PIGS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphatidylinositol glycan anchor biosynthesis, class S|This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 94005)
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Genes

340 genes differentially expressed following the PIGS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC35D3 solute carrier family 35, member D3 2.71601
NANOS2 nanos homolog 2 (Drosophila) 2.71601
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.71601
MILR1 mast cell immunoglobulin-like receptor 1 2.71601
TMEM151A transmembrane protein 151A 2.71601
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.71601
DPEP2 dipeptidase 2 2.71601
SIRPB1 signal-regulatory protein beta 1 2.71601
OSR2 odd-skipped related transciption factor 2 2.71601
TMEM100 transmembrane protein 100 2.71601
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.71601
CARD18 caspase recruitment domain family, member 18 2.71601
PVRIG poliovirus receptor related immunoglobulin domain containing 2.71601
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.71601
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.71601
PLVAP plasmalemma vesicle associated protein 2.71601
SIX6 SIX homeobox 6 2.71601
TMPRSS11F transmembrane protease, serine 11F 2.71601
NKAPL NFKB activating protein-like 2.71601
FGF21 fibroblast growth factor 21 2.71601
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.71601
AADACL3 arylacetamide deacetylase-like 3 2.71601
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.71601
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.71601
MEIKIN meiotic kinetochore factor 2.71601
DLL4 delta-like 4 (Drosophila) 2.71601
S100A7 S100 calcium binding protein A7 2.71601
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.71601
IL2RA interleukin 2 receptor, alpha 2.71601
ACOT12 acyl-CoA thioesterase 12 2.71601
LGALS4 lectin, galactoside-binding, soluble, 4 2.71601
RNF39 ring finger protein 39 2.71601
RTP3 receptor (chemosensory) transporter protein 3 2.71601
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.71601
ACTL7A actin-like 7A 2.71601
DSG3 desmoglein 3 2.71601
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.71601
GDNF glial cell derived neurotrophic factor 2.71601
FNDC7 fibronectin type III domain containing 7 2.71601
OTUD6A OTU deubiquitinase 6A 2.71601
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.71601
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.71601
RPL3L ribosomal protein L3-like 2.71601
USP50 ubiquitin specific peptidase 50 2.71601
FEM1A fem-1 homolog a (C. elegans) 2.71601
GGT5 gamma-glutamyltransferase 5 2.71601
LRTM3 leucine rich repeat transmembrane protein 3 2.71601
ANKRD40CL ANKRD40 C-terminal like 2.71601
CRPPA CDP-L-ribitol pyrophosphorylase A 2.71601
PWWP3B PWWP domain containing 3B 2.71601
H3-5 H3.5 histone 2.71601
NECTIN4 nectin cell adhesion molecule 4 2.71601
GOLGA6L7 golgin A6 family like 7 2.71601
MCHR1 melanin-concentrating hormone receptor 1 2.71601
AVPR1B arginine vasopressin receptor 1B 2.71601
PROP1 PROP paired-like homeobox 1 2.71601
CIROP ciliated left-right organizer metallopeptidase 2.71601
DUSP29 dual specificity phosphatase 29 2.71601
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.71601
SPATA31G1 SPATA31 subfamily G member 1 2.71601
FAM90A12 family with sequence similarity 90 member A12 2.71601
SPMIP9 sperm microtubule inner protein 9 2.71601
ERLN endoregulin 2.71601
PRR20G proline rich 20G 2.71601
CIMAP1B ciliary microtubule associated protein 1B 2.71601
CCDC201 coiled-coil domain containing 201 2.71601
H2BC26 H2B clustered histone 26 2.71601
RHCG Rh family, C glycoprotein 2.71601
FMO1 flavin containing monooxygenase 1 2.71601
ANO3 anoctamin 3 2.71601
MYH13 myosin, heavy chain 13, skeletal muscle 2.71601
TPTE transmembrane phosphatase with tensin homology 2.71601
TLR1 toll-like receptor 1 2.71601
ZIC4 Zic family member 4 2.71601
CUL3 cullin 3 2.71601
HPR haptoglobin-related protein 2.71601
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.71601
ZBTB16 zinc finger and BTB domain containing 16 2.71601
TMIE transmembrane inner ear 2.71601
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.71601
