PINK1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PTEN induced putative kinase 1|This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 65018)
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Genes

315 genes differentially expressed following the PINK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.46246
PARP3 poly (ADP-ribose) polymerase family, member 3 2.46246
CDH5 cadherin 5, type 2 (vascular endothelium) 2.46246
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.46246
SPATA31A5 SPATA31 subfamily A, member 5 2.46246
AKR1C2 aldo-keto reductase family 1, member C2 2.46246
PGAM2 phosphoglycerate mutase 2 (muscle) 2.46246
EPPIN epididymal peptidase inhibitor 2.46246
TM4SF1 transmembrane 4 L six family member 1 2.46246
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.46246
SIX1 SIX homeobox 1 2.46246
TSSK4 testis-specific serine kinase 4 2.46246
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.46246
SCN10A sodium channel, voltage gated, type X alpha subunit 2.46246
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 2.46246
LGALS7B lectin, galactoside-binding, soluble, 7B 2.46246
TUBA3D tubulin, alpha 3d 2.46246
ACTL10 actin-like 10 2.46246
RLBP1 retinaldehyde binding protein 1 2.46246
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.46246
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.46246
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.46246
UPB1 ureidopropionase, beta 2.46246
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.46246
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.46246
S100A7 S100 calcium binding protein A7 2.46246
S100A5 S100 calcium binding protein A5 2.46246
TMEM121 transmembrane protein 121 2.46246
LRRC63 leucine rich repeat containing 63 2.46246
TAS2R10 taste receptor, type 2, member 10 2.46246
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 2.46246
CLEC14A C-type lectin domain family 14, member A 2.46246
ATG4B autophagy related 4B, cysteine peptidase 2.46246
CARD18 caspase recruitment domain family, member 18 2.46246
OR13C3 olfactory receptor, family 13, subfamily C, member 3 2.46246
RAPSN receptor-associated protein of the synapse 2.46246
GJB3 gap junction protein, beta 3, 31kDa 2.46246
CORT cortistatin 2.46246
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.46246
NPSR1 neuropeptide S receptor 1 2.46246
BATF basic leucine zipper transcription factor, ATF-like 2.46246
ASB12 ankyrin repeat and SOCS box containing 12 2.46246
MUSK muscle, skeletal, receptor tyrosine kinase 2.46246
KCNRG potassium channel regulator 2.46246
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.46246
SPHK1 sphingosine kinase 1 2.46246
CATSPERT catsper channel auxiliary subunit tau 2.46246
FAM237B family with sequence similarity 237 member B 2.46246
RETREG1 reticulophagy regulator 1 2.46246
ANGPTL8 angiopoietin like 8 2.46246
H3-5 H3.5 histone 2.46246
GBP7 guanylate binding protein 7 2.46246
YIPF7 Yip1 domain family, member 7 2.46246
ROPN1L rhophilin associated tail protein 1-like 2.46246
OPRM1 opioid receptor, mu 1 2.46246
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 2.46246
SMIM40 small integral membrane protein 40 2.46246
PLAAT4 phospholipase A and acyltransferase 4 2.46246
KASH5 KASH domain containing 5 2.46246
SPATA31G1 SPATA31 subfamily G member 1 2.46246
GOLGA6L25 golgin A6 family like 25 2.46246
OR56B2 olfactory receptor family 56 subfamily B member 2 2.46246
TEX50 testis expressed 50 2.46246
H2BK1 H2B.K variant histone 1 2.46246
C17ORF113 chromosome 17 open reading frame 113 2.46246
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.46246
CLEC20A C-type lectin domain containing 20A 2.46246
RTL5 retrotransposon Gag like 5 2.46246
ZG16 zymogen granule protein 16 2.46246
SPI1 Spi-1 proto-oncogene 2.46246
C7ORF57 chromosome 7 open reading frame 57 2.46246
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.46246
