PK1 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000307
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Genes

359 gene knockdowns changing fitness of PK1 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
VRK2 vaccinia related kinase 2 11.0546
C1ORF112 chromosome 1 open reading frame 112 8.24106
ZNF444 zinc finger protein 444 7.44079
ZNF233 zinc finger protein 233 6.01767
IL1RN interleukin 1 receptor antagonist 5.77362
DAPL1 death associated protein-like 1 5.74636
HPCAL4 hippocalcin like 4 5.70939
MMRN2 multimerin 2 5.68614
IRF2 interferon regulatory factor 2 5.59691
FIGNL1 fidgetin-like 1 5.46401
LRRC8B leucine rich repeat containing 8 family, member B 5.33787
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) 5.2814
CRYBB1 crystallin, beta B1 5.27653
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 5.24428
CKAP2L cytoskeleton associated protein 2-like 5.13988
EMX1 empty spiracles homeobox 1 4.9452
ZNF280B zinc finger protein 280B 4.81984
C1ORF216 chromosome 1 open reading frame 216 4.79982
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 4.66727
SPTBN4 spectrin, beta, non-erythrocytic 4 4.61974
ZNF488 zinc finger protein 488 4.61816
PNLIP pancreatic lipase 4.57296
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 4.44277
XPO4 exportin 4 4.40729
TTC36 tetratricopeptide repeat domain 36 4.32896
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 4.29546
TMEM61 transmembrane protein 61 4.28573
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 4.24508
MGAM maltase-glucoamylase 4.19673
LYG2 lysozyme G-like 2 4.17676
FAM19A4 family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 4.15916
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 4.1556
KLHL31 kelch-like family member 31 4.14609
PCED1A PC-esterase domain containing 1A 4.13852
PCDHGA9 protocadherin gamma subfamily A, 9 4.10601
EDF1 endothelial differentiation-related factor 1 4.10072
CAPRIN1 cell cycle associated protein 1 4.04302
CD40 CD40 molecule, TNF receptor superfamily member 5 4.00104
TMC4 transmembrane channel-like 4 3.98955
RIN2 Ras and Rab interactor 2 3.95152
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 3.92159
PGPEP1L pyroglutamyl-peptidase I-like 3.90037
PPP1R35 protein phosphatase 1, regulatory subunit 35 3.88584
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 3.86178
LTA lymphotoxin alpha 3.83017
USP6NL USP6 N-terminal like 3.81717
FAM110B family with sequence similarity 110, member B 3.80027
FAM89A family with sequence similarity 89, member A 3.79449
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 3.76898
RLF rearranged L-myc fusion 3.74037
ZDHHC11 zinc finger, DHHC-type containing 11 3.7075
GRHL2 grainyhead-like 2 (Drosophila) 3.69694
KIFC2 kinesin family member C2 3.69268
AGBL2 ATP/GTP binding protein-like 2 3.64359
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase 3.63176
CD163L1 CD163 molecule-like 1 3.62608
TP63 tumor protein p63 3.59427
PPAPDC3 phosphatidic acid phosphatase type 2 domain containing 3 3.59351
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 3.56994
FABP12 fatty acid binding protein 12 3.47682
MICALL1 MICAL-like 1 3.47459
ERBB3 erb-b2 receptor tyrosine kinase 3 3.46252
PSKH2 protein serine kinase H2 3.45279
CELF4 CUGBP, Elav-like family member 4 3.43588
FAM109B family with sequence similarity 109, member B 3.40833
AURKC aurora kinase C 3.40019
PCDH12 protocadherin 12 3.38342
SMAD3 SMAD family member 3 3.35571
RAI1 retinoic acid induced 1 3.3214
MPHOSPH8 M-phase phosphoprotein 8 3.31547
TMEM132D transmembrane protein 132D 3.28638
CATIP ciliogenesis associated TTC17 interacting protein 3.2799
HORMAD1 HORMA domain containing 1 3.27698
PTP4A2 protein tyrosine phosphatase type IVA, member 2 3.26734
ZDHHC20 zinc finger, DHHC-type containing 20 3.2663
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.26297
PAX6 paired box 6 3.25979
GSC2 goosecoid homeobox 2 3.24841
TTYH2 tweety family member 2 3.23581
FYN FYN proto-oncogene, Src family tyrosine kinase 3.23245
OR4C11 olfactory receptor, family 4, subfamily C, member 11 3.21105
ASCC2 activating signal cointegrator 1 complex subunit 2 3.19066
PEX11A peroxisomal biogenesis factor 11 alpha 3.18949
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 3.18734
FIBIN fin bud initiation factor homolog (zebrafish) 3.18507
SLC16A12 solute carrier family 16, member 12 3.1791
CABP2 calcium binding protein 2 3.16138
CARTPT CART prepropeptide 3.14346
