PIGF_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/PIGF_UP.V1_UP
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Genes

383 genes differentially expressed following the PIGF_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADAM9 ADAM metallopeptidase domain 9
AGA aspartylglucosaminidase
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHCYL2 adenosylhomocysteinase-like 2
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKAP9 A kinase (PRKA) anchor protein 9
AMPH amphiphysin
ANAPC13 anaphase promoting complex subunit 13
ANGPT2 angiopoietin 2
ARL4A ADP-ribosylation factor-like 4A
ARMC6 armadillo repeat containing 6
ARMCX2 armadillo repeat containing, X-linked 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP13A3 ATPase type 13A3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATR ATR serine/threonine kinase
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCAS2 breast carcinoma amplified sequence 2
BCLAF1 BCL2-associated transcription factor 1
BPGM 2,3-bisphosphoglycerate mutase
C9ORF114 chromosome 9 open reading frame 114
CALB2 calbindin 2
CCL22 chemokine (C-C motif) ligand 22
CCPG1 cell cycle progression 1
CD2AP CD2-associated protein
CDC27 cell division cycle 27
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP350 centrosomal protein 350kDa
CFH complement factor H
CLEC2B C-type lectin domain family 2, member B
COL8A1 collagen, type VIII, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CR2 complement component (3d/Epstein Barr virus) receptor 2
CREB1 cAMP responsive element binding protein 1
CRYBG3 beta-gamma crystallin domain containing 3
CRYZ crystallin, zeta (quinone reductase)
DCP2 decapping mRNA 2
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNASE2 deoxyribonuclease II, lysosomal
DZIP1 DAZ interacting zinc finger protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F11 coagulation factor XI
FABP4 fatty acid binding protein 4, adipocyte
FAM208A family with sequence similarity 208, member A
GGCX gamma-glutamyl carboxylase
GJA4 gap junction protein, alpha 4, 37kDa
GLRB glycine receptor, beta
GMFB glia maturation factor, beta
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB14 growth factor receptor-bound protein 14
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H2BM histone cluster 1, H2bm
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA13 heat shock protein 70kDa family, member 13
IL1RL1 interleukin 1 receptor-like 1
IL6ST interleukin 6 signal transducer
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1
IREB2 iron-responsive element binding protein 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITSN2 intersectin 2
KIAA0040 KIAA0040
KIAA1033 KIAA1033
KIF5B kinesin family member 5B
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LARP4 La ribonucleoprotein domain family, member 4
LGALS8 lectin, galactoside-binding, soluble, 8
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MARK2 MAP/microtubule affinity-regulating kinase 2
MAST2 microtubule associated serine/threonine kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MICU2 mitochondrial calcium uptake 2
MIPEP mitochondrial intermediate peptidase
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP10 matrix metallopeptidase 10
MMRN1 multimerin 1
MTF2 metal response element binding transcription factor 2
MTM1 myotubularin 1
N4BP2L2 NEDD4 binding protein 2-like 2
NAP1L3 nucleosome assembly protein 1-like 3
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NECAP1 NECAP endocytosis associated 1
NEK1 NIMA-related kinase 1
NEK7 NIMA-related kinase 7
NRCAM neuronal cell adhesion molecule
NUCB2 nucleobindin 2
NUP155 nucleoporin 155kDa
OPA1 optic atrophy 1 (autosomal dominant)
OSBPL8 oxysterol binding protein-like 8
PAPOLA poly(A) polymerase alpha
PCDHA12 protocadherin alpha 12
PDCD10 programmed cell death 10
PEX1 peroxisomal biogenesis factor 1
PGAP1 post-GPI attachment to proteins 1
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF3 PHD finger protein 3
PISD phosphatidylserine decarboxylase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAT phosphoribosyl pyrophosphate amidotransferase
PPID peptidylprolyl isomerase D
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSPH phosphoserine phosphatase
PSPHP1 phosphoserine phosphatase pseudogene 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1A RAP1A, member of RAS oncogene family
RARB retinoic acid receptor, beta
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RECQL RecQ helicase-like
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFK riboflavin kinase
RGS2 regulator of G-protein signaling 2
RIF1 replication timing regulatory factor 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF13 ring finger protein 13
RNF6 ring finger protein (C3H2C3 type) 6
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPGR retinitis pigmentosa GTPase regulator
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SACS sacsin molecular chaperone
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF11 SR-related CTD-associated factor 11
SGMS1 sphingomyelin synthase 1
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A6 solute carrier family 38, member 6
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SOCS5 suppressor of cytokine signaling 5
SP3 Sp3 transcription factor
SPRYD7 SPRY domain containing 7
SREK1 splicing regulatory glutamine/lysine-rich protein 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAU2 staufen double-stranded RNA binding protein 2
STK38L serine/threonine kinase 38 like
STON1 stonin 1
STXBP3 syntaxin binding protein 3
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TDG thymine-DNA glycosylase
TDP2 tyrosyl-DNA phosphodiesterase 2
TDRD3 tudor domain containing 3
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
THOC2 THO complex 2
THSD7A thrombospondin, type I, domain containing 7A
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM259 transmembrane protein 259
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIP11 thyroid hormone receptor interactor 11
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN8 tetraspanin 8
TTC37 tetratricopeptide repeat domain 37
TTR transthyretin
TWF1 twinfilin actin binding protein 1
TWISTNB TWIST neighbor
UFL1 UFM1-specific ligase 1
UGP2 UDP-glucose pyrophosphorylase 2
