| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | PTEN induced putative kinase 1|This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 65018) |
| External Link | https://ncbi.nlm.nih.gov/gene/65018 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the PINK1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | 0.0214655 |
| MAGEA3 | melanoma antigen family A3 | 0.0177077 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0173653 |
| CA2 | carbonic anhydrase II | 0.0161885 |
| GOLM1 | golgi membrane protein 1 | 0.0132484 |
| CLC | Charcot-Leyden crystal galectin | 0.0123128 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0122533 |
| PHACTR2 | phosphatase and actin regulator 2 | 0.0122511 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0120964 |
| PCLAF | PCNA clamp associated factor | 0.012012 |
| ASS1 | argininosuccinate synthase 1 | 0.0119576 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.0117569 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.0117064 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0116587 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.0116547 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0113618 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0113468 |
| PLIN2 | perilipin 2 | 0.011226 |
| TYMS | thymidylate synthetase | 0.0110599 |
| PLBD1 | phospholipase B domain containing 1 | 0.0109366 |
| PDE8A | phosphodiesterase 8A | 0.0108951 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.0108199 |
| S100P | S100 calcium binding protein P | 0.010719 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0107083 |
| TMEM176B | transmembrane protein 176B | 0.0105917 |
| CHN1 | chimerin 1 | 0.0105772 |
| SOCS1 | suppressor of cytokine signaling 1 | 0.0105687 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.0105539 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.0103609 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.0103244 |
| HHEX | hematopoietically expressed homeobox | 0.0102134 |
| WT1 | Wilms tumor 1 | 0.0101595 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0101348 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0100641 |
| GOLGA8A | golgin A8 family, member A | 0.0100587 |
| DUT | deoxyuridine triphosphatase | 0.00994053 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 0.00986337 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00977392 |
| PFDN4 | prefoldin subunit 4 | 0.00966313 |
| ARMT1 | acidic residue methyltransferase 1 | 0.00948397 |
| TNFSF13B | tumor necrosis factor (ligand) superfamily, member 13b | 0.00945283 |
| MAGEA12 | melanoma antigen family A12 | 0.00944071 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00942732 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0093041 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.00926501 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00925522 |
| ANKRD10 | ankyrin repeat domain 10 | 0.00913488 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00912389 |
| ARG1 | arginase 1 | 0.00910707 |
| HBD | hemoglobin, delta | 0.00908993 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00908651 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00897213 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.00886188 |
| CAB39 | calcium binding protein 39 | 0.00883404 |
| TMEM106B | transmembrane protein 106B | 0.00879929 |
| PTER | phosphotriesterase related | 0.00879756 |
| HMG20B | high mobility group 20B | 0.00873432 |
| CHGB | chromogranin B | 0.0087332 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.0087209 |
| DCLK1 | doublecortin-like kinase 1 | 0.00869728 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | 0.0086922 |
| MMP2 | matrix metallopeptidase 2 | 0.00867754 |
| SLC25A46 | solute carrier family 25, member 46 | 0.00866706 |
| SSX1 | synovial sarcoma, X breakpoint 1 | 0.00866174 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | 0.00864999 |
| LUM | lumican | 0.00849826 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.00845429 |
| ABHD3 | abhydrolase domain containing 3 | 0.00842302 |
| GCH1 | GTP cyclohydrolase 1 | 0.00835436 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00819197 |
| MAGEA4 | melanoma antigen family A4 | 0.00815317 |
| TSPO | translocator protein (18kDa) | 0.00810758 |
| ZWINT | ZW10 interacting kinetochore protein | 0.00810597 |
| SNX13 | sorting nexin 13 | 0.00805012 |
| CPE | carboxypeptidase E | 0.00804107 |
| ZNF267 | zinc finger protein 267 | 0.0079812 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.00796911 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00795382 |
| NIT1 | nitrilase 1 | 0.00792068 |
| ABAT | 4-aminobutyrate aminotransferase | 0.00791589 |
| NELL2 | NEL-like 2 (chicken) | 0.00787617 |
| XIC | X chromosome inactivation center | 0.00787299 |
| TMEM176A | transmembrane protein 176A | 0.00780714 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.0077814 |
| PERP | PERP, TP53 apoptosis effector | 0.0077779 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00774699 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.00773565 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.00757406 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.00756626 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00755112 |
| FAM13B | family with sequence similarity 13, member B | 0.00754955 |
| HK2 | hexokinase 2 | 0.00745416 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00742519 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | 0.00739781 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00736397 |
| TPD52L1 | tumor protein D52-like 1 | 0.0073581 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.00735105 |
