PKD1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description polycystic kidney disease 1 (autosomal dominant)|This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5310)
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Genes

323 genes differentially expressed following the PKD1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
BCAS1 breast carcinoma amplified sequence 1 3.40191
PTK6 protein tyrosine kinase 6 3.40191
NSG2 neuronal vesicle trafficking associated 2 3.40191
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.40191
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.40191
GPR35 G protein-coupled receptor 35 3.40191
CD19 CD19 molecule 3.40191
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 3.40191
KRT81 keratin 81, type II 3.40191
CLRN1 clarin 1 3.40191
LRRD1 leucine-rich repeats and death domain containing 1 3.40191
CFHR3 complement factor H-related 3 3.40191
PNPLA1 patatin-like phospholipase domain containing 1 3.40191
PLEK2 pleckstrin 2 3.40191
STARD6 StAR-related lipid transfer (START) domain containing 6 3.40191
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.40191
RAMACL RNA guanine-7 methyltransferase activating subunit like 3.40191
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 3.40191
GJB6 gap junction protein, beta 6, 30kDa 3.40191
ERAS ES cell expressed Ras 3.40191
LOC124902436 talanin 3.40191
CD27 CD27 molecule 3.40191
MTTP microsomal triglyceride transfer protein 3.40191
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.40191
TEX46 testis expressed 46 3.40191
CFAP99 cilia and flagella associated protein 99 3.31307
LRRC8E leucine rich repeat containing 8 family, member E 3.31307
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.31307
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.31307
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.31307
CLEC3B C-type lectin domain family 3, member B 3.31307
EDAR ectodysplasin A receptor 3.31307
TRIM77 tripartite motif containing 77 3.31307
FABP9 fatty acid binding protein 9, testis 3.31307
PTGDR2 prostaglandin D2 receptor 2 3.31307
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.31307
SPRR1B small proline-rich protein 1B 3.31307
PMFBP1 polyamine modulated factor 1 binding protein 1 3.31307
GZMM granzyme M (lymphocyte met-ase 1) 3.31307
RXFP2 relaxin/insulin-like family peptide receptor 2 3.31307
CCL3 chemokine (C-C motif) ligand 3 3.31307
STRA8 stimulated by retinoic acid 8 3.31307
SIRPB2 signal-regulatory protein beta 2 3.31307
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.31307
HES5 hes family bHLH transcription factor 5 3.31307
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.31307
CELA3B chymotrypsin-like elastase family, member 3B 3.31307
DNASE1L2 deoxyribonuclease I-like 2 3.31307
NXPH3 neurexophilin 3 3.31307
ASB17 ankyrin repeat and SOCS box containing 17 3.31307
CD1A CD1a molecule 3.31307
GIMAP4 GTPase, IMAP family member 4 3.31307
HEATR9 HEAT repeat containing 9 3.31307
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.31307
RIMBP2 RIMS binding protein 2 3.31307
DUXB double homeobox B 3.31307
CCL5 chemokine (C-C motif) ligand 5 3.31307
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.31307
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.31307
GASK1B golgi associated kinase 1B 3.31307
TMEM271 transmembrane protein 271 3.31307
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 3.31307
ZNF728 zinc finger protein 728 3.31307
ZNF726 zinc finger protein 726 3.31307
AVPR1B arginine vasopressin receptor 1B 3.31307
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.31307
HBG2 hemoglobin, gamma G 3.31307
PLAAT2 phospholipase A and acyltransferase 2 3.31307
DEFB131B defensin beta 131B 3.31307
KIF1C-AS1 KIF1C antisense RNA 1 3.31307
H2BK1 H2B.K variant histone 1 3.31307
SMIM45 small integral membrane protein 45 3.31307
H3-7 H3.7 histone (putative) 3.31307
LY6L lymphocyte antigen 6 family member L 3.31307
GSG1L2 GSG1 like 2 3.31307
IHO1 interactor of HORMAD1 1 3.31307