CAMSAP1 calmodulin regulated spectrin-associated protein 1 3.1261
MAST4 microtubule associated serine/threonine kinase family member 4 3.12048
TRIT1 tRNA isopentenyltransferase 1 3.11854
EDC3 enhancer of mRNA decapping 3 3.11706
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 3.1125
UGDH UDP-glucose 6-dehydrogenase 3.08422
ACR acrosin 3.06484
SMYD5 SMYD family member 5 3.06195
HOXC12 homeobox C12 3.05022
OR5B12 olfactory receptor, family 5, subfamily B, member 12 3.03497
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 3.03321
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 3.0289
RWDD2B RWD domain containing 2B 3.01442
LCMT2 leucine carboxyl methyltransferase 2 2.99103
BEND4 BEN domain containing 4 2.97568
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.97248
VTA1 vesicle (multivesicular body) trafficking 1 2.9693
ANKRD34A ankyrin repeat domain 34A 2.9664
HBS1L HBS1-like translational GTPase 2.96277
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.95737
F3 coagulation factor III (thromboplastin, tissue factor) 2.95704
IDI2 isopentenyl-diphosphate delta isomerase 2 2.95285
FOXB1 forkhead box B1 2.9505
ANKRD16 ankyrin repeat domain 16 2.925
ZNF606 zinc finger protein 606 2.92492
KLHL14 kelch-like family member 14 2.91553
RLN3 relaxin 3 2.91536
SGMS1 sphingomyelin synthase 1 2.90272
RPRML reprimo-like 2.8963
SCN4A sodium channel, voltage gated, type IV alpha subunit 2.887
CCDC81 coiled-coil domain containing 81 2.85153
ZNF578 zinc finger protein 578 2.84517
TM2D1 TM2 domain containing 1 2.83297
ASCC1 activating signal cointegrator 1 complex subunit 1 2.82399
HOMER2 homer scaffolding protein 2 2.815
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.81405
MYL7 myosin, light chain 7, regulatory 2.80809
KLK15 kallikrein-related peptidase 15 2.80713
FOXE3 forkhead box E3 2.79784
TREM1 triggering receptor expressed on myeloid cells 1 2.78826
JAKMIP2 janus kinase and microtubule interacting protein 2 2.78551
B3GAT3 beta-1,3-glucuronyltransferase 3 2.78486
KLHDC8A kelch domain containing 8A 2.77557
TENM1 teneurin transmembrane protein 1 2.77349
HMG20A high mobility group 20A 2.77293
SSR1 signal sequence receptor, alpha 2.76956
NEUROD2 neuronal differentiation 2 2.76613
PTCHD4 patched domain containing 4 2.74199
CGGBP1 CGG triplet repeat binding protein 1 2.73889
TPPP2 tubulin polymerization-promoting protein family member 2 2.73687
FAM193A family with sequence similarity 193, member A 2.7365
KIAA1109 KIAA1109 2.73357
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 2.72687
NPFF neuropeptide FF-amide peptide precursor 2.72245
CRABP2 cellular retinoic acid binding protein 2 2.71387
CDK20 cyclin-dependent kinase 20 2.71152
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.70766
DLL4 delta-like 4 (Drosophila) 2.70658
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.70532
C14ORF93 chromosome 14 open reading frame 93 2.69653
SHROOM4 shroom family member 4 2.69186
ARHGAP23 Rho GTPase activating protein 23 2.69158
MMP26 matrix metallopeptidase 26 2.69092
TEP1 telomerase-associated protein 1 2.68754
STYXL2 serine/threonine/tyrosine interacting like 2 2.68653
NSD1 nuclear receptor binding SET domain protein 1 2.68413
ZBTB5 zinc finger and BTB domain containing 5 2.68192
OR52M1 olfactory receptor, family 52, subfamily M, member 1 2.67598
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.67519
NECAP1 NECAP endocytosis associated 1 2.67343
A4GALT alpha 1,4-galactosyltransferase 2.6694
RSPO2 R-spondin 2 2.66692
LAP3 leucine aminopeptidase 3 2.66368
COMMD8 COMM domain containing 8 2.65637
ERBB2 erb-b2 receptor tyrosine kinase 2 2.65452
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 2.63707
RANBP10 RAN binding protein 10 2.6354
CEP43 centrosomal protein 43 2.6233
ZNF575 zinc finger protein 575 2.61571
DOCK5 dedicator of cytokinesis 5 2.61174
FSTL5 follistatin-like 5 2.59946
GPR37L1 G protein-coupled receptor 37 like 1 2.59801
CNTN2 contactin 2 (axonal) 2.59733
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.58756
CNOT10 CCR4-NOT transcription complex, subunit 10 2.58216
KIF1B kinesin family member 1B 2.57542
RASAL1 RAS protein activator like 1 (GAP1 like) 2.57531
TRIM28 tripartite motif containing 28 2.57283
SDK1 sidekick cell adhesion molecule 1 2.56173
MCTS1 malignant T cell amplified sequence 1 2.55711
PROP1 PROP paired-like homeobox 1 2.5557
MYPOP Myb-related transcription factor, partner of profilin 2.5517
