PIGQ Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphatidylinositol glycan anchor biosynthesis, class Q|This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 9091)
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Genes

310 genes differentially expressed following the PIGQ gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PHOSPHO1 phosphatase, orphan 1 2.84171
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.84171
EVPL envoplakin 2.84171
TMPRSS4 transmembrane protease, serine 4 2.84171
CDC20B cell division cycle 20B 2.84171
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.84171
LRRC56 leucine rich repeat containing 56 2.84171
RDH8 retinol dehydrogenase 8 (all-trans) 2.84171
WFDC10A WAP four-disulfide core domain 10A 2.84171
RRH retinal pigment epithelium-derived rhodopsin homolog 2.84171
PCDHGA3 protocadherin gamma subfamily A, 3 2.84171
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.84171
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.84171
ANGPTL6 angiopoietin-like 6 2.84171
GLP2R glucagon-like peptide 2 receptor 2.84171
RPS21-DT RPS21 divergent transcript 2.84171
H4C14 H4 clustered histone 14 2.84171
DRP2 dystrophin related protein 2 2.84171
VXN vexin 2.84171
CRYGB crystallin, gamma B 2.84171
SPRR1B small proline-rich protein 1B 2.84171
GPR52 G protein-coupled receptor 52 2.81825
HBA2 hemoglobin, alpha 2 2.81825
ADGRE1 adhesion G protein-coupled receptor E1 2.81825
FPR2 formyl peptide receptor 2 2.81825
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.81825
ACTRT1 actin-related protein T1 2.81825
SYCP2 synaptonemal complex protein 2 2.81825
CARD18 caspase recruitment domain family, member 18 2.81825
CARD16 caspase recruitment domain family, member 16 2.81825
TPBGL trophoblast glycoprotein-like 2.81825
HNF4A hepatocyte nuclear factor 4, alpha 2.81825
PLVAP plasmalemma vesicle associated protein 2.81825
FOXL1 forkhead box L1 2.81825
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.81825
FAM90A26 family with sequence similarity 90, member A26, pseudogene 2.81825
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.81825
TMEM176A transmembrane protein 176A 2.81825
FOXR1 forkhead box R1 2.81825
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.81825
PLXNB3 plexin B3 2.81825
MYOM3 myomesin 3 2.81825
HCRTR2 hypocretin (orexin) receptor 2 2.81825
RFPL3 ret finger protein-like 3 2.81825
OTUD6A OTU deubiquitinase 6A 2.81825
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.81825
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.81825
SFTPB surfactant protein B 2.81825
ASB10 ankyrin repeat and SOCS box containing 10 2.81825
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.81825
NXPH3 neurexophilin 3 2.81825
TSGA13 testis specific, 13 2.81825
PNMA5 paraneoplastic Ma antigen family member 5 2.81825
RIMBP2 RIMS binding protein 2 2.81825
EPB42 erythrocyte membrane protein band 4.2 2.81825
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.81825
CCL5 chemokine (C-C motif) ligand 5 2.81825
FETUB fetuin B 2.81825
PLCH2 phospholipase C, eta 2 2.81825
MAGEA8 melanoma antigen family A8 2.81825
LOC107986837 uncharacterized LOC107986837 2.81825
CLDN14 claudin 14 2.81825
CCER2 coiled-coil glutamate-rich protein 2 2.81825
SPI1 Spi-1 proto-oncogene 2.81825
SPATA31C1 SPATA31 subfamily C, member 1 2.81825
TFF2 trefoil factor 2 2.81825
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.81825
TREX2 three prime repair exonuclease 2 2.81825
GC group-specific component (vitamin D binding protein) 2.81825
DOK7 docking protein 7 2.81825
GPX6 glutathione peroxidase 6 2.81825
MSANTD5 Myb/SANT DNA binding domain containing 5 2.81825
RTL5 retrotransposon Gag like 5 2.81825
SPATA31G1 SPATA31 subfamily G member 1 2.81825
OR56B2 olfactory receptor family 56 subfamily B member 2 2.81825
