PKIG Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein kinase (cAMP-dependent, catalytic) inhibitor gamma|This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 11142)
Similar Terms
Downloads & Tools

Genes

323 genes differentially expressed following the PKIG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FPR1 formyl peptide receptor 1 2.90051
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.90051
FAM110D family with sequence similarity 110, member D 2.90051
AVP arginine vasopressin 2.90051
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.90051
MAEL maelstrom spermatogenic transposon silencer 2.90051
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.90051
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.90051
CLDN22 claudin 22 2.90051
APOB apolipoprotein B 2.90051
IL5 interleukin 5 2.90051
TLR7 toll-like receptor 7 2.90051
GPR12 G protein-coupled receptor 12 2.90051
IL21R interleukin 21 receptor 2.90051
HIPK4 homeodomain interacting protein kinase 4 2.90051
NHLH1 nescient helix loop helix 1 2.90051
KCNRG potassium channel regulator 2.90051
CFAP52 cilia and flagella associated protein 52 2.90051
CD38 CD38 molecule 2.90051
ZNF324 zinc finger protein 324 2.90051
DRC1 dynein regulatory complex subunit 1 2.90051
TPTE transmembrane phosphatase with tensin homology 2.90051
PKP3 plakophilin 3 2.90051
PGAP2 post-GPI attachment to proteins 2 2.85869
ATG4A autophagy related 4A, cysteine peptidase 2.83658
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.83658
PITX3 paired-like homeodomain 3 2.83658
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.83658
LKAAEAR1 LKAAEAR motif containing 1 2.83658
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.83658
ZNF556 zinc finger protein 556 2.83658
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.83658
PSCA prostate stem cell antigen 2.83658
SBSN suprabasin 2.83658
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.83658
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.83658
MEIG1 meiosis/spermiogenesis associated 1 2.83658
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.83658
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.83658
PCDHGB5 protocadherin gamma subfamily B, 5 2.83658
CLCF1 cardiotrophin-like cytokine factor 1 2.83658
LEP leptin 2.83658
CORO6 coronin 6 2.83658
EPHB3 EPH receptor B3 2.83658
BTBD19 BTB (POZ) domain containing 19 2.83658
GJD3 gap junction protein, delta 3, 31.9kDa 2.83658
OVOL1 ovo-like zinc finger 1 2.83658
GRM6 glutamate receptor, metabotropic 6 2.83658
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.83658
MOGAT3 monoacylglycerol O-acyltransferase 3 2.83658
SPATA31A6 SPATA31 subfamily A, member 6 2.83658
CD19 CD19 molecule 2.83658
COLEC10 collectin sub-family member 10 (C-type lectin) 2.83658
ASB15 ankyrin repeat and SOCS box containing 15 2.83658
TMPRSS11F transmembrane protease, serine 11F 2.83658
GJA5 gap junction protein, alpha 5, 40kDa 2.83658
IL31RA interleukin 31 receptor A 2.83658
CD48 CD48 molecule 2.83658
SCARA5 scavenger receptor class A, member 5 2.83658
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.83658
ACTL10 actin-like 10 2.83658
GGTLC2 gamma-glutamyltransferase light chain 2 2.83658
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.83658
OASL 2'-5'-oligoadenylate synthetase-like 2.83658
WSCD2 WSC domain containing 2 2.83658
TMIE transmembrane inner ear 2.83658
IL22RA1 interleukin 22 receptor, alpha 1 2.83658
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.83658
CLEC19A C-type lectin domain family 19, member A 2.83658
UBA7 ubiquitin-like modifier activating enzyme 7 2.83658
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.83658
C1QL4 complement component 1, q subcomponent-like 4 2.83658
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.83658
RUNX3 runt-related transcription factor 3 2.83658
STRA8 stimulated by retinoic acid 8 2.83658
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 2.83658
SHCBP1L SHC SH2-domain binding protein 1-like 2.83658
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.83658
GDNF glial cell derived neurotrophic factor 2.83658
CEP295NL CEP295 N-terminal like 2.83658
PAX7 paired box 7 2.83658
CXCL14 chemokine (C-X-C motif) ligand 14 2.83658
FOXR1 forkhead box R1 2.83658
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.83658
C10ORF67 chromosome 10 open reading frame 67 2.83658
CLDN9 claudin 9 2.83658
RLN3 relaxin 3 2.83658
SLC36A3 solute carrier family 36, member 3 2.83658
NFILZ NFIL3 like basic leucine zipper 2.83658
SAMD9 sterile alpha motif domain containing 9 2.83658
ALKAL1 ALK and LTK ligand 1 2.83658
MINAR2 membrane integral NOTCH2 associated receptor 2 2.83658
GK3 glycerol kinase 3 2.83658
KLK3 kallikrein-related peptidase 3 2.83658
LOC124906892 uncharacterized LOC124906892 2.83658
KLK15 kallikrein-related peptidase 15 2.83658
ISL2 ISL LIM homeobox 2 2.83658
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.83658
BCO1 beta-carotene oxygenase 1 2.83658
ALOXE3 arachidonate lipoxygenase 3 2.83658
DRD1 dopamine receptor D1 2.83658
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.83658
CLEC4C C-type lectin domain family 4, member C 2.83658
GOLGA6L7 golgin A6 family like 7 2.83658
CDH10 cadherin 10, type 2 (T2-cadherin) 2.83658
BEAN1 brain expressed, associated with NEDD4, 1 2.83658
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.83658
CFP complement factor properdin 2.83658
CIMAP1C ciliary microtubule associated protein 1C 2.83658
H3C14 H3 clustered histone 14 2.83658
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.83658
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.83658
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.83658
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.83658
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.83658
QRFP pyroglutamylated RFamide peptide 2.83658
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.83658
SLC38A3 solute carrier family 38, member 3 2.83658
GSG1L2 GSG1 like 2 2.83658
CTSF cathepsin F 2.83658
DMRT1 doublesex and mab-3 related transcription factor 1 2.83658
PLD6 phospholipase D family, member 6 2.83658
MAJIN membrane anchored junction protein 2.83658
GLO1 glyoxalase I 2.83658
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.83658
CD53 CD53 molecule 2.83658
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.83658
TSPAN32 tetraspanin 32 2.83658
CALML5 calmodulin-like 5 2.83658
NDP Norrie disease (pseudoglioma) 2.83658
STMND1 stathmin domain containing 1 2.83658
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.83658
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.83658
AMER2 APC membrane recruitment protein 2 2.83658
RNF183 ring finger protein 183 2.83658
RERGL RERG/RAS-like 2.83658
TMEM86A transmembrane protein 86A 2.83658
CD8A CD8a molecule 2.83658
PRG4 proteoglycan 4 2.83658
TEX36 testis expressed 36 2.83658
EIF3E eukaryotic translation initiation factor 3, subunit E 2.83658
MTMR11 myotubularin related protein 11 2.83658
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.83658
LEKR1 leucine, glutamate and lysine rich 1 2.83658
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.83658
AKNAD1 AKNA domain containing 1 2.83658
OAZ3 ornithine decarboxylase antizyme 3 2.83658
MCHR2 melanin-concentrating hormone receptor 2 2.83658
WFDC1 WAP four-disulfide core domain 1 2.83658
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.83658
LTB4R2 leukotriene B4 receptor 2 2.83658
NOX1 NADPH oxidase 1 2.83658
ADGRG7 adhesion G protein-coupled receptor G7 2.83658
SIM1 single-minded family bHLH transcription factor 1 2.83658
C11ORF91 chromosome 11 open reading frame 91 2.83658
C15ORF62 chromosome 15 open reading frame 62 2.83658
CCDC152 coiled-coil domain containing 152 2.83658
FCMR Fc fragment of IgM receptor 2.83658
RSAD2 radical S-adenosyl methionine domain containing 2 2.83658
BRDT bromodomain, testis-specific 2.83658
CST1 cystatin SN 2.83658
POF1B premature ovarian failure, 1B 2.83658
UBALD1 UBA-like domain containing 1 2.82193
NDFIP1 Nedd4 family interacting protein 1 2.81492
SNX13 sorting nexin 13 2.76801
FAM222A family with sequence similarity 222, member A 2.75197
CDC37L1 cell division cycle 37-like 1 2.75197
GDF5 growth differentiation factor 5 2.75197
CBR4 carbonyl reductase 4 2.73716
TYMS thymidylate synthetase 2.67797
OCEL1 occludin/ELL domain containing 1 2.67747
H2BC5 H2B clustered histone 5 2.6242
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 2.61325
HHLA1 HERV-H LTR-associating 1 2.54179
MED16 mediator complex subunit 16 2.48155
FNDC7 fibronectin type III domain containing 7 2.47825
RNF222 ring finger protein 222 2.46146
DCLK2 doublecortin-like kinase 2 2.46146
CYSRT1 cysteine-rich tail protein 1 2.46146
TRIM68 tripartite motif containing 68 2.4515
TMEM47 transmembrane protein 47 2.44815
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.43006
APOD apolipoprotein D 2.3951
MYL5 myosin, light chain 5, regulatory 2.3951
TSPOAP1 TSPO associated protein 1 2.39467
PFDN1 prefoldin subunit 1 2.37401
ZFPM2 zinc finger protein, FOG family member 2 2.33984
CDCA8 cell division cycle associated 8 2.33984
ABHD3 abhydrolase domain containing 3 2.3347
KDM2A lysine (K)-specific demethylase 2A 2.33131
VCAN versican 2.32938
STXBP6 syntaxin binding protein 6 (amisyn) 2.32434
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 2.3042
COA8 cytochrome c oxidase assembly factor 8 2.28794
H3C10 H3 clustered histone 10 2.26049
PSENEN presenilin enhancer gamma secretase subunit 2.25871
ATP5MG ATP synthase membrane subunit g 2.24243
GARIN5A golgi associated RAB2 interactor 5A 2.23171
PLS1 plastin 1 2.22134
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2.20984
ANGEL1 angel homolog 1 (Drosophila) 2.19171
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.17155
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 2.15213
CCT2 chaperonin containing TCP1, subunit 2 (beta) 2.15213
GLCE glucuronic acid epimerase 2.13801
SEC11C SEC11 homolog C (S. cerevisiae) 2.13801
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 2.12809
STK26 serine/threonine protein kinase 26 2.12604
EIF6 eukaryotic translation initiation factor 6 2.12369
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.12272
KCNK6 potassium channel, two pore domain subfamily K, member 6 2.11974
GLB1L3 galactosidase, beta 1-like 3 2.11974
CCNC cyclin C 2.11958
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.0852
LUC7L LUC7-like (S. cerevisiae) 2.07299
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.0696
CNMD chondromodulin 2.06044
TMEM141 transmembrane protein 141 2.05856
ANGPT2 angiopoietin 2 2.05207
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.03388
RAD9A RAD9 homolog A (S. pombe) 2.03265
FOXM1 forkhead box M1 2.0209
OSBP2 oxysterol binding protein 2 2.0209
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.0209
XKR4 XK, Kell blood group complex subunit-related family, member 4 2.01163
ASCC3 activating signal cointegrator 1 complex subunit 3 2.00616
H2BC17 H2B clustered histone 17 2.00143
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2.00143

decreased expression

Symbol Name Standardized Value
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit -2.90051
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.90051
INAFM1 InaF-motif containing 1 -2.90051
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -2.85869
ZNF784 zinc finger protein 784 -2.85869
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.85869
COL11A2 collagen, type XI, alpha 2 -2.85869
ADI1 acireductone dioxygenase 1 -2.85869
PCGF1 polycomb group ring finger 1 -2.85869
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 -2.85869
MOK MOK protein kinase -2.85869
TMEM171 transmembrane protein 171 -2.85869
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.85869
VAT1 vesicle amine transport 1 -2.83658
RAD51AP1 RAD51 associated protein 1 -2.83658
DENND1A DENN/MADD domain containing 1A -2.83658
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -2.83658
FBXO41 F-box protein 41 -2.83658
KIF2C kinesin family member 2C -2.83014
SMIM20 small integral membrane protein 20 -2.76801
TMEM278 transmembrane protein 278 -2.75197
LINC02798 long intergenic non-protein coding RNA 2798 -2.75197
SLC22A31 solute carrier family 22, member 31 -2.75197
GJA4 gap junction protein, alpha 4, 37kDa -2.75197
IDNK idnK, gluconokinase homolog (E. coli) -2.75197
RDH16 retinol dehydrogenase 16 (all-trans) -2.75197
PYGM phosphorylase, glycogen, muscle -2.75197
NOTO notochord homeobox -2.75197
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.75197
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.75197
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.75197
EPPIN epididymal peptidase inhibitor -2.75197
SH2D5 SH2 domain containing 5 -2.75197
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 -2.75197
SNPH syntaphilin -2.75197
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.75197
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.75197
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.75197
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 -2.75197
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -2.75197
RRH retinal pigment epithelium-derived rhodopsin homolog -2.75197
DYNAP dynactin associated protein -2.75197
DCDC2B doublecortin domain containing 2B -2.75197
PCDHA13 protocadherin alpha 13 -2.75197
CCDC121 coiled-coil domain containing 121 -2.75197
ZNF750 zinc finger protein 750 -2.75197
LMOD1 leiomodin 1 (smooth muscle) -2.75197
GRAPL GRB2-related adaptor protein-like -2.75197
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.75197
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.75197
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.72974
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.69461
TSPAN2 tetraspanin 2 -2.68453
DCPH1 damage control phosphatase 1 -2.55745
LPAR4 lysophosphatidic acid receptor 4 -2.55486
KLHL9 kelch-like family member 9 -2.47825
KLHL21 kelch-like family member 21 -2.46146
ZNF146 zinc finger protein 146 -2.45977
DGKE diacylglycerol kinase, epsilon 64kDa -2.39924
EIF3C eukaryotic translation initiation factor 3, subunit C -2.35255
CLUH clustered mitochondria (cluA/CLU1) homolog -2.33984
WASF1 WAS protein family, member 1 -2.33984
INCENP inner centromere protein antigens 135/155kDa -2.32963
ANXA11 annexin A11 -2.31553
SLFN13 schlafen family member 13 -2.30763
MOB2 MOB kinase activator 2 -2.29934
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.23776
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -2.23598
FAM161A family with sequence similarity 161, member A -2.2322
DAGLA diacylglycerol lipase, alpha -2.23171
LRRC34 leucine rich repeat containing 34 -2.23171
SPATA21 spermatogenesis associated 21 -2.23171
C1QTNF6 C1q and tumor necrosis factor related protein 6 -2.23171
PRSS53 protease, serine, 53 -2.19735
DZIP3 DAZ interacting zinc finger protein 3 -2.17511
ECT2 epithelial cell transforming 2 -2.15993
COX5A cytochrome c oxidase subunit Va -2.15833
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.15183
C16ORF96 chromosome 16 open reading frame 96 -2.15092
AHCTF1 AT hook containing transcription factor 1 -2.14778
CEP70 centrosomal protein 70kDa -2.1444
GUSB glucuronidase, beta -2.12965
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.12809
PROSER3 proline and serine rich 3 -2.12604
CD37 CD37 molecule -2.11974
HAP1 huntingtin-associated protein 1 -2.11974
SETX senataxin -2.1006
H2BC26 H2B clustered histone 26 -2.06203
FBXO9 F-box protein 9 -2.03388
COMMD7 COMM domain containing 7 -2.03265
WBP4 WW domain binding protein 4 -2.0209
NUP93 nucleoporin 93kDa -2.0209
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -2.0209
RAB5A RAB5A, member RAS oncogene family -2.01877
BSDC1 BSD domain containing 1 -2.00807