| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | polycystic kidney disease 1 (autosomal dominant)|This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5310) |
| External Link | https://ncbi.nlm.nih.gov/gene/5310 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the PKD1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | 0.0178217 |
| SRGN | serglycin | 0.0162526 |
| TXNDC9 | thioredoxin domain containing 9 | 0.0158655 |
| MAP7 | microtubule-associated protein 7 | 0.0146291 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0135759 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0130337 |
| PLK1 | polo-like kinase 1 | 0.0119854 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.0119232 |
| CANT1 | calcium activated nucleotidase 1 | 0.0116911 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.0116166 |
| KIF20A | kinesin family member 20A | 0.0114744 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0114736 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 0.0109747 |
| KRT7 | keratin 7, type II | 0.0109509 |
| CSTA | cystatin A (stefin A) | 0.01066 |
| HOXB7 | homeobox B7 | 0.0106506 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.0104807 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00997045 |
| RGS10 | regulator of G-protein signaling 10 | 0.00992221 |
| HOPX | HOP homeobox | 0.0099033 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00967107 |
| CRIP2 | cysteine-rich protein 2 | 0.00965082 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00959622 |
| S100A9 | S100 calcium binding protein A9 | 0.00941388 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00911284 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00904276 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00898854 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.00894781 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00888507 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0087386 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.00869718 |
| NNMT | nicotinamide N-methyltransferase | 0.00867381 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00847531 |
| SAP30 | Sin3A-associated protein, 30kDa | 0.00847187 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 0.00846802 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | 0.00843928 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.00833317 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00831238 |
| NCALD | neurocalcin delta | 0.00824008 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0080624 |
| UPK1B | uroplakin 1B | 0.00804684 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.00799647 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00798506 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.00790001 |
| ANXA6 | annexin A6 | 0.00781097 |
| KRT17 | keratin 17, type I | 0.00779786 |
| S100A12 | S100 calcium binding protein A12 | 0.00774146 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.00774117 |
| HOXB6 | homeobox B6 | 0.00770016 |
| CBR3 | carbonyl reductase 3 | 0.00767972 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.007671 |
| KIAA0100 | KIAA0100 | 0.00765939 |
| LYZ | lysozyme | 0.0076464 |
| TFF1 | trefoil factor 1 | 0.00762769 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.0076065 |
| COL3A1 | collagen, type III, alpha 1 | 0.00759377 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.0075832 |
| RPS5 | ribosomal protein S5 | 0.00757781 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00752088 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00748486 |
| SPR | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | 0.00746468 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00743773 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00743345 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.00740707 |
| CYTIP | cytohesin 1 interacting protein | 0.00737955 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.0073528 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00732715 |
| LTF | lactotransferrin | 0.00730088 |
| CA2 | carbonic anhydrase II | 0.00726874 |
| CCR2 | chemokine (C-C motif) receptor 2 | 0.00725909 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.00722816 |
| RWDD1 | RWD domain containing 1 | 0.00717839 |
| ATG3 | autophagy related 3 | 0.0071558 |
| PYGB | phosphorylase, glycogen; brain | 0.0071321 |
| NDNF | neuron-derived neurotrophic factor | 0.00712812 |
| C7 | complement component 7 | 0.00712277 |
| EVI2A | ecotropic viral integration site 2A | 0.00709954 |
| SUSD4 | sushi domain containing 4 | 0.00709014 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00708624 |
| RPA3 | replication protein A3, 14kDa | 0.00705592 |