PNMA6F PNMA family member 6F 2.81825
EXOC1L exocyst complex component 1 like 2.81825
MYMK myomaker, myoblast fusion factor 2.81825
TEX13D TEX13 family member D 2.81825
TEX46 testis expressed 46 2.81825
DEFB131B defensin beta 131B 2.81825
CATSPERZ catsper channel auxiliary subunit zeta 2.81825
SPATA22 spermatogenesis associated 22 2.81825
C15ORF62 chromosome 15 open reading frame 62 2.81825
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.81825
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.81825
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.81825
GZMM granzyme M (lymphocyte met-ase 1) 2.81825
TPTE transmembrane phosphatase with tensin homology 2.81825
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.81825
CLDN9 claudin 9 2.81825
CFAP99 cilia and flagella associated protein 99 2.81825
PCDHB11 protocadherin beta 11 2.81825
RHOXF2 Rhox homeobox family, member 2 2.81825
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.81825
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.81825
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.81825
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.81825
ASIC3 acid sensing (proton gated) ion channel 3 2.81825
GPR84 G protein-coupled receptor 84 2.81825
GPR83 G protein-coupled receptor 83 2.81825
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.81825
FAM131C family with sequence similarity 131, member C 2.81825
STARD6 StAR-related lipid transfer (START) domain containing 6 2.81825
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 2.81825
SPDYC speedy/RINGO cell cycle regulator family member C 2.81825
NKX2-6 NK2 homeobox 6 2.81825
TMEM72 transmembrane protein 72 2.81825
GOLGA6B golgin A6 family, member B 2.81825
EGR2 early growth response 2 2.81825
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.81825
CARNS1 carnosine synthase 1 2.81825
USP17L2 ubiquitin specific peptidase 17-like family member 2 2.81825
TEX12 testis expressed 12 2.81825
GH1 growth hormone 1 2.81825
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.81825
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.81825
CETP cholesteryl ester transfer protein, plasma 2.81825
PRAP1 proline-rich acidic protein 1 2.81825
PTCRA pre T-cell antigen receptor alpha 2.81825
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.81825
DUOXA1 dual oxidase maturation factor 1 2.81825
SYTL4 synaptotagmin-like 4 2.81825
AGR2 anterior gradient 2 2.81825
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.81825
IL12B interleukin 12B 2.81825
TMEM207 transmembrane protein 207 2.81825
CXCR5 chemokine (C-X-C motif) receptor 5 2.81825
RETNLB resistin like beta 2.81825
CST1 cystatin SN 2.81825
CSTA cystatin A (stefin A) 2.81825
EDN1 endothelin 1 2.81825
TCP11X2 t-complex 11 family, X-linked 2 2.81825
TTC9B tetratricopeptide repeat domain 9B 2.81825
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.81825
CCL27 chemokine (C-C motif) ligand 27 2.81825
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 2.81825
CFB complement factor B 2.81825
CCL19 chemokine (C-C motif) ligand 19 2.81825
ISL1 ISL LIM homeobox 1 2.81825
FCAR Fc fragment of IgA receptor 2.81825
HK3 hexokinase 3 (white cell) 2.81825
TMEM156 transmembrane protein 156 2.81825
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.81825
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.81825
HMX3 H6 family homeobox 3 2.81825
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.81825
LGALS2 lectin, galactoside-binding, soluble, 2 2.81825
LMX1A LIM homeobox transcription factor 1, alpha 2.81825
MUC22 mucin 22 2.81825
CXORF58 chromosome X open reading frame 58 2.81825
GNRH2 gonadotropin-releasing hormone 2 2.81825
NPIPA8 nuclear pore complex interacting protein family, member A8 2.81825
CLEC5A C-type lectin domain family 5, member A 2.81825