GSTT4 glutathione S-transferase theta 4 3.31307
MYH4 myosin, heavy chain 4, skeletal muscle 3.31307
SPEM1 spermatid maturation 1 3.31307
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.31307
IL1R2 interleukin 1 receptor, type II 3.31307
CLEC17A C-type lectin domain family 17, member A 3.31307
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.31307
EXOC3L4 exocyst complex component 3-like 4 3.31307
GJD4 gap junction protein, delta 4, 40.1kDa 3.31307
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.31307
TBX5 T-box 5 3.31307
FGFBP1 fibroblast growth factor binding protein 1 3.31307
HNF1B HNF1 homeobox B 3.31307
SPRR2A small proline-rich protein 2A 3.31307
FMOD fibromodulin 3.31307
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.31307
WDR64 WD repeat domain 64 3.31307
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.31307
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.31307
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.31307
ZG16B zymogen granule protein 16B 3.31307
KDM4F lysine demethylase 4F 3.31307
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.31307
ZPLD1 zona pellucida-like domain containing 1 3.31307
IFITM10 interferon induced transmembrane protein 10 3.31307
FAM163A family with sequence similarity 163, member A 3.31307
TMEM88 transmembrane protein 88 3.31307
CALHM3 calcium homeostasis modulator 3 3.31307
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.31307
TRADD TNFRSF1A-associated via death domain 3.31307
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.31307
C5ORF46 chromosome 5 open reading frame 46 3.31307
IRX1 iroquois homeobox 1 3.31307
WNK4 WNK lysine deficient protein kinase 4 3.31307
PITX1 paired-like homeodomain 1 3.31307
CD34 CD34 molecule 3.31307
HHATL hedgehog acyltransferase-like 3.31307
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.31307
HHLA2 HERV-H LTR-associating 2 3.31307
KRT12 keratin 12, type I 3.31307
IL17REL interleukin 17 receptor E-like 3.31307
STMND1 stathmin domain containing 1 3.31307
SHOX2 short stature homeobox 2 3.31307
ADGRF5 adhesion G protein-coupled receptor F5 3.31307
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.31307
ERICH3 glutamate-rich 3 3.31307
CETP cholesteryl ester transfer protein, plasma 3.31307
TNR tenascin R 3.31307
GRAP2 GRB2-related adaptor protein 2 3.31307
IL10RA interleukin 10 receptor, alpha 3.31307
FATE1 fetal and adult testis expressed 1 3.31307
AGBL1 ATP/GTP binding protein-like 1 3.31307
PCDHGA12 protocadherin gamma subfamily A, 12 3.31307
FGF9 fibroblast growth factor 9 3.31307
MAB21L3 mab-21-like 3 (C. elegans) 3.31307
PABPN1L poly(A) binding protein, nuclear 1-like (cytoplasmic) 3.31307
S100A1 S100 calcium binding protein A1 3.31307
FSHR follicle stimulating hormone receptor 3.31307
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 3.31307
ADAT3 adenosine deaminase, tRNA-specific 3 3.31307
OTOP2 otopetrin 2 3.31307
BCL2L15 BCL2-like 15 3.31307
F9 coagulation factor IX 3.31307
CRX cone-rod homeobox 3.31307
ETFB electron-transfer-flavoprotein, beta polypeptide 3.31307
RGS4 regulator of G-protein signaling 4 3.31307
DRC1 dynein regulatory complex subunit 1 3.31307
TEX29 testis expressed 29 3.31307
TREML1 triggering receptor expressed on myeloid cells-like 1 3.31307
MAPK11 mitogen-activated protein kinase 11 3.31307
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.31307
NMUR2 neuromedin U receptor 2 3.31307
TBC1D26 TBC1 domain family, member 26 3.31307
C2ORF78 chromosome 2 open reading frame 78 3.31307
TEX26 testis expressed 26 3.31307
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.31307
SP5 Sp5 transcription factor 3.31307
DRD2 dopamine receptor D2 3.31307
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 3.31307
KLLN killin, p53-regulated DNA replication inhibitor 3.31307
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.31307
BMP5 bone morphogenetic protein 5 3.31307
KISS1 KiSS-1 metastasis-suppressor 3.31307
HRCT1 histidine rich carboxyl terminus 1 3.31307
