| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | polycystic kidney disease 1 (autosomal dominant)|This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5310) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/5310 |
| Similar Terms | |
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34 interacting proteins for PKD1 from the Pathway Commons Protein-Protein Interactions dataset.
| Symbol | Name |
|---|---|
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase |
| ACTN1 | actinin, alpha 1 |
| ATF7IP | activating transcription factor 7 interacting protein |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide |
| BCAR1 | breast cancer anti-estrogen resistance 1 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) |
| COL1A1 | collagen, type I, alpha 1 |
| COL2A1 | collagen, type II, alpha 1 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa |
| DES | desmin |
| FN1 | fibronectin 1 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| HDAC9 | histone deacetylase 9 |
| JAK2 | Janus kinase 2 |
| JUP | junction plakoglobin |
| KRT18 | keratin 18, type I |
| KRT8 | keratin 8, type II |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 |
| NPHP1 | nephronophthisis 1 (juvenile) |
| NRF1 | nuclear respiratory factor 1 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha |
| PRKX | protein kinase, X-linked |
| PTK2 | protein tyrosine kinase 2 |
| PXN | paxillin |
| RGS7 | regulator of G-protein signaling 7 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase |
| TLN1 | talin 1 |
| UBC | ubiquitin C |
| VCL | vinculin |
| VIM | vimentin |
