PIP4K2A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphatidylinositol-5-phosphate 4-kinase, type II, alpha|Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5305)
Similar Terms
Downloads & Tools

Genes

311 genes differentially expressed following the PIP4K2A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.555
HYAL4 hyaluronoglucosaminidase 4 2.555
OR10A3 olfactory receptor, family 10, subfamily A, member 3 2.555
GJB4 gap junction protein, beta 4, 30.3kDa 2.555
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.555
DSG3 desmoglein 3 2.555
EPHX4 epoxide hydrolase 4 2.555
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.555
TAS2R1 taste receptor, type 2, member 1 2.555
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.555
PGBDF plakoglobin binding and degradation factor 2.555
TM4SF4 transmembrane 4 L six family member 4 2.555
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.555
USP26 ubiquitin specific peptidase 26 2.555
IZUMO3 IZUMO family member 3 2.555
PLIN1 perilipin 1 2.555
TMEM176A transmembrane protein 176A 2.555
BTK Bruton agammaglobulinemia tyrosine kinase 2.555
PGAM4 phosphoglycerate mutase family member 4 2.555
PCDHB8 protocadherin beta 8 2.555
SLC35G5 solute carrier family 35, member G5 2.555
MYOM2 myomesin 2 2.555
FHL5 four and a half LIM domains 5 2.555
PFDN6 prefoldin subunit 6 2.555
TRIM42 tripartite motif containing 42 2.555
TMEM89 transmembrane protein 89 2.555
OC90 otoconin 90 2.555
GMNC geminin coiled-coil domain containing 2.555
S100A5 S100 calcium binding protein A5 2.555
TMEM121 transmembrane protein 121 2.555
TREML2 triggering receptor expressed on myeloid cells-like 2 2.555
THEMIS thymocyte selection associated 2.555
F2 coagulation factor II (thrombin) 2.555
DLX4 distal-less homeobox 4 2.555
GFI1 growth factor independent 1 transcription repressor 2.555
NRROS negative regulator of reactive oxygen species 2.555
SENP5 SUMO1/sentrin specific peptidase 5 2.555
ATF6 activating transcription factor 6 2.555
C1ORF141 chromosome 1 open reading frame 141 2.555
C1ORF146 chromosome 1 open reading frame 146 2.555
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.555
CD69 CD69 molecule 2.555
CPB1 carboxypeptidase B1 (tissue) 2.555
PRR22 proline rich 22 2.555
GJA4 gap junction protein, alpha 4, 37kDa 2.555
SAXO6 stabilizer of axonemal microtubules 6 2.555
H1-6 H1.6 linker histone, cluster member 2.555
CFAP251 cilia and flagella associated protein 251 2.555
ERVW-1 endogenous retrovirus group W, member 1 2.555
CES4A carboxylesterase 4A 2.555
MT4 metallothionein 4 2.555
CLDN16 claudin 16 2.555
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 2.555
FRG2C FSHD region gene 2 family, member C 2.555
SPATA22 spermatogenesis associated 22 2.555
VSIR V-set immunoregulatory receptor 2.555
MYL11 myosin light chain 11 2.555
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.555
DPEP2NB DPEP2 neighbor 2.555
ZNF593OS ZNF593 opposite strand 2.555
H2BC12L H2B clustered histone 12 like 2.555
MAJIN membrane anchored junction protein 2.555
H2BC3 H2B clustered histone 3 2.555
DYNLT4 dynein light chain Tctex-type 4 2.555
TBXT T-box transcription factor T 2.555
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.555
KAT6A K(lysine) acetyltransferase 6A 2.555
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.555
TFEC transcription factor EC 2.555
TLR1 toll-like receptor 1 2.555
TACSTD2 tumor-associated calcium signal transducer 2 2.555
TMCO2 transmembrane and coiled-coil domains 2 2.555
CBLN3 cerebellin 3 precursor 2.555
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.555
TRIM67 tripartite motif containing 67 2.555
MAGEB1 melanoma antigen family B1 2.555
