PIK3CD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta|Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 5293)
Similar Terms
Downloads & Tools

Genes

344 genes differentially expressed following the PIK3CD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NKPD1 NTPase, KAP family P-loop domain containing 1 3.26705
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 3.26705
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.26705
NT5DC4 5'-nucleotidase domain containing 4 3.26705
IGFL4 IGF-like family member 4 3.26705
RUFY4 RUN and FYVE domain containing 4 3.26705
WDR72 WD repeat domain 72 3.26705
TSPAN1 tetraspanin 1 3.26705
RAPSN receptor-associated protein of the synapse 3.26705
MAGEA12 melanoma antigen family A12 3.26705
CD160 CD160 molecule 3.26705
PAX6 paired box 6 3.26705
RRAD Ras-related associated with diabetes 3.26705
MMP12 matrix metallopeptidase 12 3.26705
ZC3H11A zinc finger CCCH-type containing 11A 3.26705
CPO carboxypeptidase O 3.26705
SIX1 SIX homeobox 1 3.26705
SOX30 SRY (sex determining region Y)-box 30 3.26705
GP1BA glycoprotein Ib (platelet), alpha polypeptide 3.26705
IL15RA interleukin 15 receptor, alpha 3.26705
GPR6 G protein-coupled receptor 6 3.26705
GJA4 gap junction protein, alpha 4, 37kDa 3.26705
EHD3 EH-domain containing 3 3.24736
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.24736
SLC35G5 solute carrier family 35, member G5 3.24736
UPK3B uroplakin 3B 3.24736
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.24736
IGFL3 IGF-like family member 3 3.24736
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.24736
TMPRSS11F transmembrane protease, serine 11F 3.24736
FOLR1 folate receptor 1 (adult) 3.24736
PRDM12 PR domain containing 12 3.24736
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 3.24736
ZAN zonadhesin (gene/pseudogene) 3.24736
PKP1 plakophilin 1 3.24736
TKTL1 transketolase-like 1 3.24736
CLEC5A C-type lectin domain family 5, member A 3.24736
TRIM42 tripartite motif containing 42 3.24736
RIMBP3C RIMS binding protein 3C 3.24736
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.24736
MRC1 mannose receptor, C type 1 3.24736
MYL7 myosin, light chain 7, regulatory 3.24736
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.24736
PCDHGA11 protocadherin gamma subfamily A, 11 3.24736
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.24736
PSCA prostate stem cell antigen 3.24736
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.24736
SMIM5 small integral membrane protein 5 3.24736
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.24736
MYOM3 myomesin 3 3.24736
SLC39A2 solute carrier family 39 (zinc transporter), member 2 3.24736
GCKR glucokinase (hexokinase 4) regulator 3.24736
SFTPB surfactant protein B 3.24736
GUCY2F guanylate cyclase 2F, retinal 3.24736
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.24736
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.24736
C1ORF146 chromosome 1 open reading frame 146 3.24736
WFDC13 WAP four-disulfide core domain 13 3.24736
SPMAP1 sperm microtubule associated protein 1 3.24736
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.24736
CES4A carboxylesterase 4A 3.24736
PTH1R parathyroid hormone 1 receptor 3.24736
OTOF otoferlin 3.24736
GBP3 guanylate binding protein 3 3.24736
AVPR1B arginine vasopressin receptor 1B 3.24736
RHCG Rh family, C glycoprotein 3.24736
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.24736
RAB36 RAB36, member RAS oncogene family 3.24736
LY6K lymphocyte antigen 6 complex, locus K 3.24736
STING1 stimulator of interferon response cGAMP interactor 1 3.24736
GPAT3 glycerol-3-phosphate acyltransferase 3 3.24736
SPEGNB SPEG neighbor 3.24736
EXOC1L exocyst complex component 1 like 3.24736
RPS21-DT RPS21 divergent transcript 3.24736
LOC124902436 talanin 3.24736
ZNF593OS ZNF593 opposite strand 3.24736
H3C14 H3 clustered histone 14 3.24736
TMEM272 transmembrane protein 272 3.24736
CPHXL cytoplasmic polyadenylated homeobox like 3.24736
STPG3 sperm-tail PG-rich repeat containing 3 3.24736
MINAR2 membrane integral NOTCH2 associated receptor 2 3.24736
IMPG1 interphotoreceptor matrix proteoglycan 1 3.24736
