PKCD Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description protein kinase C, delta|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5580)
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Genes

100 substrates of the kinase PKCD from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
ZFYVE26 zinc finger, FYVE domain containing 26
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
NCF1 neutrophil cytosolic factor 1
BTK Bruton agammaglobulinemia tyrosine kinase
PRICKLE3 prickle homolog 3 (Drosophila)
SEPT2 septin 2
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
SRSF2 serine/arginine-rich splicing factor 2
NEO1 neogenin 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
HEXIM1 hexamethylene bis-acetamide inducible 1
PLXNB1 plexin B1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
UBE2O ubiquitin-conjugating enzyme E2O
LEMD2 LEM domain containing 2
GANAB glucosidase, alpha; neutral AB
RAB25 RAB25, member RAS oncogene family
TACC2 transforming, acidic coiled-coil containing protein 2
ATF1 activating transcription factor 1
BIRC6 baculoviral IAP repeat containing 6
HIST1H2BB histone cluster 1, H2bb
MARCKSL1 MARCKS-like 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
ARHGAP9 Rho GTPase activating protein 9
AIM1 absent in melanoma 1
FRMD4B FERM domain containing 4B
GATA2 GATA binding protein 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
ADD3 adducin 3 (gamma)
ADD2 adducin 2 (beta)
ADD1 adducin 1 (alpha)
LDB1 LIM domain binding 1
BCCIP BRCA2 and CDKN1A interacting protein
PRRC2A proline-rich coiled-coil 2A
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
ARHGAP10 Rho GTPase activating protein 10
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
MAPKAP1 mitogen-activated protein kinase associated protein 1
PA2G4 proliferation-associated 2G4, 38kDa
TACSTD2 tumor-associated calcium signal transducer 2
S1PR1 sphingosine-1-phosphate receptor 1
OXR1 oxidation resistance 1
CENPA centromere protein A
PLEKHA5 pleckstrin homology domain containing, family A member 5
RASAL3 RAS protein activator like 3
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
WIPF2 WAS/WASL interacting protein family, member 2
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
KDM1A lysine (K)-specific demethylase 1A
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
PHF2 PHD finger protein 2
ANKRD33B ankyrin repeat domain 33B
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
FEN1 flap structure-specific endonuclease 1
PRM2 protamine 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
MAP3K11 mitogen-activated protein kinase kinase kinase 11
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
NOP2 NOP2 nucleolar protein
AEBP2 AE binding protein 2
CHERP calcium homeostasis endoplasmic reticulum protein
FAM219A family with sequence similarity 219, member A
FHOD1 formin homology 2 domain containing 1
SYT6 synaptotagmin VI
ILF3 interleukin enhancer binding factor 3, 90kDa
WHSC1 Wolf-Hirschhorn syndrome candidate 1
CYTH2 cytohesin 2
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
FGF1 fibroblast growth factor 1 (acidic)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
ZCCHC17 zinc finger, CCHC domain containing 17
DSP desmoplakin
SRRM2 serine/arginine repetitive matrix 2
MARCKS myristoylated alanine-rich protein kinase C substrate
KCNK12 potassium channel, two pore domain subfamily K, member 12
NUMB numb homolog (Drosophila)
NOLC1 nucleolar and coiled-body phosphoprotein 1
FXYD1 FXYD domain containing ion transport regulator 1
TWIST1 twist family bHLH transcription factor 1
SPN sialophorin
CREB1 cAMP responsive element binding protein 1
MYO1F myosin IF
MYO1E myosin IE
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SYTL1 synaptotagmin-like 1
COIL coilin
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
NSD1 nuclear receptor binding SET domain protein 1
KPNA3 karyopherin alpha 3 (importin alpha 4)
SOGA1 suppressor of glucose, autophagy associated 1
INCENP inner centromere protein antigens 135/155kDa
IFI16 interferon, gamma-inducible protein 16
NOP56 NOP56 ribonucleoprotein
LIMK2 LIM domain kinase 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
IL2RA interleukin 2 receptor, alpha