C1QL2 complement component 1, q subcomponent-like 2 2.46246
TBX6 T-box 6 2.46246
IL5 interleukin 5 2.46246
DMBX1 diencephalon/mesencephalon homeobox 1 2.46246
TACSTD2 tumor-associated calcium signal transducer 2 2.46246
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.46246
TMEM233 transmembrane protein 233 2.46246
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.46246
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.46246
HNF1A HNF1 homeobox A 2.46246
RHCG Rh family, C glycoprotein 2.46246
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.46246
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.46246
PAPOLB poly(A) polymerase beta (testis specific) 2.46246
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.46246
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.46246
FOXC2 forkhead box C2 2.46246
SMTNL1 smoothelin-like 1 2.46246
OSTN osteocrin 2.46246
CKM creatine kinase, muscle 2.46246
CIDEA cell death-inducing DFFA-like effector a 2.46246
GRK7 G protein-coupled receptor kinase 7 2.46246
THTPA thiamine triphosphatase 2.46246
CRYBB3 crystallin, beta B3 2.46246
CXCR2 chemokine (C-X-C motif) receptor 2 2.46246
CPSF4L cleavage and polyadenylation specific factor 4-like 2.46246
DGCR6 DiGeorge syndrome critical region gene 6 2.46246
F11 coagulation factor XI 2.46246
FAM177B family with sequence similarity 177, member B 2.46246
NIPAL4 NIPA-like domain containing 4 2.46246
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.46246
EXTL1 exostosin-like glycosyltransferase 1 2.46246
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.46246
KRT16 keratin 16, type I 2.46246
CPM carboxypeptidase M 2.46246
APOB apolipoprotein B 2.46246
VAX2 ventral anterior homeobox 2 2.46246
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.46246
HAMP hepcidin antimicrobial peptide 2.46246
RAD21L1 RAD21-like 1 (S. pombe) 2.46246
RNF112 ring finger protein 112 2.46246
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.46246
C22ORF42 chromosome 22 open reading frame 42 2.46246
TP63 tumor protein p63 2.46246
GPR68 G protein-coupled receptor 68 2.46246
QRFP pyroglutamylated RFamide peptide 2.46246
TYR tyrosinase 2.46246
ESPNL espin-like 2.46246
LMX1B LIM homeobox transcription factor 1, beta 2.46246
CLEC18B C-type lectin domain family 18, member B 2.46246
SAP30 Sin3A-associated protein, 30kDa 2.46246
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.46246
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 2.46246
KIFC2 kinesin family member C2 2.46246
MUC17 mucin 17, cell surface associated 2.46246
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.46246
BCO1 beta-carotene oxygenase 1 2.46246
SLC22A24 solute carrier family 22, member 24 2.46246
CATIP ciliogenesis associated TTC17 interacting protein 2.46246
DMRTA2 DMRT-like family A2 2.46246
CHIT1 chitinase 1 (chitotriosidase) 2.46246
ITGA11 integrin, alpha 11 2.46246
PDCD1LG2 programmed cell death 1 ligand 2 2.46246
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.46246
PRDM1 PR domain containing 1, with ZNF domain 2.46246
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.46246
NKPD1 NTPase, KAP family P-loop domain containing 1 2.46246
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.46246
GH1 growth hormone 1 2.46246
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.46246
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.46246
TGM3 transglutaminase 3 2.46246
TEX38 testis expressed 38 2.46246
PATE2 prostate and testis expressed 2 2.46246
APOL1 apolipoprotein L, 1 2.46246
ITPKA inositol-trisphosphate 3-kinase A 2.46246
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.46246
CLCNKB chloride channel, voltage-sensitive Kb 2.46246
SNTN sentan, cilia apical structure protein 2.46246
THEMIS thymocyte selection associated 2.46246
SLITRK1 SLIT and NTRK-like family, member 1 2.46246
IL18R1 interleukin 18 receptor 1 2.46246
CELA2B chymotrypsin-like elastase family, member 2B 2.46246