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.555
GDF10 growth differentiation factor 10 2.555
PGC progastricsin (pepsinogen C) 2.555
ROPN1 rhophilin associated tail protein 1 2.555
BEST3 bestrophin 3 2.555
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing 2.555
FRK fyn-related Src family tyrosine kinase 2.555
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.555
BLNK B-cell linker 2.555
CAPN8 calpain 8 2.555
SASH3 SAM and SH3 domain containing 3 2.555
S100P S100 calcium binding protein P 2.555
TAS2R5 taste receptor, type 2, member 5 2.555
HES2 hes family bHLH transcription factor 2 2.555
TMEM182 transmembrane protein 182 2.555
ADORA3 adenosine A3 receptor 2.555
SPATA31A1 SPATA31 subfamily A, member 1 2.555
CDHR5 cadherin-related family member 5 2.555
TBC1D10C TBC1 domain family, member 10C 2.555
WFDC6 WAP four-disulfide core domain 6 2.555
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.555
PKDREJ polycystin (PKD) family receptor for egg jelly 2.555
HKDC1 hexokinase domain containing 1 2.555
BTNL3 butyrophilin-like 3 2.555
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.555
CRHBP corticotropin releasing hormone binding protein 2.555
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.555
CPZ carboxypeptidase Z 2.555
OR6X1 olfactory receptor, family 6, subfamily X, member 1 2.555
MORC1 MORC family CW-type zinc finger 1 2.555
APOD apolipoprotein D 2.555
VHLL von Hippel-Lindau tumor suppressor-like 2.555
OR51V1 olfactory receptor, family 51, subfamily V, member 1 2.555
BRD8 bromodomain containing 8 2.555
PCDHGA3 protocadherin gamma subfamily A, 3 2.555
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.555
BCL2L15 BCL2-like 15 2.555
DEFB136 defensin, beta 136 2.555
GPR149 G protein-coupled receptor 149 2.555
GPR142 G protein-coupled receptor 142 2.555
OTP orthopedia homeobox 2.555
CNGB1 cyclic nucleotide gated channel beta 1 2.555
C1ORF185 chromosome 1 open reading frame 185 2.555
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 2.555
IGLL1 immunoglobulin lambda-like polypeptide 1 2.555
OTOP2 otopetrin 2 2.555
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.555
DHH desert hedgehog 2.555
HOPX HOP homeobox 2.555
RNF225 ring finger protein 225 2.555
PATE4 prostate and testis expressed 4 2.555
SST somatostatin 2.555
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.555
ITGB6 integrin, beta 6 2.555
GLRB glycine receptor, beta 2.555
BCL2A1 BCL2-related protein A1 2.555
FITM1 fat storage-inducing transmembrane protein 1 2.555
IL17B interleukin 17B 2.555
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.555
TGM4 transglutaminase 4 2.555
MT1A metallothionein 1A 2.555
TGM3 transglutaminase 3 2.555
GLTPD2 glycolipid transfer protein domain containing 2 2.555
GRAPL GRB2-related adaptor protein-like 2.555
FGF19 fibroblast growth factor 19 2.555
VWC2L von Willebrand factor C domain containing protein 2-like 2.555
TMEM132C transmembrane protein 132C 2.555
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.555
C5AR2 complement component 5a receptor 2 2.555
TPRX1 tetra-peptide repeat homeobox 1 2.555
GREM1 gremlin 1, DAN family BMP antagonist 2.555
MAEL maelstrom spermatogenic transposon silencer 2.555
ASCL5 achaete-scute family bHLH transcription factor 5 2.555
R3HDML R3H domain containing-like 2.555
SHB Src homology 2 domain containing adaptor protein B 2.54564
SENP1 SUMO1/sentrin specific peptidase 1 2.54471
CCDC88B coiled-coil domain containing 88B 2.48722
USP34 ubiquitin specific peptidase 34 2.47502
TLDC2 TBC/LysM-associated domain containing 2 2.47386
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.47386