| NPR3 | natriuretic peptide receptor 3 | 0.00705114 |
| TMX1 | thioredoxin-related transmembrane protein 1 | 0.00699895 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00698484 |
| AGR2 | anterior gradient 2 | 0.00698458 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 0.00696371 |
| TOB1 | transducer of ERBB2, 1 | 0.00693297 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.00691599 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0068951 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00687127 |
| PLXNC1 | plexin C1 | 0.00685599 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.00685424 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.00684803 |
| PRKD3 | protein kinase D3 | 0.00682469 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.006796 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00678314 |
| PTCH1 | patched 1 | 0.00678167 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00678109 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.00668159 |
| TRIM29 | tripartite motif containing 29 | 0.00667123 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | 0.00665543 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00661804 |
| PRF1 | perforin 1 (pore forming protein) | 0.00660803 |
| CD2 | CD2 molecule | 0.00659967 |
| TRIM28 | tripartite motif containing 28 | 0.00656899 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00655884 |
| C1ORF115 | chromosome 1 open reading frame 115 | 0.00650621 |
| FJX1 | four jointed box 1 (Drosophila) | 0.00648415 |
| LY75 | lymphocyte antigen 75 | 0.00648159 |
| NIT2 | nitrilase family, member 2 | 0.0064486 |
| KRT10 | keratin 10, type I | 0.00644618 |
| ITPA | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | 0.00643866 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00643648 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00643277 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.00642863 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00642552 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00642208 |
| TMEM45A | transmembrane protein 45A | 0.00640675 |
| HIST3H2A | histone cluster 3, H2a | 0.00639364 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | 0.00639185 |
| MCOLN1 | mucolipin 1 | 0.00639137 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00638362 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00635515 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00634816 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | 0.00633804 |
| EPCAM | epithelial cell adhesion molecule | 0.00632474 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00629903 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.00628584 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00627756 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00626607 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00624754 |
| PCGF2 | polycomb group ring finger 2 | 0.0062437 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | 0.00622611 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00622052 |
| CA12 | carbonic anhydrase XII | 0.0062167 |
| CRYM | crystallin, mu | 0.0062144 |
| DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding) | 0.00620982 |
| TDP1 | tyrosyl-DNA phosphodiesterase 1 | 0.00618946 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00618798 |
| COMMD3 | COMM domain containing 3 | 0.00617544 |
| CD14 | CD14 molecule | 0.00615855 |
| CENPX | centromere protein X | 0.0061533 |
| CDC42 | cell division cycle 42 | 0.0061532 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | 0.00614473 |
| MCM6 | minichromosome maintenance complex component 6 | 0.0061382 |
| C2CD5 | C2 calcium-dependent domain containing 5 | 0.00611195 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.00609969 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00609893 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00609016 |
| ELAPOR1 | endosome-lysosome associated apoptosis and autophagy regulator 1 | 0.00608615 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | 0.00608068 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | 0.00608007 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00607343 |
| S100A8 | S100 calcium binding protein A8 | 0.00606725 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.00604579 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00601763 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.00599767 |
| GUCY2C | guanylate cyclase 2C | 0.00599737 |
| KRT19 | keratin 19, type I | 0.00599262 |
| MMP9 | matrix metallopeptidase 9 | 0.00599246 |
| ABHD10 | abhydrolase domain containing 10 | 0.00598917 |
| MKKS | McKusick-Kaufman syndrome | 0.00598627 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 0.00597893 |