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.46246
SPAG6 sperm associated antigen 6 2.46246
MAPK11 mitogen-activated protein kinase 11 2.46246
WFDC13 WAP four-disulfide core domain 13 2.46246
TSKS testis-specific serine kinase substrate 2.46246
LPAR5 lysophosphatidic acid receptor 5 2.46246
TSSK1B testis-specific serine kinase 1B 2.46246
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.46246
IRX3 iroquois homeobox 3 2.46246
REEP1 receptor accessory protein 1 2.46246
IFT70A intraflagellar transport 70A 2.45732
ZNF557 zinc finger protein 557 2.45269
ZNF699 zinc finger protein 699 2.44861
FEM1C fem-1 homolog c (C. elegans) 2.44625
STRN striatin, calmodulin binding protein 2.44595
GDF11 growth differentiation factor 11 2.41178
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.40739
ZMYM5 zinc finger, MYM-type 5 2.38302
CER1 cerberus 1, DAN family BMP antagonist 2.32076
SPMIP2 sperm microtubule inner protein 2 2.32076
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 2.31033
CCKBR cholecystokinin B receptor 2.29858
HMBS hydroxymethylbilane synthase 2.28327
TACR3 tachykinin receptor 3 2.28186
NTNG2 netrin G2 2.23637
KIF4A kinesin family member 4A 2.23429
ZNF747 zinc finger protein 747 2.21252
RSPO4 R-spondin 4 2.18692
MAGEF1 melanoma antigen family F1 2.16631
AGO1 argonaute RISC catalytic component 1 2.16631
SLC25A51 solute carrier family 25, member 51 2.16132
TRABD TraB domain containing 2.16132
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.16126
CATSPERG catsper channel auxiliary subunit gamma 2.16126
GATD1 glutamine amidotransferase class 1 domain containing 1 2.15718
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 2.13914
ZBTB11 zinc finger and BTB domain containing 11 2.12383
ZNF234 zinc finger protein 234 2.12355
RUBCN rubicon autophagy regulator 2.12317
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.12317
PIAS3 protein inhibitor of activated STAT, 3 2.12317
RANBP3 RAN binding protein 3 2.10354
HSPA13 heat shock protein 70kDa family, member 13 2.0891
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 2.06662
CNOT7 CCR4-NOT transcription complex, subunit 7 2.05507
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.04284
HSPB1 heat shock 27kDa protein 1 2.04284
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 2.04284
YPEL4 yippee-like 4 (Drosophila) 2.04284
ZNF256 zinc finger protein 256 2.04092
PPP1R10 protein phosphatase 1, regulatory subunit 10 2.04092

decreased expression

Symbol Name Standardized Value
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -2.46246
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.46246
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) -2.46246
DET1 de-etiolated homolog 1 (Arabidopsis) -2.46246
TNK2 tyrosine kinase, non-receptor, 2 -2.46246
HGD homogentisate 1,2-dioxygenase -2.46246
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.46246
NPPC natriuretic peptide C -2.46246
FGF20 fibroblast growth factor 20 -2.46246
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.46246
LCN10 lipocalin 10 -2.46246
SIAE sialic acid acetylesterase -2.46246
SLC35E3 solute carrier family 35, member E3 -2.46246
FXYD3 FXYD domain containing ion transport regulator 3 -2.46246
GRM2 glutamate receptor, metabotropic 2 -2.46246
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.46246
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -2.46246
CATSPERQ catsper channel auxiliary subunit theta -2.46246
S100A2 S100 calcium binding protein A2 -2.46246
KIRREL2 kin of IRRE like 2 (Drosophila) -2.46246
C19ORF73 chromosome 19 open reading frame 73 -2.46246
MIER2 mesoderm induction early response 1, family member 2 -2.46246
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.46246
LAMA3 laminin, alpha 3 -2.46246
HSPA4 heat shock 70kDa protein 4 -2.46246
CCNL2 cyclin L2 -2.46246
FMO1 flavin containing monooxygenase 1 -2.46246
