PIGT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphatidylinositol glycan anchor biosynthesis, class T|This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 51604)
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Genes

298 genes differentially expressed following the PIGT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SIX6 SIX homeobox 6 2.25234
PRICKLE4 prickle homolog 4 (Drosophila) 2.25234
PGAM4 phosphoglycerate mutase family member 4 2.25234
MGAM2 maltase-glucoamylase 2 (putative) 2.25234
GLUD2 glutamate dehydrogenase 2 2.25234
FOXA2 forkhead box A2 2.25234
ATXN1 ataxin 1 2.25234
LRRC14B leucine rich repeat containing 14B 2.25234
GSTM5 glutathione S-transferase mu 5 2.25234
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.25234
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.25234
IGFL3 IGF-like family member 3 2.25234
FAM187B family with sequence similarity 187, member B 2.25234
FAM90A26 family with sequence similarity 90, member A26, pseudogene 2.25234
AGTR1 angiotensin II receptor, type 1 2.25234
ZCCHC3 zinc finger, CCHC domain containing 3 2.25234
MPST mercaptopyruvate sulfurtransferase 2.25234
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.25234
ZNF503 zinc finger protein 503 2.25234
SCGN secretagogin, EF-hand calcium binding protein 2.25234
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.25234
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.25234
EPHX4 epoxide hydrolase 4 2.25234
DMRTC1B DMRT-like family C1B 2.25234
CCDC42 coiled-coil domain containing 42 2.25234
F9 coagulation factor IX 2.25234
ANKK1 ankyrin repeat and kinase domain containing 1 2.25234
TREML1 triggering receptor expressed on myeloid cells-like 1 2.25234
TREML2 triggering receptor expressed on myeloid cells-like 2 2.25234
CNOT6L CCR4-NOT transcription complex, subunit 6-like 2.25234
ATOH8 atonal homolog 8 (Drosophila) 2.25234
NMB neuromedin B 2.25234
CLEC14A C-type lectin domain family 14, member A 2.25234
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.25234
SMIM5 small integral membrane protein 5 2.25234
ZNF718 zinc finger protein 718 2.25234
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.25234
SSTR5 somatostatin receptor 5 2.25234
GPR26 G protein-coupled receptor 26 2.25234
LMBR1 limb development membrane protein 1 2.25234
SPRR1B small proline-rich protein 1B 2.25234
OTUD6A OTU deubiquitinase 6A 2.25234
ADAMTSL2 ADAMTS-like 2 2.25234
TPSD1 tryptase delta 1 2.25234
GRP gastrin-releasing peptide 2.25234
GPR75 G protein-coupled receptor 75 2.25234
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.25234
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.25234
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.25234
WDR64 WD repeat domain 64 2.25234
PAPOLB poly(A) polymerase beta (testis specific) 2.25234
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.25234
CDKL3 cyclin-dependent kinase-like 3 2.25234
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.25234
ASIC3 acid sensing (proton gated) ion channel 3 2.25234
LRRC70 leucine rich repeat containing 70 2.25234
PLCZ1 phospholipase C, zeta 1 2.25234
FMO4 flavin containing monooxygenase 4 2.25234
CIMIP2B ciliary microtubule inner protein 2B 2.25234
SMIM45 small integral membrane protein 45 2.25234
MAJIN membrane anchored junction protein 2.25234
ODAPH odontogenesis associated phosphoprotein 2.25234
RTL5 retrotransposon Gag like 5 2.25234
TBXT T-box transcription factor T 2.25234
HDGFL3 HDGF like 3 2.25234
GBP6 guanylate binding protein family, member 6 2.25234
PNLIPRP2 pancreatic lipase-related protein 2 2.25234
OOSP1 oocyte secreted protein 1, pseudogene 2.25234
SAA1 serum amyloid A1 2.25234
GJD2 gap junction protein, delta 2, 36kDa 2.25234
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 2.25234
PVRIG poliovirus receptor related immunoglobulin domain containing 2.25234
CPNE9 copine family member IX 2.25234
KLHL35 kelch-like family member 35 2.25234
FABP9 fatty acid binding protein 9, testis 2.25234
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) 2.25234
PLVAP plasmalemma vesicle associated protein 2.25234
LOX lysyl oxidase 2.25234
MBNL1 muscleblind-like splicing regulator 1 2.25234
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.25234
SCN10A sodium channel, voltage gated, type X alpha subunit 2.25234
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.25234
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.25234
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.25234
GPATCH1 G patch domain containing 1 2.25234
ZNF575 zinc finger protein 575 2.25234
DMBX1 diencephalon/mesencephalon homeobox 1 2.25234
TMCO1 transmembrane and coiled-coil domains 1 2.25234
LDHAL6B lactate dehydrogenase A-like 6B 2.25234
CD79A CD79a molecule, immunoglobulin-associated alpha 2.25234
CFHR3 complement factor H-related 3 2.25234
ENDOU endonuclease, polyU-specific 2.25234
SNX31 sorting nexin 31 2.25234
C2CD4B C2 calcium-dependent domain containing 4B 2.25234