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.24736
NHLRC4 NHL repeat containing 4 3.24736
SCRT1 scratch family zinc finger 1 3.24736
SP140 SP140 nuclear body protein 3.24736
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 3.24736
CCR6 chemokine (C-C motif) receptor 6 3.24736
PTGDR2 prostaglandin D2 receptor 2 3.24736
CAPN14 calpain 14 3.24736
ACTL10 actin-like 10 3.24736
HHEX hematopoietically expressed homeobox 3.24736
MBL2 mannose-binding lectin (protein C) 2, soluble 3.24736
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.24736
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.24736
PRDM6 PR domain containing 6 3.24736
CSAG1 chondrosarcoma associated gene 1 3.24736
NDP Norrie disease (pseudoglioma) 3.24736
HNF1A HNF1 homeobox A 3.24736
ASIC5 acid sensing (proton gated) ion channel family member 5 3.24736
LRRC73 leucine rich repeat containing 73 3.24736
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.24736
PLEK2 pleckstrin 2 3.24736
C6ORF118 chromosome 6 open reading frame 118 3.24736
C1QL2 complement component 1, q subcomponent-like 2 3.24736
FABP9 fatty acid binding protein 9, testis 3.24736
CDK20 cyclin-dependent kinase 20 3.24736
NGB neuroglobin 3.24736
LRRC32 leucine rich repeat containing 32 3.24736
MPZL2 myelin protein zero-like 2 3.24736
PLD1 phospholipase D1, phosphatidylcholine-specific 3.24736
KRT17 keratin 17, type I 3.24736
NBPF8 neuroblastoma breakpoint family, member 8 3.24736
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 3.24736
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.24736
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 3.24736
ANKRD62 ankyrin repeat domain 62 3.24736
PRSS55 protease, serine, 55 3.24736
KIF4B kinesin family member 4B 3.24736
CD177 CD177 molecule 3.24736
ECM1 extracellular matrix protein 1 3.24736
TBC1D21 TBC1 domain family, member 21 3.24736
SIGLEC15 sialic acid binding Ig-like lectin 15 3.24736
RNF222 ring finger protein 222 3.24736
GLRB glycine receptor, beta 3.24736
ALAS2 5'-aminolevulinate synthase 2 3.24736
PCDHGB1 protocadherin gamma subfamily B, 1 3.24736
COMP cartilage oligomeric matrix protein 3.24736
VWA3A von Willebrand factor A domain containing 3A 3.24736
CAGE1 cancer antigen 1 3.24736
CYS1 cystin 1 3.24736
ZCCHC12 zinc finger, CCHC domain containing 12 3.24736
MAMLD1 mastermind-like domain containing 1 3.24736
KLK12 kallikrein-related peptidase 12 3.24736
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.24736
LYG1 lysozyme G-like 1 3.24736
CHIT1 chitinase 1 (chitotriosidase) 3.24736
MAOB monoamine oxidase B 3.24736
RAD51AP2 RAD51 associated protein 2 3.24736
ZC3H12D zinc finger CCCH-type containing 12D 3.24736
LCNL1 lipocalin-like 1 3.24736
RGS11 regulator of G-protein signaling 11 3.24736
RAD21L1 RAD21-like 1 (S. pombe) 3.24736
RPA4 replication protein A4, 30kDa 3.24736
FGF16 fibroblast growth factor 16 3.24736
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.24736
VWC2L von Willebrand factor C domain containing protein 2-like 3.24736
A1CF APOBEC1 complementation factor 3.24736
LHB luteinizing hormone beta polypeptide 3.24736
SPNS3 spinster homolog 3 (Drosophila) 3.24736
ADRB2 adrenoceptor beta 2, surface 3.24736
TM4SF19 transmembrane 4 L six family member 19 3.24736
ITGA8 integrin, alpha 8 3.24736
KCNK16 potassium channel, two pore domain subfamily K, member 16 3.24736
CPA3 carboxypeptidase A3 (mast cell) 3.24736
ASCL5 achaete-scute family bHLH transcription factor 5 3.24736
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 3.24736
ICAM2 intercellular adhesion molecule 2 3.24736
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.24736
ZNF835 zinc finger protein 835 3.24736
PHACTR3 phosphatase and actin regulator 3 3.24736
CLCNKA chloride channel, voltage-sensitive Ka 3.24736
EPN3 epsin 3 3.24736
RGS8 regulator of G-protein signaling 8 3.24736
GOLGA8K golgin A8 family, member K 3.24736
LRRC74A leucine rich repeat containing 74A 3.24736
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 3.24736
HRK harakiri, BCL2 interacting protein 3.23171
DBP D site of albumin promoter (albumin D-box) binding protein 3.21683
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 3.09828