CSHL1 chorionic somatomammotropin hormone-like 1 2.81825
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.81825
IL18R1 interleukin 18 receptor 1 2.81825
PHGR1 proline/histidine/glycine-rich 1 2.81825
LRRC25 leucine rich repeat containing 25 2.81825
TGM6 transglutaminase 6 2.81825
UTS2R urotensin 2 receptor 2.81825
AMDHD1 amidohydrolase domain containing 1 2.81825
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.81825
FOXG1 forkhead box G1 2.81825
GLRA3 glycine receptor, alpha 3 2.81825
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.81825
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.81825
PFN3 profilin 3 2.81825
PSG1 pregnancy specific beta-1-glycoprotein 1 2.81825
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.81825
TPH1 tryptophan hydroxylase 1 2.81825
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.81825
KIAA2012 KIAA2012 2.66896
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.65717
METTL22 methyltransferase like 22 2.57079
CERS3 ceramide synthase 3 2.54745
CFAP100 cilia and flagella associated protein 100 2.54745
ITGB4 integrin, beta 4 2.49076
TXNRD1 thioredoxin reductase 1 2.46
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.43758
DERPC DERPC proline and glycine rich nuclear protein 2.43004
CPO carboxypeptidase O 2.42075
HINFP histone H4 transcription factor 2.32655
FA2H fatty acid 2-hydroxylase 2.31286
SPATA6 spermatogenesis associated 6 2.29682
BAX BCL2-associated X protein 2.29633
PATJ PATJ crumbs cell polarity complex component 2.27893
ATP5MC1 ATP synthase membrane subunit c locus 1 2.27893
RIOK2 RIO kinase 2 2.24605
BCAM basal cell adhesion molecule (Lutheran blood group) 2.24515
MOV10 Mov10 RISC complex RNA helicase 2.23295
DPY19L2 dpy-19-like 2 (C. elegans) 2.23141
ZNF74 zinc finger protein 74 2.23109
GRM4 glutamate receptor, metabotropic 4 2.21259
COMMD10 COMM domain containing 10 2.2106
E4F1 E4F transcription factor 1 2.20438
MEAK7 MTOR associated protein, eak-7 homolog 2.20072
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.19292
ARL6 ADP-ribosylation factor-like 6 2.19292
MCTS1 malignant T cell amplified sequence 1 2.16649
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.1577
FBN3 fibrillin 3 2.15528
PRH2 proline-rich protein HaeIII subfamily 2 2.15528
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.13962
MMP24 matrix metallopeptidase 24 (membrane-inserted) 2.13582
ARHGAP27 Rho GTPase activating protein 27 2.1357
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2.13541
CENPL centromere protein L 2.13201
SPDYE2 speedy/RINGO cell cycle regulator family member E2 2.12566
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.11897
IL17RD interleukin 17 receptor D 2.10305
CORIN corin, serine peptidase 2.08794
LYRM9 LYR motif containing 9 2.08794
CD63 CD63 molecule 2.08381
ERBIN erbb2 interacting protein 2.07714
NSUN6 NOP2/Sun domain family, member 6 2.07695
IGSF8 immunoglobulin superfamily, member 8 2.0751
CENPF centromere protein F, 350/400kDa 2.06271
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 2.05202
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.04885
RAB6B RAB6B, member RAS oncogene family 2.02213
RNF146 ring finger protein 146 2.01504
EXOC3 exocyst complex component 3 2.0067
ZNF275 zinc finger protein 275 2.00174

decreased expression

Symbol Name Standardized Value
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -2.84171
FNDC7 fibronectin type III domain containing 7 -2.84171
ATP8B4 ATPase, class I, type 8B, member 4 -2.84171
FANCL Fanconi anemia, complementation group L -2.84171
RNF103 ring finger protein 103 -2.84171
ALPK2 alpha-kinase 2 -2.81825
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.81825
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.81825
SERTM1 serine-rich and transmembrane domain containing 1 -2.81825
LEP leptin -2.81825