PCDHGA3 protocadherin gamma subfamily A, 3 2.25234
SHISA8 shisa family member 8 2.25234
ISL1 ISL LIM homeobox 1 2.25234
HELT helt bHLH transcription factor 2.25234
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.25234
FBXO40 F-box protein 40 2.25234
APOC1 apolipoprotein C-I 2.25234
CPA2 carboxypeptidase A2 (pancreatic) 2.25234
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.25234
APLNR apelin receptor 2.25234
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.25234
OTC ornithine carbamoyltransferase 2.25234
PCP2 Purkinje cell protein 2 2.25234
LCN2 lipocalin 2 2.25234
F2RL3 coagulation factor II (thrombin) receptor-like 3 2.25234
SERINC4 serine incorporator 4 2.25234
KDM8 lysine (K)-specific demethylase 8 2.25234
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.25234
PRPH peripherin 2.25234
SAMD5 sterile alpha motif domain containing 5 2.25234
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.25234
PSG8 pregnancy specific beta-1-glycoprotein 8 2.25234
TRPT1 tRNA phosphotransferase 1 2.25234
GPR149 G protein-coupled receptor 149 2.25234
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.25234
ZNF831 zinc finger protein 831 2.25234
BTG4 B-cell translocation gene 4 2.25234
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.25234
NCR3 natural cytotoxicity triggering receptor 3 2.25234
PGR progesterone receptor 2.25234
NOBOX NOBOX oogenesis homeobox 2.25234
ZC3H11D zinc finger CCCH-type containing 11D 2.25234
PRR35 proline rich 35 2.25234
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.25234
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.25234
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.25234
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.25234
SYNGR4 synaptogyrin 4 2.25234
DAW1 dynein assembly factor with WDR repeat domains 1 2.25234
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 2.25234
NGB neuroglobin 2.25234
PITX2 paired-like homeodomain 2 2.25234
ALOX15B arachidonate 15-lipoxygenase, type B 2.25234
GPBAR1 G protein-coupled bile acid receptor 1 2.25234
COL22A1 collagen, type XXII, alpha 1 2.25234
APOA1 apolipoprotein A-I 2.25234
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.25234
LRRC38 leucine rich repeat containing 38 2.25234
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.25234
NNMT nicotinamide N-methyltransferase 2.25234
TGM1 transglutaminase 1 2.25234
ANXA1 annexin A1 2.25234
SSX1 synovial sarcoma, X breakpoint 1 2.25234
STEAP4 STEAP family member 4 2.25234
ARSH arylsulfatase family, member H 2.25234
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.25234
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.25234
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.25234
KIF4B kinesin family member 4B 2.25234
PLA2G4E phospholipase A2, group IVE 2.25234
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.25234
CUZD1 CUB and zona pellucida-like domains 1 2.25234
DNAAF5 dynein, axonemal, assembly factor 5 2.25234
TBPL2 TATA box binding protein like 2 2.25234
PADI6 peptidyl arginine deiminase, type VI 2.25234
LALBA lactalbumin, alpha- 2.25234
DISP1 dispatched homolog 1 (Drosophila) 2.25234
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.25234
TRAPPC14 trafficking protein particle complex subunit 14 2.2256
CDK19 cyclin-dependent kinase 19 2.21969
CSNK2A1 casein kinase 2, alpha 1 polypeptide 2.21192
ACADVL acyl-CoA dehydrogenase, very long chain 2.21192
CENPK centromere protein K 2.20801
ESYT2 extended synaptotagmin-like protein 2 2.20801
RGS22 regulator of G-protein signaling 22 2.20573
COPS5 COP9 signalosome subunit 5 2.20348
JCAD junctional cadherin 5 associated 2.19961
TMEM65 transmembrane protein 65 2.19961
NF2 neurofibromin 2 (merlin) 2.18868
KLF8 Kruppel-like factor 8 2.18644
RNF31 ring finger protein 31 2.18641
MRPL35 mitochondrial ribosomal protein L35 2.18011
GLIS3 GLIS family zinc finger 3 2.17557
MFAP3 microfibrillar-associated protein 3 2.17557
FAAP100 FA core complex associated protein 100 2.1752
SYPL1 synaptophysin-like 1 2.1752
RHOQ ras homolog family member Q 2.16387
CYTL1 cytokine-like 1 2.15768
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.15011
GANC glucosidase, alpha; neutral C 2.14317
CIBAR1 CBY1 interacting BAR domain containing 1 2.13267
GFM2 G elongation factor, mitochondrial 2 2.09967
PPP1R12B protein phosphatase 1, regulatory subunit 12B 2.09967
SYCE2 synaptonemal complex central element protein 2 2.0837
MED6 mediator complex subunit 6 2.0656
CKLF chemokine-like factor 2.0656
IL3RA interleukin 3 receptor, alpha (low affinity) 2.0656
MEGF10-DT MEGF10 divergent transcript 2.0656
INSR insulin receptor 2.0656
CDC40 cell division cycle 40 2.0656
TMEM11 transmembrane protein 11 2.0656
SEPTIN11 septin 11 2.0656
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 2.0656
PLD6 phospholipase D family, member 6 2.0656
THEMIS2 thymocyte selection associated family member 2 2.06468
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 2.05691