TMEM185A transmembrane protein 185A 3.07894
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.99464
XYLT1 xylosyltransferase I 2.88594
STMN2 stathmin 2 2.86785
TBK1 TANK-binding kinase 1 2.82109
HDGFL2 HDGF like 2 2.8055
RGS7 regulator of G-protein signaling 7 2.78555
FKBP1B FK506 binding protein 1B, 12.6 kDa 2.73795
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.69837
CTTNBP2 cortactin binding protein 2 2.63287
SGMS2 sphingomyelin synthase 2 2.60585
ALS2CL ALS2 C-terminal like 2.60585
PBRM1 polybromo 1 2.60012
PABPC1 poly(A) binding protein, cytoplasmic 1 2.57425
RAB43 RAB43, member RAS oncogene family 2.57083
AMACR alpha-methylacyl-CoA racemase 2.55352
TLNRD1 talin rod domain containing 1 2.55052
VPS26C VPS26 endosomal protein sorting factor C 2.54769
RCAN2 regulator of calcineurin 2 2.54576
CLASP2 cytoplasmic linker associated protein 2 2.54179
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.48374
HCST hematopoietic cell signal transducer 2.48374
PNMA8B PNMA family member 8B 2.48374
ANGEL1 angel homolog 1 (Drosophila) 2.46591
AMPD2 adenosine monophosphate deaminase 2 2.45474
YBX2 Y box binding protein 2 2.39937
CLTA clathrin, light chain A 2.39937
CASKIN1 CASK interacting protein 1 2.36784
SVOPL SVOP-like 2.36525
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.3628
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.35677
MST1R macrophage stimulating 1 receptor 2.34965
TMEM102 transmembrane protein 102 2.34965
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.34965
GALC galactosylceramidase 2.34965
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.34498
MMS22L MMS22-like, DNA repair protein 2.30924
LTC4S leukotriene C4 synthase 2.25635
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) 2.23696
NGLY1 N-glycanase 1 2.23369
IFRD2 interferon-related developmental regulator 2 2.22039
TGFBR3L transforming growth factor, beta receptor III-like 2.21212
NUP107 nucleoporin 107kDa 2.20068
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.19973
DCAF16 DDB1 and CUL4 associated factor 16 2.19973
GPATCH2L G patch domain containing 2-like 2.19346
RBM10 RNA binding motif protein 10 2.1831
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 2.17935
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.17567
NELFA negative elongation factor complex member A 2.15028
PKP2 plakophilin 2 2.14812
ZNFX1 zinc finger, NFX1-type containing 1 2.14812
LZTS2 leucine zipper, putative tumor suppressor 2 2.13037
MFN2 mitofusin 2 2.12935
LINS1 lines homolog 1 2.11467
PPP1R8 protein phosphatase 1, regulatory subunit 8 2.10609
SGO1 shugoshin 1 2.1036
ARHGAP39 Rho GTPase activating protein 39 2.0941
SRSF8 serine/arginine-rich splicing factor 8 2.08612
EFCAB10 EF-hand calcium binding domain 10 2.07247
XK X-linked Kx blood group 2.07214
ARMC12 armadillo repeat containing 12 2.07214
BEAN1 brain expressed, associated with NEDD4, 1 2.07214
ZFP28 ZFP28 zinc finger protein 2.07214
TMEM150B transmembrane protein 150B 2.07214
ZFP57 ZFP57 zinc finger protein 2.07214
CORT cortistatin 2.07214
FBXW12 F-box and WD repeat domain containing 12 2.0702
VDAC3 voltage-dependent anion channel 3 2.0702
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.0419
ADAM33 ADAM metallopeptidase domain 33 2.0419
GATAD1 GATA zinc finger domain containing 1 2.03674
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.03015
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.0228
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.00644

decreased expression

Symbol Name Standardized Value
MOGAT1 monoacylglycerol O-acyltransferase 1 -3.26705
PODNL1 podocan-like 1 -3.26705
INSL6 insulin-like 6 -3.26705
TLE2 transducin-like enhancer of split 2 -3.26705
RGS2 regulator of G-protein signaling 2 -3.25756
S100A2 S100 calcium binding protein A2 -3.24736
NPIPA2 nuclear pore complex interacting protein family, member A2 -3.24736
CD8B CD8b molecule -3.24736
LOC124904542 uncharacterized LOC124904542 -3.24736
NRGN neurogranin (protein kinase C substrate, RC3) -3.24736
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -3.24736
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -3.24736