| SMC2 | structural maintenance of chromosomes 2 | 0.00734559 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.00733706 |
| HEPH | hephaestin | 0.00732716 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.0073166 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | 0.0073014 |
| ANKRD12 | ankyrin repeat domain 12 | 0.00728473 |
| CREB1 | cAMP responsive element binding protein 1 | 0.0072573 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00725474 |
| SRPK2 | SRSF protein kinase 2 | 0.00723142 |
| ANXA4 | annexin A4 | 0.00721652 |
| TMEM45A | transmembrane protein 45A | 0.00720825 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00718625 |
| ZNF43 | zinc finger protein 43 | 0.00717918 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.00717163 |
| MINK1 | misshapen-like kinase 1 | 0.00713973 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | 0.00708754 |
| NFE2 | nuclear factor, erythroid 2 | 0.00707513 |
| AIM2 | absent in melanoma 2 | 0.00706589 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00706215 |
| AZF1 | azoospermia factor 1 | 0.0070392 |
| OLFM4 | olfactomedin 4 | 0.00702756 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.00702072 |
| PLXNC1 | plexin C1 | 0.0069969 |
| TPTE | transmembrane phosphatase with tensin homology | 0.00698248 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.00695855 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00692216 |
| GATA2 | GATA binding protein 2 | 0.00691026 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00690052 |
| DPP8 | dipeptidyl-peptidase 8 | 0.00686695 |
| RAB33A | RAB33A, member RAS oncogene family | 0.00686001 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.00684675 |
| PDCD10 | programmed cell death 10 | 0.0068368 |
| TMEM70 | transmembrane protein 70 | 0.00681484 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.00679551 |
| OLFM1 | olfactomedin 1 | 0.00678789 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | 0.00676517 |
| CUX1 | cut-like homeobox 1 | 0.0067465 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.00674261 |
| MBTPS1 | membrane-bound transcription factor peptidase, site 1 | 0.00672193 |
| RPS27L | ribosomal protein S27-like | 0.0067179 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.00670231 |
| MCM7 | minichromosome maintenance complex component 7 | 0.00670165 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.0066915 |
| HIC2 | hypermethylated in cancer 2 | 0.00667946 |
| MAPK6 | mitogen-activated protein kinase 6 | 0.00666601 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00665792 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.00665557 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.00665346 |
| DNM1L | dynamin 1-like | 0.00663881 |
| TDO2 | tryptophan 2,3-dioxygenase | 0.0066359 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.00662813 |
| SLBP | stem-loop binding protein | 0.00662798 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.00662497 |
| EDRF1 | erythroid differentiation regulatory factor 1 | 0.00661931 |
| SNAP23 | synaptosomal-associated protein, 23kDa | 0.00661807 |
| CHN2 | chimerin 2 | 0.00661571 |
| XK | X-linked Kx blood group | 0.00661013 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00660214 |
| MID1IP1 | MID1 interacting protein 1 | 0.00660188 |
| PRDX2 | peroxiredoxin 2 | 0.00658721 |
| PCP4 | Purkinje cell protein 4 | 0.00656452 |
| DOCK9 | dedicator of cytokinesis 9 | 0.00656274 |
| TENM1 | teneurin transmembrane protein 1 | 0.0065573 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.00655298 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | 0.00654931 |
| ELANE | elastase, neutrophil expressed | 0.00652581 |
| MOB4 | MOB family member 4, phocein | 0.00652581 |
| COMT | catechol-O-methyltransferase | 0.00651826 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | 0.00648908 |
| MYO1D | myosin ID | 0.00648234 |
| RRM2 | ribonucleotide reductase M2 | 0.00646795 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.00646659 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00646452 |
| BRD4 | bromodomain containing 4 | 0.006462 |
| MGAM | maltase-glucoamylase | 0.0064556 |
| PSMA2 | proteasome (prosome, macropain) subunit, alpha type, 2 | 0.00645483 |
| METTL7A | methyltransferase like 7A | 0.00643625 |
| POGLUT2 | protein O-glucosyltransferase 2 | 0.00640983 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00640772 |
| MICU2 | mitochondrial calcium uptake 2 | 0.00640456 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 0.00640196 |
| H2AX | H2A.X variant histone | 0.00639676 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.00637818 |
| CTSA | cathepsin A | 0.00636203 |
| CD46 | CD46 molecule, complement regulatory protein | 0.00635554 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.00634446 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00633673 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.0063269 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00632617 |
| PHTF2 | putative homeodomain transcription factor 2 | 0.00631987 |
| DSE | dermatan sulfate epimerase | 0.00631316 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.00630311 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.00629439 |
| COL15A1 | collagen, type XV, alpha 1 | 0.00624478 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.00623767 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.00623667 |
| ZNF91 | zinc finger protein 91 | 0.00623666 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0062332 |
| SCARB2 | scavenger receptor class B, member 2 | 0.00622069 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00621948 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.00621255 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | 0.00620102 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.006194 |
| BID | BH3 interacting domain death agonist | 0.00617568 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00615949 |
| TMEM165 | transmembrane protein 165 | 0.0061518 |
| INTS6 | integrator complex subunit 6 | 0.0061502 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00614658 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.00613104 |
| MAML1 | mastermind-like 1 (Drosophila) | 0.00612449 |
| IL32 | interleukin 32 | 0.00612109 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | 0.00611492 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | 0.00611088 |
| TBL2 | transducin (beta)-like 2 | 0.00610824 |
| CENPU | centromere protein U | 0.00610787 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00610104 |
| SNAI2 | snail family zinc finger 2 | 0.00609807 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00608685 |
| CPOX | coproporphyrinogen oxidase | 0.00608173 |
| DENND1B | DENN/MADD domain containing 1B | 0.00607835 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00607543 |
| SHTN1 | shootin 1 | 0.00606517 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.00606015 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | 0.00605082 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.00604357 |
| PRPF3 | pre-mRNA processing factor 3 | 0.00602619 |
| SOHLH2 | spermatogenesis and oogenesis specific basic helix-loop-helix 2 | 0.0060152 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00601029 |
| ANKRD27 | ankyrin repeat domain 27 (VPS9 domain) | 0.00599121 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 0.00599065 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.00597813 |
| ERI2 | ERI1 exoribonuclease family member 2 | 0.00597742 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00597012 |
| SLC43A3 | solute carrier family 43, member 3 | 0.00596957 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.0059587 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.00595793 |
| MPO | myeloperoxidase | 0.00595067 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00594363 |
| TASOR2 | transcription activation suppressor family member 2 | 0.00594036 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | 0.00593136 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00590446 |
| KIF2A | kinesin heavy chain member 2A | 0.00589459 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | 0.00588743 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.00587853 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00587426 |
| NCOA3 | nuclear receptor coactivator 3 | 0.00587054 |
| TMEM97 | transmembrane protein 97 | 0.00586711 |
| ZNF281 | zinc finger protein 281 | 0.00586086 |
| CCNC | cyclin C | 0.00584896 |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) | 0.00584541 |
| E2F8 | E2F transcription factor 8 | 0.00584446 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BAMBI | BMP and activin membrane-bound inhibitor | -0.0200124 |
| CCN2 | cellular communication network factor 2 | -0.0186432 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0153662 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.0152894 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0145834 |
| PRKCA | protein kinase C, alpha | -0.0143589 |
| RGS4 | regulator of G-protein signaling 4 | -0.0143401 |
| RCAN1 | regulator of calcineurin 1 | -0.0138582 |
| KRT7 | keratin 7, type II | -0.0138459 |
| MXRA7 | matrix-remodelling associated 7 | -0.0130458 |
| PODXL | podocalyxin-like | -0.0122759 |
| MIA | melanoma inhibitory activity | -0.0122276 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.0121453 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0118766 |
| THBS1 | thrombospondin 1 | -0.0117975 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.0115705 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0114556 |
| GPX3 | glutathione peroxidase 3 | -0.0113993 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.0113977 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.0113375 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0112084 |
| RAI14 | retinoic acid induced 14 | -0.0111511 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | -0.0111212 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.0109295 |
| TNNC1 | troponin C type 1 (slow) | -0.0108653 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.010841 |
| ZW10 | zw10 kinetochore protein | -0.0107738 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.0107088 |
| PLAT | plasminogen activator, tissue | -0.0106998 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0106753 |
| ANXA2P2 | annexin A2 pseudogene 2 | -0.0106687 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0104365 |
| FABP7 | fatty acid binding protein 7, brain | -0.0104321 |
| S100A10 | S100 calcium binding protein A10 | -0.0103882 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0103695 |
| TUBA1A | tubulin, alpha 1a | -0.0101244 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0101026 |
| ACLY | ATP citrate lyase | -0.01007 |
| NNMT | nicotinamide N-methyltransferase | -0.0100154 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00996567 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00995495 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00985587 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | -0.00984615 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.00984383 |
| FN1 | fibronectin 1 | -0.00982607 |
| MMP10 | matrix metallopeptidase 10 | -0.00982358 |
| TPM2 | tropomyosin 2 (beta) | -0.00966555 |
| ASRGL1 | asparaginase like 1 | -0.00964066 |
| KAT6A | K(lysine) acetyltransferase 6A | -0.00945113 |
| RGS2 | regulator of G-protein signaling 2 | -0.00944472 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.00937464 |
| NDRG4 | NDRG family member 4 | -0.00936354 |
| SIRT3 | sirtuin 3 | -0.00935776 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00931727 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00930997 |
| ECI2 | enoyl-CoA delta isomerase 2 | -0.00925845 |
| COG7 | component of oligomeric golgi complex 7 | -0.0091848 |
| CNN3 | calponin 3, acidic | -0.0091628 |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | -0.00913799 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00906774 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00905118 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | -0.00901463 |
| GPX1 | glutathione peroxidase 1 | -0.0089807 |
| TMEM100 | transmembrane protein 100 | -0.00895379 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00894541 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00891562 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.0088888 |
| SYNM | synemin, intermediate filament protein | -0.00888548 |
| VLDLR | very low density lipoprotein receptor | -0.0088806 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00885838 |
| AXL | AXL receptor tyrosine kinase | -0.00879937 |
| ABLIM1 | actin binding LIM protein 1 | -0.00876624 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | -0.00876436 |
| CYB561 | cytochrome b561 | -0.00875651 |
| PALLD | palladin, cytoskeletal associated protein | -0.00874399 |
| HOXA5 | homeobox A5 | -0.00872525 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00872516 |
| RXYLT1 | ribitol xylosyltransferase 1 | -0.00871595 |
| RAB4A | RAB4A, member RAS oncogene family | -0.0086643 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | -0.00866266 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.00864667 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.00858434 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.00855698 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00851513 |
| KRT81 | keratin 81, type II | -0.00843606 |
| BAALC | brain and acute leukemia, cytoplasmic | -0.00843021 |
| EPHB3 | EPH receptor B3 | -0.00840298 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | -0.00840264 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00837414 |
| FSTL1 | follistatin-like 1 | -0.00837003 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00835952 |
| EREG | epiregulin | -0.0082243 |
| ECM1 | extracellular matrix protein 1 | -0.00816831 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00816458 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.008132 |
| DCHS1 | dachsous cadherin-related 1 | -0.00812594 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | -0.0081164 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00809906 |
| SDC1 | syndecan 1 | -0.00809785 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00806873 |
| MALL | mal, T-cell differentiation protein-like | -0.00802987 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00802802 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00802775 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.00801733 |
| SMAD3 | SMAD family member 3 | -0.00795885 |
| HTRA1 | HtrA serine peptidase 1 | -0.00794042 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | -0.00791654 |
| CTSB | cathepsin B | -0.0079068 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00789057 |
| E2F2 | E2F transcription factor 2 | -0.00786555 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00786328 |
| LAPTM5 | lysosomal protein transmembrane 5 | -0.0078543 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | -0.00784301 |
| CRYAB | crystallin, alpha B | -0.00783179 |
| ABHD2 | abhydrolase domain containing 2 | -0.00782904 |
| JUN | jun proto-oncogene | -0.00782272 |
| SMAGP | small cell adhesion glycoprotein | -0.00781779 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | -0.00780882 |
| A2M | alpha-2-macroglobulin | -0.00780787 |
| TMEM131L | transmembrane 131 like | -0.0078067 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | -0.00780484 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00776989 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00773338 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.00772557 |
| CCNA2 | cyclin A2 | -0.00769855 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00769533 |
| RUNX1 | runt-related transcription factor 1 | -0.00769137 |
| DUSP4 | dual specificity phosphatase 4 | -0.00766694 |
| FAM171A1 | family with sequence similarity 171, member A1 | -0.00765683 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | -0.00762524 |
| CHRDL1 | chordin-like 1 | -0.00762117 |
| THBS4 | thrombospondin 4 | -0.00759883 |
| TAGLN2 | transgelin 2 | -0.00759278 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.00758753 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00755264 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -0.00754716 |
| TP53I3 | tumor protein p53 inducible protein 3 | -0.00754557 |
| ZNF451 | zinc finger protein 451 | -0.00746958 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | -0.0074654 |
| LAMB1 | laminin, beta 1 | -0.00746459 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -0.00746401 |
| RGCC | regulator of cell cycle | -0.00746272 |
| SMYD3 | SET and MYND domain containing 3 | -0.00742494 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -0.00740564 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | -0.00737519 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -0.00735825 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.00734787 |
| THBD | thrombomodulin | -0.00734637 |