MIXL1 Mix paired-like homeobox -2.81825
PRSS22 protease, serine, 22 -2.81825
NFE2 nuclear factor, erythroid 2 -2.81825
EPSTI1 epithelial stromal interaction 1 (breast) -2.81825
XCL1 chemokine (C motif) ligand 1 -2.81825
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.81825
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.81825
GARIN1A golgi associated RAB2 interactor 1A -2.81825
FLACC1 flagellum associated containing coiled-coil domains 1 -2.81825
C9ORF78 chromosome 9 open reading frame 78 -2.81825
MYEOV myeloma overexpressed -2.81825
CINP cyclin-dependent kinase 2 interacting protein -2.81825
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.81825
GATA4 GATA binding protein 4 -2.81825
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.81825
CLDN5 claudin 5 -2.81825
ZNF436 zinc finger protein 436 -2.81825
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.81825
CLEC20A C-type lectin domain containing 20A -2.81825
COX14 COX14 cytochrome c oxidase assembly factor -2.81825
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.81825
DCLK1 doublecortin-like kinase 1 -2.81825
FAHD2A fumarylacetoacetate hydrolase domain containing 2A -2.81825
GOLGA8R golgin A8 family, member R -2.81825
TMEM150B transmembrane protein 150B -2.81825
RHCE Rh blood group, CcEe antigens -2.81825
PCDHGA6 protocadherin gamma subfamily A, 6 -2.81825
UPK1B uroplakin 1B -2.81825
FRMPD2 FERM and PDZ domain containing 2 -2.81825
ZNF316 zinc finger protein 316 -2.81825
TRAM1L1 translocation associated membrane protein 1-like 1 -2.81825
TMOD1 tropomodulin 1 -2.73021
NAGA N-acetylgalactosaminidase, alpha- -2.68281
RLN1 relaxin 1 -2.65441
FNDC5 fibronectin type III domain containing 5 -2.65441
TBXA2R thromboxane A2 receptor -2.65441
TTC23L tetratricopeptide repeat domain 23-like -2.62868
DIAPH3 diaphanous-related formin 3 -2.47158
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.46668
OTUD5 OTU deubiquitinase 5 -2.41112
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.41112
SMIM38 small integral membrane protein 38 -2.40155
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.39517
ZDHHC17 zinc finger, DHHC-type containing 17 -2.39371
SSC5D scavenger receptor cysteine rich family, 5 domains -2.3591
TMEM51 transmembrane protein 51 -2.35782
LEPROT leptin receptor overlapping transcript -2.34056
TMEM9B TMEM9 domain family, member B -2.32021
KAT14 lysine acetyltransferase 14 -2.30157
ADGRB1 adhesion G protein-coupled receptor B1 -2.24683
FMO4 flavin containing monooxygenase 4 -2.19956
CASP6 caspase 6, apoptosis-related cysteine peptidase -2.19292
ZDHHC22 zinc finger, DHHC-type containing 22 -2.18086
ZNF83 zinc finger protein 83 -2.17032
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.1618
BCLAF1 BCL2-associated transcription factor 1 -2.1357
ZNF776 zinc finger protein 776 -2.13541
TSG101 tumor susceptibility 101 -2.13541
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -2.13201
C13ORF42 chromosome 13 open reading frame 42 -2.12803
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 -2.12511
TMEM198 transmembrane protein 198 -2.11897
GRPEL2 GrpE-like 2, mitochondrial (E. coli) -2.11441
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.11057
TIAM1 T-cell lymphoma invasion and metastasis 1 -2.10305
ZMAT3 zinc finger, matrin-type 3 -2.09303
UBE2J2 ubiquitin-conjugating enzyme E2, J2 -2.08794
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.05202
CCND3 cyclin D3 -2.03279
FAM222A family with sequence similarity 222, member A -2.02213
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.02213
AOAH acyloxyacyl hydrolase (neutrophil) -2.02213
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.02213
GLB1L galactosidase, beta 1-like -2.02213
AKAP9 A kinase (PRKA) anchor protein 9 -2.02213
ADAP2 ArfGAP with dual PH domains 2 -2.01399