ACP2 acid phosphatase 2, lysosomal 2.45651
VTI1B vesicle transport through interaction with t-SNAREs 1B 2.45651
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 2.44741
GPR137C G protein-coupled receptor 137C 2.43371
DBNL drebrin-like 2.37742
POU3F2 POU class 3 homeobox 2 2.37742
CCNB1 cyclin B1 2.35539
ERG28 ergosterol biosynthesis 28 homolog 2.34513
CHSY1 chondroitin sulfate synthase 1 2.34409
MPZL1 myelin protein zero-like 1 2.33364
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 2.27667
WLS wntless Wnt ligand secretion mediator 2.27275
ATL2 atlastin GTPase 2 2.27275
LOC124903233 uncharacterized LOC124903233 2.27275
PDE5A phosphodiesterase 5A, cGMP-specific 2.27224
PAX7 paired box 7 2.27224
NPIPB8 nuclear pore complex interacting protein family, member B8 2.27224
ZNF623 zinc finger protein 623 2.26155
C9 complement component 9 2.25984
XPO7 exportin 7 2.24181
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.21398
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 2.20897
FBXO27 F-box protein 27 2.19972
S1PR5 sphingosine-1-phosphate receptor 5 2.1972
MAML2 mastermind-like 2 (Drosophila) 2.17319
RSPRY1 ring finger and SPRY domain containing 1 2.16449
SLAIN1 SLAIN motif family, member 1 2.16108
ZRANB1 zinc finger, RAN-binding domain containing 1 2.15953
B9D1 B9 protein domain 1 2.14572
IQUB IQ motif and ubiquitin domain containing 2.13466
STEAP1B STEAP family member 1B 2.13349
PRR15 proline rich 15 2.11352
LIPG lipase, endothelial 2.09192
PKN2 protein kinase N2 2.0725
CBR4 carbonyl reductase 4 2.07003
LARP1B La ribonucleoprotein domain family, member 1B 2.06047
TFCP2 transcription factor CP2 2.05804
LRTM1 leucine-rich repeats and transmembrane domains 1 2.04228
IGSF6 immunoglobulin superfamily, member 6 2.03758
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 2.03707
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 2.02927
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 2.02927
CRNKL1 crooked neck pre-mRNA splicing factor 1 2.02819
CPXM1 carboxypeptidase X (M14 family), member 1 2.02819
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.00854
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.00853
PTGES3L prostaglandin E synthase 3 (cytosolic)-like 2.00474
PHRF1 PHD and ring finger domains 1 2.00474
FGF13 fibroblast growth factor 13 2.00474

decreased expression

Symbol Name Standardized Value
CLEC20A C-type lectin domain containing 20A -2.555
AKAP6 A kinase (PRKA) anchor protein 6 -2.555
ARV1 ARV1 homolog (S. cerevisiae) -2.555
NANOS3 nanos homolog 3 (Drosophila) -2.555
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.555
CCPG1 cell cycle progression 1 -2.555
OSGIN1 oxidative stress induced growth inhibitor 1 -2.555
UPB1 ureidopropionase, beta -2.555
PAX9 paired box 9 -2.555
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -2.555
C11ORF87 chromosome 11 open reading frame 87 -2.555
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.555
DPPA3 developmental pluripotency associated 3 -2.555
HEPHL1 hephaestin-like 1 -2.555
LOC390937 Ets2 repressor factor-like -2.555
ACRBP acrosin binding protein -2.555
TMEM221 transmembrane protein 221 -2.555
HBA2 hemoglobin, alpha 2 -2.555
KRTDAP keratinocyte differentiation-associated protein -2.555
WDR31 WD repeat domain 31 -2.555
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -2.555
CFAP65 cilia and flagella associated protein 65 -2.555
ZAR1 zygote arrest 1 -2.555
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.555
ALX4 ALX homeobox 4 -2.555
ALX1 ALX homeobox 1 -2.555
AHNAK2 AHNAK nucleoprotein 2 -2.555
HNF1B HNF1 homeobox B -2.555
LTB lymphotoxin beta (TNF superfamily, member 3) -2.555
