PLAGL1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description pleiomorphic adenoma gene-like 1|This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 5325)
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Genes

328 genes differentially expressed following the PLAGL1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZACN zinc activated ligand-gated ion channel 3.0719
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.0719
CEP295NL CEP295 N-terminal like 3.0719
ASB10 ankyrin repeat and SOCS box containing 10 3.0719
SLC39A2 solute carrier family 39 (zinc transporter), member 2 3.0719
UNC45B unc-45 homolog B (C. elegans) 3.0719
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.0719
BAAT bile acid CoA:amino acid N-acyltransferase 3.0719
TDRD9 tudor domain containing 9 3.0719
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.0719
OLIG3 oligodendrocyte transcription factor 3 3.0719
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 3.0719
GJB1 gap junction protein, beta 1, 32kDa 3.0719
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.0719
SCGN secretagogin, EF-hand calcium binding protein 3.0719
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.0719
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.0719
CTRC chymotrypsin C (caldecrin) 3.0719
MAGEA2 melanoma antigen family A2 3.0719
IQCJ IQ motif containing J 3.0719
SGPP2 sphingosine-1-phosphate phosphatase 2 3.0719
WT1 Wilms tumor 1 3.0719
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.0719
TMEM71 transmembrane protein 71 3.0719
UMODL1 uromodulin-like 1 3.0719
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.0719
EMCN endomucin 3.0719
FGF6 fibroblast growth factor 6 3.0719
R3HDML R3H domain containing-like 3.0719
ABRA actin binding Rho activating protein 3.0719
PITX3 paired-like homeodomain 3 3.0719
NLRP6 NLR family, pyrin domain containing 6 3.0719
LPA lipoprotein, Lp(a) 3.0719
ZNF648 zinc finger protein 648 3.0719
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.0719
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 3.0719
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.0719
GNRH2 gonadotropin-releasing hormone 2 3.0719
LRRC63 leucine rich repeat containing 63 3.0719
PTK6 protein tyrosine kinase 6 3.0719
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.0719
FAM216B family with sequence similarity 216, member B 3.0719
TAS2R13 taste receptor, type 2, member 13 3.0719
TAS2R19 taste receptor, type 2, member 19 3.0719
AVP arginine vasopressin 3.0719
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.0719
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.0719
CST11 cystatin 11 3.0719
SAXO4 stabilizer of axonemal microtubules 4 3.0719
STYXL2 serine/threonine/tyrosine interacting like 2 3.0719
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.0719
ALDOB aldolase B, fructose-bisphosphate 3.0719
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.0719
GBP1 guanylate binding protein 1, interferon-inducible 3.0719
TYROBP TYRO protein tyrosine kinase binding protein 3.0719
ADGRG3 adhesion G protein-coupled receptor G3 3.0719
KRT86 keratin 86, type II 3.0719
SRGN serglycin 3.0719
H1-6 H1.6 linker histone, cluster member 3.0719
SMIM38 small integral membrane protein 38 3.0719
TOMT transmembrane O-methyltransferase 3.0719
PRRT1B proline rich transmembrane protein 1B 3.0719
C17ORF113 chromosome 17 open reading frame 113 3.0719
ZNF593OS ZNF593 opposite strand 3.0719
LHFPL7 LHFPL tetraspan subfamily member 7 3.0719
CIBAR2 CBY1 interacting BAR domain containing 2 3.0719
MEIOSIN meiosis initiator 3.0719
TEX55 testis expressed 55 3.0719
TAFA3 TAFA chemokine like family member 3 3.0719
CALHM5 calcium homeostasis modulator family member 5 3.0719
TMPRSS3 transmembrane protease, serine 3 3.0719
TFF2 trefoil factor 2 3.0719
MAGIX MAGI family member, X-linked 3.0719
IRF2-DT IRF2 divergent transcript 3.0719
TRIM60 tripartite motif containing 60 3.0719
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.0719
OR2A7 olfactory receptor, family 2, subfamily A, member 7 3.0719
PVRIG poliovirus receptor related immunoglobulin domain containing 3.0719