| SPAG5 | sperm associated antigen 5 | 0.00597156 |
| NAGK | N-acetylglucosamine kinase | 0.00595798 |
| NANS | N-acetylneuraminic acid synthase | 0.00595527 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.00591593 |
| MTARC2 | mitochondrial amidoxime reducing component 2 | 0.00590735 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | 0.00590464 |
| BLVRB | biliverdin reductase B | 0.00587975 |
| COMMD8 | COMM domain containing 8 | 0.00587866 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00584497 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.00583569 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00583324 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00583256 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | 0.00582681 |
| COPS4 | COP9 signalosome subunit 4 | 0.0057947 |
| EFNA3 | ephrin-A3 | 0.00579423 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.00578391 |
| MUC1 | mucin 1, cell surface associated | 0.00575683 |
| RHOT1 | ras homolog family member T1 | 0.00575454 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.00575123 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.00574256 |
| NXT1 | nuclear transport factor 2-like export factor 1 | 0.00574013 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00569772 |
| ZW10 | zw10 kinetochore protein | 0.00569223 |
| PDE8A | phosphodiesterase 8A | 0.00568667 |
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 0.00568397 |
| BGN | biglycan | 0.00567347 |
| FASTKD3 | FAST kinase domains 3 | 0.00567331 |
| S100A7 | S100 calcium binding protein A7 | 0.00566539 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00564539 |
| LASP1 | LIM and SH3 protein 1 | 0.00563619 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00563196 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.00563191 |
| IQCE | IQ motif containing E | 0.00561922 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | 0.00561287 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.00560728 |
| VAMP4 | vesicle-associated membrane protein 4 | 0.00560697 |
| PCTP | phosphatidylcholine transfer protein | 0.0056039 |
| TMPO | thymopoietin | 0.00559768 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.00558797 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | 0.00557593 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | 0.00557544 |
| KYAT3 | kynurenine aminotransferase 3 | 0.00556619 |
| MT1F | metallothionein 1F | 0.00556612 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.00556207 |
| LIPT1 | lipoyltransferase 1 | 0.00555472 |
| LSR | lipolysis stimulated lipoprotein receptor | 0.00554579 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00554568 |
| MT1HL1 | metallothionein 1H-like 1 | 0.0055407 |
| TSEN34 | TSEN34 tRNA splicing endonuclease subunit | 0.00552963 |
| VBP1 | von Hippel-Lindau binding protein 1 | 0.00552103 |
| ARMT1 | acidic residue methyltransferase 1 | 0.00551442 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00551172 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.00550519 |
| CD48 | CD48 molecule | 0.00547917 |
| LMNB1 | lamin B1 | 0.00546642 |
| CCNF | cyclin F | 0.00546266 |
| POMZP3 | POM121 and ZP3 fusion | 0.00546014 |
| LUM | lumican | 0.00545044 |
| RBBP8 | retinoblastoma binding protein 8 | 0.00544974 |
| CALML4 | calmodulin-like 4 | 0.00544307 |
| UFSP2 | UFM1-specific peptidase 2 | 0.00543562 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.00541416 |
| NTS | neurotensin | 0.00540689 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00539207 |
| FDXR | ferredoxin reductase | 0.0053902 |
| STX7 | syntaxin 7 | 0.0053616 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.00536073 |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 | 0.00535681 |
| CRNKL1 | crooked neck pre-mRNA splicing factor 1 | 0.00535373 |
| NOP56 | NOP56 ribonucleoprotein | 0.00532567 |
| S100P | S100 calcium binding protein P | 0.00532458 |
| TMEM106C | transmembrane protein 106C | 0.00532433 |
| AATF | apoptosis antagonizing transcription factor | 0.00531421 |
| NUP37 | nucleoporin 37kDa | 0.00530724 |
| GSS | glutathione synthetase | 0.0053038 |
| LRRC59 | leucine rich repeat containing 59 | 0.00529355 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | 0.00528513 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | 0.00528051 |
| MMP12 | matrix metallopeptidase 12 | 0.00527783 |
| ATP5G1 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) | 0.00527536 |
| CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | 0.00526964 |
| DAXX | death-domain associated protein | 0.00525065 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | 0.00525053 |
| TEFM | transcription elongation factor, mitochondrial | 0.00524642 |