FGF4 fibroblast growth factor 4 -3.24736
PSD4 pleckstrin and Sec7 domain containing 4 -3.24736
H3C13 H3 clustered histone 13 -3.24736
RGPD6 RANBP2-like and GRIP domain containing 6 -3.24736
JAML junction adhesion molecule like -3.24736
CFAP119 cilia and flagella associated protein 119 -3.24736
INKA1 inka box actin regulator 1 -3.24736
TACR2 tachykinin receptor 2 -3.24736
TRIM68 tripartite motif containing 68 -3.24736
LTBP2 latent transforming growth factor beta binding protein 2 -3.24736
AGTR1 angiotensin II receptor, type 1 -3.24736
MSC musculin -3.24736
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -3.24736
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.24736
ADM5 adrenomedullin 5 (putative) -3.24736
DRC1 dynein regulatory complex subunit 1 -3.24736
ERICH6B glutamate-rich 6B -3.24736
WFDC8 WAP four-disulfide core domain 8 -3.24736
CEND1 cell cycle exit and neuronal differentiation 1 -3.24736
INSM1 insulinoma-associated 1 -3.24736
ISL1 ISL LIM homeobox 1 -3.24736
KLK4 kallikrein-related peptidase 4 -3.24736
DAW1 dynein assembly factor with WDR repeat domains 1 -3.24736
ALOX12B arachidonate 12-lipoxygenase, 12R type -3.24736
PYY peptide YY -3.24736
AOAH acyloxyacyl hydrolase (neutrophil) -3.24736
DENND2D DENN/MADD domain containing 2D -3.24736
GOLGA8H golgin A8 family, member H -3.24736
SLFN5 schlafen family member 5 -3.22706
COMMD3 COMM domain containing 3 -3.21683
ZNF25 zinc finger protein 25 -3.07832
SIAE sialic acid acetylesterase -2.99622
ADAM22 ADAM metallopeptidase domain 22 -2.96809
MRPL21 mitochondrial ribosomal protein L21 -2.8923
TMEM177 transmembrane protein 177 -2.78766
HSF2 heat shock transcription factor 2 -2.78664
STK16 serine/threonine kinase 16 -2.75254
COPS3 COP9 signalosome subunit 3 -2.71072
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 -2.69988
PBK PDZ binding kinase -2.65594
ZNF84 zinc finger protein 84 -2.64055
STK3 serine/threonine kinase 3 -2.60915
TSPOAP1 TSPO associated protein 1 -2.591
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -2.56759
ARL16 ADP-ribosylation factor-like 16 -2.53086
DGKE diacylglycerol kinase, epsilon 64kDa -2.48374
AUP1 ancient ubiquitous protein 1 -2.30076
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -2.27525
IRF7 interferon regulatory factor 7 -2.26937
CLC Charcot-Leyden crystal galectin -2.26937
CRACDL CRACD like -2.26937
HAPLN1 hyaluronan and proteoglycan link protein 1 -2.26937
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.26503
EMILIN2 elastin microfibril interfacer 2 -2.26503
RNF152 ring finger protein 152 -2.23579
EFCAB5 EF-hand calcium binding domain 5 -2.21935
MTPN myotrophin -2.20173
ZBTB14 zinc finger and BTB domain containing 14 -2.20113
IL17RA interleukin 17 receptor A -2.19346
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.19289
UBXN4 UBX domain protein 4 -2.18981
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.1869
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase -2.17733
BEX2 brain expressed X-linked 2 -2.17733
VEPH1 ventricular zone expressed PH domain-containing 1 -2.13877
MNS1 meiosis-specific nuclear structural 1 -2.12298
CNKSR3 CNKSR family member 3 -2.0941
NHLRC2 NHL repeat containing 2 -2.09373
NCSTN nicastrin -2.09373
PRR16 proline rich 16 -2.07268
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 -2.07214
TRIM69 tripartite motif containing 69 -2.0702
NUDT22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 -2.0702
CD44 CD44 molecule (Indian blood group) -2.0702
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -2.0702
MYO15A myosin XVA -2.06844
DIABLO diablo, IAP-binding mitochondrial protein -2.06844
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -2.06844
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.04819
EIF3M eukaryotic translation initiation factor 3, subunit M -2.04713
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -2.0399
ADAT1 adenosine deaminase, tRNA-specific 1 -2.03884
NRSN2 neurensin 2 -2.03491
TRAPPC1 trafficking protein particle complex 1 -2.01835
PLCB4 phospholipase C, beta 4 -2.01034
KCTD1 potassium channel tetramerization domain containing 1 -2.00869
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.00693