FKBP6 FK506 binding protein 6, 36kDa -2.46246
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.46246
ZNF723 zinc finger protein 723 -2.46246
MLANA melan-A -2.46246
ARL8B ADP-ribosylation factor-like 8B -2.46246
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.46246
WSCD2 WSC domain containing 2 -2.46246
TLE3 transducin-like enhancer of split 3 -2.46246
LDHAL6A lactate dehydrogenase A-like 6A -2.46246
MIB2 mindbomb E3 ubiquitin protein ligase 2 -2.46246
CXCL14 chemokine (C-X-C motif) ligand 14 -2.46246
ZAN zonadhesin (gene/pseudogene) -2.46246
MON1A MON1 secretory trafficking family member A -2.46246
SYT15B synaptotagmin 15B -2.46246
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -2.46246
ZNF296 zinc finger protein 296 -2.46246
PDCL2 phosducin-like 2 -2.46246
PRPH2 peripherin 2 (retinal degeneration, slow) -2.46246
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.46246
PLCL1 phospholipase C-like 1 -2.46246
EBF2 early B-cell factor 2 -2.46246
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.46246
TMEM61 transmembrane protein 61 -2.46246
ZNF628 zinc finger protein 628 -2.46246
CBX6 chromobox homolog 6 -2.46246
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.46246
LYG1 lysozyme G-like 1 -2.46246
KLHDC3 kelch domain containing 3 -2.46246
JPH2 junctophilin 2 -2.46246
CPN1 carboxypeptidase N, polypeptide 1 -2.46246
MED30 mediator complex subunit 30 -2.46246
NAP1L5 nucleosome assembly protein 1-like 5 -2.46246
NACAD NAC alpha domain containing -2.46246
CERS3 ceramide synthase 3 -2.46246
ZNF471 zinc finger protein 471 -2.46246
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.46246
NGB neuroglobin -2.46246
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like -2.46246
PTRH2 peptidyl-tRNA hydrolase 2 -2.44373
TMPRSS9 transmembrane protease, serine 9 -2.42094
EMID1 EMI domain containing 1 -2.42094
CYB5R1 cytochrome b5 reductase 1 -2.40293
VMP1 vacuole membrane protein 1 -2.38583
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.35883
RNFT1 ring finger protein, transmembrane 1 -2.35883
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.3314
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.32601
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.23793
TSPAN4 tetraspanin 4 -2.23733
SLA2 Src-like-adaptor 2 -2.23659
SCN1B sodium channel, voltage gated, type I beta subunit -2.23659
SMIM10 small integral membrane protein 10 -2.23659
CRYGD crystallin, gamma D -2.23659
TFCP2L1 transcription factor CP2-like 1 -2.23659
F13A1 coagulation factor XIII, A1 polypeptide -2.23128
TDRD5 tudor domain containing 5 -2.23128
TJP1 tight junction protein 1 -2.21258
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -2.21252
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.20502
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.19499
ZNF33A zinc finger protein 33A -2.19034
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.18602
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -2.18048
NINL ninein-like -2.17995
NDC80 NDC80 kinetochore complex component -2.1773
GLI2 GLI family zinc finger 2 -2.14511
MRE11 MRE11 homolog, double strand break repair nuclease -2.14229
TECTA tectorin alpha -2.14155
BPTF bromodomain PHD finger transcription factor -2.08538
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.0834
CREB3L4 cAMP responsive element binding protein 3-like 4 -2.07184
COQ10A coenzyme Q10 homolog A (S. cerevisiae) -2.06391
EXOC2 exocyst complex component 2 -2.05822
COG2 component of oligomeric golgi complex 2 -2.05506
ZFYVE1 zinc finger, FYVE domain containing 1 -2.05236
ADCY7 adenylate cyclase 7 -2.04284
DUOX1 dual oxidase 1 -2.04284
SWAP70 SWAP switching B-cell complex 70kDa subunit -2.04284
IMPACT impact RWD domain protein -2.04186
CNKSR1 connector enhancer of kinase suppressor of Ras 1 -2.03041
PARD6A par-6 family cell polarity regulator alpha -2.0225
GAR1 GAR1 ribonucleoprotein -2.01793