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.71601
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.71601
MYEOV myeloma overexpressed 2.71601
LY6K lymphocyte antigen 6 complex, locus K 2.71601
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.71601
TBX10 T-box 10 2.71601
GATA2 GATA binding protein 2 2.71601
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.71601
GPR83 G protein-coupled receptor 83 2.71601
LRRC71 leucine rich repeat containing 71 2.71601
ARL5C ADP-ribosylation factor-like 5C 2.71601
SCML4 sex comb on midleg-like 4 (Drosophila) 2.71601
KLK11 kallikrein-related peptidase 11 2.71601
ENDOU endonuclease, polyU-specific 2.71601
CPA3 carboxypeptidase A3 (mast cell) 2.71601
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 2.71601
MSMP microseminoprotein, prostate associated 2.71601
LRRC32 leucine rich repeat containing 32 2.71601
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.71601
AICDA activation-induced cytidine deaminase 2.71601
ITGB7 integrin, beta 7 2.71601
C21ORF58 chromosome 21 open reading frame 58 2.71601
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.71601
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.71601
SMYD1 SET and MYND domain containing 1 2.71601
GPR50 G protein-coupled receptor 50 2.71601
RIPPLY2 ripply transcriptional repressor 2 2.71601
PLA1A phospholipase A1 member A 2.71601
CHI3L2 chitinase 3-like 2 2.71601
TEKT5 tektin 5 2.71601
EME2 essential meiotic structure-specific endonuclease subunit 2 2.71601
TPSB2 tryptase beta 2 (gene/pseudogene) 2.71601
CDHR5 cadherin-related family member 5 2.71601
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.71601
TESPA1 thymocyte expressed, positive selection associated 1 2.71601
SERINC4 serine incorporator 4 2.71601
CST1 cystatin SN 2.71601
PSKH2 protein serine kinase H2 2.71601
ZNF703 zinc finger protein 703 2.71601
WNT7A wingless-type MMTV integration site family, member 7A 2.71601
LMOD2 leiomodin 2 (cardiac) 2.71601
VWA3B von Willebrand factor A domain containing 3B 2.71601
AKR1B15 aldo-keto reductase family 1, member B15 2.71601
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.71601
RRH retinal pigment epithelium-derived rhodopsin homolog 2.71601
ANKRD62 ankyrin repeat domain 62 2.71601
ANXA2R annexin A2 receptor 2.71601
KCTD5 potassium channel tetramerization domain containing 5 2.71601
MMP12 matrix metallopeptidase 12 2.71601
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.71601
KCNK17 potassium channel, two pore domain subfamily K, member 17 2.71601
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 2.71601
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.71601
MOBP myelin-associated oligodendrocyte basic protein 2.71601
SHISA3 shisa family member 3 2.71601
NYX nyctalopin 2.71601
SFTA2 surfactant associated 2 2.71601
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.71601
ZNF831 zinc finger protein 831 2.71601
ZNF492 zinc finger protein 492 2.71601
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.71601
ANXA9 annexin A9 2.71601
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.71601
CARD9 caspase recruitment domain family, member 9 2.71601
MAEL maelstrom spermatogenic transposon silencer 2.71601
NUTM2D NUT family member 2D 2.71601
NT5DC4 5'-nucleotidase domain containing 4 2.71601
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.71601
CHRM4 cholinergic receptor, muscarinic 4 2.71601
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.71601
BCL2A1 BCL2-related protein A1 2.71601
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.71601
PFN4 profilin family, member 4 2.71601
CD8A CD8a molecule 2.71601
TMEM45B transmembrane protein 45B 2.71601
TEX36 testis expressed 36 2.71601
GJC2 gap junction protein, gamma 2, 47kDa 2.71601
TBX6 T-box 6 2.63061
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.63061
PFDN2 prefoldin subunit 2 2.63061
CD177 CD177 molecule 2.63061
ZNF732 zinc finger protein 732 2.62949
SHISA2 shisa family member 2 2.62332
MRAP2 melanocortin 2 receptor accessory protein 2 2.59478
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.55566
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.4926
SH3PXD2A SH3 and PX domains 2A 2.48037
TEAD2 TEA domain family member 2 2.46546
PAQR8 progestin and adipoQ receptor family member VIII 2.43916
SLA Src-like-adaptor 2.4175
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.40233
RPS15A ribosomal protein S15a 2.38967
DTNBP1 dystrobrevin binding protein 1 2.3877
ZFP57 ZFP57 zinc finger protein 2.3877
CHODL chondrolectin 2.35381
THUMPD1 THUMP domain containing 1 2.33962
CPEB2 cytoplasmic polyadenylation element binding protein 2 2.28798
GOLPH3L golgi phosphoprotein 3-like 2.26964
MTERF1 mitochondrial transcription termination factor 1 2.26719
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.26573
KIAA1217 KIAA1217 2.24172
RABEP2 rabaptin, RAB GTPase binding effector protein 2 2.23847
MATN1 matrilin 1, cartilage matrix protein 2.22944
MRPS14 mitochondrial ribosomal protein S14 2.20778
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.20588
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 2.19714
ZNF600 zinc finger protein 600 2.16103
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 2.15509
MCL1 myeloid cell leukemia 1 2.15336
CFAP70 cilia and flagella associated protein 70 2.14372
ADAP2 ArfGAP with dual PH domains 2 2.14372
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 2.12081
REXO5 RNA exonuclease 5 2.12081
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.10636
RECQL RecQ helicase-like 2.09858
FLOT2 flotillin 2 2.09848
ZNF280C zinc finger protein 280C 2.09389
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.08332
STRN striatin, calmodulin binding protein 2.08289
BTN3A2 butyrophilin, subfamily 3, member A2 2.08165
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 2.07669
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 2.07166
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.06363
AARS1 alanyl-tRNA synthetase 1 2.06198
MCEE methylmalonyl CoA epimerase 2.06198
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.04936
SLC9D1 solute carrier family 9 member D1 2.04825
ACYP2 acylphosphatase 2, muscle type 2.0375
INO80D INO80 complex subunit D 2.03634
CCDC32 coiled-coil domain containing 32 2.03634
EBP emopamil binding protein (sterol isomerase) 2.0348
MEGF6 multiple EGF-like-domains 6 2.02962
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.02944
HSBP1 heat shock factor binding protein 1 2.02829
TMEM182 transmembrane protein 182 2.02429
AKAP1 A kinase (PRKA) anchor protein 1 2.02328
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.02058
ARHGAP25 Rho GTPase activating protein 25 2.01879
TCN2 transcobalamin II 2.01879
NMRK1 nicotinamide riboside kinase 1 2.00488
ENDOV endonuclease V 2.00488
TMEM94 transmembrane protein 94 2.00103

decreased expression

Symbol Name Standardized Value
NALCN sodium leak channel, non selective -2.71601
DCTN2 dynactin 2 (p50) -2.71601
AMOT angiomotin -2.71601
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.71601
TFEB transcription factor EB -2.71601
OCIAD2 OCIA domain containing 2 -2.71601
ARMC2 armadillo repeat containing 2 -2.71601
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.71601
CTHRC1 collagen triple helix repeat containing 1 -2.71601
LCN10 lipocalin 10 -2.71601
TMEM106C transmembrane protein 106C -2.71601
PHF20 PHD finger protein 20 -2.71601
CLUL1 clusterin-like 1 (retinal) -2.71601
TCL1B T-cell leukemia/lymphoma 1B -2.71601
UBN1 ubinuclein 1 -2.67423
ILF3 interleukin enhancer binding factor 3, 90kDa -2.64657
PFKM phosphofructokinase, muscle -2.64082
CD300A CD300a molecule -2.6376
REEP1 receptor accessory protein 1 -2.6376
GRID1 glutamate receptor, ionotropic, delta 1 -2.6376
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 -2.63061
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -2.63061
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.63061
VPREB3 pre-B lymphocyte 3 -2.63061
TMEM200C transmembrane protein 200C -2.63061
KISS1R KISS1 receptor -2.63061
FGF4 fibroblast growth factor 4 -2.63061
SGCZ sarcoglycan, zeta -2.63061
RP2 retinitis pigmentosa 2 (X-linked recessive) -2.63061
PTGER4 prostaglandin E receptor 4 (subtype EP4) -2.63061
GADL1 glutamate decarboxylase-like 1 -2.63061
LHFPL7 LHFPL tetraspan subfamily member 7 -2.63061
CATSPERZ catsper channel auxiliary subunit zeta -2.63061
