 -0.00835448
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.00822959
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.00822707
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.00822153
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.00820453
GPI glucose-6-phosphate isomerase -0.00819569
KLF6 Kruppel-like factor 6 -0.00818354
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -0.00817191
AKR1C2 aldo-keto reductase family 1, member C2 -0.00815425
LRRN3 leucine rich repeat neuronal 3 -0.00815097
MAGEA3 melanoma antigen family A3 -0.00813832
PLSCR1 phospholipid scramblase 1 -0.00811797
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.00810232
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.00809422
SH3BP4 SH3-domain binding protein 4 -0.00805167
TGIF1 TGFB-induced factor homeobox 1 -0.00801846
OXA1L oxidase (cytochrome c) assembly 1-like -0.00800592
PLXND1 plexin D1 -0.00800573
CEMIP cell migration inducing protein, hyaluronan binding -0.00799372
SPRR1B small proline-rich protein 1B -0.00798587
EGFL6 EGF-like-domain, multiple 6 -0.00796499
KIF2C kinesin family member 2C -0.00796266
DAD1 defender against cell death 1 -0.00794366
KRT18 keratin 18, type I -0.00789568
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.00787566
PELI1 pellino E3 ubiquitin protein ligase 1 -0.00785176
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.00784942
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00781715
KRT7 keratin 7, type II -0.0077984
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.00778823
AKR1C1 aldo-keto reductase family 1, member C1 -0.00778617
MET MET proto-oncogene, receptor tyrosine kinase -0.00774857
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.00772776
IRF9 interferon regulatory factor 9 -0.00769006
DSG3 desmoglein 3 -0.00768374
CX3CL1 chemokine (C-X3-C motif) ligand 1 -0.00767505
TAC1 tachykinin, precursor 1 -0.00765879
CPA3 carboxypeptidase A3 (mast cell) -0.00765597
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0076116
IFITM2 interferon induced transmembrane protein 2 -0.00758984
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.007574
HOXB2 homeobox B2 -0.00755571
MYOF myoferlin -0.00751823
S100A12 S100 calcium binding protein A12 -0.00750465
HLA-B major histocompatibility complex, class I, B -0.00747481
EDN1 endothelin 1 -0.00746879
CD59 CD59 molecule, complement regulatory protein -0.00746471
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0074583
PLK2 polo-like kinase 2 -0.00744665
IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.0074187
SP100 SP100 nuclear antigen -0.0074174
TENT5A terminal nucleotidyltransferase 5A -0.00741516
ECM1 extracellular matrix protein 1 -0.00740026
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00739991
HMOX1 heme oxygenase 1 -0.00739413
PDGFD platelet derived growth factor D -0.00738572
KRT15 keratin 15, type I -0.00735285
IFITM3 interferon induced transmembrane protein 3 -0.00734922
BAMBI BMP and activin membrane-bound inhibitor -0.00730813
DDIT3 DNA-damage-inducible transcript 3 -0.0072992
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.00729687
SAMD9 sterile alpha motif domain containing 9 -0.00727137
KLK11 kallikrein-related peptidase 11 -0.00726608
CYB5R2 cytochrome b5 reductase 2 -0.0072533
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00723196
GJA1 gap junction protein, alpha 1, 43kDa -0.00721748
CCNG2 cyclin G2 -0.00721266
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.00720848
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -0.00718678
INHBB inhibin, beta B -0.00716507
CYB5R1 cytochrome b5 reductase 1 -0.00712717
GSTK1 glutathione S-transferase kappa 1 -0.00712303
TP53I3 tumor protein p53 inducible protein 3 -0.00710591
CLDN7 claudin 7 -0.00707713
STX3 syntaxin 3 -0.00707519
STON1 stonin 1 -0.00705889
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -0.0070568
GPR137B G protein-coupled receptor 137B -0.00703901
MUC16 mucin 16, cell surface associated -0.00703592
IER5 immediate early response 5 -0.00703331
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.00701545
PLAUR plasminogen activator, urokinase receptor -0.00700729
GAB2 GRB2-associated binding protein 2 -0.00700599
TPBG trophoblast glycoprotein -0.00697019
EZR ezrin -0.00690975
LYPD3 LY6/PLAUR domain containing 3 -0.00690045
ALOX5AP arachidonate 5-lipoxygenase-activating protein -0.00688237
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.00687753
UBE3C ubiquitin protein ligase E3C -0.00686337
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.00686263
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.00685198
SQSTM1 sequestosome 1 -0.00682987
HLA-F major histocompatibility complex, class I, F -0.00682935
CRIP1 cysteine-rich protein 1 (intestinal) -0.006789
IL1A interleukin 1, alpha -0.00678746
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0067846
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -0.00678018
IFIH1 interferon induced with helicase C domain 1 -0.00677388
AAMDC adipogenesis associated, Mth938 domain containing -0.00676801
S100A7 S100 calcium binding protein A7 -0.00676098
EREG epiregulin -0.00672267
NEU1 sialidase 1 (lysosomal sialidase) -0.00671963
TBX2 T-box 2 -0.00669998
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -0.00668965
EFNA1 ephrin-A1 -0.00666552
VSNL1 visinin-like 1 -0.00666118
SPRR1A small proline-rich protein 1A -0.00665864
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.00664662
ANXA11 annexin A11 -0.00662281
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -0.00661527
MVP major vault protein -0.00661477
RRAGC Ras-related GTP binding C -0.00657589
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.00655225
CHMP5 charged multivesicular body protein 5 -0.00652924
NDRG1 N-myc downstream regulated 1 -0.00652434
IRF1 interferon regulatory factor 1 -0.00651589
TUBB3 tubulin, beta 3 class III -0.00648894
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00648834
GRN granulin -0.00647807
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.00647712
CFB complement factor B -0.00647074
RGS3 regulator of G-protein signaling 3 -0.00646643
ADIRF adipogenesis regulatory factor -0.00646385
SPRR3 small proline-rich protein 3 -0.00645087
EIF4A3 eukaryotic translation initiation factor 4A3 -0.00642791
CTSA cathepsin A -0.00642638
KLF4 Kruppel-like factor 4 (gut) -0.00641555
SCGB2A2 secretoglobin, family 2A, member 2 -0.00641194
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.00639316
MXRA7 matrix-remodelling associated 7 -0.00637454
MID1IP1 MID1 interacting protein 1 -0.00637151
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00636961
HOXB7 homeobox B7 -0.00634034
SFN stratifin -0.00633942
RPL10 ribosomal protein L10 -0.0063381
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.00633026
PRSS23 protease, serine, 23 -0.00632757
MPO myeloperoxidase -0.00630883
CCNE1 cyclin E1 -0.00630017
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -0.00629984
ZFP36 ZFP36 ring finger protein -0.00628663
FMO2 flavin containing monooxygenase 2 (non-functional) -0.00627913
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.00626982
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -0.00626908
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.00625719
PDCD6 programmed cell death 6 -0.00625137
TPP1 tripeptidyl peptidase I -0.00623285
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.00621895
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.00620171
ADD3 adducin 3 (gamma) -0.00620094