| ENO1 | enolase 1, (alpha) | 0.00523753 |
| PODXL | podocalyxin-like | 0.00522643 |
| MALL | mal, T-cell differentiation protein-like | 0.00521468 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | 0.00520525 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.0150028 |
| ASS1 | argininosuccinate synthase 1 | -0.0148536 |
| FHL1 | four and a half LIM domains 1 | -0.0132636 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0131319 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.0127253 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0124311 |
| TTN | titin | -0.012212 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0121828 |
| XIC | X chromosome inactivation center | -0.0120037 |
| ATF3 | activating transcription factor 3 | -0.011932 |
| TNNC1 | troponin C type 1 (slow) | -0.0115714 |
| CALCA | calcitonin-related polypeptide alpha | -0.0113055 |
| PEG10 | paternally expressed 10 | -0.0112687 |
| MXRA5 | matrix-remodelling associated 5 | -0.010964 |
| SST | somatostatin | -0.0109098 |
| TUBB2B | tubulin, beta 2B class IIb | -0.0109035 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.0106371 |
| KLHL41 | kelch-like family member 41 | -0.010253 |
| CRYAB | crystallin, alpha B | -0.0100609 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | -0.0100456 |
| MFSD10 | major facilitator superfamily domain containing 10 | -0.0100337 |
| KLF6 | Kruppel-like factor 6 | -0.00991491 |
| TAC1 | tachykinin, precursor 1 | -0.0098615 |
| KLF2 | Kruppel-like factor 2 | -0.00981386 |
| EREG | epiregulin | -0.00971016 |
| NKX2-1 | NK2 homeobox 1 | -0.00970306 |
| MYBPC1 | myosin binding protein C, slow type | -0.0096522 |
| IFI44L | interferon-induced protein 44-like | -0.00962503 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00957839 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00957733 |
| THBS4 | thrombospondin 4 | -0.00942261 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.00931379 |
| TSC22D2 | TSC22 domain family, member 2 | -0.00928024 |
| MYOT | myotilin | -0.00927635 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00923373 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00921926 |
| SC5D | sterol-C5-desaturase | -0.00920399 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00908078 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.00904965 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00894327 |
| SMPX | small muscle protein, X-linked | -0.00888086 |
| OLFML2A | olfactomedin-like 2A | -0.00887751 |
| CKM | creatine kinase, muscle | -0.00882647 |
| BMP2 | bone morphogenetic protein 2 | -0.00881348 |
| DIPK1A | divergent protein kinase domain 1A | -0.00876164 |
| BEX1 | brain expressed, X-linked 1 | -0.00874323 |
| GAS7 | growth arrest-specific 7 | -0.00870012 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | -0.00867205 |
| SIRT3 | sirtuin 3 | -0.00859164 |
| TNNC2 | troponin C type 2 (fast) | -0.00840523 |
| KIF1A | kinesin family member 1A | -0.00839983 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00839581 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.00836606 |
| TPM3 | tropomyosin 3 | -0.00825799 |
| AMOTL2 | angiomotin like 2 | -0.00820965 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.00818964 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00812311 |
| PGC | progastricsin (pepsinogen C) | -0.00807165 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | -0.00789285 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00786211 |
| PTN | pleiotrophin | -0.0078494 |
| OGN | osteoglycin | -0.00783654 |
| ENAH | enabled homolog (Drosophila) | -0.00783029 |
| FXYD1 | FXYD domain containing ion transport regulator 1 | -0.00781742 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00781191 |
| BEX4 | brain expressed, X-linked 4 | -0.00780771 |
| YBX3 | Y box binding protein 3 | -0.00777962 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00777255 |
| MAB21L1 | mab-21-like 1 (C. elegans) | -0.00776029 |
| RTN2 | reticulon 2 | -0.00761958 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00761488 |
| MX1 | MX dynamin-like GTPase 1 | -0.00761437 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00760233 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.00758269 |
| VGLL4 | vestigial-like family member 4 | -0.00757624 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | -0.00756693 |
| MYBPC2 | myosin binding protein C, fast type | -0.00752794 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00746284 |
| IRS2 | insulin receptor substrate 2 | -0.00746003 |
| SV2C | synaptic vesicle glycoprotein 2C | -0.00742514 |
| GTPBP2 | GTP binding protein 2 | -0.00739852 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.00735601 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00734986 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00732613 |