TBATA thymus, brain and testes associated 3.31307
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 3.21919
SHLD2 shieldin complex subunit 2 3.21347
SUSD2 sushi domain containing 2 3.20528
TMEM81 transmembrane protein 81 3.20528
SHD Src homology 2 domain containing transforming protein D 3.20528
RFX2 regulatory factor X, 2 (influences HLA class II expression) 3.18356
SVOP SV2 related protein homolog (rat) 3.08764
MTG2 mitochondrial ribosome-associated GTPase 2 2.91497
ADSS2 adenylosuccinate synthase 2 2.79579
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.78937
SWSAP1 SWIM-type zinc finger 7 associated protein 1 2.75928
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.69125
ASB7 ankyrin repeat and SOCS box containing 7 2.6897
HORMAD1 HORMA domain containing 1 2.67312
COQ9 coenzyme Q9 2.66886
HVCN1 hydrogen voltage gated channel 1 2.56513
ASPNAT aspartate N-acetyltransferase 2.54649
BST2 bone marrow stromal cell antigen 2 2.52332
SS18 synovial sarcoma translocation, chromosome 18 2.48404
WDR59 WD repeat domain 59 2.48175
ARFIP2 ADP-ribosylation factor interacting protein 2 2.45794
STXBP6 syntaxin binding protein 6 (amisyn) 2.44554
POLR1G RNA polymerase I subunit G 2.43862
CFAP276 cilia and flagella associated protein 276 2.41289
GRID2 glutamate receptor, ionotropic, delta 2 2.40164
FANCD2 Fanconi anemia, complementation group D2 2.39588
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.38962
NT5C2 5'-nucleotidase, cytosolic II 2.38943
CIMAP3 ciliary microtubule associated protein 3 2.32608
C5ORF15 chromosome 5 open reading frame 15 2.31482
ARHGAP29 Rho GTPase activating protein 29 2.30501
SETD1A SET domain containing 1A 2.29944
CD300A CD300a molecule 2.27513
PRRT4 proline-rich transmembrane protein 4 2.27513
HES3 hes family bHLH transcription factor 3 2.27326
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.26067
CD177 CD177 molecule 2.26067
TOR4A torsin family 4, member A 2.23725
ATXN3 ataxin 3 2.19391
ATG10 autophagy related 10 2.1834
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.16706
MYO9A myosin IXA 2.14777
PJVK pejvakin 2.1443
CYS1 cystin 1 2.13968
TRAM1L1 translocation associated membrane protein 1-like 1 2.13968
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.13968
CRYBA4 crystallin, beta A4 2.13968
PCDHB4 protocadherin beta 4 2.13968
ETV2 ets variant 2 2.13968
SH2D4B SH2 domain containing 4B 2.13968
DUSP8 dual specificity phosphatase 8 2.13968
IL5RA interleukin 5 receptor, alpha 2.13968
PEX14 peroxisomal biogenesis factor 14 2.13828
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 2.13828
MRPL51 mitochondrial ribosomal protein L51 2.13301
SNX27 sorting nexin family member 27 2.12447
PRKDC protein kinase, DNA-activated, catalytic polypeptide 2.11059
RAB43 RAB43, member RAS oncogene family 2.06074
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 2.05475
C6ORF47 chromosome 6 open reading frame 47 2.04408
STRN4 striatin, calmodulin binding protein 4 2.04155
ZNF646 zinc finger protein 646 2.03184

decreased expression

Symbol Name Standardized Value
TDRD12 tudor domain containing 12 -3.40191
ACSM1 acyl-CoA synthetase medium-chain family member 1 -3.40191
ANO3 anoctamin 3 -3.40191
S100B S100 calcium binding protein B -3.40191
FSD1 fibronectin type III and SPRY domain containing 1 -3.31307
TM4SF1 transmembrane 4 L six family member 1 -3.31307
ADRB2 adrenoceptor beta 2, surface -3.31307
NPIPB15 nuclear pore complex interacting protein family, member B15 -3.31307
ZNF491 zinc finger protein 491 -3.31307
BRDT bromodomain, testis-specific -3.31307
CARD18 caspase recruitment domain family, member 18 -3.31307
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -3.31307
VAMP5 vesicle-associated membrane protein 5 -3.31307
CD101 CD101 molecule -3.31307
LOC105378220 macrophage receptor MARCO-like -3.31307
SHISA3 shisa family member 3 -3.31307
A1CF APOBEC1 complementation factor -3.31307
S100A2 S100 calcium binding protein A2 -3.31307
RTN4RL1 reticulon 4 receptor-like 1 -3.31307