| FBN2 | fibrillin 2 | -0.00730501 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00729898 |
| LOXL2 | lysyl oxidase-like 2 | -0.00729347 |
| TRIB2 | tribbles pseudokinase 2 | -0.00727329 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | -0.00725703 |
| SIX1 | SIX homeobox 1 | -0.00724022 |
| SEC14L2 | SEC14-like 2 (S. cerevisiae) | -0.00723508 |
| PLIN3 | perilipin 3 | -0.00721895 |
| RRAS | related RAS viral (r-ras) oncogene homolog | -0.0071923 |
| KLF6 | Kruppel-like factor 6 | -0.00719 |
| COPS7A | COP9 signalosome subunit 7A | -0.00717814 |
| SH3BGR | SH3 domain binding glutamate-rich protein | -0.00715714 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00713954 |
| PSAP | prosaposin | -0.00713624 |
| NEBL | nebulette | -0.00713423 |
| MSLN | mesothelin | -0.00712572 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00712152 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00711667 |
| TRIP10 | thyroid hormone receptor interactor 10 | -0.00711545 |
| RAB25 | RAB25, member RAS oncogene family | -0.00711036 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | -0.00710729 |
| RHCG | Rh family, C glycoprotein | -0.00709008 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00706582 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00706427 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00705962 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00703995 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.00701746 |
| APH1A | APH1A gamma secretase subunit | -0.00700428 |
| MGP | matrix Gla protein | -0.00699705 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | -0.00698666 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.00698169 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | -0.00696734 |
| PLK2 | polo-like kinase 2 | -0.00692743 |
| EPS8L2 | EPS8-like 2 | -0.00689926 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -0.00687164 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -0.00686344 |
| RPA2 | replication protein A2, 32kDa | -0.00685497 |
| YLPM1 | YLP motif containing 1 | -0.00685325 |
| GYPC | glycophorin C (Gerbich blood group) | -0.00683276 |
| PCTP | phosphatidylcholine transfer protein | -0.00682193 |
| COL4A1 | collagen, type IV, alpha 1 | -0.00681396 |
| FOSL1 | FOS-like antigen 1 | -0.00679361 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.00679193 |
| SIK1 | salt-inducible kinase 1 | -0.00679152 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00677403 |
| MSX1 | msh homeobox 1 | -0.00675572 |
| GSTA4 | glutathione S-transferase alpha 4 | -0.00674764 |
| FSCN1 | fascin actin-bundling protein 1 | -0.00672795 |
| SGPL1 | sphingosine-1-phosphate lyase 1 | -0.00672546 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | -0.00672429 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0067156 |
| CAST | calpastatin | -0.00670564 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.00670214 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00669754 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00669484 |
| PXDN | peroxidasin | -0.00668565 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00665422 |
| PRMT1 | protein arginine methyltransferase 1 | -0.00664006 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.006637 |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 | -0.00661985 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00661446 |
| CORO1A | coronin, actin binding protein, 1A | -0.00660795 |
| SFTPD | surfactant protein D | -0.00660129 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | -0.00660082 |
| CAPNS1 | calpain, small subunit 1 | -0.00659699 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.00659174 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00658692 |
| INHBA | inhibin, beta A | -0.00658468 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | -0.00657721 |
| COL1A1 | collagen, type I, alpha 1 | -0.00657062 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -0.00656593 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00656193 |
| COMP | cartilage oligomeric matrix protein | -0.00655233 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | -0.0065458 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0065335 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.00652735 |
| XYLT1 | xylosyltransferase I | -0.00652008 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | -0.00651873 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.00649607 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00649536 |
| XPO7 | exportin 7 | -0.00648633 |
| ACP6 | acid phosphatase 6, lysophosphatidic | -0.00648542 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.00646915 |
| TCTN2 | tectonic family member 2 | -0.00646175 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | -0.00645024 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | -0.00644973 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.0064497 |
| RAB5C | RAB5C, member RAS oncogene family | -0.00644494 |
| COCH | cochlin | -0.00644269 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.00643756 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.00643031 |
| GSDME | gasdermin E | -0.00642216 |
| H3F3B | H3 histone, family 3B (H3.3B) | -0.00641999 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00641265 |
| BAX | BCL2-associated X protein | -0.00640449 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.00640398 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.00640363 |
| OXTR | oxytocin receptor | -0.00640117 |
| NUTF2 | nuclear transport factor 2 | -0.00638789 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.00637271 |
| BLMH | bleomycin hydrolase | -0.00636292 |
| NIP7 | NIP7, nucleolar pre-rRNA processing protein | -0.00635607 |
