PIK3CG Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma|This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] (NCBI Entrez Gene Database, 5294)
External Link http://www.ncbi.nlm.nih.gov/gene/5294
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Genes

287 interacting proteins for PIK3CG from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ACTB actin, beta
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADAP1 ArfGAP with dual PH domains 1
ADRBK1 adrenergic, beta, receptor kinase 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMOT angiomotin
ANGPT1 angiopoietin 1
APC adenomatous polyposis coli
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF6 ADP-ribosylation factor 6
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATG14 autophagy related 14
ATG2A autophagy related 2A
ATG3 autophagy related 3
ATG4B autophagy related 4B, cysteine peptidase
ATG7 autophagy related 7
BAIAP2 BAI1-associated protein 2
BAIAP2L1 BAI1-associated protein 2-like 1
BCR breakpoint cluster region
BECN1 beclin 1, autophagy related
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
CD247 CD247 molecule
CD28 CD28 molecule
CD37 CD37 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD80 CD80 molecule
CD86 CD86 molecule
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CEP170B centrosomal protein 170B
CLINT1 clathrin interactor 1
CNTRL centriolin
CORO1C coronin, actin binding protein, 1C
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CUL3 cullin 3
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DCC DCC netrin 1 receptor
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DYX1C1 dyslexia susceptibility 1 candidate 1
EFNA5 ephrin-A5
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EPHA8 EPH receptor A8
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPS8 epidermal growth factor receptor pathway substrate 8
ERAS ES cell expressed Ras
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FGFR1OP2 FGFR1 oncogene partner 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLCN folliculin
FLNA filamin A, alpha
FNIP1 folliculin interacting protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GBAS glioblastoma amplified sequence
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GSN gelsolin
GYG1 glycogenin 1
GYS1 glycogen synthase 1 (muscle)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HRAS Harvey rat sarcoma viral oncogene homolog
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
IL6ST interleukin 6 signal transducer
IPO5 importin 5
ITK IL2-inducible T-cell kinase
JAK2 Janus kinase 2
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLB klotho beta
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
MLF2 myeloid leukemia factor 2
MRAS muscle RAS oncogene homolog
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12B myosin, light chain 12B, regulatory
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO10 myosin X
MYO18A myosin XVIIIA
NCK1 NCK adaptor protein 1
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK9 NIMA-related kinase 9
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOTCH1 notch 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NTN1 netrin 1
NTN3 netrin 3
NTN4 netrin 4
NTNG1 netrin G1
NTNG2 netrin G2
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
PRMT7 protein arginine methyltransferase 7
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RABGAP1 RAB GTPase activating protein 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALY RALY heterogeneous nuclear ribonucleoprotein
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RB1CC1 RB1-inducible coiled-coil 1
RBMX RNA binding motif protein, X-linked
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTCA RNA 3'-terminal phosphate cyclase
SAFB scaffold attachment factor B
SEC14L2 SEC14-like 2 (S. cerevisiae)
SET SET nuclear proto-oncogene
SF3A2 splicing factor 3a, subunit 2, 66kDa
SGK1 serum/glucocorticoid regulated kinase 1
SH3PXD2A SH3 and PX domains 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMC1A structural maintenance of chromosomes 1A
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOS1 son of sevenless homolog 1 (Drosophila)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY3 sprouty homolog 3 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
SRBD1 S1 RNA binding domain 1
STBD1 starch binding domain 1
STIM1 stromal interaction molecule 1
STIM2 stromal interaction molecule 2
SYK spleen tyrosine kinase
TBC1D2B TBC1 domain family, member 2B
TEC tec protein tyrosine kinase
TEK TEK tyrosine kinase, endothelial
TMEM160 transmembrane protein 160
TMOD3 tropomodulin 3 (ubiquitous)
TP63 tumor protein p63
TPM2 tropomyosin 2 (beta)
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRIM24 tripartite motif containing 24
TXK TXK tyrosine kinase
UBC ubiquitin C
ULK1 unc-51 like autophagy activating kinase 1
USP45 ubiquitin specific peptidase 45
UTRN utrophin
UVRAG UV radiation resistance associated
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WASL Wiskott-Aldrich syndrome-like
WDR11 WD repeat domain 11
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
YLPM1 YLP motif containing 1
ZFR zinc finger RNA binding protein
ZMYM2 zinc finger, MYM-type 2
ZNF282 zinc finger protein 282