TRPM5 transient receptor potential cation channel, subfamily M, member 5 -3.31307
FITM2 fat storage-inducing transmembrane protein 2 -3.31307
RASL12 RAS-like, family 12 -3.31307
MIF4GD MIF4G domain containing -3.31307
EGFLAM EGF-like, fibronectin type III and laminin G domains -3.31307
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -3.31307
HIGD2B HIG1 hypoxia inducible domain family, member 2B -3.31307
UBXN10 UBX domain protein 10 -3.31307
CSDC2 cold shock domain containing C2, RNA binding -3.31307
CFAP126 cilia and flagella associated protein 126 -3.31307
LEKR1 leucine, glutamate and lysine rich 1 -3.31307
BTG4 B-cell translocation gene 4 -3.31307
STX11 syntaxin 11 -3.31307
TMOD4 tropomodulin 4 (muscle) -3.31307
ITGAD integrin, alpha D -3.31307
CTSO cathepsin O -3.31307
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -3.31307
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -3.31307
VASH1 vasohibin 1 -3.31307
CD248 CD248 molecule, endosialin -3.31307
ZEB1 zinc finger E-box binding homeobox 1 -3.31307
CFAP57 cilia and flagella associated protein 57 -3.27305
SEC14L4 SEC14-like 4 (S. cerevisiae) -3.24697
COPS3 COP9 signalosome subunit 3 -2.95651
ANO2 anoctamin 2, calcium activated chloride channel -2.88677
RFESD Rieske (Fe-S) domain containing -2.88677
PGRMC2 progesterone receptor membrane component 2 -2.81348
STX6 syntaxin 6 -2.76391
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog -2.69538
TM7SF3 transmembrane 7 superfamily member 3 -2.67312
SLAIN1 SLAIN motif family, member 1 -2.66648
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.65053
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -2.62883
PTMS parathymosin -2.62539
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -2.61468
IRF8 interferon regulatory factor 8 -2.57502
ANKRD31 ankyrin repeat domain 31 -2.57502
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.52332
PCDHGB7 protocadherin gamma subfamily B, 7 -2.49663
GLRB glycine receptor, beta -2.49663
CIMAP2 ciliary microtubule associated protein 2 -2.49663
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -2.49663
COL6A2 collagen, type VI, alpha 2 -2.4712
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.47029
PCDHA1 protocadherin alpha 1 -2.43233
SLA2 Src-like-adaptor 2 -2.43233
MYT1 myelin transcription factor 1 -2.41591
ZNF837 zinc finger protein 837 -2.39741
PARP15 poly (ADP-ribose) polymerase family, member 15 -2.39741
H3C12 H3 clustered histone 12 -2.39741
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.36518
PROKR1 prokineticin receptor 1 -2.36455
ZNF677 zinc finger protein 677 -2.32745
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.31195
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.3081
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -2.29476
ATXN7 ataxin 7 -2.25922
TK2 thymidine kinase 2, mitochondrial -2.20007
CREB3L1 cAMP responsive element binding protein 3-like 1 -2.17655
RNPS1 RNA binding protein S1, serine-rich domain -2.17655
ZNF200 zinc finger protein 200 -2.17076
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -2.13968
NAXD NAD(P)HX dehydratase -2.13828
CSNK1E casein kinase 1, epsilon -2.13301
NECTIN2 nectin cell adhesion molecule 2 -2.13301
TMEM19 transmembrane protein 19 -2.12667
ZFAT zinc finger and AT hook domain containing -2.12594
SART3 squamous cell carcinoma antigen recognized by T cells 3 -2.12203
CDC23 cell division cycle 23 -2.12203
FAHD2B fumarylacetoacetate hydrolase domain containing 2B -2.10866
RASGEF1B RasGEF domain family, member 1B -2.10866
DLG3 discs, large homolog 3 (Drosophila) -2.09295
SEPTIN2 septin 2 -2.07651
EXOSC5 exosome component 5 -2.07059
RAP2A RAP2A, member of RAS oncogene family -2.05227
KAT8 K(lysine) acetyltransferase 8 -2.05227
NCBP3 nuclear cap binding subunit 3 -2.04877
NPC1 Niemann-Pick disease, type C1 -2.04155
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.0403
PRRC2C proline-rich coiled-coil 2C -2.03176
COL21A1 collagen, type XXI, alpha 1 -2.03176