MIA melanoma inhibitory activity -2.555
SLC45A2 solute carrier family 45, member 2 -2.555
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.555
HAPLN2 hyaluronan and proteoglycan link protein 2 -2.555
EDAR ectodysplasin A receptor -2.555
PYDC1 PYD (pyrin domain) containing 1 -2.555
IRF4 interferon regulatory factor 4 -2.555
GRM2 glutamate receptor, metabotropic 2 -2.555
NFE2 nuclear factor, erythroid 2 -2.555
KRT15 keratin 15, type I -2.555
ADCY4 adenylate cyclase 4 -2.555
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -2.555
NGF nerve growth factor (beta polypeptide) -2.555
CCDC159 coiled-coil domain containing 159 -2.555
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.555
SRRM1 serine/arginine repetitive matrix 1 -2.555
RNF112 ring finger protein 112 -2.555
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.555
SPMIP1 sperm microtubule inner protein 1 -2.555
EMP1 epithelial membrane protein 1 -2.555
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -2.555
ZCCHC12 zinc finger, CCHC domain containing 12 -2.555
CALR3 calreticulin 3 -2.555
SH3YL1 SH3 and SYLF domain containing 1 -2.555
LAMB3 laminin, beta 3 -2.555
LRRC26 leucine rich repeat containing 26 -2.555
KLHDC1 kelch domain containing 1 -2.555
NLRP6 NLR family, pyrin domain containing 6 -2.555
NRGN neurogranin (protein kinase C substrate, RC3) -2.555
PITX3 paired-like homeodomain 3 -2.555
MMP10 matrix metallopeptidase 10 -2.555
DAZAP2 DAZ associated protein 2 -2.54516
SCGB2B2 secretoglobin, family 2B, member 2 -2.517
ZNF335 zinc finger protein 335 -2.51382
CFAP45 cilia and flagella associated protein 45 -2.50056
FCRLB Fc receptor-like B -2.50056
DUSP7 dual specificity phosphatase 7 -2.45651
HRAS Harvey rat sarcoma viral oncogene homolog -2.44882
PLEC plectin -2.36946
C19ORF38 chromosome 19 open reading frame 38 -2.36699
CLEC4A C-type lectin domain family 4, member A -2.36699
GHRHR growth hormone releasing hormone receptor -2.36699
FMO5 flavin containing monooxygenase 5 -2.36089
EDNRA endothelin receptor type A -2.34513
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.34513
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.34108
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.30057
MYL5 myosin, light chain 5, regulatory -2.30057
TTC26 tetratricopeptide repeat domain 26 -2.29884
DERA deoxyribose-phosphate aldolase (putative) -2.27275
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -2.25069
RBBP7 retinoblastoma binding protein 7 -2.24181
TMOD2 tropomodulin 2 (neuronal) -2.23719
C5ORF22 chromosome 5 open reading frame 22 -2.23043
DHODH dihydroorotate dehydrogenase (quinone) -2.22454
TMEM11 transmembrane protein 11 -2.21893
CRLF3 cytokine receptor-like factor 3 -2.21726
H3-3A H3.3 histone A -2.21398
GLYCTK glycerate kinase -2.21398
CCDC85C coiled-coil domain containing 85C -2.17843
ING4 inhibitor of growth family, member 4 -2.15114
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -2.12325
SMYD2 SET and MYND domain containing 2 -2.12191
FBLN7 fibulin 7 -2.09863
DSC2 desmocollin 2 -2.09564
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.09192
DCDC2B doublecortin domain containing 2B -2.08844
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -2.07767
C1QL1 complement component 1, q subcomponent-like 1 -2.06917
SEPTIN8 septin 8 -2.04592
HASPIN histone H3 associated protein kinase -2.04118
DUSP2 dual specificity phosphatase 2 -2.03707
DPP8 dipeptidyl-peptidase 8 -2.02927
VEGFC vascular endothelial growth factor C -2.02927
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -2.02921
SOX13 SRY (sex determining region Y)-box 13 -2.01315
CPE carboxypeptidase E -2.00853