SLC22A14 solute carrier family 22, member 14 3.0719
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.0719
WEE2 WEE1 homolog 2 (S. pombe) 3.0719
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.0719
IL31RA interleukin 31 receptor A 3.0719
NPIPB9 nuclear pore complex interacting protein family, member B9 3.0719
IL6 interleukin 6 3.0719
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.0719
GATA3 GATA binding protein 3 3.0719
GATA5 GATA binding protein 5 3.0719
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.0719
RNF183 ring finger protein 183 3.0719
BEST3 bestrophin 3 3.0719
LGSN lengsin, lens protein with glutamine synthetase domain 3.0719
SAMD15 sterile alpha motif domain containing 15 3.0719
PGA4 pepsinogen 4, group I (pepsinogen A) 3.0719
SLFN11 schlafen family member 11 3.0719
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.0719
IL1A interleukin 1, alpha 3.0719
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.0719
CDHR5 cadherin-related family member 5 3.0719
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.0719
CPSF4L cleavage and polyadenylation specific factor 4-like 3.0719
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 3.0719
LMOD3 leiomodin 3 (fetal) 3.0719
EFCAB3 EF-hand calcium binding domain 3 3.0719
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.0719
CST7 cystatin F (leukocystatin) 3.0719
PDCD1LG2 programmed cell death 1 ligand 2 3.0719
SIGLEC15 sialic acid binding Ig-like lectin 15 3.0719
NIM1K NIM1 serine/threonine protein kinase 3.0719
CRHBP corticotropin releasing hormone binding protein 3.0719
VAV1 vav 1 guanine nucleotide exchange factor 3.0719
DLX3 distal-less homeobox 3 3.0719
ZSCAN4 zinc finger and SCAN domain containing 4 3.0719
TIGD3 tigger transposable element derived 3 3.0719
SEBOX SEBOX homeobox 3.0719
PCDH12 protocadherin 12 3.0719
LMOD2 leiomodin 2 (cardiac) 3.0719
RGCC regulator of cell cycle 3.0719
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 3.0719
TTC9B tetratricopeptide repeat domain 9B 3.0719
ZFP92 ZFP92 zinc finger protein 3.0719
FAM209B family with sequence similarity 209, member B 3.0719
EMP1 epithelial membrane protein 1 3.0719
TTC16 tetratricopeptide repeat domain 16 3.0719
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.0719
TRIM50 tripartite motif containing 50 3.0719
C8G complement component 8, gamma polypeptide 3.0719
CPA2 carboxypeptidase A2 (pancreatic) 3.0719
PRR33 proline rich 33 3.0719
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.0719
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.0719
NT5C1B 5'-nucleotidase, cytosolic IB 3.0719
PCDHGB4 protocadherin gamma subfamily B, 4 3.0719
C5AR2 complement component 5a receptor 2 3.0719
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.0719
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.0719
IFITM10 interferon induced transmembrane protein 10 3.0719
CNR2 cannabinoid receptor 2 (macrophage) 3.0719
BCL2A1 BCL2-related protein A1 3.0719
C22ORF31 chromosome 22 open reading frame 31 3.0719
CPTP ceramide-1-phosphate transfer protein 3.0719
APOL1 apolipoprotein L, 1 3.0719
ADAM29 ADAM metallopeptidase domain 29 3.0719
SDSL serine dehydratase-like 3.0719
TMPRSS15 transmembrane protease, serine 15 3.0719
TEX35 testis expressed 35 3.0719
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.0719
ITLN1 intelectin 1 (galactofuranose binding) 3.0719
ALOX15B arachidonate 15-lipoxygenase, type B 3.0719
CLCA1 chloride channel accessory 1 3.0719
AQP8 aquaporin 8 3.0719
RGS8 regulator of G-protein signaling 8 3.0719
LYPD5 LY6/PLAUR domain containing 5 3.0719
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.0719
PRSS57 protease, serine, 57 3.0719
PCDHAC2 protocadherin alpha subfamily C, 2 3.0719
CPN2 carboxypeptidase N, polypeptide 2 3.0719
CALML6 calmodulin-like 6 3.0719
MAPK11 mitogen-activated protein kinase 11 3.0719
UBXN10 UBX domain protein 10 3.05425
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.05425
TM7SF3 transmembrane 7 superfamily member 3 3.03109
INHA inhibin, alpha 3.00259
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.65008
MROH1 maestro heat-like repeat family member 1 2.62729
