PK45H Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Pancreatic Adenocarcinoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-000468
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Genes

284 gene knockdowns changing fitness of PK45H relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
OTULIN OTU deubiquitinase with linear linkage specificity 8.179
EDAR ectodysplasin A receptor 7.24722
CRYBB1 crystallin, beta B1 6.02468
FRMD4A FERM domain containing 4A 6.00581
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 5.86122
AXL AXL receptor tyrosine kinase 5.75251
ATP2A3 ATPase, Ca++ transporting, ubiquitous 5.68244
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 5.39598
TRIO trio Rho guanine nucleotide exchange factor 5.37246
KRT4 keratin 4, type II 5.22614
INHA inhibin, alpha 5.1677
GPR150 G protein-coupled receptor 150 5.02977
SP5 Sp5 transcription factor 4.93995
ANKRD33 ankyrin repeat domain 33 4.92271
FNDC3B fibronectin type III domain containing 3B 4.90149
BHMT2 betaine--homocysteine S-methyltransferase 2 4.79878
FREM2 FRAS1 related extracellular matrix protein 2 4.70262
STON2 stonin 2 4.65034
PSD pleckstrin and Sec7 domain containing 4.64863
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 4.60243
CCDC184 coiled-coil domain containing 184 4.59429
TNRC6C trinucleotide repeat containing 6C 4.59042
IKZF4 IKAROS family zinc finger 4 (Eos) 4.48822
KCNT1 potassium channel, sodium activated subfamily T, member 1 4.4797
CCM2L cerebral cavernous malformation 2-like 4.43929
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 4.30916
FMNL3 formin-like 3 4.29316
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 4.27163
TM4SF4 transmembrane 4 L six family member 4 4.2696
PDE8B phosphodiesterase 8B 4.20013
TULP4 tubby like protein 4 4.18979
ADCY8 adenylate cyclase 8 (brain) 4.18574
TASOR2 transcription activation suppressor family member 2 4.02589
TPPP tubulin polymerization promoting protein 4.02233
BBS1 Bardet-Biedl syndrome 1 3.99951
AQP6 aquaporin 6, kidney specific 3.97818
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 3.95473
HOXD11 homeobox D11 3.93797
PARD6A par-6 family cell polarity regulator alpha 3.9262
RAB39B RAB39B, member RAS oncogene family 3.92167
KRT77 keratin 77, type II 3.87477
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 3.87106
GPRIN2 G protein regulated inducer of neurite outgrowth 2 3.86847
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 3.85301
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 3.77629
DGKZ diacylglycerol kinase, zeta 3.749
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.74389
NR2F6 nuclear receptor subfamily 2, group F, member 6 3.62673
PELI3 pellino E3 ubiquitin protein ligase family member 3 3.59193
DNAH5 dynein, axonemal, heavy chain 5 3.58393
HECA headcase homolog (Drosophila) 3.57185
SSBP4 single stranded DNA binding protein 4 3.56972
RPL3L ribosomal protein L3-like 3.54805
DOCK5 dedicator of cytokinesis 5 3.51386
NAP1L2 nucleosome assembly protein 1-like 2 3.51127
CD44 CD44 molecule (Indian blood group) 3.49312
CD248 CD248 molecule, endosialin 3.49287
POSTN periostin, osteoblast specific factor 3.47338
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.45039
ATG3 autophagy related 3 3.44344
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.43147
TNS3 tensin 3 3.4259
OR6C2 olfactory receptor, family 6, subfamily C, member 2 3.42446
TMEM251 transmembrane protein 251 3.40002
MELK maternal embryonic leucine zipper kinase 3.3684
AKAP7 A kinase (PRKA) anchor protein 7 3.36569
DLG5 discs, large homolog 5 (Drosophila) 3.3622
MOB3C MOB kinase activator 3C 3.36076
ZNF12 zinc finger protein 12 3.34753
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.34407
RNF17 ring finger protein 17 3.33679
KIFC3 kinesin family member C3 3.33449
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 3.31081
NGF nerve growth factor (beta polypeptide) 3.31046
PDE4C phosphodiesterase 4C, cAMP-specific 3.30465
HOMER3 homer scaffolding protein 3 3.29917
C6ORF15 chromosome 6 open reading frame 15 3.29138
IP6K3 inositol hexakisphosphate kinase 3 3.27997
CRK v-crk avian sarcoma virus CT10 oncogene homolog 3.26496
SH2D3C SH2 domain containing 3C 3.20133
UHRF1BP1 UHRF1 binding protein 1 3.18716
FAIM2 Fas apoptotic inhibitory molecule 2 3.1589
PSD4 pleckstrin and Sec7 domain containing 4 3.14678
BRICD5 BRICHOS domain containing 5 3.14584
CAPN2 calpain 2, (m/II) large subunit 3.11355
LIMK1 LIM domain kinase 1 3.10706
HOXA9 homeobox A9 3.10427
CPNE5 copine V 3.10239
KRT86 keratin 86, type II 3.10099
ZNF532 zinc finger protein 532 3.08668
KIF21B kinesin family member 21B 3.06925