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZC3H14 zinc finger CCCH-type containing 14
ZNF117 zinc finger protein 117
ZNF268 zinc finger protein 268
ZNF354A zinc finger protein 354A
ZNF451 zinc finger protein 451
ZNF674 zinc finger protein 674
ZZZ3 zinc finger, ZZ-type containing 3

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTL6B actin-like 6B
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMELX amelogenin, X-linked
ANGEL1 angel homolog 1 (Drosophila)
AOC4P amine oxidase, copper containing 4, pseudogene
APOC1 apolipoprotein C-I
ARC activity-regulated cytoskeleton-associated protein
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
AURKC aurora kinase C
AVPR1B arginine vasopressin receptor 1B
BCAM basal cell adhesion molecule (Lutheran blood group)
BMP2 bone morphogenetic protein 2
C21ORF2 chromosome 21 open reading frame 2
C22ORF24 chromosome 22 open reading frame 24
C9 complement component 9
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC9 coiled-coil domain containing 9
CCL16 chemokine (C-C motif) ligand 16
CD5 CD5 molecule
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFAP20 cilia and flagella associated protein 20
CLASRP CLK4-associating serine/arginine rich protein
CLDN9 claudin 9
CLPTM1 cleft lip and palate associated transmembrane protein 1
COL11A2 collagen, type XI, alpha 2
COL18A1 collagen, type XVIII, alpha 1
CREBZF CREB/ATF bZIP transcription factor
CRX cone-rod homeobox
CSHL1 chorionic somatomammotropin hormone-like 1
CTF1 cardiotrophin 1
CTRL chymotrypsin-like
CTSW cathepsin W
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
DAAM2 dishevelled associated activator of morphogenesis 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLEC1 deleted in lung and esophageal cancer 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DOLPP1 dolichyldiphosphatase 1
DPF1 D4, zinc and double PHD fingers family 1
EDN2 endothelin 2
EFNA5 ephrin-A5
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERF Ets2 repressor factor
ERVK-6 endogenous retrovirus group K, member 6
EVPL envoplakin
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGA fibrinogen alpha chain
FOXG1 forkhead box G1
FZD7 frizzled class receptor 7
GATA4 GATA binding protein 4
GFRA2 GDNF family receptor alpha 2
GH1 growth hormone 1
GLYAT glycine-N-acyltransferase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPR17 G protein-coupled receptor 17
GPR182 G protein-coupled receptor 182
GPR37L1 G protein-coupled receptor 37 like 1
GRAP2 GRB2-related adaptor protein 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRM2 glutamate receptor, metabotropic 2
GSTTP2 glutathione S-transferase theta pseudogene 2
GYPC glycophorin C (Gerbich blood group)
HBZ hemoglobin, zeta
HOMER2 homer scaffolding protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker)
IQCK IQ motif containing K
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGB4 integrin, beta 4
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLK10 kallikrein-related peptidase 10
KRT31 keratin 31, type I
KRT9 keratin 9, type I
LOC441178 uncharacterized LOC441178
LOC730101 uncharacterized LOC730101
LOXL1 lysyl oxidase-like 1
LRRC23 leucine rich repeat containing 23
LTK leukocyte receptor tyrosine kinase
LY6E lymphocyte antigen 6 complex, locus E
MAP1A microtubule-associated protein 1A
MAST1 microtubule associated serine/threonine kinase 1
MCF2L MCF.2 cell line derived transforming sequence-like
MEF2B myocyte enhancer factor 2B
MSI1 musashi RNA-binding protein 1
MTSS1L metastasis suppressor 1-like
MYL9 myosin, light chain 9, regulatory
MYO1F myosin IF
MYOG myogenin (myogenic factor 4)
NCAM1 neural cell adhesion molecule 1
NCR3 natural cytotoxicity triggering receptor 3
NELL2 NEL-like 2 (chicken)
NFASC neurofascin
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOX1 NADPH oxidase 1
NPAS3 neuronal PAS domain protein 3
NPR2 natriuretic peptide receptor 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUCB1 nucleobindin 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PAIP2B poly(A) binding protein interacting protein 2B
PAX2 paired box 2
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDPN podoplanin
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITX3 paired-like homeodomain 3
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKLR pyruvate kinase, liver and RBC
PKP3 plakophilin 3
POU2F3 POU class 2 homeobox 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRPF19 pre-mRNA processing factor 19
PSG11 pregnancy specific beta-1-glycoprotein 11
PTGFR prostaglandin F receptor (FP)
PTPRH protein tyrosine phosphatase, receptor type, H
PTPRU protein tyrosine phosphatase, receptor type, U
PXN paxillin
RAB5C RAB5C, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIMS3 regulating synaptic membrane exocytosis 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
S100A4 S100 calcium binding protein A4
SDC4 syndecan 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP1 SH3-domain binding protein 1
SHBG sex hormone-binding globulin
SHH sonic hedgehog
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC30A10 solute carrier family 30, member 10
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMG6 SMG6 nonsense mediated mRNA decay factor
SNX29 sorting nexin 29
SPN sialophorin
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTB spectrin, beta, erythrocytic
SRCAP Snf2-related CREBBP activator protein
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSTR2 somatostatin receptor 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAOK2 TAO kinase 2
TAS2R14 taste receptor, type 2, member 14
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TMSB4Y thymosin beta 4, Y-linked
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOP3B topoisomerase (DNA) III beta
TPTEP1 transmembrane phosphatase with tensin homology pseudogene 1
TRIO trio Rho guanine nucleotide exchange factor
TROAP trophinin associated protein
TTLL3 tubulin tyrosine ligase-like family member 3
UBE2H ubiquitin-conjugating enzyme E2H
USP9Y ubiquitin specific peptidase 9, Y-linked
UTF1 undifferentiated embryonic cell transcription factor 1
VGF VGF nerve growth factor inducible
ZFHX2 zinc finger homeobox 2
ZFR2 zinc finger RNA binding protein 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF646 zinc finger protein 646