FAM114A2 family with sequence similarity 114, member A2 2.57534
PARP9 poly (ADP-ribose) polymerase family, member 9 2.55725
UBE3B ubiquitin protein ligase E3B 2.55575
CCDC7 coiled-coil domain containing 7 2.54508
PF4 platelet factor 4 2.4962
ARB2A ARB2 cotranscriptional regulator A 2.4373
MRPS12 mitochondrial ribosomal protein S12 2.42827
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 2.42661
PTCH1 patched 1 2.41634
OTOF otoferlin 2.41431
SHISAL2A shisa like 2A 2.41431
COCH cochlin 2.41121
MTARC2 mitochondrial amidoxime reducing component 2 2.4062
MSX1 msh homeobox 1 2.36408
ZDHHC8 zinc finger, DHHC-type containing 8 2.34846
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.33955
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.33175
ZC2HC1B zinc finger, C2HC-type containing 1B 2.33175
SHBG sex hormone-binding globulin 2.33175
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.33175
ZNF791 zinc finger protein 791 2.33175
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.33175
IGSF21 immunoglobin superfamily, member 21 2.3304
LCA5L Leber congenital amaurosis 5-like 2.3214
ADGRB3 adhesion G protein-coupled receptor B3 2.27427
CRLF1 cytokine receptor-like factor 1 2.26117
C19ORF12 chromosome 19 open reading frame 12 2.26117
RAB11FIP4 RAB11 family interacting protein 4 (class II) 2.24957
H3C10 H3 clustered histone 10 2.21675
BRD9 bromodomain containing 9 2.18188
SMAD7 SMAD family member 7 2.16505
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.15325
UBE2J2 ubiquitin-conjugating enzyme E2, J2 2.14195
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 2.13252
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.1226
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.12097
ADA2 adenosine deaminase 2 2.11344
RPP25L ribonuclease P/MRP 25kDa subunit-like 2.10313
KIF24 kinesin family member 24 2.10313
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2.08959
LRRC4C leucine rich repeat containing 4C 2.08641
LGI4 leucine-rich repeat LGI family, member 4 2.06285
ACAD10 acyl-CoA dehydrogenase family, member 10 2.06155
PRSS50 protease, serine, 50 2.06155
KLF15 Kruppel-like factor 15 2.06155
CD38 CD38 molecule 2.06155
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.06155
SPDYE17 speedy/RINGO cell cycle regulator family member E17 2.06155
SPATA5L1 spermatogenesis associated 5-like 1 2.06155
IFT74 intraflagellar transport 74 2.06155
SRA1 steroid receptor RNA activator 1 2.06155
OLFML1 olfactomedin-like 1 2.06155
MASP2 mannan-binding lectin serine peptidase 2 2.06155
DAND5 DAN domain family member 5, BMP antagonist 2.06155
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa 2.05641
APLP1 amyloid beta (A4) precursor-like protein 1 2.05544
TCEAL3 transcription elongation factor A (SII)-like 3 2.04769
CHMP5 charged multivesicular body protein 5 2.03199
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 2.01894
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.01894
EBNA1BP2 EBNA1 binding protein 2 2.01502
FGFR4 fibroblast growth factor receptor 4 2.01492
IPP intracisternal A particle-promoted polypeptide 2.01352
SERGEF secretion regulating guanine nucleotide exchange factor 2.01129
NPC1 Niemann-Pick disease, type C1 2.00588
TMEM9 transmembrane protein 9 2.00342

decreased expression

Symbol Name Standardized Value
LOC124903233 uncharacterized LOC124903233 -3.0719
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -3.0719
LRRC10B leucine rich repeat containing 10B -3.0719
PSD2 pleckstrin and Sec7 domain containing 2 -3.0719
ADAM21 ADAM metallopeptidase domain 21 -3.0719
RBM8A RNA binding motif protein 8A -3.0719
DUSP26 dual specificity phosphatase 26 (putative) -3.0719
TCEA3 transcription elongation factor A (SII), 3 -3.0719
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -3.0719
STK31 serine/threonine kinase 31 -3.0719
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -3.0719
NEU4 sialidase 4 -3.0719
H3C13 H3 clustered histone 13 -3.0719
CFAP206 cilia and flagella associated protein 206 -3.0719
LOC112694756 uncharaterized LOC112694756 -3.0719
PHETA1 PH domain containing endocytic trafficking adaptor 1 -3.0719
