PIM1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description Pim-1 proto-oncogene, serine/threonine kinase|The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 5292)
External Link http://www.ncbi.nlm.nih.gov/gene/5292
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Genes

17 substrates of the kinase PIM1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AR androgen receptor
BAD BCL2-associated agonist of cell death
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CXCR4 chemokine (C-X-C motif) receptor 4
FOXO3 forkhead box O3
HIST1H3A histone cluster 1, H3a
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARK3 MAP/microtubule affinity-regulating kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
POU5F1 POU class 5 homeobox 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RUNX3 runt-related transcription factor 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase