PKR Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description eukaryotic translation initiation factor 2-alpha kinase 2|The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 5610)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase PKR from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
TJP2 tight junction protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
SACK1H scaffolding CK1 anchoring protein H
NPM3 nucleophosmin/nucleoplasmin 3
EGFR epidermal growth factor receptor
TNRC6B trinucleotide repeat containing 6B
FGD3 FYVE, RhoGEF and PH domain containing 3
VTN vitronectin
PLEK pleckstrin
ELF1 E74-like factor 1 (ets domain transcription factor)
NCF4 neutrophil cytosolic factor 4, 40kDa
APTX aprataxin
ORAI1 ORAI calcium release-activated calcium modulator 1
TRA2B transformer 2 beta homolog (Drosophila)
IRS4 insulin receptor substrate 4
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
SCAF1 SR-related CTD-associated factor 1
ALYREF Aly/REF export factor
VRK1 vaccinia related kinase 1
VRK2 vaccinia related kinase 2
CCDC85C coiled-coil domain containing 85C
CORO1A coronin, actin binding protein, 1A
ACIN1 apoptotic chromatin condensation inducer 1
HABP4 hyaluronan binding protein 4
SRSF4 serine/arginine-rich splicing factor 4
MSX2 msh homeobox 2
NHSL1 NHS-like 1
EAPP E2F-associated phosphoprotein
CDKN2A cyclin-dependent kinase inhibitor 2A
FRK fyn-related Src family tyrosine kinase
SFPQ splicing factor proline/glutamine-rich
SELL selectin L
MYH9 myosin, heavy chain 9, non-muscle
CLDN18 claudin 18
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ANKHD1 ankyrin repeat and KH domain containing 1
PA2G4 proliferation-associated 2G4, 38kDa
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
SRSF7 serine/arginine-rich splicing factor 7
SRSF2 serine/arginine-rich splicing factor 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
AKAP5 A kinase (PRKA) anchor protein 5
DOT1L DOT1-like histone H3K79 methyltransferase
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
RPS14 ribosomal protein S14
TUBA3E tubulin, alpha 3e
TUBA3D tubulin, alpha 3d
PTGDR2 prostaglandin D2 receptor 2
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
KDM1A lysine (K)-specific demethylase 1A
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
DRD2 dopamine receptor D2
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
PRM2 protamine 2
HOOK2 hook microtubule-tethering protein 2
DKC1 dyskeratosis congenita 1, dyskerin
DAPK3 death-associated protein kinase 3
STK10 serine/threonine kinase 10
PNP purine nucleoside phosphorylase
SRRM2 serine/arginine repetitive matrix 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
CARHSP1 calcium regulated heat stable protein 1, 24kDa
FHOD1 formin homology 2 domain containing 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
DONSON downstream neighbor of SON
WDR11 WD repeat domain 11
TUBA1C tubulin, alpha 1c
TUBA1B tubulin, alpha 1b
TUBA1A tubulin, alpha 1a
CYTH3 cytohesin 3
CYTH2 cytohesin 2
CDCA2 cell division cycle associated 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
NPAT nuclear protein, ataxia-telangiectasia locus
LTB4R leukotriene B4 receptor
FXYD1 FXYD domain containing ion transport regulator 1
NUMA1 nuclear mitotic apparatus protein 1
FTSJ3 FtsJ homolog 3 (E. coli)
MYL9 myosin, light chain 9, regulatory
CHD1L chromodomain helicase DNA binding protein 1-like
CHD1 chromodomain helicase DNA binding protein 1
IL2RA interleukin 2 receptor, alpha
PLK1 polo-like kinase 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
KCNK12 potassium channel, two pore domain subfamily K, member 12
BRAF B-Raf proto-oncogene, serine/threonine kinase
LMNA lamin A/C
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
MEPCE methylphosphate capping enzyme
PDCD11 programmed cell death 11
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
LIMK2 LIM domain kinase 2
DLG1 discs, large homolog 1 (Drosophila)
TGM1 transglutaminase 1
TMEM217 transmembrane protein 217