RASD2 RASD family, member 2 -3.0719
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.0719
TMEM191C transmembrane protein 191C -3.0719
NFAM1 NFAT activating protein with ITAM motif 1 -3.0719
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -3.0719
TEX11 testis expressed 11 -3.0719
TEKT2 tektin 2 (testicular) -3.0719
TMEM50B transmembrane protein 50B -3.0719
PFN4 profilin family, member 4 -3.0719
SCNN1B sodium channel, non voltage gated 1 beta subunit -3.0719
HLA-G major histocompatibility complex, class I, G -3.0719
GPR146 G protein-coupled receptor 146 -3.0719
PLA2G5 phospholipase A2, group V -3.0719
RAD9B RAD9 homolog B (S. pombe) -3.0719
CDC73 cell division cycle 73 -2.91494
TNK1 tyrosine kinase, non-receptor, 1 -2.83047
VWA8 von Willebrand factor A domain containing 8 -2.73783
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -2.67503
MBLAC1 metallo-beta-lactamase domain containing 1 -2.64675
TLE2 transducin-like enhancer of split 2 -2.62905
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.61177
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.57749
ZNF587B zinc finger protein 587B -2.55275
DIABLO diablo, IAP-binding mitochondrial protein -2.5307
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.5261
ARMC7 armadillo repeat containing 7 -2.47176
GIPR gastric inhibitory polypeptide receptor -2.46126
TMEM229B transmembrane protein 229B -2.46126
WASHC5 WASH complex subunit 5 -2.41634
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 -2.41431
MRPL20 mitochondrial ribosomal protein L20 -2.41431
RPL37A ribosomal protein L37a -2.40111
RAD54B RAD54 homolog B (S. cerevisiae) -2.38963
NCAPD2 non-SMC condensin I complex, subunit D2 -2.3857
MRPL23 mitochondrial ribosomal protein L23 -2.38294
ARHGAP22 Rho GTPase activating protein 22 -2.37723
NDE1 nudE neurodevelopment protein 1 -2.36823
YJEFN3 YjeF N-terminal domain containing 3 -2.33175
KRTAP5-11 keratin associated protein 5-11 -2.33175
C17ORF75 chromosome 17 open reading frame 75 -2.33175
TMEM233 transmembrane protein 233 -2.33175
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) -2.3304
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.3304
LINC02762 long intergenic non-protein coding RNA 2762 -2.3304
NSF N-ethylmaleimide-sensitive factor -2.27346
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.25846
SORBS2 sorbin and SH3 domain containing 2 -2.22953
LCMT1 leucine carboxyl methyltransferase 1 -2.22727
CD59 CD59 molecule, complement regulatory protein -2.21931
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.20244
SGMS2 sphingomyelin synthase 2 -2.20244
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.20244
PSRC1 proline/serine-rich coiled-coil 1 -2.1999
SNRPA small nuclear ribonucleoprotein polypeptide A -2.17885
TRAPPC6A trafficking protein particle complex 6A -2.16505
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.16505
TCL1A T-cell leukemia/lymphoma 1A -2.15418
QTGAL queuosine-tRNA galactosyltransferase -2.14195
YY1 YY1 transcription factor -2.10517
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.0978
LRRC28 leucine rich repeat containing 28 -2.09385
BTG1 B-cell translocation gene 1, anti-proliferative -2.08871
GCHFR GTP cyclohydrolase I feedback regulator -2.08641
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.06981
ANG angiogenin, ribonuclease, RNase A family, 5 -2.06285
ADAM23 ADAM metallopeptidase domain 23 -2.06155
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.06155
ESRRG estrogen-related receptor gamma -2.06155
CLIC4 chloride intracellular channel 4 -2.06155
RACGAP1 Rac GTPase activating protein 1 -2.06155
LYST lysosomal trafficking regulator -2.04479
RNFT1 ring finger protein, transmembrane 1 -2.04479
BBS5 Bardet-Biedl syndrome 5 -2.04479
CD63 CD63 molecule -2.039
EMC7 ER membrane protein complex subunit 7 -2.01516
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.01502
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -2.01492
PLCD3 phospholipase C, delta 3 -2.01378
GRK5 G protein-coupled receptor kinase 5 -2.00932
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -2.00557
DICER1 dicer 1, ribonuclease type III -2.00378