| VPREB1 | pre-B lymphocyte 1 | -0.00732427 |
| PYGM | phosphorylase, glycogen, muscle | -0.00731719 |
| ITGA7 | integrin, alpha 7 | -0.00724212 |
| LYPD1 | LY6/PLAUR domain containing 1 | -0.00723908 |
| EGR2 | early growth response 2 | -0.00723705 |
| KLK11 | kallikrein-related peptidase 11 | -0.00722939 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00721676 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.00720975 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -0.00720892 |
| OPHN1 | oligophrenin 1 | -0.00718516 |
| ENO3 | enolase 3 (beta, muscle) | -0.00716266 |
| DOK5 | docking protein 5 | -0.00716243 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00715102 |
| CKMT2 | creatine kinase, mitochondrial 2 (sarcomeric) | -0.00714699 |
| MEN1 | multiple endocrine neoplasia I | -0.00711171 |
| PCP4 | Purkinje cell protein 4 | -0.00709212 |
| FAM110B | family with sequence similarity 110, member B | -0.00708033 |
| CLIC5 | chloride intracellular channel 5 | -0.00704904 |
| AK1 | adenylate kinase 1 | -0.00704155 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00700745 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00699914 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00699632 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00698289 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00697839 |
| TOR1A | torsin family 1, member A (torsin A) | -0.00697258 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | -0.00694548 |
| MYOZ2 | myozenin 2 | -0.00688012 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00686175 |
| BAG2 | BCL2-associated athanogene 2 | -0.00684994 |
| CAPN6 | calpain 6 | -0.00684837 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00684188 |
| FNBP1 | formin binding protein 1 | -0.00684089 |
| OPN3 | opsin 3 | -0.006788 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -0.00678617 |
| EFNB2 | ephrin-B2 | -0.00677374 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00673266 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00670404 |
| SFTPB | surfactant protein B | -0.00666864 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | -0.00666225 |
| TARP | TCR gamma alternate reading frame protein | -0.00666193 |
| PLK2 | polo-like kinase 2 | -0.00664591 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0066456 |
| SNX7 | sorting nexin 7 | -0.00663022 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.00661804 |
| SPATA20 | spermatogenesis associated 20 | -0.00659697 |
| SSPN | sarcospan | -0.0065949 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -0.00658705 |
| CLCN4 | chloride channel, voltage-sensitive 4 | -0.0065735 |
| RETREG1 | reticulophagy regulator 1 | -0.00656665 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00655574 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.00654743 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00653951 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.00653832 |
| RGS5 | regulator of G-protein signaling 5 | -0.00653546 |
| FOSL2 | FOS-like antigen 2 | -0.00651364 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0064893 |
| MYL6B | myosin, light chain 6B, alkali, smooth muscle and non-muscle | -0.0064394 |
| MPPED2 | metallophosphoesterase domain containing 2 | -0.00642554 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | -0.0064031 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.00640031 |
| CCN3 | cellular communication network factor 3 | -0.00639607 |
| STC2 | stanniocalcin 2 | -0.0063859 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.00637602 |
| USP47 | ubiquitin specific peptidase 47 | -0.00636293 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.00633242 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.00632845 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00631841 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0063152 |
| TNNI1 | troponin I type 1 (skeletal, slow) | -0.00631428 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0062748 |
| LGI1 | leucine-rich, glioma inactivated 1 | -0.00627336 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00622477 |
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | -0.00622039 |
| CD1E | CD1e molecule | -0.00621428 |
| AHR | aryl hydrocarbon receptor | -0.00621382 |
| LDB3 | LIM domain binding 3 | -0.00620627 |
| PNMA2 | paraneoplastic Ma antigen 2 | -0.00618781 |
| LEPROT | leptin receptor overlapping transcript | -0.00618741 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00616221 |
| RGCC | regulator of cell cycle | -0.00615139 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.00612316 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00611925 |
