PKCT Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description protein kinase C, theta|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5588)
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Genes

100 substrates of the kinase PKCT from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MYO1F myosin IF
MARCKSL1 MARCKS-like 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
PLXNB1 plexin B1
ORAI1 ORAI calcium release-activated calcium modulator 1
HEXIM1 hexamethylene bis-acetamide inducible 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
NCF1 neutrophil cytosolic factor 1
BTK Bruton agammaglobulinemia tyrosine kinase
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRICKLE3 prickle homolog 3 (Drosophila)
HIST1H2BB histone cluster 1, H2bb
IRS1 insulin receptor substrate 1
TRA2A transformer 2 alpha homolog (Drosophila)
MYO1E myosin IE
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
IL2RA interleukin 2 receptor, alpha
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
UBE2O ubiquitin-conjugating enzyme E2O
LEMD2 LEM domain containing 2
KIF2C kinesin family member 2C
GANAB glucosidase, alpha; neutral AB
TACC2 transforming, acidic coiled-coil containing protein 2
ATF1 activating transcription factor 1
PLEK pleckstrin
SOX9 SRY (sex determining region Y)-box 9
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
WIPF2 WAS/WASL interacting protein family, member 2
LTF lactotransferrin
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
AIM1 absent in melanoma 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
FRMD4B FERM domain containing 4B
PELI1 pellino E3 ubiquitin protein ligase 1
LDB1 LIM domain binding 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
RASAL3 RAS protein activator like 3
PLEKHA5 pleckstrin homology domain containing, family A member 5
CENPA centromere protein A
SRSF7 serine/arginine-rich splicing factor 7
SRSF2 serine/arginine-rich splicing factor 2
NEO1 neogenin 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
ARHGAP9 Rho GTPase activating protein 9
MAPKAP1 mitogen-activated protein kinase associated protein 1
TACSTD2 tumor-associated calcium signal transducer 2
S1PR1 sphingosine-1-phosphate receptor 1
OXR1 oxidation resistance 1
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
CHKB choline kinase beta
DSP desmoplakin
CHERP calcium homeostasis endoplasmic reticulum protein
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
PHF2 PHD finger protein 2
ANKRD33B ankyrin repeat domain 33B
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
PRM2 protamine 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
DUOX1 dual oxidase 1
ZCCHC17 zinc finger, CCHC domain containing 17
CDCA2 cell division cycle associated 2
PPHLN1 periphilin 1
KDM1A lysine (K)-specific demethylase 1A
FHOD1 formin homology 2 domain containing 1
ILF3 interleukin enhancer binding factor 3, 90kDa
WDR13 WD repeat domain 13
WHSC1 Wolf-Hirschhorn syndrome candidate 1
CYTH2 cytohesin 2
KIAA0100 KIAA0100
FGG fibrinogen gamma chain
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
DAPK3 death-associated protein kinase 3
GPR15 G protein-coupled receptor 15
PTPN6 protein tyrosine phosphatase, non-receptor type 6
UBR5 ubiquitin protein ligase E3 component n-recognin 5
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
KCNK12 potassium channel, two pore domain subfamily K, member 12
FOXG1 forkhead box G1
NUMB numb homolog (Drosophila)
NOLC1 nucleolar and coiled-body phosphoprotein 1
FXYD1 FXYD domain containing ion transport regulator 1
GRM7 glutamate receptor, metabotropic 7
TWIST1 twist family bHLH transcription factor 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
LIMK2 LIM domain kinase 2
NOP56 NOP56 ribonucleoprotein
MAP3K11 mitogen-activated protein kinase kinase kinase 11
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
FAM214B family with sequence similarity 214, member B
SRRM2 serine/arginine repetitive matrix 2
RND3 Rho family GTPase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
INCENP inner centromere protein antigens 135/155kDa
IFI16 interferon, gamma-inducible protein 16
CREB1 cAMP responsive element binding protein 1