PKCA Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description protein kinase C, alpha|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5578)
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100 substrates of the kinase PKCA from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
PRICKLE3 prickle homolog 3 (Drosophila)
RNF217 ring finger protein 217
PLEC plectin
PLEK pleckstrin
SOX9 SRY (sex determining region Y)-box 9
SRSF4 serine/arginine-rich splicing factor 4
SRSF7 serine/arginine-rich splicing factor 7
SRSF2 serine/arginine-rich splicing factor 2
NEO1 neogenin 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
BTK Bruton agammaglobulinemia tyrosine kinase
PKP1 plakophilin 1
NCF1 neutrophil cytosolic factor 1
IRS1 insulin receptor substrate 1
BIRC6 baculoviral IAP repeat containing 6
HIST1H2BB histone cluster 1, H2bb
MARCKSL1 MARCKS-like 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
PLXNB1 plexin B1
ORAI1 ORAI calcium release-activated calcium modulator 1
RPP38 ribonuclease P/MRP 38kDa subunit
HEXIM1 hexamethylene bis-acetamide inducible 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
NKX3-1 NK3 homeobox 1
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
AIM1 absent in melanoma 1
FRMD4B FERM domain containing 4B
GATA1 GATA binding protein 1 (globin transcription factor 1)
ADD2 adducin 2 (beta)
ADD1 adducin 1 (alpha)
LDB1 LIM domain binding 1
BCCIP BRCA2 and CDKN1A interacting protein
PRRC2A proline-rich coiled-coil 2A
GIPC1 GIPC PDZ domain containing family, member 1
ARHGAP10 Rho GTPase activating protein 10
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
WIPF2 WAS/WASL interacting protein family, member 2
PTGDR2 prostaglandin D2 receptor 2
UNK unkempt family zinc finger
ARHGAP9 Rho GTPase activating protein 9
MAPKAP1 mitogen-activated protein kinase associated protein 1
TACSTD2 tumor-associated calcium signal transducer 2
S1PR1 sphingosine-1-phosphate receptor 1
CENPA centromere protein A
PLEKHA5 pleckstrin homology domain containing, family A member 5
RASAL3 RAS protein activator like 3
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
CHERP calcium homeostasis endoplasmic reticulum protein
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
PHF2 PHD finger protein 2
PFKP phosphofructokinase, platelet
ANKRD33B ankyrin repeat domain 33B
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
FEN1 flap structure-specific endonuclease 1
PRM2 protamine 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
FHDC1 FH2 domain containing 1
FAM219A family with sequence similarity 219, member A
DSP desmoplakin
ZCCHC17 zinc finger, CCHC domain containing 17
KDM1A lysine (K)-specific demethylase 1A
FHOD1 formin homology 2 domain containing 1
ILF3 interleukin enhancer binding factor 3, 90kDa
PGBD3 piggyBac transposable element derived 3
WHSC1 Wolf-Hirschhorn syndrome candidate 1
CYTH2 cytohesin 2
YBX3 Y box binding protein 3
GNS glucosamine (N-acetyl)-6-sulfatase
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
RBM25 RNA binding motif protein 25
DUOX1 dual oxidase 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
NUMB numb homolog (Drosophila)
NOLC1 nucleolar and coiled-body phosphoprotein 1
FXYD1 FXYD domain containing ion transport regulator 1
TWIST1 twist family bHLH transcription factor 1
TCEAL1 transcription elongation factor A (SII)-like 1
IL2RA interleukin 2 receptor, alpha
ZFYVE26 zinc finger, FYVE domain containing 26
UBE2O ubiquitin-conjugating enzyme E2O
GANAB glucosidase, alpha; neutral AB
RAB25 RAB25, member RAS oncogene family
KCNK12 potassium channel, two pore domain subfamily K, member 12
GMIP GEM interacting protein
PTPN6 protein tyrosine phosphatase, non-receptor type 6
FAM214B family with sequence similarity 214, member B
SRRM2 serine/arginine repetitive matrix 2
MARCKS myristoylated alanine-rich protein kinase C substrate
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
NSD1 nuclear receptor binding SET domain protein 1
SOGA1 suppressor of glucose, autophagy associated 1
IFI16 interferon, gamma-inducible protein 16
NOP56 NOP56 ribonucleoprotein
LIMK2 LIM domain kinase 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
TACC2 transforming, acidic coiled-coil containing protein 2