SPTBN4 spectrin, beta, non-erythrocytic 4 3.06668
PRSS35 protease, serine, 35 3.03611
NT5DC2 5'-nucleotidase domain containing 2 3.03155
TAPBPL TAP binding protein-like 3.00684
ARL5C ADP-ribosylation factor-like 5C 2.99395
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 2.97887
KRT79 keratin 79, type II 2.97345
ASIC1 acid sensing (proton gated) ion channel 1 2.96727
MARK3 MAP/microtubule affinity-regulating kinase 3 2.95736
ZDHHC11 zinc finger, DHHC-type containing 11 2.95635
ZBTB39 zinc finger and BTB domain containing 39 2.94191
FOXI2 forkhead box I2 2.94163
CRYGN crystallin, gamma N 2.93644
DNAH10 dynein, axonemal, heavy chain 10 2.9303
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 2.92744
VIPR2 vasoactive intestinal peptide receptor 2 2.91999
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.89668
SAMD14 sterile alpha motif domain containing 14 2.89122
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 2.88465
HOXC6 homeobox C6 2.88008
C1QTNF4 C1q and tumor necrosis factor related protein 4 2.87784
LUZP2 leucine zipper protein 2 2.87131
TBC1D24 TBC1 domain family, member 24 2.86513
AMDHD1 amidohydrolase domain containing 1 2.86507
STX11 syntaxin 11 2.85479
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.85345
SLITRK2 SLIT and NTRK-like family, member 2 2.85294
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 2.8515
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.85012
PYGM phosphorylase, glycogen, muscle 2.84717
TMX4 thioredoxin-related transmembrane protein 4 2.82982
ABHD18 abhydrolase domain containing 18 2.82307
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.8212
SFTPB surfactant protein B 2.77463
PLK2 polo-like kinase 2 2.77281
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 2.77056
NXPH3 neurexophilin 3 2.76754
PTPRA protein tyrosine phosphatase, receptor type, A 2.76658
AGBL2 ATP/GTP binding protein-like 2 2.75476
IGSF3 immunoglobulin superfamily, member 3 2.7521
PKN3 protein kinase N3 2.74589
CA7 carbonic anhydrase VII 2.7399
TDRD6 tudor domain containing 6 2.73735
TMEM8B transmembrane protein 8B 2.73643
TKFC triokinase/FMN cyclase 2.73075
BIN1 bridging integrator 1 2.7264
TRAM2 translocation associated membrane protein 2 2.72542
FAM81B family with sequence similarity 81, member B 2.7227
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.69901
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.69474
HRH4 histamine receptor H4 2.67724
PHACTR4 phosphatase and actin regulator 4 2.6667
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 2.64672
CDH23 cadherin-related 23 2.64134
YY2 YY2 transcription factor 2.6376
LOR loricrin 2.6196
KY kyphoscoliosis peptidase 2.6134
CRLF1 cytokine receptor-like factor 1 2.60625
SGSM1 small G protein signaling modulator 1 2.5981
CRHR1 corticotropin releasing hormone receptor 1 2.59659
INSRR insulin receptor-related receptor 2.58053
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.57279
NEURL4 neuralized E3 ubiquitin protein ligase 4 2.54293
SLITRK4 SLIT and NTRK-like family, member 4 2.52855
SCN4A sodium channel, voltage gated, type IV alpha subunit 2.52807
PSRC1 proline/serine-rich coiled-coil 1 2.50974
LMBR1 limb development membrane protein 1 2.50839
ZEB1 zinc finger E-box binding homeobox 1 2.50825
FUS FUS RNA binding protein 2.50634
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.50131
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.48828
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.48813
NCR3 natural cytotoxicity triggering receptor 3 2.48804
OSBP2 oxysterol binding protein 2 2.4838
MADD MAP-kinase activating death domain 2.48044
ZYG11B zyg-11 family member B, cell cycle regulator 2.47846
ELMO2 engulfment and cell motility 2 2.47814
AFAP1L2 actin filament associated protein 1-like 2 2.47351
ZFP92 ZFP92 zinc finger protein 2.46104
NRXN2 neurexin 2 2.45552
SP6 Sp6 transcription factor 2.44732
TARBP2 TAR (HIV-1) RNA binding protein 2 2.43932
ZSWIM5 zinc finger, SWIM-type containing 5 2.42879
FAM166A family with sequence similarity 166, member A 2.427
ADRM1 adhesion regulating molecule 1 2.40979
MAG myelin associated glycoprotein 2.40717
CATSPER1 cation channel, sperm associated 1 2.39994
BCAR1 breast cancer anti-estrogen resistance 1 2.39901
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.39793
EPHB1 EPH receptor B1 2.39335
OR4B1 olfactory receptor, family 4, subfamily B, member 1 2.3848
SUGP2 SURP and G patch domain containing 2 2.38366
XPO6 exportin 6 2.38172
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 2.37314
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.37241
MDFI MyoD family inhibitor 2.36591
MYO6 myosin VI 2.35673