| ZNF423 | zinc finger protein 423 | -0.00608171 |
| PRDX2 | peroxiredoxin 2 | -0.00606519 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.00605636 |
| MEOX2 | mesenchyme homeobox 2 | -0.00603871 |
| REG1A | regenerating islet-derived 1 alpha | -0.00601482 |
| MFAP5 | microfibrillar associated protein 5 | -0.00600771 |
| CPE | carboxypeptidase E | -0.00598537 |
| STK26 | serine/threonine protein kinase 26 | -0.00596273 |
| ELOVL4 | ELOVL fatty acid elongase 4 | -0.00594324 |
| KIAA0232 | KIAA0232 | -0.00593188 |
| PDGFD | platelet derived growth factor D | -0.00592529 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | -0.0059251 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.00591809 |
| PEG3 | paternally expressed 3 | -0.00591295 |
| C9ORF3 | chromosome 9 open reading frame 3 | -0.00591144 |
| PIGG | phosphatidylinositol glycan anchor biosynthesis, class G | -0.00589999 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00588433 |
| RYR1 | ryanodine receptor 1 (skeletal) | -0.00588379 |
| SLIT1 | slit homolog 1 (Drosophila) | -0.00588063 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.00587528 |
| TNNT3 | troponin T type 3 (skeletal, fast) | -0.00587324 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.0058728 |
| FGF9 | fibroblast growth factor 9 | -0.00587262 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.00585575 |
| PALLD | palladin, cytoskeletal associated protein | -0.00585262 |
| ISL1 | ISL LIM homeobox 1 | -0.00584971 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00584579 |
| CDC14B | cell division cycle 14B | -0.0058429 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00584194 |
| VDAC1 | voltage-dependent anion channel 1 | -0.00583444 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00582759 |
| NLGN4X | neuroligin 4, X-linked | -0.00582518 |
| AREG | amphiregulin | -0.00578526 |
| TGFA | transforming growth factor, alpha | -0.0057795 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.00577398 |
| B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | -0.00575359 |
| MAP1B | microtubule-associated protein 1B | -0.00574493 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.00573775 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00572125 |
| PFKM | phosphofructokinase, muscle | -0.00572105 |
| ZNF43 | zinc finger protein 43 | -0.0057185 |
| APOA1 | apolipoprotein A-I | -0.00571794 |
| STC1 | stanniocalcin 1 | -0.00569681 |
| SACS | sacsin molecular chaperone | -0.00569666 |
| NDRG4 | NDRG family member 4 | -0.00568942 |
| ACTN2 | actinin, alpha 2 | -0.00568399 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00566686 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.00566609 |
| ACD | adrenocortical dysplasia homolog (mouse) | -0.0056593 |
| SELENOW | selenoprotein W | -0.00565424 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00564719 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.00563607 |
| ZIC1 | Zic family member 1 | -0.00562247 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00561782 |
| NOTCH3 | notch 3 | -0.0056174 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00561158 |
| CA3 | carbonic anhydrase III | -0.00560485 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.00560343 |
| LRRC2 | leucine rich repeat containing 2 | -0.00560271 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0055881 |
| MMP3 | matrix metallopeptidase 3 | -0.00558582 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.00558385 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00557885 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00557316 |
| SGCE | sarcoglycan, epsilon | -0.00554118 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00552712 |
| HP | haptoglobin | -0.00552315 |
| CHRDL1 | chordin-like 1 | -0.0055068 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00550667 |
| JMJD1C | jumonji domain containing 1C | -0.00548509 |
| TSPAN8 | tetraspanin 8 | -0.00548439 |
| APOBEC2 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 | -0.00548106 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00547036 |
| CD1B | CD1b molecule | -0.0054623 |
| TMEM255A | transmembrane protein 255A | -0.00546079 |
| PPP2R2B | protein phosphatase 2, regulatory subunit B, beta | -0.00544906 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00544632 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.0054459 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.00544153 |
| ZNF331 | zinc finger protein 331 | -0.00543825 |
| MYOM1 | myomesin 1 | -0.00543109 |
| SH3BGR | SH3 domain binding glutamate-rich protein | -0.00541909 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.00541555 |