SLITRK4 SLIT and NTRK-like family, member 4 2.05053
MRPS34 mitochondrial ribosomal protein S34 2.04813
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 2.03404
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.03404

decreased expression

Symbol Name Standardized Value
LTAP1 lipid transport auxiliary protein 1 -2.25234
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -2.25234
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.25234
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.25234
CDYL2 chromodomain protein, Y-like 2 -2.25234
CDCP2 CUB domain containing protein 2 -2.25234
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -2.25234
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.25234
CD86 CD86 molecule -2.25234
VENTX VENT homeobox -2.25234
HDIP1 HDAC and MIER1 interacting protein 1 -2.25234
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -2.25234
ZC3H11C zinc finger CCCH-type containing 11C -2.25234
MRM2 mitochondrial rRNA methyltransferase 2 -2.25234
TKFC triokinase/FMN cyclase -2.25234
MTF1 metal-regulatory transcription factor 1 -2.25234
CALCA calcitonin-related polypeptide alpha -2.25234
ZNF597 zinc finger protein 597 -2.25234
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -2.25234
CDH4 cadherin 4, type 1, R-cadherin (retinal) -2.25234
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.25234
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.25234
MRPL15 mitochondrial ribosomal protein L15 -2.25234
ZNF660-ZNF197 ZNF660-ZNF197 readthrough -2.25234
TCAP titin-cap -2.25234
GADD45B growth arrest and DNA-damage-inducible, beta -2.25234
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.25234
STAB2 stabilin 2 -2.25234
TMEM214 transmembrane protein 214 -2.23905
ATG10 autophagy related 10 -2.21192
BRD3OS BRD3 opposite strand -2.20681
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.19685
CCNE1 cyclin E1 -2.18868
ARID5A AT rich interactive domain 5A (MRF1-like) -2.18371
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.1752
ZFAND3 zinc finger, AN1-type domain 3 -2.15768
MRPS25 mitochondrial ribosomal protein S25 -2.15145
KAT8 K(lysine) acetyltransferase 8 -2.11754
NOTCH2 notch 2 -2.11753
PBX2 pre-B-cell leukemia homeobox 2 -2.09376
GRM3 glutamate receptor, metabotropic 3 -2.09376
RSPRY1 ring finger and SPRY domain containing 1 -2.06638
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.06638
YJU2B YJU2 splicing factor homolog B -2.06638
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) -2.0656
TEAD3 TEA domain family member 3 -2.0656
CELF6 CUGBP, Elav-like family member 6 -2.0656
CHRND cholinergic receptor, nicotinic, delta (muscle) -2.0656
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -2.0656
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.0656
TTLL13 tubulin tyrosine ligase like 13 -2.0656
ROPN1L rhophilin associated tail protein 1-like -2.0656
ARHGAP40 Rho GTPase activating protein 40 -2.0656
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.0656
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -2.0656
OSTN osteocrin -2.0656
AP3B2 adaptor-related protein complex 3, beta 2 subunit -2.0656
NPIPB9 nuclear pore complex interacting protein family, member B9 -2.0656
AMBP alpha-1-microglobulin/bikunin precursor -2.0656
EDRF1 erythroid differentiation regulatory factor 1 -2.0656
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.0656
C1ORF146 chromosome 1 open reading frame 146 -2.0656
ZNF396 zinc finger protein 396 -2.0656
SHISA3 shisa family member 3 -2.0656
TMEM215 transmembrane protein 215 -2.0656
PADI4 peptidyl arginine deiminase, type IV -2.0656
AMIGO1 adhesion molecule with Ig-like domain 1 -2.0656
AKIRIN2 akirin 2 -2.0656
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -2.0656
CHAD chondroadherin -2.0656
FIBIN fin bud initiation factor homolog (zebrafish) -2.0656
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -2.0656
ZNF804A zinc finger protein 804A -2.0656
TCEAL7 transcription elongation factor A (SII)-like 7 -2.0656
SLC44A4 solute carrier family 44, member 4 -2.0656
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.0656
CLCNKA chloride channel, voltage-sensitive Ka -2.0656
IL1A interleukin 1, alpha -2.0656
SNAI2 snail family zinc finger 2 -2.0656
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -2.06536
NNT nicotinamide nucleotide transhydrogenase -2.05662
LOXHD1 lipoxygenase homology domains 1 -2.05621
TCF7 transcription factor 7 (T-cell specific, HMG-box) -2.05621
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.05483
ZNF460 zinc finger protein 460 -2.05044
PFKM phosphofructokinase, muscle -2.04048
NPC1 Niemann-Pick disease, type C1 -2.03362
PCBP4 poly(rC) binding protein 4 -2.03362
XXYLT1 xyloside xylosyltransferase 1 -2.03291
ZNF404 zinc finger protein 404 -2.016
MEIOB meiosis specific with OB domains -2.016
PTCH2 patched 2 -2.00316
GPAT4 glycerol-3-phosphate acyltransferase 4 -2.00316
ANAPC2 anaphase promoting complex subunit 2 -2.00316