VAMP3 vesicle-associated membrane protein 3 2.54715
SFRP5 secreted frizzled-related protein 5 2.54609
IL37 interleukin 37 2.54578
OR1K1 olfactory receptor, family 1, subfamily K, member 1 2.54112
RILPL2 Rab interacting lysosomal protein-like 2 2.53517
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 2.52541
RBP3 retinol binding protein 3, interstitial 2.51903
SHOX2 short stature homeobox 2 2.51413
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.51347
RNH1 ribonuclease/angiogenin inhibitor 1 2.51317
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.50947
FLNB filamin B, beta 2.50932
UNC5B unc-5 homolog B (C. elegans) 2.49949
LRP5 low density lipoprotein receptor-related protein 5 2.49702
OR7D4 olfactory receptor, family 7, subfamily D, member 4 2.49546
RAB14 RAB14, member RAS oncogene family 2.49272
MAGEF1 melanoma antigen family F1 2.48861
CDCA3 cell division cycle associated 3 2.48312
ZNF470 zinc finger protein 470 2.47417
TM2D3 TM2 domain containing 3 2.47186
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 2.46925
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 2.4641
CEP44 centrosomal protein 44kDa 2.45888
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.45671
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.45464
C1ORF233 chromosome 1 open reading frame 233 2.45324
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 2.44846
REEP1 receptor accessory protein 1 2.44749
LZTS3 leucine zipper, putative tumor suppressor family member 3 2.44686
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.42739
MAVS mitochondrial antiviral signaling protein 2.42678
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.42595
METRN meteorin, glial cell differentiation regulator 2.42228
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.41758
EREG epiregulin 2.4121
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.40836
KIF22 kinesin family member 22 2.40209
OR4C12 olfactory receptor, family 4, subfamily C, member 12 2.39986
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.39886
RNF103 ring finger protein 103 2.39354
CARD9 caspase recruitment domain family, member 9 2.38825
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2.38659
APOLD1 apolipoprotein L domain containing 1 2.38364
OTX1 orthodenticle homeobox 1 2.38057
PGLS 6-phosphogluconolactonase 2.36695
SNX21 sorting nexin family member 21 2.36619
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.36553
ENTR1 endosome associated trafficking regulator 1 2.36351
FGF8 fibroblast growth factor 8 (androgen-induced) 2.36209
TRIP10 thyroid hormone receptor interactor 10 2.35527
DAXX death-domain associated protein 2.3548
MYOM3 myomesin 3 2.35047
PGM3 phosphoglucomutase 3 2.34498
OTUD1 OTU deubiquitinase 1 2.34444
E2F1 E2F transcription factor 1 2.32929
CCDC22 coiled-coil domain containing 22 2.32628
TMEM132E transmembrane protein 132E 2.31448
TFCP2L1 transcription factor CP2-like 1 2.31306
HDDC3 HD domain containing 3 2.31067
TYR tyrosinase 2.30705
GIGYF2 GRB10 interacting GYF protein 2 2.30565
WFDC8 WAP four-disulfide core domain 8 2.30522
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 2.30258
LRTM1 leucine-rich repeats and transmembrane domains 1 2.29506
ATXN7L2 ataxin 7-like 2 2.29505
CEP85 centrosomal protein 85kDa 2.29202
HDGFL2 HDGF like 2 2.29102
NOSTRIN nitric oxide synthase trafficking 2.28598
FAM229A family with sequence similarity 229, member A 2.2859
STXBP1 syntaxin binding protein 1 2.27915
STYK1 serine/threonine/tyrosine kinase 1 2.27608
C2ORF80 chromosome 2 open reading frame 80 2.27466
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.27461
LHX5 LIM homeobox 5 2.27315
CXCL2 chemokine (C-X-C motif) ligand 2 2.27168
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.2681
GBP2 guanylate binding protein 2, interferon-inducible 2.26756
HTT huntingtin 2.26729
GSDME gasdermin E 2.26715
LTBP2 latent transforming growth factor beta binding protein 2 2.26272
CCDC88B coiled-coil domain containing 88B 2.2575
C11ORF91 chromosome 11 open reading frame 91 2.25476
CDCP2 CUB domain containing protein 2 2.24743
SBK2 SH3 domain binding kinase family, member 2 2.22839
TTC5 tetratricopeptide repeat domain 5 2.22755
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.22749
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.22211
MUC16 mucin 16, cell surface associated 2.2211
ANXA2R annexin A2 receptor 2.2202