CFAP157 cilia and flagella associated protein 157 -2.63061
AJM1 apical junction component 1 homolog -2.63061
BNC1 basonuclin 1 -2.63061
FAM186A family with sequence similarity 186, member A -2.63061
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.63061
AKAP14 A kinase (PRKA) anchor protein 14 -2.63061
KITLG KIT ligand -2.63061
RAG2 recombination activating gene 2 -2.63061
PAX5 paired box 5 -2.63061
SLC15A5 solute carrier family 15, member 5 -2.63061
TMEM272 transmembrane protein 272 -2.63061
GOLGA8K golgin A8 family, member K -2.63061
SLC22A24 solute carrier family 22, member 24 -2.63061
FAM209B family with sequence similarity 209, member B -2.63061
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.63061
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled -2.63061
ZNF471 zinc finger protein 471 -2.63061
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.63061
LOX lysyl oxidase -2.63061
PCDHGB2 protocadherin gamma subfamily B, 2 -2.63061
CRYBB3 crystallin, beta B3 -2.63061
EBF2 early B-cell factor 2 -2.63061
PGM5 phosphoglucomutase 5 -2.63061
ANKRD63 ankyrin repeat domain 63 -2.63061
SNAPIN SNAP-associated protein -2.62902
FAM53A family with sequence similarity 53, member A -2.56672
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.55246
TRIP4 thyroid hormone receptor interactor 4 -2.55213
MICB MHC class I polypeptide-related sequence B -2.5246
DLEC1 deleted in lung and esophageal cancer 1 -2.52081
CATSPER4 cation channel, sperm associated 4 -2.52081
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.48244
KIRREL2 kin of IRRE like 2 (Drosophila) -2.48244
COPS6 COP9 signalosome subunit 6 -2.3932
CCNJ cyclin J -2.39087
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -2.37906
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -2.35971
GEMIN5 gem (nuclear organelle) associated protein 5 -2.35876
SORT1 sortilin 1 -2.35558
PRDM4 PR domain containing 4 -2.35448
SCN2A sodium channel, voltage gated, type II alpha subunit -2.31197
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.30649
H2BC12 H2B clustered histone 12 -2.29455
TSLIG3C tRNA splicing ligase complex subunit 3C -2.26719
CLDN1 claudin 1 -2.26719
DSCAM Down syndrome cell adhesion molecule -2.26719
C1RL complement component 1, r subcomponent-like -2.25304
COL6A2 collagen, type VI, alpha 2 -2.22808
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.19344
NEO1 neogenin 1 -2.16918
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.16792
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.15336
UNC50 unc-50 homolog (C. elegans) -2.14441
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.14246
OMD osteomodulin -2.11857
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -2.10831
PRICKLE3 prickle homolog 3 (Drosophila) -2.10756
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.10636
PPP1R12C protein phosphatase 1, regulatory subunit 12C -2.09076
USP53 ubiquitin specific peptidase 53 -2.08046
PCGF1 polycomb group ring finger 1 -2.07149
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -2.06532
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.06286
ERICH5 glutamate-rich 5 -2.04936
PLAC8 placenta-specific 8 -2.04936
C19ORF44 chromosome 19 open reading frame 44 -2.04936
SYCE3 synaptonemal complex central element protein 3 -2.04936
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.03839
BAG1 BCL2-associated athanogene -2.03634
LRRC37B leucine rich repeat containing 37B -2.03634
THAP8 THAP domain containing 8 -2.03634
ANKIB1 ankyrin repeat and IBR domain containing 1 -2.03602
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -2.03132
OPRD1 opioid receptor, delta 1 -2.02373
ICOSLG inducible T-cell co-stimulator ligand -2.02142
SELENOI selenoprotein I -2.02058
PCDH9 protocadherin 9 -2.01879
CCDC86 coiled-coil domain containing 86 -2.01879
SMAD5 SMAD family member 5 -2.01879
HDLBP high density lipoprotein binding protein -2.01405
COL25A1 collagen, type XXV, alpha 1 -2.01153
CTCFL CCCTC-binding factor (zinc finger protein)-like -2.01153
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -2.01153
RANBP9 RAN binding protein 9 -2.01153
PGBD1 piggyBac transposable element derived 1 -2.00927