FAM43B family with sequence similarity 43, member B 2.35627
CSDE1 cold shock domain containing E1, RNA-binding 2.35274
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 2.34712
AMER2 APC membrane recruitment protein 2 2.34567
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 2.34563
GRM4 glutamate receptor, metabotropic 4 2.34234
GJD2 gap junction protein, delta 2, 36kDa 2.33224
STXBP1 syntaxin binding protein 1 2.33127
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.32411
TRHR thyrotropin-releasing hormone receptor 2.3023
NLGN2 neuroligin 2 2.29285
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 2.29133
PRR15 proline rich 15 2.28646
CCL14 chemokine (C-C motif) ligand 14 2.28536
PDS5A PDS5 cohesin associated factor A 2.28185
CACFD1 calcium channel flower domain containing 1 2.28032
REEP2 receptor accessory protein 2 2.27564
AURKC aurora kinase C 2.27272
CSMD1 CUB and Sushi multiple domains 1 2.27017
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.26574
STK11 serine/threonine kinase 11 2.25966
TENT4A terminal nucleotidyltransferase 4A 2.25876
MACROH2A1 macroH2A.1 histone 2.25396
C16ORF86 chromosome 16 open reading frame 86 2.24605
OR5B12 olfactory receptor, family 5, subfamily B, member 12 2.24426
ZNF497 zinc finger protein 497 2.23588
NPR1 natriuretic peptide receptor 1 2.22959
UNC5A unc-5 homolog A (C. elegans) 2.22718
LRRC14 leucine rich repeat containing 14 2.22083
BICDL2 BICD family like cargo adaptor 2 2.21745
CCDC51 coiled-coil domain containing 51 2.21462
EHD3 EH-domain containing 3 2.21377
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.20429
NLGN1 neuroligin 1 2.20148
RAB40A RAB40A, member RAS oncogene family 2.2004
ADRA1D adrenoceptor alpha 1D 2.20037
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.19528
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.19443
SNPH syntaphilin 2.18981
EPHB2 EPH receptor B2 2.18358
CD164L2 CD164 sialomucin-like 2 2.18004
PKD2L1 polycystic kidney disease 2-like 1 2.17032
CCDC88B coiled-coil domain containing 88B 2.16384
SOWAHB sosondowah ankyrin repeat domain family member B 2.16123
AMIGO1 adhesion molecule with Ig-like domain 1 2.15734
EPB42 erythrocyte membrane protein band 4.2 2.1495
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.14762
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.14683
RANBP10 RAN binding protein 10 2.14278
DAZAP1 DAZ associated protein 1 2.14188
CXXC4 CXXC finger protein 4 2.14126
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.13431
OPTC opticin 2.1247
CCDC74B coiled-coil domain containing 74B 2.1194
AKAP11 A kinase (PRKA) anchor protein 11 2.11555
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.11419
SIRPB1 signal-regulatory protein beta 1 2.10937
APIP APAF1 interacting protein 2.0994
SLMAP sarcolemma associated protein 2.09797
SLC51B solute carrier family 51, beta subunit 2.09775
LZTS2 leucine zipper, putative tumor suppressor 2 2.09458
BRMS1 breast cancer metastasis suppressor 1 2.09354
ADAM11 ADAM metallopeptidase domain 11 2.09237
ERF Ets2 repressor factor 2.09056
KDSR 3-ketodihydrosphingosine reductase 2.08958
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.08781
ZNF236 zinc finger protein 236 2.08534
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.07993
ZNF318 zinc finger protein 318 2.0749
MARCO macrophage receptor with collagenous structure 2.06931
CCDC126 coiled-coil domain containing 126 2.06876
SLC25A45 solute carrier family 25, member 45 2.06642
TEAD4 TEA domain family member 4 2.06524
COL28A1 collagen, type XXVIII, alpha 1 2.06337
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.06051
EDA2R ectodysplasin A2 receptor 2.05995
CLIC5 chloride intracellular channel 5 2.05868
KRT33A keratin 33A, type I 2.04854
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 2.04683
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.04596
IL36A interleukin 36, alpha 2.04533
NAP1L5 nucleosome assembly protein 1-like 5 2.03877
RPL41 ribosomal protein L41 2.03781
OR4A5 olfactory receptor, family 4, subfamily A, member 5 2.03771
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.03271
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.03057
NPAS4 neuronal PAS domain protein 4 2.02539
COL4A5 collagen, type IV, alpha 5 2.02321
ZC3H12B zinc finger CCCH-type containing 12B 2.0195
MYOM3 myomesin 3 2.01891
WWTR1 WW domain containing transcription regulator 1 2.01508
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.01396
CABP4 calcium binding protein 4 2.01275
GFUS GDP-L-fucose synthase 2.00417
STK38L serine/threonine kinase 38 like 2.00336
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 2.00125