TPRA1 transmembrane protein, adipocyte asscociated 1 2.21399
ZNF714 zinc finger protein 714 2.21318
SEC31B SEC31 homolog B (S. cerevisiae) 2.21253
GPR148 G protein-coupled receptor 148 2.21064
IQCF6 IQ motif containing F6 2.21051
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 2.20771
GAL3ST4 galactose-3-O-sulfotransferase 4 2.20643
ZBTB4 zinc finger and BTB domain containing 4 2.19982
RABIF RAB interacting factor 2.19834
ITGB6 integrin, beta 6 2.19566
RNF121 ring finger protein 121 2.19199
GFRA1 GDNF family receptor alpha 1 2.184
CBLN4 cerebellin 4 precursor 2.18317
SP1 Sp1 transcription factor 2.18163
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 2.17767
RRAGC Ras-related GTP binding C 2.16995
CCDC69 coiled-coil domain containing 69 2.16932
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.16604
TM2D2 TM2 domain containing 2 2.16293
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 2.15807
CXCR4 chemokine (C-X-C motif) receptor 4 2.1475
NCR2 natural cytotoxicity triggering receptor 2 2.14727
CEPT1 choline/ethanolamine phosphotransferase 1 2.1464
PTGIS prostaglandin I2 (prostacyclin) synthase 2.14587
CRLF1 cytokine receptor-like factor 1 2.14532
EFS embryonal Fyn-associated substrate 2.14477
GLTP glycolipid transfer protein 2.14223
EIPR1 EARP complex and GARP complex interacting protein 1 2.14075
PPP5C protein phosphatase 5, catalytic subunit 2.13076
CLCF1 cardiotrophin-like cytokine factor 1 2.12927
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.12765
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 2.12653
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.12209
HEBP1 heme binding protein 1 2.11851
AP5B1 adaptor-related protein complex 5, beta 1 subunit 2.11204
WNT11 wingless-type MMTV integration site family, member 11 2.10861
C19ORF44 chromosome 19 open reading frame 44 2.108
TESPA1 thymocyte expressed, positive selection associated 1 2.1077
ACAA2 acetyl-CoA acyltransferase 2 2.10069
WIZ widely interspaced zinc finger motifs 2.09375
TMEM208 transmembrane protein 208 2.09324
STRIP1 striatin interacting protein 1 2.09284
SLC30A10 solute carrier family 30, member 10 2.09195
LAMC3 laminin, gamma 3 2.08808
SCP2 sterol carrier protein 2 2.0879
ERI3 ERI1 exoribonuclease family member 3 2.0863
POC1A POC1 centriolar protein A 2.08527
PTTG2 pituitary tumor-transforming 2 2.08395
PRMT6 protein arginine methyltransferase 6 2.08238
CACUL1 CDK2-associated, cullin domain 1 2.08133
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.0789
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 2.07764
BRSK2 BR serine/threonine kinase 2 2.07739
TRAF3 TNF receptor-associated factor 3 2.07543
FAM170B family with sequence similarity 170, member B 2.07309
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.07238
ITGA10 integrin, alpha 10 2.06753
RASA3 RAS p21 protein activator 3 2.0655
FLAD1 flavin adenine dinucleotide synthetase 1 2.06498
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.0646
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.064
MTMR8 myotubularin related protein 8 2.06362
A1BG alpha-1-B glycoprotein 2.06224
UXS1 UDP-glucuronate decarboxylase 1 2.06168
OR7C2 olfactory receptor, family 7, subfamily C, member 2 2.05953
ACTG2 actin, gamma 2, smooth muscle, enteric 2.05871
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 2.05762
L3MBTL2 l(3)mbt-like 2 (Drosophila) 2.05609
C8ORF74 chromosome 8 open reading frame 74 2.05598
RBBP8NL RBBP8 N-terminal like 2.05141
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.05043
KRT4 keratin 4, type II 2.04961
KRTAP19-3 keratin associated protein 19-3 2.04744
PSD4 pleckstrin and Sec7 domain containing 4 2.0463
TM9SF1 transmembrane 9 superfamily member 1 2.04317
ATF3 activating transcription factor 3 2.03631
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.03075
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.02969
NUP37 nucleoporin 37kDa 2.02739
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 2.02651
CTRB2 chymotrypsinogen B2 2.02626
FBXO28 F-box protein 28 2.02179
RPIA ribose 5-phosphate isomerase A 2.01967
CTC1 CTS telomere maintenance complex component 1 2.01874
SH2D7 SH2 domain containing 7 2.01541
ARHGAP44 Rho GTPase activating protein 44 2.01362
MAEA macrophage erythroblast attacher 2.00794
NUSAP1 nucleolar and spindle associated protein 1 2.00385
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2.00204
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2.00169